Arizona Cardinals quarterback Jacoby Brissett played his way into the NFL record books for most completions in a regular-season game (47) during Week 11 against the San Francisco 49ers. After a historic performance, the 32-year-old veteran enters Week 12 as RotoBaller's 10th overall-ranked quarterback in a favorable matchup against the Jacksonville Jaguars at home. The Jaguars' defense has allowed the 10th-most passing yards, the fifth-most passing touchdowns, and recorded the third-fewest sacks this season. He should have plenty of time in the pocket to pick apart a vulnerable Jaguars secondary and continue stuffing the stat sheet. Since taking over the offense, Brissett has averaged over 40 passing attempts per game and has taken the Cardinals' passing game to the next level. Brissett should be comfortably inserted into lineups as a QB1 playing in a high-volume passing attack against a struggling defense.

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San Francisco 49ers running back Brian Robinson Jr.'s recent surge in production hit a snag in Week 11, but he could bounce back against a Carolina Panthers defense that has struggled against the run lately. In Weeks 9 and 10, Robinson scored touchdowns and posted his two highest rushing yard totals of 2025. He fell back to earth in Week 11, though, gaining 24 yards on eight carries in the 49ers' rout of the Cardinals. Despite his minimal role behind Christian McCaffrey, Robinson stands to benefit from the 49ers' upcoming matchup against the Panthers. Over the last four weeks, Carolina has given up 5.23 yards per carry to opposing running backs and the fourth-most fantasy points per game to the position. Robinson projects as an RB4 in Week 12 and has flex potential for fantasy football managers in a bind with four NFL teams on bye.

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San Francisco 49ers wide receiver Ricky Pearsall's (knee) returned to action in Week 11 after a six-week absence due to a knee injury sustained in Week 4. Unfortunately, the second-year wideout had just one catch for no gain on two targets in the 49ers' 41-22 trouncing of the Cardinals. On the positive side, Pearsall's knee injury appears to be in the rearview. Pearsall had a 75% snap share in Week 11 and logged a full practice on Thursday and Friday ahead of the 49ers' upcoming game against the Carolina Panthers. Fantasy football managers are advised to keep an eye out for the 49ers' final injury report, which will be due out Saturday as the team plays on Monday night. Barring any sort of reinjury in his final practice of the week, Pearsall projects as a WR3 and can be plugged into starting lineups for Week 12.

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San Francisco 49ers quarterback Brock Purdy (toe) put forth a solid effort in his return to action in Week 11 after missing the previous six games. In what was just his third start of the season, Purdy threw for just 200 yards but did so with a tidy 73.1% completion percentage and completed three touchdown passes with no turnovers. Purdy finished as the overall QB6 in the 49ers' win over the Cardinals and will be in the mix for another top-10 performance when San Francisco squares off against the Carolina Panthers on Monday night in Week 12. The Panthers rank in the bottom five in the league in sack rate and pressure rate, so Purdy should have plenty of time to pick apart their secondary, which has allowed the sixth-most passing yards over the last four weeks. Fantasy football managers can plug Purdy into starting lineups with confidence in Week 12.

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San Francisco 49ers running back Christian McCaffrey was the overall RB1 in Week 11, his third such finish in the last five weeks and his tenth top-10 finish in 2025. McCaffrey is in a good spot to attempt a repeat against the Carolina Panthers on Monday night. Much of McCaffrey's production in 2025 has come as a pass-catcher, but with Carolina offering up 4.72 yards per carry to opposing running backs this season, there is reason to believe he will do more damage on the ground than usual in Week 12. Carolina has been especially bad over the last four weeks, giving up a league-worst six rushing touchdowns and the fourth-most fantasy points per game to running backs. It goes without saying that McCaffrey should be in starting lineups in Week 12, but fantasy football managers are justified in feeling especially optimistic about what the superstar will produce in his first game against his former team.

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New England Patriots running back Rhamondre Stevenson has been removed from the injury report after a toe injury sidelined him for three consecutive games. He'll return to action this Sunday against the Cincinnati Bengals, presumably without any limitations. This week's backfield dynamic in New England is a little unclear. Stevenson held the lead-back role when healthy, but rookie TreVeyon Henderson looked excellent in his three-week stint as the starter. We expect to see Henderson remain heavily involved this weekend, and he even has a strong chance to lead the backfield in snaps. Nevertheless, the coaching staff has shown its commitment to Stevenson time and time again, which means we should expect him to handle healthy volume in his return to play. He's averaging 12.4 touches per game this season, and even if that number drops a little in Week 12, he's still a solid RB3/flex option. It also helps that he's facing off against a Bengals defense allowing the most fantasy points and second-most receiving yards to opposing running backs in 2025.

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New England Patriots running back TreVeyon Henderson looked terrific as the team's lead back over the last few weeks, but the coaching staff refused to commit to him as their top option out of the backfield for Week 12 against the Cincinnati Bengals. Henderson's increased role was a result of Rhamondre Stevenson (toe) missing time, but now that Stevenson has been removed from the injury report, we expect the backfield dynamic to look a little different. While we expected Henderson to lose some volume when Stevenson came back, we'd be a little surprised to see the rookie lose his lead-back role after he tallied 264 rushing yards, 66 receiving yards, and five touchdowns over the last three games. Nevertheless, head coach Mike Vrabel wouldn't name Henderson the starter. Don't be surprised if Stevenson remains a thorn in Henderson's fantasy managers' sides once again this week. The rookie has RB1 upside, but he ranks as more of an RB2 with Stevenson back in the mix.

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New England Patriots quarterback Drake Maye should bounce back as a high-end fantasy QB1 for Sunday's Week 12 contest against the Cincinnati Bengals. The former No. 3 pick delivered a modest 281 yards and one touchdown last week, falling shy of his high-end QB1 upside. He should get back to that tier this week, though, as the Bengals have allowed the fifth-most fantasy points to opposing quarterbacks in 2025, as well as the third-most passing touchdowns. In addition to Maye getting a favorable matchup, he'll also benefit from the return of two key targets. Both Kayshon Boutte (hamstring) and Rhamondre Stevenson (toe) have been removed from the injury report and will return following their multi-game absences. Maye is the overall QB2 in fantasy scoring this season, and he's well on his way to a phenomenal MVP candidacy. He should be started in all fantasy leagues as he takes on the Bengals.

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Detroit Lions running back David Montgomery was held in check by the Philadelphia Eagles in Week 11, recording 27 rushing yards on just six carries. Montgomery has now failed to score a touchdown in four out of his last five games, cracking 45 rushing yards just once in that span. While there's no question Montgomery has taken a backseat to Lions running back Jahmyr Gibbs this season, there could be reason for optimism around Montgomery's outlook for Week 12 against the New York Giants. Through 11 weeks, New York is allowing the most yards per carry (5.5) to opposing running backs in the NFL. The Giants have also given up 15 rushing touchdowns, tied for second-most among NFL defenses. If there's a game for Montgomery to rediscover his touchdown-scoring ways, it could be against New York. Fantasy managers should view him as a solid RB2 option in Week 12.

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Detroit Lions kicker Jake Bates had an underwhelming game in Week 11, making just one field goal and missing his lone extra-point try in his team's 16-9 loss to the Philadelphia Eagles. On paper, Bates has a much lighter matchup in Week 12, when the Lions host the New York Giants inside the domed Ford Field. In his career to this point, Bates is averaging 8.5 points per game at home, compared to 7.4 per game on the road. The Giants have also been one of the easiest teams for opposing offenses to light up the scoreboard against so far this season. New York enters Week 12 allowing 27.3 points per game and has allowed 31.2 points per game over the last five weeks. Bates could have plenty of chances to put points on the board for the Lions against the Giants and profiles as a must-start fantasy kicker in Week 12.

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Detroit Lions wide receiver Kalif Raymond was blanked by the Philadelphia Eagles in Week 11, finishing the game with zero receptions on zero targets. The 31-year-old has just 13 receptions across 10 games this season, and he's gone without a catch in four out of his last six outings. On a more positive note, Raymond played 64% of Detroit's offensive snaps against Philadelphia, his highest rate since Week 1. With Lions tight end Sam LaPorta (back) on Injured Reserve due to a back injury, Detroit may be forced to lean more heavily on three-wide receiver sets. Raymond also gets a more favorable matchup on paper in Week 12 against the New York Giants. New York has allowed the sixth-most passing yards (2,641) in the NFL so far this season. Still, Raymond has not proven to be a consistent enough target-earner to be a fantasy-relevant producer so far this season. He remains a risky start in Week 12.

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With Detroit Lions tight end Sam LaPorta (back) on Injured Reserve due to a back injury, there's an opportunity for rookie wide receiver Isaac TeSlaa (oblique) to step up as a more consistent target-earner in Detroit. However, TeSlaa recorded zero catches on one target in the Lions' first game without LaPorta, a Week 11 loss to the Philadelphia Eagles. TeSlaa has not earned more than one target in a game since Week 3 and has hauled in just four catches for the entire season. Additionally, he remains behind Kalif Raymond on his team's wide receiver depth chart and has played 18 fewer offensive snaps than Raymond in each of the last two weeks. TeSlaa is officially listed as questionable to play in Week 12 due to an oblique injury, but he played through the same injury in Week 11. The Lions have a favorable matchup on paper in Week 12 against the New York Giants, who have allowed the sixth-most passing yards (2,641) in the NFL through 11 weeks. Still, TeSlaa remains an unreliable option for fantasy managers until he proves to be a more consistent part of the Detroit passing game.

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Chicago Bears running back Roschon Johnson (thumb) missed two consecutive practices and has been ruled out for Sunday's Week 12 contest against the Pittsburgh Steelers. Johnson was added to the injury report on Thursday and hasn't been able to get on the field since. The extent of his injury is unknown, but it won't have major ramifications in fantasy football anyway. He has just two carries for 17 yards through seven games this season, remaining buried in a depth role behind veteran D'Andre Swift and rookie Kyle Monangai. Travis Homer (hamstring, knee) has also been ruled out for this week, meaning Chicago may have to activate Brittain Brown from the practice squad to fill the No. 3 running back role.

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Detroit Lions running back Jahmyr Gibbs was one of his team's lone bright spots in their 16-9 Week 11 loss to the Philadelphia Eagles. Gibbs rushed for just 39 yards on 12 carries against the Eagles, but he hauled in five receptions for 107 yards on eight targets. The 23-year-old has now recorded at least 140 scrimmage yards in three out of his last four games and has already topped 1,000 scrimmage yards for the season. On paper, Gibbs has a good chance to extend his hot streak in Week 12 against the New York Giants. New York is allowing the most yards per carry (5.5) to opposing running backs in the NFL so far this season. There's also reason to believe that Gibbs will continue to feature heavily in Detroit's passing game. In the two games since Lions head coach Dan Campbell has taken over as the team's play-caller, Gibbs has been targeted 12 times. He profiles as a must-start fantasy running back in Week 12 against New York.

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Las Vegas Raiders running back Zamir White continues to be a non-factor with his team, and he remains off the fantasy radar in all leagues. The 26-year-old has been a healthy scratch for five games in a row, and he's likely headed for his sixth consecutive absence in Week 12 as the Raiders take on the Cleveland Browns. Ashton Jeanty has control of the top spot in Vegas' backfield, while Raheem Mostert and Dylan Laube have edged out White for depth roles. In the four games he did play earlier this year, White averaged just 2.5 carries, 6.3 rushing yards, 0.8 catches, and 4.8 receiving yards. Even if one of the running backs ahead of White were to get injured, he'd likely still be a non-factor in all fantasy football leagues.

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After an underwhelming start to the 2025 season, Detroit Lions wide receiver Jameson Williams has caught fire in recent weeks. Over his last five games, the 24-year-old has recorded 20 receptions for 339 yards and four touchdowns on 29 targets. On paper, Williams should have a good chance to extend his hot streak in Week 12 against the New York Giants. Through 11 weeks, the Giants have allowed the sixth-most passing yards (2,641) and seventh-most passing touchdowns (19) in the NFL. Recent developments in Detroit also favor Williams. In the two games since head coach Dan Campbell took over as his team's play-caller, Williams has been targeted 14 times and is averaging 20.7 yards per reception. Additionally, the Lions will be without tight end Sam LaPorta (back) in Week 12, which will lessen the target competition in Detroit. Williams profiles as a high-end fantasy WR2 in Week 12.

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Tampa Bay Buccaneers wide receiver Kameron Johnson has failed to capitalize on new opportunities with his teammates injured. The second-year receiver has just four catches in 2025, and all four of them came in one game. Outside of that anomalous contest, he has two targets and zero receptions. Johnson played just nine percent of the snaps last Sunday against Buffalo, primarily contributing on special teams. He has 16 kick returns for 394 yards this season, plus 17 punt returns for an additional 219 yards. It has been a bit surprising to see Johnson remain in a depth role despite injuries to his teammates. Chris Godwin (leg), Mike Evans (collarbone), and Jalen McMillan (neck) have all missed significant time, but it hasn't created much of an increase in opportunities for Johnson. Godwin could return this week against the Los Angeles Rams, which would figure to knock down Johnson's involvement even further. He can be dropped in most fantasy leagues.

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With top Lions tight end Sam LaPorta (back) currently on Injured Reserve due to a back injury, veteran Brock Wright has been elevated to TE1 status in Detroit. In his first game without LaPorta in Week 11, Wright was targeted seven times but hauled in just two catches for eight yards against the Philadelphia Eagles. On paper, Wright has an easier matchup in Week 12 against the New York Giants. So far this season, New York has allowed the sixth-most passing yards (2,641) and seventh-most passing touchdowns (19) in the NFL. However, Wright's lack of proven track record as a receiving threat makes him tough to trust for fantasy managers. Across 68 career games with Detroit, the 26-year-old has recorded 67 receptions. He profiles as a low-end fantasy TE2 in Week 12 against the Giants.

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Carolina Panthers running back Trevor Etienne has essentially been a non-factor lately. He didn't log a snap in Week 10, and he played just four snaps with one carry last Sunday against the Atlanta Falcons. The rookie has primarily played on special teams, logging either a kick or punt return in all but one game this year. In total, he has just 20 carries for 94 rushing yards in 2025, plus two catches for an additional nine yards. He also fumbled once. Most of his volume came during Weeks 4-6 when Chuba Hubbard was banged up. As long as Hubbard and Rico Dowdle are healthy, Etienne will be a non-factor on offense. Managers should continue to patiently stash him in dynasty leagues, but they can leave him on waivers in redraft formats. That remains true in Week 12 against the San Francisco 49ers.

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Detroit Lions quarterback Jared Goff had one of his worst games in a Lions uniform in Week 11, completing just 14 of 37 pass attempts for 255 yards, one touchdown, and one interception in a loss to the Philadelphia Eagles. On paper, Goff has a much easier matchup in Week 12 when Detroit hosts the New York Giants. Through 11 weeks, the Giants have allowed the sixth-most passing yards (2,641) in the NFL. New York will also remain without cornerback Paulson Adebo (knee), who has been out since Week 7 with a knee injury. The Lions are dealing with some health issues themselves, as Goff will be without tight end Sam LaPorta (back), and multiple Detroit offensive linemen are playing through nagging injuries. Still, Goff could have a chance to do damage against the struggling Giants defense and profiles as a must-start fantasy QB1 in Week 12.

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