Jacksonville Jaguars tight end Hunter Long enters Week 6 atop the depth chart after Brenton Strange (quad) was placed on injured reserve. While Long's exact volume is uncertain, he did step up and play 60 percent of the snaps after Strange went down last week, so he should definitely get involved. He also has six catches and a touchdown over his last three games, indicating that Trevor Lawrence is comfortable throwing him the football. Long ranks as a mid-to-low TE2 with some streaming appeal in deeper leagues. Fortunately for Long, he has upside given his matchup against the Seattle Seahawks, who have surrendered the most receptions and seventh-most fantasy points to tight ends in 2025.

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San Francisco 49ers wide receiver Kendrick Bourne remains an intriguing fantasy option despite teammate Jauan Jennings (ankle, rib) returning. The veteran receiver is coming off a career performance in which he caught 10 passes for 142 yards. Ricky Pearsall (knee) remains sidelined for the Niners, so Bourne should still start and carve out a sizable role alongside Jennings. Also working in Bourne's favor is the quarterback situation. Brock Purdy (toe) will miss his fourth game, leaving Mac Jones in line to start. Jones and Bourne have a great rapport from their time together in New England, as well as last week's big game, and should continue to strengthen their connection during Week 6 against the Tampa Bay Buccaneers. While Jennings' return may lower Bourne's ceiling, the veteran receiver is still an intriguing WR3/flex in leagues with at least 12 teams.

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Los Angeles Chargers running back Hassan Haskins is expected to operate as the primary option out of the backfield during Sunday's Week 6 contest against the Miami Dolphins, according to Mike Garafolo of NFL Network. Haskins will take on an expanded role this weekend with both Omarion Hampton (ankle) and Najee Harris (Achilles) on injured reserve. Haskins' newfound role at the top of the depth chart isn't necessarily a surprise since he was routinely active as the No. 3 running back when Hampton and Harris were healthy. Now, he'll slide into the lead-back role while Kimani Vidal offers a change of pace. It's possible that Vidal could carve out a low-end fantasy role, but for now, Haskins is the only Chargers running back worth starting in fantasy football. He ranks as an RB3/flex but could have RB2 upside in a favorable matchup against Miami.

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ESPN's NFL Insider Adam Schefter reports that Carolina Panthers tight end Ja'Tavion Sanders (ankle) is unlikely to play in his team's home outing against the Dallas Cowboys in Week 6. Sanders' practice participation was up and down this week, leading up to the Panthers' matchup with Dallas, with a full session on Thursday being bookended by two limited ones. Per Schefter, he'll need another week to recover. Teammates Tommy Tremble and Mitchell Evans have operated as Carolina's first and second option at TE, respectively, in Sanders' absence, and they figure to do so again Sunday against the Cowboys. However, neither project to be a particularly enticing option for fantasy.

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Los Angeles Chargers running back Omarion Hampton (ankle) is expected to spend more than the minimum four weeks on injured reserve, according to Mike Garafolo of NFL Network. The injury that the rookie suffered in Week 5 appears to be serious enough that he'll be out through at least Week 10, and perhaps longer. The Chargers have a Week 12 bye, so it wouldn't be surprising to see Los Angeles hold him out until Week 13, giving him an extra week off to rest. Losing both Hampton and Najee Harris (Achilles) is a major blow for the Chargers, who will turn to Hassan Haskins and Kimani Vidal but could also look to make external running back additions.

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Dallas Cowboys wide receiver CeeDee Lamb (ankle) has already been ruled out ahead of the Week 6 matchup against the Carolina Panthers. This marks the third straight absence for Lamb, but he might not be out too much longer. According to Ian Rapoport, Lamb could return for next week's matchup against the Washington Commanders. This is great news for fantasy managers who only got two solid games out of Lamb before he went down. For now, George Pickens and Jake Ferguson figure to be the primary receiving options with Ryan Flournoy being mixed in as well.

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New Orleans Saints running back Alvin Kamara has been a possible mid-season trade target given the direction the organization is going right now. The Los Angeles Chargers are reportedly in the market for a running back with multiple backs going down with injuries. On paper, Kamara makes sense for the Chargers, but the 30-year-old doesn't want to leave New Orleans. Kamara said he wants to stay with the Saints and retire with the organization. It remains to be seen if something will change over the next few weeks, but for now Kamara is resistant to any trades.

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Las Vegas Raiders tight end Brock Bowers (knee) has already been ruled out ahead of the Week 6 matchup against the Tennessee Titans. According to Ian Rapoport, Bowers is unlikely to suit up for next week's matchup versus the Kansas City Chiefs. Bowers has been dealing with a PCL injury that he suffered Week 1. His timetable was revealed as week-to-week, so fantasy managers shouldn't be shocked if Bowers misses a third straight game. His absence means that Michael Mayer will take over as the primary tight end on this offense. Mayer is worth a stash for tight end needy fantasy managers, but isn't a recommended streaming option in Week 6.

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New York Jets running back Khalil Herbert and wide receiver Allen Lazard are inactive ahead of the Week 6 matchup against the Denver Broncos. As expected, Lazard is out as he didn't make the trip to England due to personal reasons. His absence won't mean much for this offense given he has four receptions for 24 yards and one touchdown this season. Arian Smith figures to see a majority of the snaps as the third wideout. As for Herbert, he's a healthy scratch as he's too far down on this depth chart to make a serious impact. Kene Nwangwu figures to do the kick returning with Herbert out.

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San Francisco 49ers wide receiver Ricky Pearsall (knee) has already been ruled out ahead of the Week 6 matchup against the Tampa Bay Buccaneers. He'll miss his second straight game due to a lingering knee issue. According to Adam Schefter, Pearsall could make his return to the field for the Week 7 matchup against the Atlanta Falcons. Given the injuries to this offense, Pearsall figures to be a focal point in the receiving game once he's healthy enough to play. Hopefully, fantasy managers will only be without him for one more week. His absence figures to mean more involvement for Jauan Jennings (rib, ankle) and Kendrick Bourne.

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Dallas Cowboys running back Jaydon Blue is set for an increase in playing time Sunday against Carolina after the team previously announced that Miles Sanders (knee, ankle) would miss the rest of the season following surgery. The elevation, however, will still keep Blue behind starter Javonte Williams, who is in the midst of a resurgent 2025 season. The rookie was a healthy inactive for the first month of the season, then played 11 snaps in his first game last week against the New York Jets. Although Blue will factor into the Dallas offense, he's not likely to earn enough volume to be playable yet, at least while Williams is healthy.

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Dallas Cowboys wide receiver Ryan Flournoy is coming off a fantastic performance in Week 5. Flournoy hauled in six of his nine targets for 114 yards in the win over the New York Jets. The 25-year-old came out of nowhere and posted a career-game last week. The assumption is that the Cowboys are going to keep him involved going forward. This offense remains without their top option in CeeDee Lamb (ankle) for Week 6. That being said, George Pickens figures to draw the most attention on defense, which could leave Flournoy in favorable coverage. The lack of prior success does make Flournoy a risky choice. He's more of a flex option in deep leagues because it's unclear if he can duplicate that performance.

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Washington Commanders wide receiver Terry McLaurin (quad) could return to the lineup in Week 7, according to Tom Pelissero of NFL Network. The former Ohio State star is slated to miss his third consecutive game on Monday against the Chicago Bears, although it appears next week's game against the Dallas Cowboys could be in play. McLaurin has not yet had a breakout week this season after scoring a new contract, but he finished as PPR WR No. 7 last year and figures to be highly involved once back to full health.

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On a Tampa Bay Buccaneers team hampered by injuries at wide receiver, veteran Sterling Shepard has seen a rapid increase in fantasy value as his team prepares to play San Francisco in Week 6. Chris Godwin (leg) and Mike Evans (hamstring) already have been ruled out for the game, slotting in Shepard as the team's likely second receiver behind Emeka Egbuka. Shepard has seen at least four targets in every game this season and scored his first touchdown of the year last week. The Niners are mid-tier against fantasy receivers, but Shepard should receive enough volume to be considered a flex option, especially in deeper leagues.

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Ian Rapoport of NFL Network is reporting that Dallas Cowboys cornerback Trevon Diggs (knee) is expected to play when his team takes on the Carolina Panthers on Sunday. The corner was listed as questionable on the final injury report. The Cowboys are also likely to have DaRon Bland (shoulder), who was also listed as questionable on the injury report, giving Dallas its top two corners against Carolina. Dallas is allowing 7.5 net yards per attempt this season, which ranks dead last in the NFL.

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San Francisco 49ers quarterback Brock Purdy (toe) could return in Week 7, according to ESPN's Adam Schefter. Already ruled out for Week 6, Purdy will have missed four of six games going into next week. Mac Jones (oblique) is expected to play on Sunday, which should provide stability for a 49ers team that ranks second in the league in passing yards. The irony is that fantasy managers who took Purdy because of his reliability have gotten anything but, as injury issues have made his availability a weekly guessing game. If Purdy is finally ready to return full-time next week, he should once again deserve lineup consideration, especially in two-quarterback formats.

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The Dallas Cowboys are likely to have cornerback DaRon Bland (shoulder) active when they take on the Carolina Panthers on Sunday, according to NFL Network's Ian Rapoport. Bland was limited in practice all week. The fourth-year corner missed a pair of games this season with a foot injury and is listed as questionable for Sunday, though it appears he will play. Rapoport also reported that Dallas is likely to have fellow corner Trevon Diggs (knee), giving the Cowboys another option to match against Carolina rookie wide receiver Tetairoa McMillan.

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ESPN's Adam Schefter reports that San Francisco 49ers wide receiver Jauan Jennings (ankle, rib) is expected to be available for Sunday's road matchup with the Tampa Bay Buccaneers. Jennings has been in and out of the lineup this season while battling through an ankle injury and other secondary injuries, but he's projected to gut it out in Week 6 against the hosting Buccaneers. San Francisco's offense still has a way to go before returning to full strength, but Jennings' return will also coincide with quarterback Mac Jones (knee, oblique) getting the nod to play, so they won't be without all of their playmakers. With teammate Ricky Pearsall (knee) still sidelined, fellow WRs Kendrick Bourne and Demarcus Robinson will continue to see extra playing time behind Jennings. It wouldn't be surprising to see the 28-year-old eased back in.

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According to ESPN's Adam Schefter, San Francisco 49ers quarterback Mac Jones (oblique) is expected to be active for his team's matchup with the hosting Tampa Bay Buccaneers. Jones has now dealt with knee and oblique injuries over the past few weeks, but will again get the start for the 49ers despite logging a week's worth of limited practices. Schefter also notes that teammate Brock Purdy (toe) has a "chance" to return in Week 7. It's excellent news for San Francisco, as the team is dealing with a mess of injuries on both sides of the ball. Reportedly, the team should also have wide receiver Jauan Jennings (ankle, rib) active, aiding Jones with Ricky Pearsall (knee) still at least a week away.

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Baltimore Ravens wide receiver Zay Flowers (shoulder) is expected to be available for his team's matchup with visiting Los Angeles Rams, according to ESPN's Adam Schefter. The Boston College alum was a limited participant in practice this week due to a shoulder injury. Despite the questionable designation, Flowers will prepare to play on Sunday, but will again be without quarterback Lamar Jackson (hamstring), lowering the floor and ceiling of all Ravens' skill players. The 25-year-old was the team's leading receiver in Week 5 with Cooper Rush at the helm, but it's unclear if his ailing shoulder will limit his snaps. If that's the case, teammates DeAndre Hopkins and Rashod Bateman are the most likely wideouts to see an uptick in targets, with tight end Mark Andrews set to absorb more work as well.

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