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San Francisco 49ers tight end Jake Tonges (shoulder) caught his second touchdown of the season in the team's 26-21 loss to the Jaguars on Sunday. Tonges left the game just six plays in due to a possible shoulder injury but returned near the end of the first quarter. He finished the game with three catches on five targets and had 58 receiving yards, good for second-most on the team in Week 4. Tonges has emerged as the preferred pass-catching tight end in George Kittle's (hamstring) absence. Both Ricky Pearsall (knee) and Jauan Jennings (ribs/ankle/shoulder) suffered injuries on Sunday, and on a short week (the 49ers face the Rams on Thursday), their status is up in the air. If either or both are limited or absent, then Tonges could see a greater target share than usual.

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Tennessee Titans head coach Brian Callahan said that the team is going to open the practice window for running back Tyjae Spears (ankle) this week, according to Jim Wyatt of TennesseeTitans.com. Getting Spears would be a big help to Tony Pollard in the Titans' backfield, but opening Spears' practice window doesn't guarantee he'll return in Week 5 against the Arizona Cardinals. The Titans will now have a 21-day window to officially activate the 24-year-old from the Injured Reserve after he missed the first four weeks of the season with a high-ankle sprain that he suffered during the preseason. So far, Pollard has been an every-down back for a struggling Titans offense, but his snap share will most likely go down when Spears is back in the fold. Spears should be scooped up off the waiver wire if you're searching for backfield depth, especially in PPR leagues. Just don't expect him to be active this weekend.

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When asked if running back Bucky Irving (undisclosed) was among the injured players he was concerned about following Sunday's Week 4 loss to the Philadelphia Eagles, Tampa Bay Buccaneers head coach Todd Bowles said, "Yeah, he's one of them," per Rick Stroud of the Tampa Bay Times. Bowles added that Irving underwent an MRI exam on Monday, and the team is awaiting the results. The 23-year-old had his most productive day of the year in the 31-25 loss to Philly on Sunday, carrying the ball 15 times for 63 yards and adding five receptions for a season-high 102 receiving yards and a touchdown. However, he apparently suffered an undisclosed injury along the way that could put his status in jeopardy for a Week 5 road tilt against the Seattle Seahawks. We'll monitor Irving's status closely this week. If Rachaad White is available on your league's waiver wire, pick him up immediately.

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Tennessee Titans head coach Brian Callahan said that wide receiver Calvin Ridley (undisclosed) was dealing with an undisclosed in-game injury on Sunday in the shutout loss to the Houston Texans and played through it, according to Jim Wyatt of TennesseeTitans.com. Ridley had played at least 86% of the offensive snaps through the first three weeks, but he played a season-low 54% of the snaps on Sunday because he wasn't 100% healthy. The 30-year-old veteran continued to be a disappointment for his fantasy managers, catching two of his three targets for 30 yards and no touchdowns. He has failed to exceed 30 yards in three of four games so far in 2025 and has caught just 10 passes for 141 yards and no scores on 24 targets so far this year. Ridley has not been efficient with rookie quarterback Cameron Ward and the rest of the Titans' offense struggling, and now he could be in danger of missing Week 5 against the Arizona Cardinals.

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San Francisco 49ers wide receiver Jauan Jennings (ribs/ankle/shoulder) sustained yet another injury in the team's 26-21 loss to the Jaguars on Sunday. Jennings was sandwiched between two defenders while making the catch on a successful two-point conversion in the third quarter. He held onto the ball but was writhing on the ground in pain after the play. Jennings returned to action on the next drive but saw only one target for the rest of the game. He finished the day with two catches for 24 yards on four targets. San Francisco is playing on Thursday night in Week 5, meaning less time for Jennings to recover, and leaving his status up in the air per Matt Barrows of The Athletic. With Ricky Pearsall (knee) also suffering an injury on Sunday, Demarcus Robinson and Kendrick Bourne might see an increased role against the Los Angeles Rams.

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The New Orleans Saints are designating tight end Taysom Hill (knee) to return from the Physically Unable to Perform list this week, according to Ari Meirov of The 33rd Team. To be clear, this doesn't mean that Hill is officially activated from the PUP or that he'll make his 2025 debut in Week 5 against the New York Giants, but only that he will be available to practice this week as the team opens up his 21-day practice window. If the 35-year-old veteran isn't activated from PUP by the time his 21 days are up, he'll be forced to miss the entire season. In addition to Hill, fellow tight end Foster Moreau (knee) will return to practice this week. Hill is trying to make it back after tearing the ACL in his left knee in Week 13 of last year. It's unclear exactly how new head coach Kellen Moore will use the versatile offensive weapon when he's healthy enough to return, but Hill can remain on the waiver wire for now in 12-team fantasy leagues.

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Detroit Lions wide receiver Jameson Williams caught only two of his seven targets in Sunday's win over the Browns, and he has not topped two receptions in a game since the season opener. In speaking with reporters on Monday, head coach Dan Campbell addressed the connection between Williams and quarterback Jared Goff, saying, "We're just a little bit off." Campbell was quick to downplay any issues of chemistry, saying the team will get back to the drawing board, and "Those guys are gonna be fine." Although Williams has caught only 10 balls on the season, his 21.4-yard average reception is among the highest in the league, so he has not been completely irrelevant for fantasy managers. The Lions face the Bengals in Week 5, and Cincinnati has been one of the most favorable matchups for wide receivers through four weeks. With bye weeks starting around the NFL this week, Williams should make for a fine flex option.

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Cleveland Browns rookie wide receiver Isaiah Bond has seen his targets and receiving yards increase in each of his four games this season. With Cedric Tillman (hamstring) now sidelined for multiple weeks, Bond could be leaned on more heavily as part of the Browns' passing attack. Tillman left Sunday's game against the Lions in the second quarter, and Bond ended the day as the team's leading receiver, bringing in three of his six targets for 58 yards. With five NFL teams on a Week 5 bye, now is the time in the schedule for fantasy managers to get creative, and Bond at least offers big-play upside for those in a roster bind. With the Browns traveling to London to play the Vikings in Week 5, any Cleveland players will need to be inserted into lineups early, stymying flexibility and making Bond a player to monitor rather than play for at least one more week.

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Cleveland Browns third-year wide receiver Cedric Tillman (hamstring) exited during the second quarter of his team's loss to the Lions on Sunday and is now expected to miss multiple weeks. Through four games, Tillman's 20 targets are the third most on the team, and trail only Jerry Jeudy among wide receivers, and he is the only Cleveland pass-catcher with multiple touchdowns. Rookie wide receiver Isaiah Bond, who led the team in targets and receiving yards on Sunday, is expected to see an increased workload, but Browns quarterback Joe Flacco has not topped 200 passing yards since the team's season-opener against a porous Bengals defense. With Cleveland's offensive line dealing with a rash of injuries and murmurs of a quarterback change coming soon, this is not a passing game in which fantasy managers should currently be looking to invest.

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Houston Texans rookie running back Woody Marks is coming off the best game of his young career, and head coach DeMeco Ryans is excited to see how much more he can handle. Marks ran for 69 yards and a touchdown while adding 50 yards and another score through the air in the team's first win of the season on Sunday. For the first time this year, Marks handled the majority of the team's rushing work, seeing 17 carries to Nick Chubb's 13. Having seemingly passed that test, a pleased Ryans suggested to reporters that more will be put on his young back's plate. Marks was a prolific pass-catcher in college, keeping his fantasy floor high even in less favorable matchups. Now, with an increased workload on the horizon and no timeline for Joe Mixon's return, Marks becomes a high-priority waiver add wherever he is still unrostered.

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San Francisco 49ers head coach Kyle Shanahan said Monday morning that quarterback Brock Purdy (toe) is "complaining of some real soreness" in his toe, per Eric Branch of the San Francisco Chronicle. Purdy returned to action on Sunday after missing the previous two games with turf toe and went 22-for-38 for 309 yards with two touchdowns, two interceptions, and a lost fumble late in the fourth quarter that sealed San Francisco's fate in their 26-21 loss to Jacksonville. The 49ers play on Thursday night in Week 5, giving Purdy less time to recover than he would usually see. Wide receivers Ricky Pearsall (knee) and Jauan Jennings (ribs) also got banged up in Week 4, leaving their status up in the air. Fantasy football managers rostering Purdy should take a long look at the waiver wire for help in Week 5.

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Having started the year on the IR, Tennessee Titans running back Tyjae Spears (ankle) is eligible to make his season debut in Week 5 against the Cardinals. The Titans are expected to open Spear's 21-day practice this window, giving the team three weeks to decide on when he will be activated. The third-year running back suffered a high ankle sprain in early August, so he has had almost two months to recover and could quickly work his way back into an offense badly in need of playmakers. The Titans' offense is currently dead last in total yards and points. Fellow running back Tony Pollard has been one of the team's most reliable contributors, and even in a full-time role, he has yet to make an impact on fantasy rosters. With Spears' return potentially creating more of a timeshare, neither back is an attractive option while the Titans work through their early-season struggles.

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San Francisco 49ers wide receiver Ricky Pearsall (knee) may have a "minor PCL" injury, according to head coach Kyle Shanahan, casting doubt on his availability in Week 5, per Eric Branch of the San Francisco Chronicle. Pearsall went down hard on his knee trying to make a catch early in the third quarter on Sunday's eventual 26-21 loss to the Jaguars. Pearsall was removed for evaluation and made it back into the game in the fourth quarter, though he saw zero targets after his return. He finished the day with four catches on five targets and 46 receiving yards. The 49ers are scheduled to play the Rams on Thursday night, leaving Pearsall with less time than usual to recover. If he does miss the game, Demarcus Robinson and Kendrick Bourne can be expected to be more involved.

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Houston Texans head coach DeMeco Ryans indicated that running back Joe Mixon (ankle, foot) is not ready to return at this time, according to Aaron Wilson of KPRC 2 Sports. According to sources, it will be much longer, if at all this year, for Mixon "to get back on the field this season." Fantasy managers who have been stashing Mixon must decide if they're going to remain patient or cut bait entirely. The 29-year-old did it all out of the backfield for the Texans last year, rushing for over 1,000 yards for the fifth time in his career while also scoring 11 rushing touchdowns in 14 regular-season starts. However, it's already looking like his 2025 campaign is a wash, and he could struggle for efficiency if he does return behind a bad offensive line. Houston will move forward with veteran Nick Chubb as the RB1, but rookie Woody Marks, who had two scores in Week 4, is quickly ascending.

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Kansas City Chiefs wide receiver Tyquan Thornton scored a touchdown for the third straight game in Sunday's 37-20 Week 4 win over the visiting Baltimore Ravens as the Chiefs' offense looked the best it has all year against a beleaguered Ravens defense. However, with Xavier Worthy returning from a dislocated shoulder that he suffered in Week 1, Thornton's role declined, and he caught just one of his two targets on the day for an 11-yard touchdown in the second half. The 25-year-old will continue to be a factor in KC's offense moving forward, but there's no denying that Worthy's return puts a pretty big dent in Thornton's fantasy upside as the primary deep threat. Rashee Rice will return in Week 7, too, which will be another big blow to Thornton's fantasy appeal for the rest of the season. We might have already seen the best from him in 2025.

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Cleveland Browns quarterback Deshaun Watson (Achilles) is not expected to have his practice window opened this week, even though he's eligible after four weeks on the Reserve/Physically Unable to Perform list, according to Mary Kay Cabot of The Cleveland Plain Dealer. Watson tore his Achilles in Week 7 of last year and started the 2025 season on the PUP list as a result. The 30-year-old veteran is not anywhere near a return and probably should be considered a long shot to play at all this year. In fact, most people believe Watson has already played his last snap with the Browns. For now, the Browns will roll forward with veteran Joe Flacco as their starter under center, although there are already questions about how much longer the team will keep him as their starter, given how bad he's looked through four weeks. It could only be a matter of time before we see rookies Dillon Gabriel and Shedeur Sanders.

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Fantasy managers who scooped Dallas Cowboys wide receiver KaVontae Turpin off the waiver wire in deeper leagues were hoping to see him more involved in the Week 4 Sunday night showdown against the Green Bay Packers with CeeDee Lamb (ankle) missing the game, but Turpin's production didn't see a boost in the 40-40 tie in overtime. Turpin caught three of his four targets for 30 yards and ran for four yards on his lone rushing attempt. It was actually a step back from the previous two games, when the 29-year-old combined for six catches, 111 yards, and a touchdown on seven targets. Jalen Tolbert was the one who benefited more from Lamb's absence, as he caught four of his six targets for 61 yards. George Pickens also went off for eight receptions, 134 yards, and two touchdowns. Turpin has made more of an impact as a receiver this year than he did in 2024, but it looks like he won't necessarily take another leap forward for however long Lamb is sidelined with his high-ankle sprain.

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Washington Commanders quarterback Marcus Mariota got going late in the 34-27 loss to his former team, the Atlanta Falcons, in Week 4, in what could be his final start with Jayden Daniels targeting a return from his knee sprain in Week 5 against the Los Angeles Chargers. Mariota finished Sunday's loss by going 16-for-27 passing for 156 yards, two touchdowns, and one interception. He added two carries for 20 yards and was sacked twice for a loss of nine yards. The 31-year-old veteran's touchdown passes went to receivers Luke McCaffrey and Deebo Samuel Sr. In two games in place of the injured Daniels, Mariota has been decent, completing 64.6% of his 48 pass attempts for 363 yards, three touchdowns, and one interception. It's not a lock that Daniels will play in Week 5, but if Mariota makes a third straight start, he'll be a low-end QB2 play against a tough Chargers defense on the road.

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Jacksonville Jaguars tight end Brenton Strange pulled in 6-of-7 passes for 45 yards in his team's 26-21 win over the hosting San Francisco 49ers. Strange has been a reliable target as quarterback Trevor Lawrence has at the moment, recording exactly six receptions and seven targets in each of the previous two weeks. The 24-year-old's receiving output leaves us wanting more, but he's easily pacing Jacksonville's TE room in snaps -- accruing 129 more than the next closest teammate. Moreover, he's leading the Jags in receptions (19) and yards (182). Strange and the team will get a true test next Monday night when they square off against the Kansas City Chiefs at home. For now, he's a high-end TE2 with PPR upside..

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Kansas City Chiefs running back Brashard Smith rushed for nine yards on four carries, adding another 27 through the air on 3-of-4 receiving in Week 4's 37-20 win against the Baltimore Ravens. He also returned two kicks for 55 additional yards. The rookie was finally utilized more in the passing game on Sunday, and played considerably more snaps than he had in his first three appearances. At least for this past weekend, Isiah Pacheco took the biggest hit in workload, getting the SMU product involved. Smith doesn't profile as a short-yardage banger, so it's challenging to assume that he'll eventually take on all aspects of Kansas City's ground attack. That said, if the 22-year-old continues to perform well in his receiving role, there could be some low-end PPR value here. He's a dynasty buy if you can acquire him at a reasonable price.

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