San Francisco 49ers running back Christian McCaffrey had another explosive performance in Week 16. McCaffrey ran for 117 yards on 21 carries and caught six of his eight targets for 29 yards and two touchdowns in the 49ers' 48-27 win over the Colts on Monday night. It was one of McCaffrey's better running performances of the season, having averaged 3.6 yards per carry coming into the game. McCaffrey's recent downward trend in receiving yards continued, though he was back to being one of the team's leaders in targets, due in part to Ricky Pearsall's (knee, ankle) absence. McCaffrey is now 151 yards away from achieving 1,000 yards in the rushing and receiving categories for the second time in his career. His next opportunity to add to his total will be against the Bears, who have allowed their opponents 348.1 offensive yards per game.

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Chicago Bears wide receiver Rome Odunze (foot) has now missed three consecutive games with a foot injury, but head coach Ben Johnson told reporters on Tuesday that his second-year wideout is right on track in his injury recovery and is expected to help the team again this season. The Bears face the 49ers in a Week 17 Sunday night tilt that could reshuffle the NFC playoff picture, so fantasy managers will need to monitor Odunze's status throughout the week and have a pivot ready in the event he becomes a game-time decision. The game features one of the highest projected point totals of the week, and with Bears quarterback Caleb Williams having thrown multiple touchdown passes in three straight games, Odunze is very much in play for fantasy championship weekend if he is able to suit up.

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Atlanta Falcons tight end Kyle Pitts Sr. continued his recent stretch of success in Sunday's 26-19 win over theCardinals, hauling in seven of nine targets for 57 yards and a touchdown. It was the fourth straight game with at least eight targets and at least six catches, and the 25-year-old has quickly vaulted himself into the position of second-ranked tight endfor fantasy this year after recordingfour touchdownsin the last two weeks alone (five on the season). The 6-foot-6 pass catcher was able to perform in Week 16 despite the returnof Drake London (knee),whoplayed just 69 percent of the team's offensive snaps. Pitts draws a home matchup against the Rams in what is most likely the championship round of the fantasy playoffs for most managers, a defense that is middle of the packin terms of fantasy points allowed to opposing tight ends, although the Seahawks'AJ Barner just registered a 4-49-1 line in Week 16 against Los Angeles. With a solid role in the Atlanta offense, Pitts will surely be a TE1 in Week 17.

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San Francisco 49ers quarterback Brock Purdy came through in a big way for those relying on him for a Monday night miracle to advance to the fantasy football championship round. Purdy went 25-for-34 for 295 yards, five touchdowns, and one interception in the 49ers' 48-27 win over the Colts. Two of his touchdown throws went to running back Christian McCaffrey, with tight end George Kittle and wide receivers Jauan Jennings and Demarcus Robinson each getting one. Once again, Purdy concentrated the majority of his attempts on McCaffrey, Kittle, and Jennings, though Kendrick Bourne worked in for five targets with Ricky Pearsall (knee, ankle) out. Purdy and the 49ers host the Chicago Bears in Week 17. It will be a welcome matchup for Purdy, as the Bears have allowed the eighth-most fantasy points per game to opposing quarterbacks this season.

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According to head coach Todd Bowles, Tampa Bay Buccaneers running back Rachaad White could be given a larger role during their contest against the Miami Dolphins on Sunday afternoon. When asked about White's usage during their loss to the Panthers in Week 16, Bowles noted that he "completely agrees" that White should have been given more rushing attempts, given the success he enjoyed in his limited opportunities. In this contest, White took five carries for 45 yards and two receptions of 15 yards. Over the previous two games, White showed similar upside, tallying 73 yards on 12 rushing attempts. White's eight rushing attempts on Sunday placed him second on the depth chart, above Sean Tucker's four carries and behind Bucky Irving's 19 carries. Given that White seems poised for a larger role in Week 17, managers in deeper 12-team formats could consider him as a viable FLEX play facing a Miami defense that is allowing the eighth-most PPR points to opposing RBs.

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Tennessee Titans running back Tony Pollard could be trending towards a timeshare during their week 17 contest against the Saints. According to OC Nick Holtz, the split workload between Tyjae Spears and Pollard was "how he envisioned" their usage given their respective skill sets. In their victory over the Chiefs, Pollard took the bulk of the carries on the ground, logging 21 compared to Spears' 13. However, in the passing game, Spears took the load as he was targeted five times and brought in all five for 53 yards, while Pollard was not targeted once. While Pollard's upside as a pass catcher may continue to be limited, he is finding his footing on the ground, averaging a strong 122.3 rushing yards per game over his last three contests. During these three games, Pollard has only drawn two total targets in the receiving game. Pollard should still be viewed as a high-floor RB2 in all formats heading into a Week 17 tilt against the Saints. Spears has entered FLEX territory for those in deeper PPR formats.

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Tennessee Titans tight end Chig Okonkwo had one of his better games of the 2025 season in Week 16 against the Kansas City Chiefs, recording six catches for 44 yards and a touchdown on eight targets. Across 15 games this season, the 26-year-old has hauled in 51 receptions for 503 yards and a score on 67 targets. Okonkwo is averaging exactly five targets per game over his last five contests and has scored at least seven PPR fantasy points in four out of his last six games. However, his ceiling is limited by the presence of Titans tight end Gunnar Helm, as Tennessee has split playing time between its two tight ends throughout the second half of the season. Still, Okonkwo has proven that he can provide a relatively stable production floor. In fantasy leagues with 14 or more teams, he could be a viable streaming option in his Week 17 matchup against the New Orleans Saints for managers in need of help at the tight end position.

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New England Patriots head coach Mike Vrabel said on Tuesday that wide receiver Kayshon Boutte (concussion) is in the NFL's concussion protocol, per ESPN's Mike Reiss. Boutte will need to clear the league's testing to be available for New England's Week 17 matchup against the New York Jets. Across 13 games this season, the 23-year-old has hauled in 31 receptions for 527 yards and six touchdowns on 42 targets. Boutte's production has tailed off a bit of late, as he has not recorded more than 35 receiving yards in a game since Week 8. If he's unable to play in Week 17, Patriots wide receivers Mack Hollins and Stefon Diggs would likely both see a slight increase in target share. Additionally, rookie wideout Kyle Williams could step into Boutte's role as the team's top deep-ball threat.

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Eric Branch of the San Francisco Chronicle reports that San Francisco 49ers tight end George Kittle (ankle) "felt confident he didn't suffer a dreaded high-ankle sprain" during the team's Week 16 win, but "didn't sound as certain" about his availability for the team's Week 17 matchup against the Chicago Bears. Across 10 games this season, Kittle has recorded 52 catches for 599 yards and seven touchdowns on 62 targets. The 32-year-old has been particularly effective in recent weeks, hauling in 15 receptions for 203 yards and two scores on 17 targets over his last two games. If Kittle is unable to play, Luke Farrell and Jake Tonges would likely split tight end snaps for San Francisco against Chicago. Across the five games Kittle missed earlier this season with a hamstring injury, Tonges recorded 22 catches for 209 yards and two touchdowns on 31 targets.

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New England Patriots head coach Mike Vrabel said on Tuesday that running back TreVeyon Henderson (concussion) is in the NFL's concussion protocol, per ESPN's Mike Reiss. Henderson was forced to exit early from New England's Week 16 win over the Baltimore Ravens after suffering a head injury. He will now need to clear the league's testing to be available for the Patriots' Week 17 matchup against the New York Jets. Across 15 games this season, the 23-year-old has racked up 997 scrimmage yards and eight touchdowns on 183 touches. Coming into Week 16, Henderson had recorded at least 75 scrimmage yards in seven straight games, scoring seven touchdowns in that stretch. If he's unavailable in Week 17, Rhamondre Stevenson would likely be in line to dominate New England's backfield snaps against the Jets.

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After recording more than seven touches in just one game before Week 16, New Orleans Saints tight end Taysom Hill saw a significant workload increase in his team's Week 16 win over the New York Jets. Hill recorded 12 carries for 48 yards and four receptions for 36 yards on six targets. The Saints will be without running backs Kendre Miller (knee) and Devin Neal (hamstring) for the remainder of the 2025 season, and veteran back Alvin Kamara (knee, ankle) has missed four straight games. If Kamara remains sidelined for the Saints' Week 17 matchup against the Tennessee Titans, Hill could see another week with a sizable role in the offense. Hill has proven to be a red zone threat throughout the course of his career, as he's scored 34 rushing touchdowns on 486 career carries. In fantasy leagues with 12 or more teams, Hill is a player to target on the waiver wire heading into Week 17.

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Seattle Seahawks Quarterback Sam Darnold led his team to a big win last Thursday against the Rams, throwing for 270 yards with two touchdowns and two interceptions. He's had a few down games lately, but has also thrown for at least 249 yards in three straight games. When the touchdowns are there, he's typically a solid, QB2 or low-end option in single-QB deep leagues. Darnold and the Seahawks have a tough matchup on the road against the Panthers in Week 17, in a battle of teams pushing towards the playoffs. He's not in an elite spot, but he still brings enough upside to be a decent pickup if you need help at the position in two-QB formats or deep leagues.

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Kansas City Chiefs quarterback Gardner Minshew (knee) got good news from an MRI on his injured knee, as his ACL was not torn as initially feared. He's still out for the rest of the season on IR, but his recovery will be quicker since it's a "non-displaced tibial plateau fracture," which is basically a severe bone bruise but does not require surgery. The seventh-year QB was on a one-year deal with the Chiefs, but only played two games this season. He'll be a free agent this offseason, and the fact that he won't have to recover from a torn ACL will make him one of the better backup options on the market. He could return to Kansas City or land with a new team, but wherever he ends up, the fact that he doesn't have a torn ACL should improve his chances of being ready for offseason activities and the start of next season.

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Minnesota Vikings QB J.J. McCarthy (hand) missed practice on Monday after having to leave last week's game at halftime with a hand injury. The Vikings have a favorable matchup this week and a chance to play spoiler against the Lions, but McCarthy will need to overcome his injury to be a viable option. He was excellent in his last two full games before the injury, producing three total touchdowns in wins over the Commanders and the Cowboys. McCarthy has the potential to be a streamer in two-QB or deep leagues if healthy, so keep a close eye on his practice participation if you're in the market for some help. If he's out, Max Brosmer would likely start, but he has not yet proven he can be a fantasy option.

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Jacksonville Jaguars quarterback Trevor Lawrence is on a heater as the Jaguars push to the playoffs, and he makes a good start in almost all formats this week. He's still available in about one-third of leagues despite his recent success, and he has a favorable matchup in Week 17 against the Colts, who were just carved up by Brock Purdy on Monday Night Football. Lawrence led the Jags to a huge win in Denver by throwing for 279 passing yards, three touchdowns, and running for a fourth score. Lawrence has thrown multiple touchdowns in five straight weeks and added a rushing score in each of the last two weeks as well. He finishes the season with division matchups against the Colts and Titans, and will be an elite play as long as he isn't rested before the playoffs.

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Kansas City Chiefs running back Isiah Pacheco took back over as the lead back for the Chiefs this week, stepping in ahead of veteran Kareem Hunt and taking eight carries for 34 yards while adding six catches for 41 yards in the team's loss to the Titans last week. Pacheco could be in for a heavy workload moving forward, since the team could phase out Hunt now that the playoffs are no longer a possibility. The team could take the next two weeks to evaluate Pacheco and rookie Brashard Smith for their future roles, but Pacheco is in a brutal matchup this week against the Broncos, who have been elite against the run. Pacheco does have touchdown-dependent upside and should get a good workload, but he's still a long-shot flex play to add off the waiver wire this week due to the matchup.

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Arizona Cardinals quarterback Jacoby Brissett had a rough week against the Falcons in Week 16, but he should be poised to bounce back in a big way against the Bengals in Week 17. Brissett has thrown multiple touchdowns in eight of his previous nine games, but he only threw for one score and a season-low 203 passing yards last week against Atlanta. The Bengals have allowed the fifth-most fantasy points to quarterbacks this season, allowing 30 QB touchdowns (passing and rushing) in 15 games, along with an average of 256 passing yards per week. In what should be a much better matchup, Brissett can be a great addition and streaming play in Week 17 if you need help at the position.

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Indianapolis Colts QB Philip Rivers completed 23 of 35 passes for 277 yards, two touchdowns, and an interception against the San Francisco 49ers in Week 16. With the game out of hand late, Rivers was replaced by QB Riley Leonard on the final drive.

Fantasy Spin: Rivers came out on fire versus the 49ers, leading the Colts to touchdowns on their first two drives. After a punt, Rivers would lead three additional scoring drives in a row, though just one touchdown. Things fell apart late, but it was still a highly impressive effort from the 44-year-old. While the loss essentially puts an end to Indy's playoff dreams, Rivers could still start against Jacksonville this week as they remain mathematically alive at the moment. Even if he does play, Rivers would be a tough sell against a solid Jaguars defense.

From TheHuddle

San Francisco 49ers TE George Kittle (ankle) collected seven receptions for 115 yards and a touchdown against the Indianapolis Colts in Week 16 before departing with an ankle injury. After the game, head coach Kyle Shanahan indicated it was too early to determine the severity of the injury.

Fantasy Spin: Kittle owners will be waiting with bated breath for an update on the star tight end's condition ahead of the team's Week 17 showdown with the Bears. If everything checks out, and Kittle is ready to roll, he'd belong in your lineup as a TE1. If Kittle is ruled out, Jake Tonges would become a very interesting plug-and-play option based on what he did earlier this year when Kittle was on IR. Kittle owners might want to preemptively move to add Tonges if they have an available roster spot to make sure they're covered either way.

From TheHuddle

San Francisco 49ers WR Demarcus Robinson had two catches, 23 yards, and a touchdown in Week 16 against the Indianapolis Colts.

From TheHuddle