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Despite getting a questionable tag on the final Week 6 injury report on Friday, San Francisco 49ers quarterback Mac Jones (knee, oblique) is expected to play and make his second straight start against the Tampa Bay Buccaneers with Brock Purdy (toe) missing his fourth game of the year, according to ESPN's Nick Wagoner. Jones was limited in practice all week with left-knee and oblique injuries, but head coach Kyle Shanahan said on Thursday that the former Patriots QB is slated to start on Sunday. The 27-year-old's knee injury dates back to a preseason game before he aggravated it in Week 3. Jones strained his oblique on the final offensive snap in last Thursday's win over the Los Angeles Rams. He's clearly not 100% going into Week 6, making a repeat of his 300-yard performance in Week 5 unlikely, especially with receiver Ricky Pearsall (knee) out for a second straight game. Consider Jones a low-end QB2 this weekend.

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Miami Dolphins wide receiver Jaylen Waddle will have an opportunity to step up as the team's top receiver the rest of the season after Tyreek Hill (knee) was lost for the season in Week 4. In Week 5, Waddle delivered a big game, hauling in six of his nine targets for 110 yards and a touchdown against the Panthers. He set season highs in catches, targets, and yards, while scoring his third touchdown in the last four weeks. Waddle and the Dolphins will look to bounce back from last week's loss to Carolina, as they host the Chargers. The Chargers' defense has done a good job against receivers this season, but Deebo Samuel did light them up for eight catches, 96 yards, and a touchdown last week. Waddle should be primed for another high-volume game and is the WR17 in RotoBaller's Week 6 rankings.

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Las Vegas Raiders wide receiver Tre Tucker remains an intriguing name for fantasy managers, but continues to struggle with consistency heading into Week 6. The speedy wideout has shown flashes of big-play ability, yet his week-to-week production remains unpredictable, making him a tough player to trust in starting lineups. Tucker's boom-or-bust nature keeps him just outside of the flex range for most fantasy formats, though his increasing involvement in the Raiders' offense makes him a worthy stash candidate. As the team continues to search for reliable playmakers with Brock Bowers sidelined, Tucker's explosive potential gives him long-term appeal, but until he develops steadier usage and target volume, he's best viewed as a bench stash in all leagues rather than a dependable weekly starter.

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Las Vegas Raiders wide receiver Jakobi Meyers has seen his fantasy relevance fade in recent weeks and should be avoided in starting lineups heading into Week 6. Despite the Raiders frequently playing from behind, their passing game ranks just 15th through five weeks, with Meyers failing to separate himself from the pack. He saw an even target share with Tre Tucker and practice-squad call-up Albert Okwuegbunam in Week 5, signaling a troubling trend for the veteran wideout. The emergence of Tucker, combined with the Raiders' growing emphasis on the running game led by Ashton Jeanty, has further diminished Meyers' role. Until he reclaims consistent targets, Meyers should be treated as a low-end WR3 or bench option in standard formats heading into this week's matchup.

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Miami Dolphins running back Ollie Gordon II has played about 25% of snaps in four of his five games, usually logging about 15 snaps per game. He had a season-high nine carries in Week 3 against the Bills, when he scored his only touchdown of the year as well. The last two weeks, though, he hasn't been able to move into a larger role. Last week against the Panthers, he only managed -2 yards on three carries against the Panthers. The rookie does have some potential, but De'Von Achane is dominating the workload and production in the Dolphins' backfield for now. He will likely get some work against the Chargers in Week 6, but as the RB50 in RotoBaller's rankings, he's not a strong play in most leagues since his role has been so limited.

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Miami Dolphins running back De'Von Achane has been one of the best running backs all season, despite his team's offense running hot and cold. Achane hasn't run for 100 yards in any game, but he has supplemented with great production in the passing game. He has at least six catches in three of his last four games after hauling in six of his seven targets for 30 yards and a touchdown last week. He has four total touchdowns in five games while averaging 65.5 rushing yards and 34.6 passing yards per contest. This week, he and the Dolphins will take on the Chargers, who have been very good against the run this season, but did give up two running back touchdowns and 124 rushing yards against the Commanders. Achane's consistently high volume and big-play ability have kept him an elite RB1 in every matchup. In RotoBaller's Week 6 rankings, he is the No. 3 RB in PPR leagues and the No. 8 RB in standard leagues.

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Tampa Bay Buccaneers tight end Cade Otton finally was able to do some damage on the field last week. Otton hauled in four of his five targets for 81 yards during last week's win over the Seattle Seahawks. Before that, Otton was held to six receptions for 34 yards during the first four games. Recently, Bucs offensive coordinator Josh Grizzard said the team wants to get Otton more involved. The Bucs are going to be without wide receivers Mike Evans (hamstring) and Chris Godwin (leg) for Sunday's game against the San Francisco 49ers. That should mean that Otton sees more targets coming his way. All things are pointing to Otton getting more chances, so he should offer TE2 value in Week 6.

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Tampa Bay Buccaneers wide receiver Tez Johnson is expected to have an increased role during Sunday's game against the San Francisco 49ers. The Bucs will be without Mike Evans (hamstring) and Chris Godwin (leg) for Sunday's game. That being said, Johnson figures to move into the No. 3 receiver role for this Week 6 contest. Last week, Johnson hauled in four receptions for 59 yards in the win over the Seattle Seahawks. The rookie wideout has been quiet outside of that, but showed a promising performance in Week 5. The increased playing time could sneak Johnson onto the flex radar in deep leagues for this weekend.

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Tampa Bay Buccaneers wide receiver Sterling Shepard will move into the No. 2 role ahead of Sunday's matchup against the San Francisco 49ers. The Bucs will be without Mike Evans (hamstring) and Chris Godwin (leg) for Sunday's game. That means, Shepard will move up the depth chart this weekend. The 32-year-old has hauled in four receptions in three of the first five games. The problem has been the yardage as Shepard has 39 receiving yards or less in every game but one. There should be a handful of targets coming Shepard's way, but it's unclear what damage he'll do on the field. In most formats, Shepard should be viewed as a flex option for Week 6.

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Miami Dolphins quarterback Tua Tagovailoa will face the Chargers in a tough test at home during Week 6. Last week, Tua had one of his best games of the year, even though he was playing his first game without top receiver Tyreek Hill (knee). He completed 27-of-36 pass attempts for 256 passing yards and three touchdowns. He has thrown multiple touchdowns in four straight weeks and is up to 10 touchdowns on the year with just four interceptions. He's averaging just over 200 passing yards per game, while adding almost no rushing production. His recent success has been in favorable matchups, but this week, he'll face the Chargers, who have allowed the seventh-fewest fantasy points to the position. They have allowed just four passing scores all year and an average of only 188.2 passing yards per game. In the tough matchup, Tua is the No. 23 QB in RotoBaller's rankings, making him a borderline second QB but not a starter in most standard leagues.

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Tampa Bay Buccaneers running back Sean Tucker moved into the No. 2 role in the backfield during last week's game against the Seattle Seahawks. The assumption was that Tucker would see a handful of carries with Bucky Irving (foot) sidelined. Tucker didn't see much of the field as Rachaad White did most of the work on offense. Tucker rushed the ball three times for three yards while hauling in three passes for -4 yards in the win. The expectation is that Tucker will see a handful of touches this weekend, but isn't a trustworthy starter. Fantasy managers should keep Tucker on the bench for the Week 6 matchup against the San Francisco 49ers.

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Cincinnati Bengals star wide receiver Ja'Marr Chase (illness), who was listed as questionable for Week 6 on Sunday after missing Friday's practice due to an illness, is expected to play against the Green Bay Packers at Lambeau Field, sources told Matt Zenitz of CBS Sports. Chase was feeling a little under the weather on Friday, but he should be fine to play in a couple of days in what will be new quarterback Joe Flacco's starting debut in Cincinnati. The 25-year-old Chase has had three quiet games and two 100-yard games so far in 2025. A 6-110-2 line in last week's loss to the Detroit Lions proves why Chase is still a must-start in fantasy despite quarterback Joe Burrow (toe) potentially being out for the rest of the year. It remains to be seen what kind of chemistry Chase will have with Flacco, but the veteran signal-caller figures to target him heavily.

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Tampa Bay Buccaneers wide receiver Emeka Egbuka was unstoppable during last week's game against the Seattle Seahawks. Egbuka hauled in all seven of his targets for 163 yards and a touchdown in the win. The rookie wideout has now posted back-to-back games with at least 100 receiving yards. The Bucs are going to be without Mike Evans (hamstring) and Chris Godwin (leg) for Sunday's game against the San Francisco 49ers. That being said, Egbuka is expected to serve as the focal point in the receiving game. The 22-year-old has shown no signs of slowing down so he belongs as a strong WR1 for Week 6.

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Tampa Bay Buccaneers running back Rachaad White is set to make another start this Sunday versus the San Francisco 49ers. White made his first start of the season during last week's win over the Seattle Seahawks. The 26-year-old rushed 14 times for 41 yards with two touchdowns. He also hauled in four receptions for an additional 30 yards through the air. White figures to remain a focal point on offense with Bucky Irving (foot), Mike Evans (hamstring), and Chris Godwin (leg) all expected to miss Week 6. The Bucs really have no choice but to get White involved. He's a capable option in both the running and receiving game, which gives him borderline RB1 value for this weekend.

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Washington Commanders running back Jeremy McNichols worked mostly behind rookie Jacory Croskey-Merritt in Week 5, rushing just once for six yards and catching one of two targets for 12 yards. McNichols matched third-year running back Chris Rodriguez Jr. in snaps, each playing 13 snaps, while Croskey-Merritt led the way with 28. McNichols' role in pass protection is highly valued by the Washington coaching staff and will keep him involved in Washington's backfield committee. But his floor for touches is low, which limits his appeal in fantasy.

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Washington Commanders running back Jacory Croskey-Merritt broke out with his best game of the season in Week 5 against the Chargers, totaling 150 yards and two touchdowns on 16 touches. The Croskey-Merritt takeover finally happened in Week 5, posting a season-high 50.9% snap share, handling 50% of the team's rush attempts, and running 31.3% of the team's routes. All marks were the highest of any Washington back in Week 5, and he delivered with a remarkable performance. For the season, he's rushed 283 yards and four touchdowns on 43 carries, averaging a league-best 6.6 yards per carry. Offensive coordinator Kliff Kingsbury provided some reason to keep the optimism in check, saying that the rookie still has "ways to go" in terms of playing without the ball in his hands. His work in pass protection has improved, but that is still an area where veteran Jeremy McNichols is most trusted. Third-year back Chris Rodriguez Jr. saw his lowest snap count and fewest carries in a game since becoming active in Week 5, suggesting he may be slipping back into a depth role. Croskey-Merritt should be expected to handle the bulk of the touches again in Week 6 against a Bears defense that is allowing an absurd 6.1 yards per carry and the fourth-most PPR points per game to opposing running backs. He should be fired up as a high-upside RB2 on Monday night.

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Las Vegas Raiders running back Raheem Mostert struggled to make an impact in his change-of-pace role during Week 5, totaling just 22 yards on a season-high seven touches. While the 33-year-old veteran still flashes big-play ability--highlighted by a 37-yard run against the Bears earlier this year--his current workload leaves him well outside fantasy relevance. Mostert should be viewed strictly as a handcuff to rookie standout Ashton Jeanty, who has firmly established himself as the lead back. Still, with Dylan Laube and Zamir White buried on the depth chart, Mostert remains the clear next man up if Jeanty were to miss time. For now, he's best left on the waiver wire outside of deeper leagues or as insurance for Jeanty managers looking to protect one of fantasy's rising assets.

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Tampa Bay Buccaneers quarterback Baker Mayfield (knee, arm) was removed from the injury report ahead of the Week 6 matchup against the San Francisco 49ers. Mayfield has been nursing some minor injuries, but will be fine for this weekend. Last week, Mayfield threw for a season-high 379 yards with two touchdowns and zero interceptions in the win over the Seattle Seahawks. The Bucs are banged up on offense with Bucky Irving (foot), Mike Evans (hamstring), and Chris Godwin (leg) likely all out this weekend. Despite that, Mayfield will find a way to succeed and remain an elite QB1 play.

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The Athletic's Daniel Popper speculates that if the Los Angeles Chargers explore the trade market at running back with Najee Harris (Achilles) done for the year and rookie first-rounder Omarion Hampton (ankle) on Injured Reserve, two potential options could be New York Jets RB Breece Hall and the Cleveland Browns' Jerome Ford. Both Hall and Ford are on expiring deals and could bring the Bolts a compensatory draft pick if they make it to free agency in 2026. Even when Hampton returns from IR, L.A. is going to need a second back to pair with him as a team with a run-first identity under offensive coordinator Greg Roman. At least for Week 6 against the Miami Dolphins, Hassan Haskins and Kimani Vidal are expected to share the backfield equally, giving them both flex appeal in deeper fantasy leagues. How aggressive the Chargers are on bringing in an outside RB will depend on how Haskins and Vidal fare in the coming weeks.

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Buffalo Bills tight end Dalton Kincaid (oblique) is dealing with an oblique injury and was limited in practice for the second straight day this week on Friday. Kincaid was seen wearing a no-contact jersey in practice on Thursday and again had his reps limited in practice on Friday, putting his status up in the air for Monday night's game against the Atlanta Falcons. If the 25-year-old doesn't go full in practice on Saturday, he could draw a questionable tag going into Monday's contest. Kincaid has already scored a career-high three times in his first five games in 2025 and is coming off his first 100-yard game in the Week 5 loss to the New England Patriots. As long as he's active, Kincaid should be considered a top-10 fantasy tight end, but a questionable tag this week could make for a difficult decision for fantasy managers in Week 6. Dawson Knox would be in play as a TE2 streamer if Kincaid is unable to play this week.

From RotoBaller