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Cleveland Browns defensive end Myles Garrett (ankle) is officially off the injury report for Sunday's matchup with the Minnesota Vikings in London, per NFL Network's Tom Pelissero. Garrett has already dealt with hip and ankle injuries this season, the latter of which forced him to miss Wednesday's practice. Despite logging just two limited sessions thereafter, he won't carry an injury designation into a juicy matchup across the pond against a beat-up Vikings offensive line. Cleveland may wind back the veteran's snaps a bit to keep him fresh, but fantasy managers can expect him to be without limit otherwise. The Texas A&M product leads his team with four sacks and is just one shy of the league leader through four weeks.

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New York Giants running back Tyrone Tracy Jr. (shoulder) is doing "a lot better" and is in line to get in some work at Friday's practice, according to head coach Brian Daboll. It will be the first time that Tracy has practiced since dislocating his shoulder in Week 3 against the Dallas Cowboys. It's good news for the second-year back, but it doesn't mean that Tracy will return to action for a Week 5 game in New Orleans against the Saints on Sunday. Giants.com writer Dan Salomone says that the Giants will see about Tracy's availability this weekend. In a best-case scenario, he'll be listed as questionable going into Sunday, but if he's somehow active, he'll likely be limited and play second fiddle to rookie Cam Skattebo in the backfield. Fantasy managers shouldn't be relying on Tracy in Week 5, and there's a good chance he'll be ruled out on Friday's final injury report.

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According to head coach Aaron Glenn, New York Jets running back Braelon Allen (knee) could miss 8-12 weeks with the MCL sprain he suffered in Week 4's loss to the Miami Dolphins. Reports were that Allen would miss more than the minimum number of required games, but it now appears he'll be out until at least December, with surgery still an option. In the 21-year-old's absence, teammate Isaiah Davis will take over the Jets' RB2 duties behind starter Breece Hall, and the newly-acquired Khalil Herbert will handle the RB3 role with Kene Nwangwu (hamstring) still tending to injury. Fantasy managers can safely drop Allen in all redraft formats as the likelihood of him making an impact to close out the 2025 season remains low.

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The Athletic's Zach Berman reports that Philadelphia Eagles linebacker Nakobe Dean (knee) won't be available for Sunday's matchup with the visiting Denver Broncos. The former Georgia Bulldog returned to practice this week as he continues to ramp up his activity in return from a torn patellar tendon suffered in last season's wild-card round. However, Dean could only practice in a limited fashion as he's not quite yet ready for in-game action. With Philadelphia due for a quick turnaround in Week 6 -- set to take on the New York Giants on Thursday Night Football -- it's unclear if he'll be available then either. For now, rookie Jihaad Campbell will continue to play alongside Zack Baun as Philadelphia's primary linebackers. Teammate Jeremiah Trotter Jr. is the only other Eagles linebacker to record a snap (one).

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Miami Dolphins tight end Darren Waller (hip, rest) projects to become a more prominent figure in the team's pass attack following the injury to wide receiver Tyreek Hill (knee). Waller made his season debut in Week 4's win over the New York Jets, hauling in two touchdowns on 3-of-4 receiving in his first appearance since Week 18 of 2023. The veteran's volume should increase as the Fins continue ramping up his workload, but even more promising was his work in the red zone. Despite logging just 16 snaps on Monday, Waller's two targets inside the 20-yard line match him with two other players on the team behind Jaylen Waddle (five). Miami hasn't had a big, imposing target like the 33-year-old in recent history, making him an asset to monitor ahead of their outing with the hosting Carolina Panthers this weekend.

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New York Jets running back Isaiah Davis is set to operate in an increased capacity moving forward due to the injury to teammate Braelon Allen (knee). Unfortunately, news surrounding Allen suggests that he'll miss more than the minimum of four games while on injured reserve. While he's out, Davis will operate as the primary handcuff to running back Breece Hall. With teammate Kene Nwangwu (hamstring) also battling injury, Davis is likely to see more volume than usual in their matchup against the Cowboys, considering Khalil Herbert only joined the team on Thursday. The 23-year-old was out there for a third of New York's snaps during their loss to the Dolphins in Week 4, and is worthy of a pickup -- at least for the Hall owner.

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Baltimore Ravens running back Justice Hill had his best game of the 2025 season in Week 4, recording 117 yards from scrimmage and two touchdowns on eight touches. Hill has just eight carries through four games this season and should not be expected to steal much rushing work away from Ravens RB1 Derrick Henry. However, Hill has 12 catches for 107 yards and a touchdown on 15 targets, and appears locked in as the team's primary passing-downs back. With Ravens quarterback Lamar Jackson (hamstring) potentially facing a multi-week absence and the team's defense struggling, Baltimore could be chasing points more frequently over its next few games than in years past. That would unquestionably be a good thing for Hill's fantasy outlook. He profiles as a low-end flex option in PPR leagues heading into a Week 5 matchup against the Houston Texans.

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Arizona Cardinals running back Emari Demercado served as the team's RB2 in Week 4 behind Trey Benson (knee). However, with Benson now on Injured Reserve due to a knee injury, it does not appear that Demercado is a lock to assume Arizona's RB1 role. Demercado has appeared in 31 games for the Cardinals since the start of 2023, but he has not recorded more than four carries in a game since October of his first season with the team. That could indicate that Arizona feels comfortable with Demercado as the team's passing-downs back, but that veteran back Michael Carter could assume the bulk of the early-down work. Heading into a Week 5 matchup against the Tennessee Titans, Demercado profiles as a decent flex option for fantasy managers, but Carter should be the preferred play.

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Miami Dolphins wide receiver Malik Washington could be in line to step into the team's WR2 role alongside Jaylen Waddle after Miami lost Tyreek Hill (knee) to a season-ending knee injury in Week 4. Washington has been used in a gadget role so far this season, recording eight catches for 47 yards on 15 targets and eight carries for 60 yards through four games. He's a dynamic playmaker with the ball in his hands, as evidenced by his 74-yard punt return touchdown in Week 2 against the New England Patriots. With Hill sidelined, Miami head coach Mike McDaniel could place an even greater emphasis on manufacturing touches for Washington. He profiles as a low-end flex option in deep leagues heading into a Week 5 matchup against the Carolina Panthers.

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Arizona Cardinals running back Michael Carter could be in line to take over as the team's primary early-down back with running backs James Conner (ankle) and Trey Benson (knee) both currently on Injured Reserve. Carter figures to split touches in Week 5 against the Tennessee Titans with Emari Demercado and possibly Bam Knight, but earlier reporting has indicated that Carter could be the team's preferred choice to assume the majority of the rush attempts. Carter has recorded 2,131 yards from scrimmage and nine touchdowns on 439 touches across 49 career NFL games (22 starts). He profiles as a high-end RB3/flex option in a favorable Week 5 matchup against Tennessee.

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Cincinnati Bengals tight end Noah Fant (concussion) practiced in full on Thursday after being limited on Wednesday as he attempts to return from a concussion for his team's Week 5 matchup against the Detroit Lions. Fant has recorded 12 catches for 80 yards and a touchdown on 14 targets across three games so far in 2025. The Bengals' offense has struggled in the two full games it has played without Joe Burrow (toe), scoring a combined 13 points over the last two weeks against the Minnesota Vikings and Denver Broncos. That could limit Fant's fantasy appeal even if he is healthy enough to play in Week 5.

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Tampa Bay Buccaneers running back Bucky Irving (foot) is expected to miss his team's Week 5 matchup against the Seattle Seahawks and is "in danger" of missing Week 6 against the San Francisco 49ers as well, per ESPN's Jeremy Fowler. Irving is currently battling a mid-foot sprain that is not expected to be a long-term injury, but it appears it could lead to a multi-week absence. With Irving sidelined, Buccaneers running backs Rachaad White and Sean Tucker should be expected to handle the majority of the backfield workload, with rookie Josh Williams potentially mixing in as well. White has recorded 142 yards from scrimmage and a touchdown so far this season and profiles as a low-end fantasy RB2 in Week 5. Tucker has not seen much work yet in 2025, but he's been an efficient rusher when given the opportunity in his career and could be a decent deep-league flex play while Irving is out.

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Jacksonville Jaguars wide receiver Dyami Brown (shoulder) was listed as a limited practice participant on Thursday. Brown missed Week 4 due to the shoulder injury, but his limited status early in the week could mean he's trending towards playing in his team's Week 5 matchup against the Kansas City Chiefs on Monday night. Brown has recorded 10 catches for 116 yards and a touchdown on 14 targets across three games so far this season. If he returns to the lineup in Week 5, it could mean less playing time for Jaguars wideouts Travis Hunter and Parker Washington. All three of Brown, Hunter, and Washington should be avoided by fantasy managers this week in a tough matchup against the Chiefs.

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Jacksonville Jaguars rookie running back Bhayshul Tuten (shoulder) was a limited participant in practice Thursday, as he has been dealing with a shoulder injury for the last few weeks, but has suited up for each game since suffering the injury. He will have two more practice days to log full practice time to avoid missing Monday's matchup with the Kansas City Chiefs. At this time, Tuten is nothing more than a high-upside handcuff or bench stash, so fantasy managers are unlikely to be relying on him as a starter in their starting lineups at this time. However, the shoulder issue could explain part of the reason why we haven't seen his snap percentage increase much from Week 2. He has also seen his touches go down from 10 to seven to five in the last three weeks. Lead back Travis Etienne has been solid, but Tuten remains a top bench stash as he provides top-20 running back potential should Etienne experience any setbacks. When given the chance, Tuten is averaging 4.19 YPC on his 21 rush attempts and has contributed 40 yards through the air on three receptions to go along with two touchdowns.

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NFL Insider Ian Rapoport reported on Thursday Night Football that San Francisco 49ers wide receiver Brandon Aiyuk (knee), coming off a significant knee injury, is "still weeks away" from returning. Aiyuk was placed on the PUP list to start the season, which required him to miss at least the first four games of the year. It appears he will miss more time, with an uncertain timetable for his return. Fantasy managers who have the room to continue to hold him on their IR should, but with the number of injuries that have transpired over the last two weeks, fantasy managers who need to make room on their team for players closer to returning might want to consider that, as Aiyuk is looking like he won't return anytime in the next few weeks.

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Carolina Panthers rookie running back Trevor Etienne is seemingly set to see some additional touches in Week 5 against the Miami Dolphins, with Chuba Hubbard (calf) ruled out for Week 5. Etienne saw his snap percentage and workload increase in Week 4 with the Panthers getting blown out by the Patriots 42-13, but now with Hubbard out, Rico Dowdle will be the lead back, and Etienne will back him up. Etienne will likely see anywhere between five and 10 touches. On the season, he is averaging 4.63 YPC and has 37 rushing yards with one reception. He did have a fumble in Week 3 on his only touch, which happened on a kick return. In deeper leagues, he might be worth a stash in case he breaks out during his limited opportunities and starts to challenge the team a bit to give him more touchdowns down the stretch.

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Carolina Panthers running back and former Dallas Cowboy, Rico Dowdle, is set to be the lead back in the Panthers' backfield in Week 5 against the Miami Dolphins, with Chuba Hubbard (calf) ruled out for Week 5. Hubbard is considered week-to-week, so Dowdle isn't expected to be a hot commodity for a season-long play, but he immediately rises in the Week 5 ranks and becomes a top-25 running back against the Dolphins defense, which allows the seventh most fantasy points to the running back position. Dowdle is no slouch either; last year with the Cowboys, he accumulated 1,328 all-purpose yards and five touchdowns. Rookie running back Trevor Etienne becomes the team's RB2 and should also be in line for additional carries.

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Minnesota Vikings quarterback J.J. McCarthy (ankle) has officially been ruled out for their Week 5 contest against the Cleveland Browns. McCarthy has been sidelined since suffering this high ankle sprain during their Week 2 loss to the Atlanta Falcons. As a result, fantasy managers should expect Carson Wentz to receive his third-straight start. Wentz threw for just 173 yards but tacked on two TD passes in his Minnesota debut in Week 3. In Week 4, he took a loss to the Steelers but enjoyed a productive fantasy day, totaling 350 yards with another two touchdown passes. Wentz carries solid QB2 value this weekend, despite facing a potent Cleveland defense. Given McCarthy's uncertain timetable, he is only worth stashing in deeper one-QB leagues while he remains sidelined. McCarthy will look to return to action in Week 7 when they host the Eagles, following their Week 6 bye.

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According to Joseph Person of The Athletic, Carolina Panthers running back Chubba Hubbard (calf) will miss Sunday's home game against the Miami Dolphins, according to a league source. The Panthers consider Hubbard to be week-to-week but do not plan to place him on injured reserve, the source said. The silver lining is that Hubbard's injury appears to be minor and not long-term, allowing fantasy managers to treat this situation as a bye week for Hubbard, as it seems possible he will return for Week 6. Rico Dowdle becomes an immediate must-add in 12-team formats and becomes a low-end RB2 in Week 5; meanwhile, Trevor Etienne will be in line for additional touches. Hubbard has been okay this season, averaging 4.09 YPC and 217 rushing yards to go along with 13 receptions for 94 yards and two touchdowns.

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According to Ian Rapoport of the NFL Network, Carolina Panthers running back Chuba Hubbard (calf) is not expected to play on Sunday against the Miami Dolphins. Rapoport noted that Hubbard has not practiced this week and is unlikely to turn the corner in time. As a result, the team's No. 2 running back Rico Dowdle is slated to serve in the lead role. Hubbard was dealing with this calf injury before last week's contest, but was unable to suit up. However, in this game, the running back was given his smallest workload of the season as he took just 10 carries for a modest 49 yards and was only targeted three times through the air. Dowdle was the lead back in Dallas last season and posted his first 1,000-yard campaign. Given his projected volume, he carries RB2 upside facing the Dolphins, who have allowed the 10th-most PPR points to opposing RBs this season.

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