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Las Vegas Raiders running back Ashton Jeanty erupted in Week 4 against the Bears, racking up 155 total yards and three touchdowns in a true breakout performance. Remarkably, that single-game yardage output surpassed his combined production from the first three weeks, signaling a potential turning point for the rookie back. With quarterback Geno Smith struggling to protect the football, the Raiders are expected to emphasize Jeanty in both the ground game and short passing attack heading into a Week 5 matchup with the Colts. Indianapolis boasts the ninth-ranked run defense and a disruptive unit that sits fourth in the league in turnover percentage, but Jeanty's dual-threat skill set gives him a reliable path to volume and scoring opportunities. Fantasy managers should view Jeanty as a strong RB1 moving forward, with a chance to become the centerpiece of the Raiders' offense.

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Las Vegas Raiders wide receiver Jakobi Meyers has seen his production dip in recent weeks, as younger playmakers in the offense continue to carve out larger roles. In Week 4 against the Bears, Meyers caught just four of seven targets for 30 yards, with his longest reception going for only 10 yards. The outing marked his third consecutive game with declining yardage totals, raising concerns about his ceiling moving forward. Despite those struggles, Meyers still led the team in targets last week, showing he remains a trusted option for Geno Smith in the passing game. While the lack of big plays limits his upside, his steady volume keeps him relevant as a flex play, particularly in PPR formats. Fantasy managers should view Meyers as a safe but low-ceiling option heading into Week 5.

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Buffalo Bills running back James Cook III draws a difficult matchup in Week 5 against a Patriots defense that has surrendered just 77.5 rushing yards per game, tied for second-fewest in the league. While Cook may find tough sledding between the tackles, his versatility as a receiver should keep him firmly in the RB1 mix. Last week against Baltimore, he managed only 44 yards on the ground but offset that with 58 yards through the air, showing his ability to remain productive even when the rushing lanes are clogged. In what projects to be one of Buffalo's biggest games of the season, the Bills will likely lean on Cook in multiple ways to generate offense. Fantasy managers should continue to view him as a high-end starting option in both standard and PPR formats.

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New York Giants kicker, Jude McAtamney, should remain on the waiver wire in all fantasy formats despite a seemingly favorable matchup against the New Orleans Saints. The international kicker was perfect in his 2025 debut last week, making two short field goals and an extra point while filling in for the injured Graham Gano. However, his roster spot is not secure as he competes with Younghoe Koo, and there are too many unknowns about his ability to handle pressure or long-distance kicks. While the Saints' defense allows the most points per game in the league (30.3), creating a high-scoring environment, McAtameny's uncertain role makes him too risky to trust.

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Las Vegas Raiders quarterback Geno Smith has endured a rough start to the 2025 campaign, throwing a league-high seven interceptions in just four games. Despite flashes from the Raiders' rushing attack, including Ashton Jeanty's breakout performance last week, Smith continues to force throws into tight coverage, resulting in costly turnovers. Head Coach Pete Carroll has maintained confidence in his veteran signal-caller, but with Kenny Pickett waiting on the bench, the leash may not be endless if the mistakes persist. A tough Week 5 matchup with the Indianapolis Colts looms, and fantasy managers should approach Smith with extreme caution. At this point, he should only be considered in superflex or very deep 16-plus team formats, as his turnover issues make him a risky play in standard leagues.

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Buffalo Bills quarterback Josh Allen continues to justify his elite fantasy status, entering Week 5 as the top-scoring player at his position. Allen has been electric through the air and on the ground, and he'll look to keep rolling in Sunday's matchup against the division rival New England Patriots. While New England's defense could provide a stiffer test than some of Allen's previous opponents, his dual-threat ability and chemistry with tight end Dalton Kincaid make him nearly matchup-proof. The duo's growing red zone connection has been a major boost for fantasy managers, and Allen remains an automatic QB1 start in all formats. Expect another strong outing from one of the game's premier fantasy weapons.

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New York Giants tight end Theo Johnson is a waiver-wire candidate with upside for his Week 5 matchup in New Orleans. The rookie is already heavily involved with a 74.9% snap share and has quickly built a rapport with quarterback Jaxson Dart, catching Dart's first career touchdown pass in last week's win. With the season-ending injury to top receiver Malik Nabers, Johnson's target share is set to increase, particularly as a safety blanket for his rookie quarterback. He faces a Saints defense that presents an excellent opportunity, as they have allowed the second-most passing touchdowns in the league (9) and rank 30th in the NFL in red zone defense.

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New York Giants wide receiver Jalin Hyatt is a deep-league lottery ticket who will finally get an opportunity to prove his worth in Week 5 against the Saints. With Malik Nabers out for the year, the third-year speedster will assume the WR3 role, and his familiarity with rookie quarterback Jaxson Dart from second-team reps could lead to immediate targets. Despite having zero fantasy points this season, Hyatt's world-class speed makes him an intriguing desperation play against a vulnerable New Orleans secondary. The Saints have been susceptible to big plays, allowing the second-most passing touchdowns in the NFL (9), creating a scenario where Hyatt could finally break loose for a long score.

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New York Giants wide receiver Darius Slayton enters Week 5 as a high-upside, boom-or-bust flex option with an expanded role in the offense. Following the season-ending injury to Malik Nabers, Slayton now steps in as the clear WR2 and primary deep threat for rookie quarterback Jaxson Dart. While his season statistics are modest, ranking him as the WR78, his 15.0 yards per reception average highlights his ability to make big plays. This week, he faces a Saints defense that has been vulnerable to explosive plays, having allowed the second-most passing touchdowns (9) in the league, making them the 19th-friendliest defense to fantasy wide receivers and creating a perfect opportunity for Slayton to connect on a long score.

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New York Giants wide receiver Wan'Dale Robinson is one of the week's most intriguing fantasy plays following the season-ending injury to Malik Nabers. Now the primary target for rookie QB Jaxson Dart, Robinson, who already ranks as the WR29, will see a significant volume increase from his already impressive 27 targets and 76% snap share. He faces a New Orleans Saints secondary that presents a favorable matchup for a team's top option. While the Saints are 13th in passing yards allowed, they have been susceptible to scoring, giving up the second-most passing touchdowns (9) in the NFL and ranking 19th against fantasy wide receivers.

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Arizona Cardinals running back Michael Carter is expected to see a significant workload in Week 5 after Trey Benson (knee) was placed on injured reserve. "He's played a lot of snaps for us over the last couple years and he's going to now," general manager Monti Ossenfort said regarding Carter's expected workload. Indeed, Carter played roughly 75 percent of the offensive snaps between Weeks 17 and 18 last season, rushing for 5.4 yards per carry in one of those games and scoring a touchdown in the other. He should face plenty of competition from Emari Demercado, but the general manager's comments indicate that the Cardinals could be headed for more of a true backfield split than people originally expected, even after Carter logged just one touch through the first four weeks of the season. Demercado is a high-end RB3/flex option, while Carter is best viewed as a mid-to-low RB3/flex.

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New York Giants running back Cam Skattebo is set up for another high-volume workload against the New Orleans Saints in Week 5. With Tyrone Tracy Jr. still sidelined, Skattebo has cemented his role as the team's workhorse, commanding a 70.8% timeshare last week and ranking as the RB20 on the season with an average of 11.97 fantasy points per game. He faces a Saints defense that allows the 24th-most fantasy points to running backs but has significant vulnerabilities that a high-volume back can exploit. New Orleans ranks 30th in the NFL in both points allowed per game (30.3) and red zone touchdown percentage (76.9%), setting the stage for Skattebo to capitalize on scoring opportunities.

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Tennessee Titans wide receiver Tyler Lockett has seen an appealing snap and target share over the last few weeks, and he could be headed for an expanded role in Week 5 against the Arizona Cardinals. Lockett is currently preparing for the matchup as the Titans' No. 3 receiver, as he has been doing ever since the season opener, but he could jump to second on the depth chart if Calvin Ridley (knee, elbow), who is questionable, doesn't suit up. Ridley has been underwhelming this year but would still vacate around 50 snaps, many of which would likely go to Lockett. There's a direct relationship between the two players' snap shares; every time Ridley has played at least 85 percent of the snaps, Lockett plays below 60 percent. Last week, when Ridley played just 54 percent, Lockett saw his snap share jump to 72 percent. Having someone like Lockett on the field is a good idea for the Titans, who have youth elsewhere in Cameron Ward, Elic Ayomanor, and Chig Okonkwo. A reliable veteran presence with sure hands in the short and medium passing games, Lockett has 12 targets but just six catches through his first four games in Tennessee. A Ridley absence could push Lockett closer to six or seven targets with at least a few receptions, therefore giving him some WR3/flex appeal in the deepest leagues. On the other hand, if Ridley plays, Lockett would probably see around just 50 percent of the snaps, which isn't enough to get him on the fantasy radar.

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New York Giants quarterback Jaxson Dart, has an excellent matchup in Week 5 after a solid NFL debut, where he led the Giants to a 21-18 victory over the Chargers. His dual-threat ability was on full display as he threw for 111 yards and a touchdown while adding 54 yards and another score on the ground. This week, he faces a Saints defense that, despite being sixth-best in passing yards allowed per game (177.0), has been extremely vulnerable to fantasy quarterbacks, ranking as the 28th-best defense against them by allowing an average of 20.6 fantasy points per game. New Orleans has surrendered nine passing touchdowns, the second-most in the league, and their 30th-ranked red zone defense could provide ample scoring opportunities for the rookie.

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Tennessee Titans running back Julius Chestnut could be headed for a reduced workload in Week 5 despite a favorable matchup against the Arizona Cardinals. Chestnut has operated as a backup to Tony Pollard through the first four weeks of the season. While his usage has been relatively modest given that Pollard leads all NFL running backs in snap share, Chestnut has still been his backup and did see the field in every game, logging five total carries. That marginal usage could drop to no usage as soon as Tyjae Spears (ankle) returns to game action. Spears is currently on injured reserve but has been designated to return and is questionable for Week 5. Chestnut's already limited opportunity share would surely disappear entirely as soon as another reliable, proven player like Spears is added to the backfield. If Spears plays Sunday, Chestnut, 24, might not touch the ball. Even if he remains on IR, though, the Sacred Heart product is due for just a couple of touches and remains off the fantasy radar.

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Tennessee Titans running back Tyjae Spears (ankle) could be an intriguing flex option for fantasy managers in Week 5, but only if he's activated from Injured Reserve. Spears is currently listed as questionable after logging a limited practice as the team mulls whether he's ready to rejoin the 53-man roster. He missed the first four weeks of the season while recovering from an ankle injury, but the Titans' offense looks like the worst in the NFL and could desperately use a burst of energy. Spears offers exactly that. As a rookie in 2023, we saw him command 70 targets in the passing game while maintaining 4.53 yards per carry on 100 carries. He was headed for similar numbers last year if not for missing five games due to injury. Now, he has yet another chance to carve out a role on the ground and through the air. Starter Tony Pollard has been nothing special so far, and while he'd likely continue to be the lead back for at least a little while, Spears could actually have more fantasy value due to his burst and pass-catching upside. Week 5 is a perfect opportunity for the 24-year-old to contribute as the Titans face the Arizona Cardinals, who have allowed the sixth-most targets and 12th-most fantasy points to running backs in 2025. If he suits up Sunday, Spears has the potential to be a strong flex option, especially in PPR leagues.

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Washington Commanders tight end Zach Ertz has continued to be productive in his age-34 season, catching 14 of 20 targets for 149 yards and two touchdowns. Currently the TE11 in total points scored, Ertz will benefit from having star quarterback Jayden Daniels (knee) return to the lineup, as they have built a strong rapport in their two years together. He's been less productive with veteran Marcus Mariota starting the past two games, catching five of seven targets for 59 yards. The veteran will look to get back on the right track in Week 5 against a difficult Chargers defense that has allowed the sixth fewest receptions to tight ends this season. Ertz can be trusted as a low-end TE1 for Week 5.

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Washington Commanders wide receiver Chris Moore played a big role in their Week 4 loss to the Falcons, playing the highest snap share of any Washington wide receiver. Moore ran the second-most routes on the team behind Deebo Samuel Sr. after being elevated from the practice squad ahead of Week 3. The 32-year-old wideout will likely be in line for a similar role with both outside receivers in Terry McLaurin (quadriceps) and Noah Brown (groin) ruled out. He's caught three of five receptions for 59 yards for the season. The veteran will benefit from star quarterback Jayden Daniels (knee) returning to the field, but faces a challenging matchup against the Chargers. Moore projects as a decent option in deeper leagues for Week 5 because he will likely play a good amount.

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Washington Commanders wide receiver Luke McCaffrey will have another opportunity for more playing time in Week 5. Washington continues to deal with multiple injuries at wide receiver, with Terry McLaurin (quadriceps) and Noah Brown (groin) both ruled out again for Sunday. McCaffrey has now scored touchdowns in back-to-back games without those two players, finding the end zone for the first time in his career on a 43-yard catch and run against the Raiders in Week 3. The second-year wideout, however, hasn't run a high number of routes in any game this season, despite injuries to the top of Washington's receiver room. He ran a season high of just 13 routes this past week against Atlanta. That signals that the coaching staff prefers not to use him on the outside, as journeyman receiver Chris Moore stepped into that role and ran close to a full number of routes against Atlanta. McCaffrey's role could expand this week against a stingy Chargers defense, but he's likely only playable in deeper leagues.

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Washington Commanders running back Jeremy McNichols has served as the pass-down back in their three-man running back committee. Jacory Croskey-Merritt and Chris Rodriguez Jr. have handled the bulk of the running back touches, while McNichols subs in on late downs for prowess as a pass protector. That is the driving factor behind McNichols' volume of snaps, but he's also shown some juice and physicality as a runner. He had one of the highlight runs of the season in Week 3 against the Raiders when he trucked a defender and then exploded for a 60-yard touchdown. McNichols should be expected to serve in his usual role against a tough Chargers defense, limiting his Week 5 appeal to deeper leagues.

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