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San Francisco 49ers quarterback Mac Jones (knee) was listed as a full participant on Monday's estimated practice report, according to Cam Inman of the Bay Area News Group. Meanwhile, Brock Purdy (toe) was listed as a non-participant after coming out of Sunday's Week 4 loss to the Jacksonville Jaguars with soreness in his toe. Purdy missed Weeks 2 and 3 due to turf toe and a sprained AC joint in his left shoulder, and he could be in danger of missing a third game in a short turnaround in Week 5 on Thursday night against the division-rival Los Angeles Rams. Jones suffered a PCL sprain in the Week 3 win over the Arizona Cardinals, but he was active as Purdy's backup in Week 4. If Purdy doesn't get cleared to play on Thursday night, Jones will make his third start of the year in a tough matchup against L.A. Jones would be nothing more than a low-end QB2 streamer in two-QB superflex formats if he gets another starting nod.

From RotoBaller

Baltimore Ravens head coach John Harbaugh said that quarterback Lamar Jackson (hamstring) was not in a position to return to Sunday's game against the Kansas City Chiefs in Week 4 after he tweaked his hamstring. "There was no way Lamar was going back into the game. The injury precluded it," Harbaugh said. Before Jackson left the game, he went 14-for-20 passing for 147 yards with a touchdown and an interception, adding six carries for 48 yards on the ground. Backup Cooper Rush replaced the 28-year-old superstar, who is now in danger of missing the Week 5 contest against the Houston Texans. At the time of Jackson's injury, the Ravens were down by multiple scores, leading many to believe the Ravens simply thought it was pointless to bring him back with the game likely already lost. Jackson's status will be closely watched this week. If Rush is forced to start against a stingy Texans defense, it will be a downgrade in fantasy for all of Baltimore's other offensive weapons.

From RotoBaller

San Francisco 49ers wide receiver Ricky Pearsall (knee) was listed as a non-participant on the team's Monday injury report, per Cam Inman of Bay Area News Group. The 49ers did not actually practice on Monday, so this is an estimation of Pearsall's current status heading into his Thursday night Week 5 matchup against the Los Angeles Rams. 49ers head coach Kyle Shanahan previously said that Pearsall suffered a "minor PCL" injury in Week 4. Pearsall has recorded 20 catches for 327 yards on 29 targets so far this season. It appears San Francisco could be without both Pearsall and wideout Jauan Jennings (ankle, ribs) on Thursday. If that's the case, 49ers wide receivers Kendrick Bourne and Demarcus Robinson would likely both be in line for a significant increase in playing time.

From RotoBaller

San Francisco 49ers wide receiver Jauan Jennings (ankle, ribs) was listed as a non-participant on the team's Monday injury report, according to Cam Inman of Bay Area News Group. Inman notes that San Francisco did not actually practice on Monday, so this is an estimation from the team on what Jennings' practice status would be heading into their Week 5 matchup against the Los Angeles Rams on Thursday night. The 28-year-old has dealt with myriad injuries this season and picked up a rib ailment in Week 4. In the three games he's been able to play in, Jennings has recorded nine catches for 129 yards and a touchdown on 19 targets. If he's unable to suit up on Thursday, 49ers wideouts Kendrick Bourne and Demarcus Robinson could see an increase in playing time alongside Ricky Pearsall (knee), who is dealing with a knee injury of his own. If Jennings is active, he profiles as a low-end fantasy WR3/flex option in Week 5.

From RotoBaller

Miami Dolphins wide receiver Tyreek Hill (knee) is believed to have suffered a dislocated knee during his team's Week 4 matchup against the New York Jets, according to Ian Rapoport of NFL Network. Hill was carted off the field in the third quarter with an Aircast on his left leg. The 31-year-old recorded six catches for 67 yards before getting injured in Week 4. If Hill ends up missing significant time, Dolphins wide receivers Jaylen Waddle and Malik Washington would likely see an increase in targets, as would tight end Darren Waller. Miami running back De'Von Achane's pass-game usage could also be elevated to even further heights.

From RotoBaller

Updating previous reports, Miami Dolphins WR Tyreek Hill (knee) is believed to have a suffered a dislocated knee during the Week 4 game, according to a source.

Fantasy Spin: Fantasy players will need to look for a possible timeline for Hill, but he will likely miss an extended period of time. Jaylen Waddle will take over as the No. 1 receiver for the Dolphins and can be a No. 2 or No. 3 receiver in fantasy leagues.

From TheHuddle

Indianapolis Colts head coach Shane Steichen said that wide receiver Adonai Mitchell is "going to have to earn" more opportunities going forward after his costly fumble in the team's Week 4 loss to the Los Angeles Rams. Mitchell recorded three catches for 96 yards on four targets against Los Angeles, but dropped the ball just before crossing the goal line on what should have been a 70-plus-yard touchdown. The 22-year-old has logged seven catches for 137 yards on 12 targets through four games this season. He saw increased playing time in Week 4 with Colts wideout Alec Pierce (concussion) sidelined. If Pierce returns for the team's Week 5 matchup against the Las Vegas Raiders, Mitchell could have a hard time getting on the field.

From RotoBaller

Dallas Cowboys head coach Brian Schottenheimer said rookie running back Jaydon Blue is "very close" to being active on game day and has been practicing "really, really well," per Jon Machota of The Athletic. Blue has been inactive for each of the Cowboys' first four games of 2025. Javonte Williams has been the workhorse back in Dallas so far this season, with fellow veteran back Miles Sanders (ankle) serving as the RB2. Sanders is reportedly trending towards playing in Week 5 after suffering an ankle injury in Week 4. Still, his health status could be a factor in the team's decision on whether to activate Blue. The Cowboys will face the New York Jets in Week 5, which would be a favorable matchup for Blue if he is indeed called upon to make his NFL debut.

From RotoBaller

Updating a previous report, Miami Dolphins WR Tyreek Hill (knee) suffered a knee injury during the Week 4 game and has been ruled out. Hill will be taken to a Miami hospital for imaging, evaluation and observation.

Fantasy Spin: Hill probably will miss an extended period of time, but fantasy players should know more in the next day or two. Jaylen Waddle and Darren Waller will receive bigger roles in the passing game. Waddle will be a No. 2 or No. 3 receiver in fantasy leagues, while Waller can become a low-end No. 1 tight end after a strong Week 4 performance.

From TheHuddle

Miami Dolphins wide receiver Tyreek Hill (knee) was forced to exit in the third quarter of his team's Week 4 matchup against the New York Jets with a left-knee injury. Hill's leg buckled underneath him awkwardly, and he was carted off the field with an Aircast on. It's too early to say exactly what the injury is, but it certainly doesn't look good for the 31-year-old wideout. According to NFL Network's Ian Rapoport, Hill has been ruled out and is being taken to a local hospital for imaging and evaluation. Hill will finish Week 4 with six catches for 67 yards. In his absence, Dolphins wide receivers Jaylen Waddle and Malik Washington should both see an uptick in targets. Veteran tight end Darren Waller and running back De'Von Achane could also see increased usage in the Miami passing game.

From RotoBaller

Miami Dolphins WR Tyreek Hill (leg) was carted off the field after suffering a leg injury during the Week 4 game.

Fantasy Spin: Hill appeared to have suffered a serious injury, so fantasy players should expect an extended absence. Jaylen Waddle will be the main receiver for the Dolphins and will be a weekly starting option in all leagues. Darren Waller will also a bigger role in the passing game and can be a low-end No. 1 tight end in leagues.

From TheHuddle

Detroit Lions tight end Sam LaPorta recorded three catches for 39 yards on four targets in his team's Week 4 win over the Cleveland Browns. LaPorta has now earned exactly four targets and failed to crack 40 yards in each of Detroit's last three games. For the season, the 24-year-old has logged 16 catches for 177 yards and zero touchdowns on 21 targets. On the bright side, LaPorta is tied for second on the Lions in targets with running back Jahmyr Gibbs, behind only star wideout Amon-Ra St. Brown (32). Still, LaPorta has not been able to provide consistent fantasy production so far in 2025. He has a favorable matchup on paper in Week 5 against the Cincinnati Bengals, but LaPorta may need to find the end zone to be a worthwhile fantasy starter.

From RotoBaller

New York Jets running back Braelon Allen (knee) suffered a knee injury in the first half of the Monday night game against the division-rival Miami Dolphins and has already been ruled out, according to Tom Pelissero of NFL Network. Allen's knee took a pretty nasty shot in the second quarter on a kickoff return. The 21-year-old was able to walk to the locker room under his own power, but he was quickly ruled out. Before the injury, he carried the ball four times for 26 yards. With Allen out the rest of the way to close out Week 4 action, Isaiah Davis will see more work in New York's backfield as a change-of-pace option behind Breece Hall. Allen came into Monday night's action with 14 rushing attempts for 50 yards (3.6 yards per game) and one rushing touchdown in three games in a struggling Jets offense. He's merely been a handcuff for Hall's owners, but it's possible he won't be able to play in Week 5 against the Dallas Cowboys.

From RotoBaller

Arizona Cardinals WR Zay Jones (concussion) participated in practice Monday, Sept. 29.

From TheHuddle

Detroit Lions quarterback Jared Goff did not have his best statistical day against a top-notch defense in his team's Week 4 win over the Cleveland Browns. Goff completed 16 of 27 pass attempts for 168 yards, two touchdowns, and one interception. On the season, the 30-year-old has now completed 73.8% of his pass attempts for 929 yards, nine touchdowns, and two interceptions. Goff has shown the potential for gaudy touchdown totals over the past couple of years in this Lions offense, but his lack of rushing ability (11 rushing yards this season) limits his fantasy ceiling. He profiles as a matchup-dependent low-end starter in single-quarterback leagues, and has a favorable matchup on paper in Week 5 against the Cincinnati Bengals.

From RotoBaller

Detroit Lions rookie wide receiver Isaac TeSlaa was held without a catch for the second straight game in Week 4 by the Cleveland Browns. TeSlaa burst onto the scene with a pair of highlight-reel grabs over his first two NFL games, but he remains limited to a minor role in the Detroit offense for the time being. The 23-year-old played just 20% of the Lions' offensive snaps in Week 4 and is firmly behind Detroit wideouts Amon-Ra St. Brown, Jameson Williams, and Kalif Raymond on the team's depth chart at the position. All told, TeSlaa has two catches for 42 yards and a touchdown on four targets so far this season. He maintains some appeal in dynasty leagues, but TeSlaa should be off the radar of fantasy managers in redraft formats.

From RotoBaller

Detroit Lions running back Jahmyr Gibbs recorded 97 yards from scrimmage and a touchdown on 17 total touches in his team's Week 4 win over the Cleveland Browns. The 23-year-old has now logged 271 rushing yards and four touchdowns on 58 carries to go along with 20 catches for 79 yards through four games. Gibbs has also out-touched fellow Lions running back David Montgomery in all four of Detroit's games so far in 2025. As long as he stays healthy, Gibbs should remain a must-start fantasy running back.

From RotoBaller

Denver Broncos wide receiver Marvin Mims Jr. (hip) was a late addition to the Week 4 injury report on Saturday after he was limited in practice, and he entered Monday night's matchup against the Cincinnati Bengals with a questionable tag. However, Mims has been cleared and will be active in Week 4 as the Broncos look to even their record at 2-2. The 23-year-old former second-rounder took a step forward in his sophomore year in 2024, catching 39 of 52 targets for 503 yards and six touchdowns in 17 regular-season games. However, Mims has been the WR3 through three weeks in 2025 behind Courtland Sutton and Troy Franklin in a Broncos offense that has started slow for the second straight year. He enters Monday night with six catches on 10 targets for 40 yards and a touchdown. Mims can break loose for big plays at any moment, though, and he'll be facing a Bengals defense that he torched for 103 yards and two touchdowns in the regular-season finale in 2024.

From RotoBaller

The Arizona Cardinals signed running back Michael Carter to their active roster on Monday, according to Dani Sureck of AZCardinals.com. Carter played in his first game with the Cardinals this year in last Thursday night's loss to the Seattle Seahawks now that James Conner (ankle) is out for the year, but he had just one carry for one yard. The 26-year-old former New York Jets RB will continue to provide depth in Arizona's backfield, and he could be in line for a bigger role in Week 5 against the Tennessee Titans if Trey Benson (undisclosed) is out or limited at all. Benson came down with an apparent injury in Week 4 and is considered day-to-day right now. If Benson were to miss any time, Emari Demercado would be the next man up for the Cardinals in the lead-back role.

From RotoBaller

Dallas Cowboys running back Miles Sanders (ankle) is trending toward being able to play against the New York Jets on Sunday, according to head coach Brian Schottenheimer. The head coach also said that rookie running back Jaydon Blue is "very close" to making his NFL debut after being a healthy scratch for the first four weeks of the season. Schottenheimer also said that Sanders' injury will play a part in discussions for potentially activating Phil Mafah (shoulder) from Injured Reserve if the team feels they need more backfield insurance. Sanders left the Sunday night tie against the Green Bay Packers in the second quarter with an ankle injury and did not return, but it looks like he avoided a serious injury. He's been the change-of-pace RB2 behind starter Javonte Williams. Sanders' injury may open the door enough for Blue to seize an opportunity in Dallas' backfield once and for all in 2025.

From RotoBaller