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ESPN's Nick Wagoner reports that San Francisco 49ers quarterback Mac Jones was a limited participant at practice for the second consecutive day due to a knee injury. Jones is dealing with a PCL sprain that was aggravated during last weekend's win against the Cardinals. With teammate Brock Purdy (toe, shoulder) still limited in his own right, the 49ers continue to deal with tumult regarding injuries. The sentiment around the team seems to be that Purdy has a chance to return in Week 4, barring any setbacks. However, that hinges on his status following Friday's practice. If Purdy and Jones both can't go, it will be Adrian Martinez calling signals against the visiting Jacksonville Jaguars.

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San Francisco 49ers quarterback Brock Purdy (toe, shoulder) was again listed as a limited participant in Thursday's team practice, ESPN's Nick Wagoner reports. The 25-year-old is still hampered by toe and shoulder injuries, but at least he has consistently been able to log a limited session without a setback. With fellow signal caller Mac Jones (knee) nursing an injury of his own, San Francisco is suddenly in danger of being down two QBs ahead of their Week 4 meeting with the visiting Jacksonville Jaguars. Head coach Kyle Shanahan noted on Thursday that Purdy is progressing toward a return on Sunday, stating, "I think (the toe) is feeling better each day and if that continues he should be good on Sunday." We'll know more following tomorrow's practice.

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According to the team, Houston Texans wide receiver Nico Collins (knee) practiced in full on Thursday. The 26-year-old was a surprise addition to Wednesday's practice report with a knee injury, but he's back out there a day later, insinuating that it was probably just a day of rest for him. Fantasy managers will want to monitor Collins over the next few days as Houston prepares to take on the Tennessee Titans at home in Week 4. Though, as of now, it doesn't appear to be a threat to his status for Sunday's showdown. If he were to miss time, teammates Xavier Hutchinson and Jayden Higgins would be in line for an uptick in snaps.

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Mike Garafolo of NFL Network reports that Washington Commanders wide receiver Terry McLaurin (quadriceps) will not require surgery after seeking multiple medical opinions this week, but his status for Week 4 against the Atlanta Falcons on Sunday is not looking good. Garafolo added it's uncertain exactly what McLaurin's injury is, as it's been described as a quad/groin/hip ailment. It was ominous news that McLaurin met with a core-muscle specialist this week, but at least for now, he will avoid going under the knife. Still, the 30-year-old wideout has not practiced yet this week and is looking unlikely to play this Sunday in Atlanta. Fantasy managers would be wise to replace him in their starting lineups for now. Even if he's able to practice on Friday, which seems unlikely, he wouldn't be a lock to play in Week 4. With Noah Brown trending toward a second straight missed game, Luke McCaffrey and rookie Jaylin Lane appear to be in line for increased playing time for the Commanders.

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Los Angeles Rams wide receiver Davante Adams (hamstring) missed a second straight practice this week on Thursday, according to ESPN's Sarah Barshop. It puts Adams' status in doubt for the upcoming Week 4 matchup on Sunday against the Indianapolis Colts. Head coach Sean McVay hasn't seemed too concerned about Adams missing this weekend, though, and merely called the veteran wideout's injury a sore hamstring. If the 32-year-old Pro Bowler can practice on Friday, he would appear to have a decent shot at suiting up against the 3-0 Colts. Adams has been a big part of the Rams' offense through three games in his first year with the team, as he's caught 13 of his 29 targets for 213 yards and two touchdowns. If he's active this weekend, Adams should be in all starting fantasy lineups. Check back on Friday for his official Week 4 status.

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Seattle Seahawks running back Zach Charbonnet (foot) is officially active for the Thursday night divisional tilt on the road against the Arizona Cardinals to kick off Week 4 action. Charbonnet was inactive in the team's Week 3 win over the Pittsburgh Steelers on Sunday, but he was a full-go in walk-through practices on a short week and will return to Seattle's backfield after missing just one game. In the first two weeks, Charb and Kenneth Walker III split touches right down the middle, with Charbonnet averaging a weak 2.1 yards per carry on 27 rushing attempts for 57 yards and one touchdown. The two RBs should continue to split the workload pretty evenly in Seattle going forward, but the better bet is that Charb sees a smaller workload in his return on a short week. With Charbonnet's snaps potentially being capped against Arizona, he's best left on your bench if you have other RB options.

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Cleveland Browns rookie fifth-round quarterback Shedeur Sanders said in an interview with ESPN Cleveland that he's "ready to play right now" and is "more capable" than other QBs in the league. Sanders is keeping a positive mindset on a daily basis despite being the No. 3 signal-caller on Cleveland's depth chart behind veteran Joe Flacco and fellow rookie Dillon Gabriel. His father, former NFL legend Deion Sanders, recently said that he thinks his son will be starting for the Browns at some point this year despite falling to the fifth round in April's draft. Flacco has not impressed at all through three weeks, but Gabriel will almost certainly get the first shot at starting duties under center in Cleveland before Sanders does if the Browns eventually bench Flacco. The 23-year-old looked good during preseason action, but it was also against second- and third-stringers on defense.

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Los Angeles Chargers tight end Will Dissly (knee) missed a second straight day of practice this week on Thursday, putting his availability in peril for a Week 4 road contest in New York against the winless Giants. Dissly also missed the Week 3 win over the Denver Broncos with his knee injury, so he'd be sitting out a second straight game if he's deemed inactive this weekend. The 29-year-old's absence last Sunday opened the door for rookie Oronde Gadsden to be active for the first time in his career, and he responded by catching five of seven targets for 46 yards. Gadsden is quickly gaining the trust of quarterback Justin Herbert and could be the Bolts' preferred pass-catching tight end in 2025 when it's all said and done. If Dissly misses a second straight game, Gadsden will have an elevated role once again while sharing snaps with Tyler Conklin.

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Denver Broncos running back J.K. Dobbins has been a "real good addition" for the team this year, head coach Sean Payton said. Zac Stevens of DNVR Sports writes that it's "clear" that Payton is a big fan of Dobbins, who has been the Broncos' clear RB1 through three weeks over rookie second-rounder RJ Harvey. Dobbins has seen double-digit carries in all three games of the year so far and has run for at least 63 yards each week. The 26-year-old has also scored on the ground in all three weeks. His best game so far came in the Week 3 loss to the Los Angeles Chargers, as he ran for 83 yards and a score on a season-low 11 rushing attempts. He had nine more rushing attempts than Harvey last weekend and has outcarried the UCF product 41 to 13. Harvey has one more catch than Dobbins through three weeks. Dobbins isn't going away anytime soon, and he'll be in play as an RB2 in Week 4 in a plus matchup against the Cincinnati Bengals.

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Denver Broncos tight end Evan Engram (back) was listed as a full practice participant on Thursday, which is a great sign for his availability in a Week 4 matchup against the visiting Cincinnati Bengals on Monday night, according to Zac Stevens of DNVR Sports. Engram missed practice all week before sitting out the Week 3 loss to the Los Angeles Chargers, so it's a bit surprising to see him as a full-go for the first practice of the week. It's a good indication that the 31-year-old will end his one-game absence and play on Monday night in a strong matchup for TEs. The Bengals have allowed the fifth-most half-PPR points to the position through the first three weeks of 2025. Broncos head coach Sean Payton continues to say that Engram will be a big part of the offense this year, but fantasy managers want to see it to believe it in this struggling Denver offense. In two games, Engram has caught four of six targets for 33 yards.

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Atlanta Falcons tight end Kyle Pitts Sr. (toe) returned to a full practice on Thursday after he was limited on Wednesday, according to Tori McElhaney of AtlantaFalcons.com. Pitts was also dealing with a toe injury early last week, but he upgraded to full practice and was able to play in the Week 3 loss to the Carolina Panthers. The 24-year-old should be good to go as the Falcons look to bounce back in Week 4 against the Washington Commanders' suspect secondary after they were shut out by the Carolina Panthers last Sunday. Pitts has not found the end zone yet in 2025, but he's been consistently involved and has caught 15 of his 19 targets from quarterback Michael Penix Jr. for 135 yards. He should be considered a low-end TE1/high-end TE2 play for fantasy managers in a matchup against a Commanders defense that has allowed the ninth-most half-PPR points to TEs through three weeks.

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Washington Commanders wide receiver Terry McLaurin (quadriceps) was officially a non-participant in Thursday's practice, the second straight day this week that he failed to practice. McLaurin injured his quad in the Week 3 win over the Las Vegas Raiders and has received multiple medical opinions from specialists this week, a sign that he won't be available to play this Sunday against the hosting Atlanta Falcons. The 30-year-old will most certainly need to practice in some fashion on Friday to have a shot at suiting up in Week 4, but as of now, fantasy managers should consider McLaurin more doubtful than likely to play. Noah Brown (groin, knee) has yet to practice, too, after missing Week 3, so Washington could be down to Deebo Samuel Sr., Luke McCaffrey, and rookie Jaylin Lane this weekend. It's also unclear if quarterback Jayden Daniels will be able to return from a knee sprain he suffered in Week 2.

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Tampa Bay Buccaneers wide receiver Chris Godwin (ankle) was downgraded to a non-participant in Thursday's practice after he was a full practice participant on Wednesday. It's a reminder that although the Bucs are hopeful that Godwin will make his season debut in Week 4 against the Philadelphia Eagles this Sunday, it's not guaranteed. The 29-year-old is still recovering from a dislocated left ankle that ended his 2024 season in Week 7. The fact that Godwin was able to practice in full on Wednesday is a good sign, but how much he's able to do on Friday will ultimately decide if Tampa will make him active this weekend against the reigning Super Bowl champions. The Bucs could certainly use Godwin back with Mike Evans (hamstring) out for at least a couple of weeks, but Godwin is expected to be eased into the offense whenever he returns. Sterling Shepard will be a better flex play than Godwin if Godwin is cleared to play on Sunday.

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Washington Commanders quarterback Jayden Daniels (knee) was listed as a limited participant in practice on Thursday for the second straight day this week. Daniels is making progress from a knee sprain that he suffered in the Week 2 loss to the Green Bay Packers, but he's up in the air to return this weekend for a road matchup against the Atlanta Falcons. The 24-year-old was held out of the Week 3 win over the Las Vegas Raiders. If he is unable to upgrade to a full practice on Friday, Daniels will likely go into Sunday's contest with a questionable designation. The Commanders aren't going to rush the second-year signal-caller back onto the field, especially if his lateral movement is still compromised. If Daniels can return against Atlanta, fantasy managers will want to get him back into their starting lineups, even if he's without top wideout Terry McLaurin (quadriceps).

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Cleveland Browns tight end David Njoku (knee) practiced in full on Thursday after being limited on Wednesday with a knee injury. By practicing in full on Thursday, Njoku would appear to be trending towards playing in Week 4 against the Detroit Lions. Njoku has recorded 12 catches for 117 yards on 18 targets through his first three games of 2025. The 29-year-old is still seeing steady playing time, but his target share has been limited due to the emergence of Browns' rookie tight end Harold Fannin Jr. Njoku profiles outside the top-12 for fantasy at the tight end position in Week 4, and both Browns tight ends are difficult for managers to trust as long as they share the field.

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Tennessee Titans rookie quarterback Cameron Ward (ankle/calf) was able to log a full practice on Thursday after being limited in practice on Wednesday. Ward's status is still worth monitoring heading into Friday, but he appears to be on track to play in Week 4 against the Houston Texans. Ward has struggled in the first three games of his NFL career, completing just 54.5% of his pass attempts for 506 yards, two touchdowns, and one interception. The Texans' defense has been one of the best units in the league so far in 2025, so Ward could be in for another rough game on Sunday. Even in two-quarterback formats, Ward should be avoided by fantasy managers in Week 4.

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San Francisco 49ers wide receiver Ricky Pearsall (knee) was able to return to practice on Thursday after missing Wednesday's practice with a knee injury, per David Lombardi of The San Francisco Standard. Pearsall appears to be trending towards playing in Week 4 against the Jacksonville Jaguars. The 25-year-old has his best game of the season in Week 3, posting eight catches for 117 yards against the Arizona Cardinals. Pearsall has recorded 16 catches for 281 yards on 24 targets through his first three games of the season. Assuming he can play on Sunday, Pearsall profiles as a low-end fantasy WR2 in Week 4 against Jacksonville.

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San Francisco 49ers wide receiver Jauan Jennings (ankle/shoulder) was not able to practice for the second straight day on Thursday, per David Lombardi of The San Francisco Standard. Jennings was unable to play in Week 3 against the Arizona Cardinals and could be trending towards missing his team's Week 4 contest against the Jacksonville Jaguars as well. Jennings has battled multiple injuries so far in 2025, dating back to training camp, but he recorded seven catches on 15 targets for 105 yards and a touchdown across the 49ers' first two games of the season. The 28-year-old's absence would likely mean an uptick in targets for wideout Ricky Pearsall (knee), who had 11 targets and eight catches against the Cardinals with Jennings sidelined in Week 3. If Jennings can return for Week 4, he profiles as a low-end fantasy WR3/flex option.

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Baltimore Ravens offensive coordinator Todd Monken said the team is hoping to get tight end Isaiah Likely (foot) back on the field in Week 4, per ESPN's Jamison Hensley. Likely underwent foot surgery in August and has yet to suit up in 2025. The 25-year-old recorded 42 catches for 477 yards and six touchdowns across 16 games (nine starts) in 2024. Likely will probably need a bit of a ramp-up period upon his return, so he may see a limited workload in Week 4 against the Kansas City Chiefs even if he's active for the game. Still, Likely's presence could take targets away from Ravens tight end Mark Andrews, who recorded six catches for 91 yards and two touchdowns in Week 3. Once Likely is fully re-integrated into the offense, it may be tough for either Baltimore tight end to provide consistent top-12 fantasy production at the position.

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Washington Commanders rookie running back Jacory Croskey-Merritt (knee) was held out of practice with a knee injury for the second straight day on Thursday, according to ESPN's Adam Schefter. Croskey-Merritt has logged 22 carries for 125 yards and two touchdowns through his first three games of 2025. The 24-year-old's status for the team's Week 4 matchup against the Atlanta Falcons appears to be in doubt. Croskey-Merritt was part of a backfield committee for Washington in Week 3, splitting touches with running backs Chris Rodriguez Jr. and Jeremy McNichols. If Croskey-Merritt is sidelined against the Falcons, Rodriguez Jr. could be the primary early-down back with McNichols handling the majority of the passing-down work. Should Croskey-Merritt be active, he would profile as a low-end fantasy RB3/flex option.

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