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Indianapolis Colts quarterback Anthony Richardson Sr. (eye) has been placed on Injured Reserve due to an orbital fracture, per ESPN's Stephen Holder. Richardson Sr. suffered the injury in a freak accident while warming up with a stretch band before the Colts' Week 6 matchup with the Arizona Cardinals. The 23-year-old will now miss at least the next four games for Indianapolis, leaving the team without its preferred backup to starting quarterback Daniel Jones. Sixth-round rookie signal-caller Riley Leonard would currently be next in line if Jones were to get injured. However, Holder reports that the Colts will "consider signing a veteran to back up Jones depending on (Richardson Sr.'s) timeline."

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Pittsburgh Steelers wide receiver Calvin Austin III (shoulder) was listed as a non-participant on the team's Monday injury report due to a shoulder injury. Pittsburgh did not actually hold a practice, so this is an estimation of Austin III's status heading into the Steelers' Week 7 matchup against the Cincinnati Bengals on Thursday night. Austin III did not play in Week 6 due to the injury and appears to be at risk of missing a second straight game. The 26-year-old has recorded 10 catches for 139 yards and two touchdowns across four games so far this season. In Austin III's absence in Week 6, Roman Wilson was the only Steelers wide receiver outside of DK Metcalf to record a target.

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Dallas Cowboys Executive Vice President Stephen Jones said that wide receiver KaVontae Turpin (foot) has "a chance" to play in Week 7 against the Washington Commanders, per Jon Machota of The Athletic. Turpin has missed two straight games with a foot injury. The 29-year-old has recorded 11 catches for 159 yards and a touchdown on 13 targets across four games so far this season. Dallas may also be getting star wideout CeeDee Lamb (ankle) back in Week 7, which would likely leave Turpin fighting for WR3 reps in Dallas with Jalen Tolbert and Ryan Flournoy. If Lamb remains out in Week 7, Turpin could have some flex appeal in deep leagues against Washington.

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Buffalo Bills wide receiver Joshua Palmer (ankle) injured his ankle in the first half of Monday night's game against the hosting Atlanta Falcons and is questionable to return, according to ESPN's Alaina Getzenberg. Palmer was taken to the blue medical tent to be evaluated and was seen running up and down the sideline after that to try and get his ankle loose. Buffalo's offense already came into this game short a couple of pass-catchers, with tight end Dalton Kincaid (oblique) and receiver Curtis Samuel (neck, ribs) out. If Palmer is unable to return for the rest of Monday's game, there will be more targets to go around for receivers Khalil Shakir, Keon Coleman, and Elijah Moore, as well as tight end Dawson Knox, who scored the team's first touchdown of the game. At the time of his injury, Palmer was leading the Bills with two catches for 60 yards.

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San Francisco 49ers head coach Kyle Shanahan said on Monday that he thinks wide receiver Brandon Aiyuk (knee) is getting "closer and closer" to being able to return to practice, but there's "no definitive target date for that yet," according to Nick Wagoner of ESPN. Aiyuk is getting closer to practicing after tearing his ACL and MCL in his knee in Week 7 of last year, but his return to actual game action is another story. Once the Niners designate Aiyuk to return from the Physically Unable to Perform list, they'll have 21 days to officially activate him for his 2025 debut. San Fran's receiving corps really has not been healthy all year, but they aren't going to rush Aiyuk back, and fantasy managers still should be expecting his return to come in the second half of the season. Once the former first-rounder is back in the fold, don't be surprised if he's eased back into the offense, given his long layoff.

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San Francisco 49ers head coach Kyle Shanahan said on Monday that wide receiver Ricky Pearsall (knee) will be evaluated on Wednesday with the hope that he can do more in practice this week, according to Nick Wagoner of ESPN. Pearsall suffered a PCL injury to his right knee in Week 4 and has missed the last two games as a result. He was unable to practice at all last week, but he was able to do conditioning work on side fields with trainers. The 25-year-old second-year pass-catcher appears to be making progress, but it's premature to think that he'll be able to return for a Week 7 matchup against the Atlanta Falcons on Sunday. When Pearsall does finally return, tight end George Kittle (hamstring) could be back from Injured Reserve, which would mean fewer targets in the passing game. Fellow wideout Jauan Jennings (ribs) returned in the Week 6 loss to the Tampa Bay Buccaneers, but he revealed he played with five broken ribs.

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Arizona Cardinals head coach Jonathan Gannon cleared things up on Monday for anyone thinking there might be quarterback controversy in the desert after veteran backup Jacoby Brissett's strong performance in the Week 6 loss to the Indianapolis Colts. When asked if Kyler Murray (foot) is still the starter under center when he's healthy, Gannon said, "Yeah." "He's the starting quarterback," Gannon confirmed. Brissett threw for 320 yards, two touchdowns, and an interception on Sunday. The last time that Murray went for over 300 yards passing in a game was in late October of 2022. Although it was just a one-game sample size for Brissett, he looked better than Murray has in his five starts in 2025. The Cardinals organization continues to stand behind Murray as the starting QB, but Brissett's impressive composure in his first start of the year on Sunday could afford the team more patience in bringing Murray back from his foot injury.

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San Francisco 49ers head coach Kyle Shanahan said on Monday that quarterback Brock Purdy (toe) will be evaluated on Wednesday with the hope that he will be able to do more in practice this week, according to Nick Wagoner of ESPN. Purdy aggravated a turf-toe injury in Week 4 and has now missed back-to-back games (four total this year). He did not practice at all last week, but he was seen working on his conditioning on side fields. The 25-year-old signal-caller is believed to be making progress, but his availability for Week 7 against the Atlanta Falcons will all depend on whether he can return to practice this week. There's no question that Purdy is San Fran's starting QB when healthy, but backup Mac Jones' strong play has given the 49ers the luxury of slow-playing Purdy's rehab from his toe injury. We should have a better idea of Purdy's chances of returning this weekend after the Niners hold a few practices later this week.

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Chicago Bears rookie first-round tight end Colston Loveland (hip) is officially active for Monday Night Football against the Washington Commanders to wrap up Week 6 action. Loveland will be returning for the first time since Week 3 due to a hip injury. The 21-year-old sat out of the Week 4 contest and is now ready after having extra time to heal during the team's Week 5 bye. With Loveland back in the fold, quarterback Caleb Williams will have his full complement of targets in the passing game against a suspect Washington secondary. There's a lot to like about Colston's long-term fantasy outlook, but early in his rookie season, he has struggled to produce and will likely take a back seat to Cole Kmet yet again in his return on Monday. In his first three NFL games, Loveland has caught half of his six targets for 43 yards and no touchdowns.

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Washington Commanders running back Chris Rodriguez Jr. (calf) is officially active for the Monday Night Football game against the Chicago Bears in Week 6 despite not practicing all week. Rodriguez, rookie Jacory Croskey-Merritt, and Jeremy McNichols had been operating in a committee backfield after the season-ending injury to Austin Ekeler (Achilles) earlier this year until last week, when Croskey-Merritt took hold of the lead-back role in a breakout performance in the win over the Los Angeles Chargers. It's unclear if Rodriguez will be limited at all on Monday night, but we'd expect him to take a clear back seat to JCM once again against Chicago. The 25-year-old RB should be viewed as a pretty shaky touchdown-dependent RB3/flex in fantasy lineups on Monday. In the last three games, Rodriguez has just over 100 yards rushing and no touchdowns on 23 carries.

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Washington Commanders wide receiver Deebo Samuel Sr. (heel) is officially active for the Monday night contest in Week 6 against the Chicago Bears. Samuel was only able to get in one limited practice going into Monday's game, which is why he was listed as questionable on Saturday's final injury report. However, he'll end up suiting up for Washington, which is good news, considering they will be without both Terry McLaurin (quadriceps) and Noah Brown (groin, knee) for yet another game. It's possible that Samuel won't be entirely 100% health-wise on Monday, but he still deserves to be started in all fantasy lineups now that he's active. Samuel has been the Commanders' go-to offensive weapon through the air in the last two weeks with McLaurin and Brown out, and that shouldn't change much on Monday in a plus matchup. The 29-year-old will be looking to find the end zone for the third straight week.

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In a surprise turn, the Atlanta Falcons have made wide receiver Ray-Ray McCloud III a healthy scratch from the Monday night contest against the visiting Buffalo Bills, according to Tori McElhaney of AtlantaFalcons.com. Darnell Mooney (hamstring) is inactive for the Falcons' receiving corps, so Casey Washington, KhaDarel Hodge, and Jamal Agnew could see bigger roles in the passing game behind Drake London. Both London and tight end Kyle Pitts Sr. should have slightly higher ceilings against Buffalo with Mooney out as well. McCloud has been a non-factor in fantasy in Atlanta in 2025, catching six of 14 targets for 64 yards and no touchdowns in four games played. His best game came in the season opener, when he had three catches for 51 yards in the loss to the Tampa Bay Buccaneers.

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Chicago Bears kicker Cairo Santos (thigh) has been ruled out for the Week 6 game on Monday night against the Washington Commanders. Santos drew a questionable tag on Saturday despite three full practices this week, and now he has been ruled out. The Bears elevated kicker Jake Moody from their practice squad to the active 53-man roster before the game, so he is in line to make his debut with Chicago on Monday Night Football. The 25-year-old Moody was cut by the San Francisco 49ers after going 1-for-3 in the season opener. Moody's struggles from last year continued in Week 1 in the Bay Area, but now he'll get another shot to prove himself with the Bears, with Santos injured. It could just be a one-week showcase, though, if Santos is ready to kick again for the team's Week 7 game against the New Orleans Saints.

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San Francisco 49ers head coach Kyle Shanahan said on Monday that he expects tight end George Kittle (hamstring) to return to practice this week ahead of the Week 7 game on Sunday against the Atlanta Falcons, according to Adam Schefter of ESPN. It means that the Niners should be designating Kittle to return from Injured Reserve on Wednesday so that he can rejoin the team at practice. It's good news that the Pro Bowl tight end is close to returning to the practice field, but it's not a guarantee that he'll officially be activated from IR to play in Week 7. The 32-year-old has been out since injuring his hamstring in the season opener. It's unclear if Kittle will have restrictions on his snap count when he's officially back, but his return will be a massive boost to San Fran's banged-up receiving corps. When Kittle is back, he'll be a no-doubt TE1 in fantasy that should be peppered with targets from either quarterback Mac Jones or Brock Purdy (toe).

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An MRI exam on Monday revealed that New York Jets wide receiver Garrett Wilson (knee) suffered a hyperextended knee in the Week 6 loss to the Denver Broncos on Sunday in London, according to Adam Schefter of ESPN. According to a source, Wilson is now expected to miss "a couple of weeks." While it's obviously bad news for the Jets and for fantasy managers, Wilson avoided a serious long-term injury and will be back this year. The Jets have two more games in Week 7 (against the Carolina Panthers) and in Week 8 (versus the Cincinnati Bengals) before their bye in Week 9. Fantasy managers probably should be planning for Wilson to be out through the team's Week 9 bye, which would mean the earliest he could return to play would be in Week 10 against the Cleveland Browns. The Jets already had one of the worst passing attacks in the NFL, and with Wilson out, now they'll have to lean more on rookie tight end Mason Taylor and receivers Josh Reynolds, Allen Lazard, Tyler Johnson, and Arian Smith.

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Buffalo Bills wide receiver Curtis Samuel (neck, ribs) is officially inactive for the Monday night contest on the road against the Atlanta Falcons, according to Adam Schefter of ESPN. In addition to Samuel, the Bills' offense will be missing tight end Dalton Kincaid (oblique) against what has been a much-improved Atlanta defense so far in 2025. The 29-year-old Samuel hasn't been on the fantasy radar to begin with, but his absence on Monday means less depth in the wideout corps for Buffalo behind Khalil Shakir, Keon Coleman, and Joshua Palmer. The Bills have their bye coming in Week 7, so hopefully Samuel will be ready to go for a Week 8 contest against the Carolina Panthers. Samuel has only been active for two games so far in 2025 and has caught three of his four targets for 35 yards and one touchdown. He had just one TD in 14 games a year ago for Buffalo and should remain on the waiver wire.

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Los Angeles Chargers running back Hassan Haskins started Sunday's game but quickly faded as rookie Kimani Vidal took over in the team's 29-27 win over the Miami Dolphins. Haskins managed only six carries for 14 yards and one catch for nine yards, while Vidal exploded for 138 total yards and a touchdown. Even against the league's worst run defense, Haskins struggled to produce, averaging just 2.3 yards per carry. With Omarion Hampton (ankle) still on IR for at least the next three games, Vidal appears to be the clear RB1 moving forward. Haskins can be dropped in shallow fantasy leagues or stashed in deeper formats unless injuries occur again.

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Buffalo Bills tight end Dalton Kincaid (oblique), who was listed as questionable to play in Week 6 against the Atlanta Falcons, is out for Monday night's contest, according to ESPN's Adam Schefter. In addition to Kincaid, the Bills' offense will be without veteran wide receiver Curtis Samuel (neck, ribs). Kincaid probably could have played in Monday's game, but the Bills are electing to sit him out with their bye coming in Week 7. After two full weeks of rest, we'd expect Kincaid to be ready to roll in Week 8 on Oct. 26 against the Carolina Panthers. With Kincaid out against Atlanta, backup Dawson Knox will have streaming value in DFS and for anyone who was planning to start Kincaid. Knox only has six catches on 10 targets this year for 54 scoreless yards, but he should be in line for his most production in 2025 on Monday night with Kincaid sidelined.

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Los Angeles Chargers quarterback Justin Herbert bounced back strongly in the team's 29-27 last-second win over the Miami Dolphins on Sunday. He completed 29 of 38 passes for 264 yards and two touchdowns, showing poise and evasiveness behind a depleted offensive line. Herbert stayed calm under constant pressure, leading a game-winning drive with less than 40 seconds remaining. The Chargers' rushing attack performed well throughout the game, giving Herbert some needed breathing room. In Week 7, Herbert faces the 5-1 Indianapolis Colts, who just allowed backup Arizona Cardinals quarterback Jacoby Brissett to pass for 320 yards. Expect another confident performance from Herbert as he tries to keep the Chargers' momentum going. He continues to be a reliable QB1.

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Los Angeles Chargers wide receiver Ladd McConkey had a standout performance in the team's last-second 29-27 win against the Miami Dolphins, catching seven passes for 100 yards and a touchdown on nine targets. He led the team in nearly every receiving category, stepping up with Quentin Johnston (hamstring) out, and made a crucial 42-yard reception with seconds left to set up Cameron Dicker's game-winning field goal. This is McConkey's second straight week with a touchdown after barely seeing any red zone targets in the first four games of the season. McConkey is expected to remain active in Week 7, as the 5-1 Indianapolis Colts visit the Chargers at SoFi Stadium. The Colts' pass defense has been average, and with Johnston's status still uncertain, McConkey should be in line for another productive game. His rapport with Herbert is starting to resemble that of the end of the 2024 season. McConkey is a dependable WR3 with WR2 upside moving forward.

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