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Washington Commanders running back Jacory Croskey-Merritt broke out with his best game of the season in Week 5 against the Chargers, totaling 150 yards and two touchdowns on 16 touches. The Croskey-Merritt takeover finally happened in Week 5, posting a season-high 50.9% snap share, handling 50% of the team's rush attempts, and running 31.3% of the team's routes. All marks were the highest of any Washington back in Week 5, and he delivered with a remarkable performance. For the season, he's rushed 283 yards and four touchdowns on 43 carries, averaging a league-best 6.6 yards per carry. Offensive coordinator Kliff Kingsbury provided some reason to keep the optimism in check, saying that the rookie still has "ways to go" in terms of playing without the ball in his hands. His work in pass protection has improved, but that is still an area where veteran Jeremy McNichols is most trusted. Third-year back Chris Rodriguez Jr. saw his lowest snap count and fewest carries in a game since becoming active in Week 5, suggesting he may be slipping back into a depth role. Croskey-Merritt should be expected to handle the bulk of the touches again in Week 6 against a Bears defense that is allowing an absurd 6.1 yards per carry and the fourth-most PPR points per game to opposing running backs. He should be fired up as a high-upside RB2 on Monday night.

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Las Vegas Raiders running back Raheem Mostert struggled to make an impact in his change-of-pace role during Week 5, totaling just 22 yards on a season-high seven touches. While the 33-year-old veteran still flashes big-play ability--highlighted by a 37-yard run against the Bears earlier this year--his current workload leaves him well outside fantasy relevance. Mostert should be viewed strictly as a handcuff to rookie standout Ashton Jeanty, who has firmly established himself as the lead back. Still, with Dylan Laube and Zamir White buried on the depth chart, Mostert remains the clear next man up if Jeanty were to miss time. For now, he's best left on the waiver wire outside of deeper leagues or as insurance for Jeanty managers looking to protect one of fantasy's rising assets.

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Tampa Bay Buccaneers quarterback Baker Mayfield (knee, arm) was removed from the injury report ahead of the Week 6 matchup against the San Francisco 49ers. Mayfield has been nursing some minor injuries, but will be fine for this weekend. Last week, Mayfield threw for a season-high 379 yards with two touchdowns and zero interceptions in the win over the Seattle Seahawks. The Bucs are banged up on offense with Bucky Irving (foot), Mike Evans (hamstring), and Chris Godwin (leg) likely all out this weekend. Despite that, Mayfield will find a way to succeed and remain an elite QB1 play.

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The Athletic's Daniel Popper speculates that if the Los Angeles Chargers explore the trade market at running back with Najee Harris (Achilles) done for the year and rookie first-rounder Omarion Hampton (ankle) on Injured Reserve, two potential options could be New York Jets RB Breece Hall and the Cleveland Browns' Jerome Ford. Both Hall and Ford are on expiring deals and could bring the Bolts a compensatory draft pick if they make it to free agency in 2026. Even when Hampton returns from IR, L.A. is going to need a second back to pair with him as a team with a run-first identity under offensive coordinator Greg Roman. At least for Week 6 against the Miami Dolphins, Hassan Haskins and Kimani Vidal are expected to share the backfield equally, giving them both flex appeal in deeper fantasy leagues. How aggressive the Chargers are on bringing in an outside RB will depend on how Haskins and Vidal fare in the coming weeks.

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Buffalo Bills tight end Dalton Kincaid (oblique) is dealing with an oblique injury and was limited in practice for the second straight day this week on Friday. Kincaid was seen wearing a no-contact jersey in practice on Thursday and again had his reps limited in practice on Friday, putting his status up in the air for Monday night's game against the Atlanta Falcons. If the 25-year-old doesn't go full in practice on Saturday, he could draw a questionable tag going into Monday's contest. Kincaid has already scored a career-high three times in his first five games in 2025 and is coming off his first 100-yard game in the Week 5 loss to the New England Patriots. As long as he's active, Kincaid should be considered a top-10 fantasy tight end, but a questionable tag this week could make for a difficult decision for fantasy managers in Week 6. Dawson Knox would be in play as a TE2 streamer if Kincaid is unable to play this week.

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Las Vegas Raiders rookie running back Ashton Jeanty continues to earn a larger role in the offense, showing off his versatility once again in Week 5 against the Colts. Jeanty drew seven targets, catching five passes and racking up 109 total yards from scrimmage despite not finding the end zone. His growing involvement as both a runner and receiver provides a strong floor for fantasy managers, especially with the Raiders offense increasingly leaning on him amid Geno Smith's turnover issues and Brock Bowers' absence. Heading into Week 6, Jeanty gets a dream matchup against a Tennessee Titans defense that ranks 29th against the run. With consistent usage and an expanding role in the passing game, Jeanty should be viewed as a strong RB2 with RB1 upside in PPR formats and a must-start in all standard leagues.

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Green Bay Packers kicker Brandon McManus (quadriceps) is listed as questionable to play in Week 6 on Sunday against the visiting Cincinnati Bengals at Lambeau Field, according to Wes Hodkiewicz of Packers.com. However, despite his questionable status after injuring his quad in practice on Wednesday, McManus told reporters on Thursday that, "I plan on playing." The veteran field-goal kicker felt a "tug" in his quad while warming up for field goals on Wednesday. The 12th-year kicker was limited in all three practices this week. McManus appears to be on the right side of questionable, but fantasy managers will still want to check Sunday's lineup to see if he's active. The 34-year-old will be a little riskier in fantasy lineups because of his injury, but if active, he deserves to be started against a soft Bengals defense. McManus has gone 7-for-9 on field goals and 11-for-12 on extra points in his first four games of 2025.

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Las Vegas Raiders quarterback Geno Smith continues to struggle, watching his fantasy stock take another major hit after tossing multiple interceptions against the Colts. Smith now leads the league with nine picks, a troubling trend that has tanked his reliability in all fantasy formats. With tight end Brock Bowers sidelined and the offense shifting focus toward rookie running back Ashton Jeanty, Smith has fallen to QB24 in overall rankings, rendering him unstartable in standard leagues. While a Week 6 matchup against Tennessee's 21st-ranked pass defense might appear favorable, the Titans' opportunistic secondary--boasting a 10.9% turnover rate--poses a real threat to Smith's chances of rebounding. Fantasy managers should look elsewhere until Smith proves capable of protecting the football and reigniting an offense that has lost its rhythm.

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Chicago Bears tight end Colston Loveland (hip) was a limited participant during Friday's practice session. This is now back-to-back limited practice sessions for Loveland after he missed Week 4 due to a hip issue. The rookie tight end had all last week to rest because of the bye, but is still battling a lingering hip problem. He'll get another chance to practice on Saturday ahead of the Monday night matchup against the Washington Commanders. When healthy, Loveland hasn't done much on the field this season. He has three receptions for 43 yards heading into this Week 6 matchup. Loveland isn't someone that needs to be started in fantasy leagues at the moment.

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Washington Commanders quarterback Jayden Daniels returned to action in Week 5 against the Chargers after missing two games with a knee injury. Daniels didn't miss a beat in Washington's road win in Los Angeles, completing 15 of 26 passes for 231 yards and a touchdown while adding 39 yards on the ground on eight rushes. The second-year quarterback was a bit rusty on his first couple of drives, but quickly settled in and looked like the same dynamic player that took the league by storm last year with one of the best rookie quarterback seasons of all time. Daniels and Washington will face the Bears off a bye in Week 6 in a rematch of their memorable game last season, which dramatically ended on a Hail Mary. It's an exploitable matchup versus a Chicago defense that is allowing nearly 30 points per game and a league-worst 6.7 yards per play. Daniels will rank as the top quarterback in fantasy in what could be a shootout on Monday night.

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Washington Commanders running back Chris Rodriguez Jr. (calf) was unable to practice on Friday. This marks back-to-back days that Rodriguez has been sidelined due to a lingering calf injury. He'll get one more chance to practice on Saturday ahead of the Monday night matchup against the Chicago Bears. If he sits, Jacory Croskey-Merritt should see his role increase in the backfield. The rookie back rushed for 111 yards with two touchdowns on 14 attempts in Week 5. He could see more carries if Rodriguez is unable to play.

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Washington Commanders wide receiver Deebo Samuel Sr. (heel) was a limited participant during Friday's practice session. After sitting out on Thursday, Samuel was back on the field on Friday. Fantasy managers shouldn't be too concerned as the Commanders were just resting Samuel on Thursday. He's dealing with a minor heel issue, but that shouldn't impact his status for the Monday night matchup against the Chicago Bears. Fellow wideout Terry McLaurin (quad) is still banged up, so Samuel should be a fine WR2 for Week 6.

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Detroit Lions tight end Brock Wright has just five catches for 37 yards on six targets so far this season, but two of his catches have resulted in touchdowns. The 27-year-old plays a consistent role in the Lions' offense, as he's played at least 40% of the team's offensive snaps in four out of five games this season. However, Wright's primary usage will likely be as a blocker as long as top Lions tight end Sam LaPorta remains healthy. In 63 career games played for Detroit, Wright has recorded 61 catches for 561 yards and 11 touchdowns. Wright and the Lions have a difficult matchup in Week 6 against the Kansas City Chiefs, who have allowed the ninth-fewest passing yards (999) and the fourth-fewest number of passing touchdowns (five) in the NFL so far this season. Wright should remain off the radar of fantasy managers in Week 6.

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Atlanta Falcons wide receiver Darnell Mooney (hamstring) was unable to practice on Friday. Mooney made an early exit during the Week 4 matchup versus the Washington Commanders. The 27-year-old was off last week due to a bye, but still remains uncertain to play in the Monday night matchup against the Buffalo Bills. He was a non-participant for the second straight day on Friday. He hasn't been ruled out yet, but fantasy managers should prepare to be without Mooney in Week 6. Drake London hauled in eight receptions for 110 yards with a touchdown in Week 4. He figures to be the primary focal point on offense without Mooney. Also, Kyle Pitts Sr. and Casey Washington should have increased roles.

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Los Angeles Rams tight end Tyler Higbee (hip) doesn't carry an injury designation into Sunday's Week 6 contest against the Baltimore Ravens. Higbee will be back in action after missing Week 5 and being a limited participant in practice this week. Heading into Week 6, Higbee has six receptions for 62 yards and zero touchdowns. It's worth noting that Higbee could see increased playing time with Colby Parkinson (concussion) banged up. Despite that, Higbee hasn't done enough on the field to give fantasy managers a reason to start him this weekend.

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Detroit Lions tight end Sam LaPorta had by far his best game of the 2025 season in Week 5 against the Cincinnati Bengals, recording five catches for 92 yards and a touchdown on six targets. LaPorta now has 21 catches for 269 yards and a score on 27 targets through five games. However, the Lions have a difficult matchup in Week 6 against the Kansas City Chiefs. Kansas City has allowed the ninth-fewest passing yards (999) and the fourth-fewest number of passing touchdowns (five) in the NFL so far this season. The Chiefs are also particularly stingy against tight ends, allowing an average of just 3.6 receptions and 32.8 yards per game to the position. Still, LaPorta will likely be the Lions' second-leading target-getter behind star wideout Amon-Ra St. Brown. LaPorta profiles as a must-start fantasy tight end in Week 6.

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Las Vegas Raiders tight end Michael Mayer (concussion) was a full participant in practice all week after being cleared from the league's concussion protocol, and he has been removed from the Week 6 injury report, according to Ryan McFadden of ESPN. It means that Mayer will play this Sunday in a great matchup against the Tennessee Titans after missing the last two games due to a concussion. Additionally, the 24-year-old should serve as the Raiders' primary pass-catching tight end now that Brock Bowers (knee) will officially miss his second straight game. In his first three games of 2025, before suffering a concussion, Mayer caught only six of his seven targets for 47 yards and no touchdowns, but it was also in the TE2 role behind Bowers. Even though it's Mayer's first game back in several weeks, his expanded role should at least make him worthy of consideration as a TE2 streamer in deeper fantasy leagues.

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Detroit Lions rookie wide receiver Isaac TeSlaa hauled in his second touchdown catch of the season in Week 5 against the Cincinnati Bengals and now has three catches for 54 yards and two scores through his first five NFL games. TeSlaa gets a difficult matchup in Week 6 against the Kansas City Chiefs, who have allowed the ninth-fewest passing yards (999) and the fourth-fewest number of passing touchdowns (five) in the NFL so far this season. On the bright side, TeSlaa could be in line for his largest snap share of the season with Lions WR3 Kalif Raymond (neck) officially listed as questionable to play in Week 6 due to a neck injury. TeSlaa still cannot be counted on for fantasy production in Week 6, but he's a player to monitor as a stash candidate in deep leagues for his season-long upside.

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Detroit Lions wide receiver Amon-Ra St. Brown missed the team's Wednesday practice this week due to a wrist injury, but he practiced in full on Thursday and Friday and does not carry an injury designation into Detroit's Week 6 matchup with the Kansas City Chiefs. St. Brown has been one of the most productive wideouts in the NFL so far this season, recording 35 catches for 407 yards and six touchdowns through five games. Kansas City has fielded a stingy pass defense so far this season, allowing the ninth-fewest passing yards (999) and fourth-fewest number of passing touchdowns (five) in the NFL. Still, St. Brown should see a significant target volume as the clear number one option in the Lions' passing game for quarterback Jared Goff. St. Brown profiles as a must-start fantasy wide receiver in Week 6 against the Chiefs.

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San Francisco 49ers quarterback Mac Jones (knee, oblique) is dealing with multiple injuries and is officially questionable to play in Week 6 against the Tampa Bay Buccaneers on the road on Sunday, per The Athletic's David Lombardi. Brock Purdy (toe) has already been ruled out for the fourth time this year due to a turf-toe injury, so the Niners are expecting the gritty Jones to play through his injuries this weekend. The 27-year-old Alabama product has been dealing with a minor PCL sprain in his knee early this season, and he suffered an oblique injury in last week's win over the Los Angeles Rams on Thursday night. His injuries didn't stop him from carving up the Rams' defense for over 300 yards and two touchdowns last week. While an encore probably isn't in the cards for Jones, especially without receiver Ricky Pearsall (knee), he'll be in play as a low-end QB2 in leagues that start two QBs.

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