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Detroit Lions wide receiver Jameson Williams caught only two of his seven targets in Sunday's win over the Browns, and he has not topped two receptions in a game since the season opener. In speaking with reporters on Monday, head coach Dan Campbell addressed the connection between Williams and quarterback Jared Goff, saying, "We're just a little bit off." Campbell was quick to downplay any issues of chemistry, saying the team will get back to the drawing board, and "Those guys are gonna be fine." Although Williams has caught only 10 balls on the season, his 21.4-yard average reception is among the highest in the league, so he has not been completely irrelevant for fantasy managers. The Lions face the Bengals in Week 5, and Cincinnati has been one of the most favorable matchups for wide receivers through four weeks. With bye weeks starting around the NFL this week, Williams should make for a fine flex option.

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Cleveland Browns rookie wide receiver Isaiah Bond has seen his targets and receiving yards increase in each of his four games this season. With Cedric Tillman (hamstring) now sidelined for multiple weeks, Bond could be leaned on more heavily as part of the Browns' passing attack. Tillman left Sunday's game against the Lions in the second quarter, and Bond ended the day as the team's leading receiver, bringing in three of his six targets for 58 yards. With five NFL teams on a Week 5 bye, now is the time in the schedule for fantasy managers to get creative, and Bond at least offers big-play upside for those in a roster bind. With the Browns traveling to London to play the Vikings in Week 5, any Cleveland players will need to be inserted into lineups early, stymying flexibility and making Bond a player to monitor rather than play for at least one more week.

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Cleveland Browns third-year wide receiver Cedric Tillman (hamstring) exited during the second quarter of his team's loss to the Lions on Sunday and is now expected to miss multiple weeks. Through four games, Tillman's 20 targets are the third most on the team, and trail only Jerry Jeudy among wide receivers, and he is the only Cleveland pass-catcher with multiple touchdowns. Rookie wide receiver Isaiah Bond, who led the team in targets and receiving yards on Sunday, is expected to see an increased workload, but Browns quarterback Joe Flacco has not topped 200 passing yards since the team's season-opener against a porous Bengals defense. With Cleveland's offensive line dealing with a rash of injuries and murmurs of a quarterback change coming soon, this is not a passing game in which fantasy managers should currently be looking to invest.

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Houston Texans rookie running back Woody Marks is coming off the best game of his young career, and head coach DeMeco Ryans is excited to see how much more he can handle. Marks ran for 69 yards and a touchdown while adding 50 yards and another score through the air in the team's first win of the season on Sunday. For the first time this year, Marks handled the majority of the team's rushing work, seeing 17 carries to Nick Chubb's 13. Having seemingly passed that test, a pleased Ryans suggested to reporters that more will be put on his young back's plate. Marks was a prolific pass-catcher in college, keeping his fantasy floor high even in less favorable matchups. Now, with an increased workload on the horizon and no timeline for Joe Mixon's return, Marks becomes a high-priority waiver add wherever he is still unrostered.

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San Francisco 49ers head coach Kyle Shanahan said Monday morning that quarterback Brock Purdy (toe) is "complaining of some real soreness" in his toe, per Eric Branch of the San Francisco Chronicle. Purdy returned to action on Sunday after missing the previous two games with turf toe and went 22-for-38 for 309 yards with two touchdowns, two interceptions, and a lost fumble late in the fourth quarter that sealed San Francisco's fate in their 26-21 loss to Jacksonville. The 49ers play on Thursday night in Week 5, giving Purdy less time to recover than he would usually see. Wide receivers Ricky Pearsall (knee) and Jauan Jennings (ribs) also got banged up in Week 4, leaving their status up in the air. Fantasy football managers rostering Purdy should take a long look at the waiver wire for help in Week 5.

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Having started the year on the IR, Tennessee Titans running back Tyjae Spears (ankle) is eligible to make his season debut in Week 5 against the Cardinals. The Titans are expected to open Spear's 21-day practice this window, giving the team three weeks to decide on when he will be activated. The third-year running back suffered a high ankle sprain in early August, so he has had almost two months to recover and could quickly work his way back into an offense badly in need of playmakers. The Titans' offense is currently dead last in total yards and points. Fellow running back Tony Pollard has been one of the team's most reliable contributors, and even in a full-time role, he has yet to make an impact on fantasy rosters. With Spears' return potentially creating more of a timeshare, neither back is an attractive option while the Titans work through their early-season struggles.

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San Francisco 49ers wide receiver Ricky Pearsall (knee) may have a "minor PCL" injury, according to head coach Kyle Shanahan, casting doubt on his availability in Week 5, per Eric Branch of the San Francisco Chronicle. Pearsall went down hard on his knee trying to make a catch early in the third quarter on Sunday's eventual 26-21 loss to the Jaguars. Pearsall was removed for evaluation and made it back into the game in the fourth quarter, though he saw zero targets after his return. He finished the day with four catches on five targets and 46 receiving yards. The 49ers are scheduled to play the Rams on Thursday night, leaving Pearsall with less time than usual to recover. If he does miss the game, Demarcus Robinson and Kendrick Bourne can be expected to be more involved.

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Houston Texans head coach DeMeco Ryans indicated that running back Joe Mixon (ankle, foot) is not ready to return at this time, according to Aaron Wilson of KPRC 2 Sports. According to sources, it will be much longer, if at all this year, for Mixon "to get back on the field this season." Fantasy managers who have been stashing Mixon must decide if they're going to remain patient or cut bait entirely. The 29-year-old did it all out of the backfield for the Texans last year, rushing for over 1,000 yards for the fifth time in his career while also scoring 11 rushing touchdowns in 14 regular-season starts. However, it's already looking like his 2025 campaign is a wash, and he could struggle for efficiency if he does return behind a bad offensive line. Houston will move forward with veteran Nick Chubb as the RB1, but rookie Woody Marks, who had two scores in Week 4, is quickly ascending.

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Kansas City Chiefs wide receiver Tyquan Thornton scored a touchdown for the third straight game in Sunday's 37-20 Week 4 win over the visiting Baltimore Ravens as the Chiefs' offense looked the best it has all year against a beleaguered Ravens defense. However, with Xavier Worthy returning from a dislocated shoulder that he suffered in Week 1, Thornton's role declined, and he caught just one of his two targets on the day for an 11-yard touchdown in the second half. The 25-year-old will continue to be a factor in KC's offense moving forward, but there's no denying that Worthy's return puts a pretty big dent in Thornton's fantasy upside as the primary deep threat. Rashee Rice will return in Week 7, too, which will be another big blow to Thornton's fantasy appeal for the rest of the season. We might have already seen the best from him in 2025.

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Cleveland Browns quarterback Deshaun Watson (Achilles) is not expected to have his practice window opened this week, even though he's eligible after four weeks on the Reserve/Physically Unable to Perform list, according to Mary Kay Cabot of The Cleveland Plain Dealer. Watson tore his Achilles in Week 7 of last year and started the 2025 season on the PUP list as a result. The 30-year-old veteran is not anywhere near a return and probably should be considered a long shot to play at all this year. In fact, most people believe Watson has already played his last snap with the Browns. For now, the Browns will roll forward with veteran Joe Flacco as their starter under center, although there are already questions about how much longer the team will keep him as their starter, given how bad he's looked through four weeks. It could only be a matter of time before we see rookies Dillon Gabriel and Shedeur Sanders.

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Fantasy managers who scooped Dallas Cowboys wide receiver KaVontae Turpin off the waiver wire in deeper leagues were hoping to see him more involved in the Week 4 Sunday night showdown against the Green Bay Packers with CeeDee Lamb (ankle) missing the game, but Turpin's production didn't see a boost in the 40-40 tie in overtime. Turpin caught three of his four targets for 30 yards and ran for four yards on his lone rushing attempt. It was actually a step back from the previous two games, when the 29-year-old combined for six catches, 111 yards, and a touchdown on seven targets. Jalen Tolbert was the one who benefited more from Lamb's absence, as he caught four of his six targets for 61 yards. George Pickens also went off for eight receptions, 134 yards, and two touchdowns. Turpin has made more of an impact as a receiver this year than he did in 2024, but it looks like he won't necessarily take another leap forward for however long Lamb is sidelined with his high-ankle sprain.

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Washington Commanders quarterback Marcus Mariota got going late in the 34-27 loss to his former team, the Atlanta Falcons, in Week 4, in what could be his final start with Jayden Daniels targeting a return from his knee sprain in Week 5 against the Los Angeles Chargers. Mariota finished Sunday's loss by going 16-for-27 passing for 156 yards, two touchdowns, and one interception. He added two carries for 20 yards and was sacked twice for a loss of nine yards. The 31-year-old veteran's touchdown passes went to receivers Luke McCaffrey and Deebo Samuel Sr. In two games in place of the injured Daniels, Mariota has been decent, completing 64.6% of his 48 pass attempts for 363 yards, three touchdowns, and one interception. It's not a lock that Daniels will play in Week 5, but if Mariota makes a third straight start, he'll be a low-end QB2 play against a tough Chargers defense on the road.

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Jacksonville Jaguars tight end Brenton Strange pulled in 6-of-7 passes for 45 yards in his team's 26-21 win over the hosting San Francisco 49ers. Strange has been a reliable target as quarterback Trevor Lawrence has at the moment, recording exactly six receptions and seven targets in each of the previous two weeks. The 24-year-old's receiving output leaves us wanting more, but he's easily pacing Jacksonville's TE room in snaps -- accruing 129 more than the next closest teammate. Moreover, he's leading the Jags in receptions (19) and yards (182). Strange and the team will get a true test next Monday night when they square off against the Kansas City Chiefs at home. For now, he's a high-end TE2 with PPR upside..

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Kansas City Chiefs running back Brashard Smith rushed for nine yards on four carries, adding another 27 through the air on 3-of-4 receiving in Week 4's 37-20 win against the Baltimore Ravens. He also returned two kicks for 55 additional yards. The rookie was finally utilized more in the passing game on Sunday, and played considerably more snaps than he had in his first three appearances. At least for this past weekend, Isiah Pacheco took the biggest hit in workload, getting the SMU product involved. Smith doesn't profile as a short-yardage banger, so it's challenging to assume that he'll eventually take on all aspects of Kansas City's ground attack. That said, if the 22-year-old continues to perform well in his receiving role, there could be some low-end PPR value here. He's a dynasty buy if you can acquire him at a reasonable price.

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NFL Insider Jordan Schultz reports on Monday that tests confirmed New York Giants wide receiver Malik Nabers (knee) has torn his ACL and will miss the remainder of the 2025 season. It's massively disappointing news for fantasy managers and the Giants, as Nabers will now attempt to work his way back before the start of 2026. The timing is unfortunate, considering rookie quarterback Jaxson Dart gave the team some juice in his NFL debut. With Nabers out, fellow wideouts Wan'Dale Robinson and Darius Slayton should benefit the most production-wise, and Jalin Hyatt will operate as the Giants' third WR. Slayton has been out there for the most snaps amongst his position, and figures to continue working as the deep threat, making him a moderately more interesting addition in the wake of his teammate's injury.

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New Orleans Saints running back Kendre Miller rushed for 65 yards on 11 carries and scored a touchdown in Sunday's 31- 19 loss to the Buffalo Bills. He failed to command a target in the passing game. Alvin Kamara predictably led this backfield in touches. Still, for the second straight game, Miller garnered a larger snap share, and he's looked much better off this season when given the opportunity. Kamara played an absurdly high rate of snaps in Weeks 1 and 2, but his rushing volume has tapered off since, while Miller is on the field for roughly a third of the team's snaps. It's a little too early to trust the TCU product to provide standalone value. However, if he continues stealing work from Kamara, this could become more of a 1A/1B situation than we anticipated. Miller will have a good chance to set career highs in rushing yards and touchdowns in Week 5 when New Orleans hosts the New York Giants at home.

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Dallas Cowboys running back Miles Sanders (ankle) suffered an ankle injury during the first half of his team's Week 4 matchup with the Green Bay Packers and was unable to return to the game. Sanders recorded 25 yards from scrimmage on four total touches before getting hurt, and has now totaled 147 yards from scrimmage and a touchdown on 28 total touches so far in 2025. The severity of Sanders' ankle injury is not yet clear. If he misses time, Cowboys rookie running back Jaydon Blue would likely step in as the team's RB2 behind veteran back Javonte Williams. Blue has been inactive for all four of Dallas' games to this point in the season. Still, he could be worth adding in deep fantasy leagues heading into a Week 5 matchup against the New York Jets, pending the health status of Sanders.

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Minnesota Vikings running back Zavier Scott saw heavy usage in the pass game in Week 4 against the Pittsburgh Steelers, recording six catches for 43 yards and a touchdown on eight targets. With veteran running back Aaron Jones Sr. (hamstring) on Injured Reserve through at least Week 7 due to a hamstring injury, Scott appears to be Minnesota's passing-down back next to early-down workhorse Jordan Mason. In the two games since Jones Sr. got injured, Scott has recorded 10 carries for 31 yards and seven catches for 63 yards and a score. The 26-year-old's usage will probably be game-script dependent, as he benefited from Minnesota playing from behind for most of Week 4. Scott is worth adding in deep fantasy leagues of 14 or more teams.

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Dallas Cowboys running back Miles Sanders was barely utilized in Week 4 against the Green Bay Packers, recording two carries for eight yards and two catches for 17 yards. Cowboys running back Javonte Williams remains the clear RB1 in Dallas, as he racked up 100 yards from scrimmage and a touchdown on 23 total touches. Sanders has totaled 147 yards from scrimmage and a touchdown on 28 total touches so far in 2025. He remains the clear handcuff option to Williams in Dallas for the time being, as Cowboys rookie running back Jaydon Blue was inactive for the fourth straight week against Green Bay. Still, Sanders is not worth starting in fantasy as long as Williams is healthy.

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Houston Texans rookie running back Woody Marks had a breakout game in Week 4 against the Tennessee Titans, recording 119 yards from scrimmage and two touchdowns on 21 total touches. The 24-year-old now has 209 yards from scrimmage and two scores on 35 total touches through the first four games of his NFL career. Marks earned more carries and more catches than veteran Texans back Nick Chubb in Week 4. The 29-year-old Chubb is averaging just four yards per rush attempt so far this season for a struggling Houston offense, so Marks could emerge as the team's lead back if he continues to produce. Additionally, Texans running back Joe Mixon (foot/ankle) is on the Non-Football Injury list and remains without a clear return timeline. Marks is the number one priority waiver-wire addition for fantasy managers heading into Week 5 and should be rostered in all league formats.

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