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Detroit Lions tight end Sam LaPorta had by far his best game of the 2025 season in Week 5 against the Cincinnati Bengals, recording five catches for 92 yards and a touchdown on six targets. LaPorta now has 21 catches for 269 yards and a score on 27 targets through five games. However, the Lions have a difficult matchup in Week 6 against the Kansas City Chiefs. Kansas City has allowed the ninth-fewest passing yards (999) and the fourth-fewest number of passing touchdowns (five) in the NFL so far this season. The Chiefs are also particularly stingy against tight ends, allowing an average of just 3.6 receptions and 32.8 yards per game to the position. Still, LaPorta will likely be the Lions' second-leading target-getter behind star wideout Amon-Ra St. Brown. LaPorta profiles as a must-start fantasy tight end in Week 6.

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Las Vegas Raiders tight end Michael Mayer (concussion) was a full participant in practice all week after being cleared from the league's concussion protocol, and he has been removed from the Week 6 injury report, according to Ryan McFadden of ESPN. It means that Mayer will play this Sunday in a great matchup against the Tennessee Titans after missing the last two games due to a concussion. Additionally, the 24-year-old should serve as the Raiders' primary pass-catching tight end now that Brock Bowers (knee) will officially miss his second straight game. In his first three games of 2025, before suffering a concussion, Mayer caught only six of his seven targets for 47 yards and no touchdowns, but it was also in the TE2 role behind Bowers. Even though it's Mayer's first game back in several weeks, his expanded role should at least make him worthy of consideration as a TE2 streamer in deeper fantasy leagues.

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Detroit Lions rookie wide receiver Isaac TeSlaa hauled in his second touchdown catch of the season in Week 5 against the Cincinnati Bengals and now has three catches for 54 yards and two scores through his first five NFL games. TeSlaa gets a difficult matchup in Week 6 against the Kansas City Chiefs, who have allowed the ninth-fewest passing yards (999) and the fourth-fewest number of passing touchdowns (five) in the NFL so far this season. On the bright side, TeSlaa could be in line for his largest snap share of the season with Lions WR3 Kalif Raymond (neck) officially listed as questionable to play in Week 6 due to a neck injury. TeSlaa still cannot be counted on for fantasy production in Week 6, but he's a player to monitor as a stash candidate in deep leagues for his season-long upside.

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Detroit Lions wide receiver Amon-Ra St. Brown missed the team's Wednesday practice this week due to a wrist injury, but he practiced in full on Thursday and Friday and does not carry an injury designation into Detroit's Week 6 matchup with the Kansas City Chiefs. St. Brown has been one of the most productive wideouts in the NFL so far this season, recording 35 catches for 407 yards and six touchdowns through five games. Kansas City has fielded a stingy pass defense so far this season, allowing the ninth-fewest passing yards (999) and fourth-fewest number of passing touchdowns (five) in the NFL. Still, St. Brown should see a significant target volume as the clear number one option in the Lions' passing game for quarterback Jared Goff. St. Brown profiles as a must-start fantasy wide receiver in Week 6 against the Chiefs.

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San Francisco 49ers quarterback Mac Jones (knee, oblique) is dealing with multiple injuries and is officially questionable to play in Week 6 against the Tampa Bay Buccaneers on the road on Sunday, per The Athletic's David Lombardi. Brock Purdy (toe) has already been ruled out for the fourth time this year due to a turf-toe injury, so the Niners are expecting the gritty Jones to play through his injuries this weekend. The 27-year-old Alabama product has been dealing with a minor PCL sprain in his knee early this season, and he suffered an oblique injury in last week's win over the Los Angeles Rams on Thursday night. His injuries didn't stop him from carving up the Rams' defense for over 300 yards and two touchdowns last week. While an encore probably isn't in the cards for Jones, especially without receiver Ricky Pearsall (knee), he'll be in play as a low-end QB2 in leagues that start two QBs.

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Los Angeles Chargers kicker Cameron Dicker remains perfect this season and is poised for a high-volume week against a vulnerable Miami Dolphins defense. Although the Chargers' offense has recently struggled, with fewer red-zone opportunities due to penalties and turnovers, the favorable matchup should help them move the ball more effectively. Kicker consistency is essential in fantasy, and Dicker is a proven asset capable of making long field goals, as demonstrated by his 55-yard kick last week. The hope is that the offense regains its rhythm, but even if they settle for field goals outside the 20, Dicker offers a high floor. RotoBaller projects Dicker as K4 this week. He is a clear must-start and should be included in all starting lineups.

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Detroit Lions wide receiver Jameson Williams has struggled to maintain a consistent role in his team's offense so far this season. Through five games, the 24-year-old has recorded just 11 catches for 223 yards and one touchdown on 21 targets. Williams is averaging over 20 yards per reception and remains an explosive downfield threat, but his middling target volume makes him very difficult for fantasy managers to trust. Williams' Week 6 matchup against the Kansas City Chiefs does not appear to be a great spot for him to break out. The Chiefs have allowed the ninth-fewest passing yards (999) and the fourth-fewest number of passing touchdowns (five) in the NFL so far this season. Additionally, the Lions could be without starting left tackle Taylor Decker (shoulder), which may make it difficult for quarterback Jared Goff to have the time to hit Williams for a big play down the field. Williams profiles as a low-end, boom/bust WR3/flex option in Week 6 against Kansas City.

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Even in a relatively quiet game by his standards, Detroit Lions running back Jahmyr Gibbs was still able to record 87 scrimmage yards and a touchdown on 14 touches in Week 5 against the Cincinnati Bengals. Gibbs logged fewer touches than fellow Lions back David Montgomery for the first time this season, but that could be due to Detroit holding a large lead for most of the game and the fact that Montgomery is a Cincinnati native. Gibbs will now square off against the Kansas City Chiefs in Week 6, who have been a below-average rushing defense so far this season. Through five games, Kansas City ranks 24th in rushing touchdowns allowed (six) and 26th in yards per carry allowed (4.8). Gibbs should be heavily featured in the Lions' game plan and profiles as a must-start fantasy running back in Week 6.

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San Francisco 49ers wide receiver Jauan Jennings (ankle, ribs) is officially listed as questionable to play this Sunday in a Week 6 matchup against the hosting Tampa Bay Buccaneers, according to The Athletic's David Lombardi. Jennings did not play in the Week 5 win over the Los Angeles Rams last Thursday night and didn't practice on Wednesday. However, the 28-year-old was limited in practice on Thursday and Friday, giving him a chance to return this weekend. Meanwhile, fellow wideout Ricky Pearsall (knee) has been ruled out for a second straight game, so if Jennings can get the green light to play, he should as the team's WR1, barring any snap-count restrictions. The caveat is that quarterback Brock Purdy (toe) will miss his fourth game of the year, leaving banged-up backup Mac Jones (knee, oblique) to lead the offense again. Jennings could be a game-day decision, making him a very shaky WR4/flex play for fantasy managers.

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Los Angeles Chargers running back Kimani Vidal enters Week 6 against the Miami Dolphins, sharing the backfield with Hassan Haskins after Omarion Hampton (ankle) was placed on IR this week. Vidal looked like the more explosive option last week, averaging 4.5 yards per carry on four rushes and splitting targets with Haskins. Facing the Miami Dolphins, who rank dead last in average rushing yards allowed, presents a significant opportunity for the backfield. However, OC Greg Roman confirmed a committee approach that limits Vidal's volume. Although he's capable in the passing game, don't assume Vidal is set to handle most pass-catching downs, as he only posted 18 receptions in his final year at Troy. RotoBaller ranks him as RB33. He could be more of a touchdown-dependent high-end RB3/FLEX option this week, and managers should monitor his usage throughout the game.

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Detroit Lions running back David Montgomery logged a season-high 18 carries in Week 5 against the Cincinnati Bengals, finishing with 65 rushing yards and a touchdown. The 28-year-old also tossed the second touchdown pass of his career on a trick play. Heading into a Week 6 matchup against the Kansas City Chiefs, Montgomery should be expected to return to the 1B role in the Lions' backfield alongside Jahmyr Gibbs. Kansas City has been surprisingly subpar against the run so far this season, ranking 24th in rushing touchdowns allowed (six) and 26th in yards per carry allowed (4.8). Montgomery's limited touch ceiling while playing next to Gibbs makes him reliant on touchdowns for fantasy production, but he looks like a decent bet to find the end zone against the Chiefs. In Week 6, Montgomery profiles as a low-end fantasy RB2.

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San Francisco 49ers quarterback Brock Purdy (toe) has officially been ruled out for Week 6 against the Tampa Bay Buccaneers on Sunday, according to David Lombardi of The Athletic. Purdy was unable to practice all week, although he was seen working on side fields with trainers. The 25-year-old will now miss his second straight game (fourth overall this year) after aggravating a turf-toe injury in Week 4. The Niners have been mum on when Purdy might be able to return to the starting role under center, with his next chance at doing so coming in Week 7 versus the Atlanta Falcons. Backup Mac Jones (knee, oblique) is listed as questionable with multiple injuries this weekend, but he's expected to make his fourth start of the year. Jones has been battling a knee injury since early in the year, but despite that, he's managed to play effectively and efficiently with Purdy out. Fantasy managers shouldn't be expecting a second straight 300-yard game from Jones, but he'll be in play as a low-end QB2 streamer in superflex leagues.

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Los Angeles Chargers rookie wide receiver Tre' Harris faces the Miami Dolphins this week but remains firmly behind the top three receivers on the depth chart. He recorded zero targets last week and only three catches all season, as his 21.6% route participation rate limits his weekly upside. However, he could be a desperation dart throw if teammate Quentin Johnston (hamstring) is officially ruled out, as the rookie second-rounder might get snaps against a Miami secondary that is vulnerable to deep passes (highest deep ball completion rate allowed). This matchup favors his skill set if he sees playing time, but any production would depend heavily on volume and likely be inefficient. Harris should stay on the bench and is mainly a desperation WR5/Stash option if managers face heavy bye weeks and Johnston is inactive.

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Detroit Lions quarterback Jared Goff has been a productive player through five weeks this season, recording 1,187 passing yards and 12 touchdowns compared to just two interceptions. However, he may be a quarterback for fantasy managers to move away from in a difficult Week 6 matchup against the Kansas City Chiefs. The Chiefs have allowed the ninth-fewest passing yards (999) and fourth-fewest number of passing touchdowns (five) in the NFL so far this season. Additionally, Goff could be without starting left tackle Taylor Decker (shoulder), which may limit Detroit's ability to push the ball downfield. In two-quarterback formats, Goff still profiles as a solid QB2, but he may be a player to avoid in Week 6 in single-QB leagues.

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San Francisco 49ers wide receiver Ricky Pearsall (knee) has been ruled out for the second straight week for the team's Week 6 contest this Sunday against the Tampa Bay Buccaneers, according to The Athletic's David Lombardi. Pearsall last played in Week 4 with a PCL injury that will now keep him out for a second straight week. Quarterback Brock Purdy (toe) will miss his fourth game in six weeks, but the good news for San Fran's offense is that they could be getting wideout Jauan Jennings (ankle, ribs) back this weekend in Tampa. The next time Pearsall will be able to get back into game action will be in Week 7 against the Atlanta Falcons, at which point both Jennings and tight end George Kittle (hamstring) could be back in the fold and taking valuable targets away. With Pearsall missing another game, Kendrick Bourne will be in play as a flex in fantasy again, even if Jennings is active.

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Los Angeles Chargers running back Hassan Haskins is now stepping into a primary role after Omarion Hampton (ankle) was placed on IR this week as the team faces the Miami Dolphins on Sunday. Haskins, who had an unimpressive five carries for 13 yards last week following Hampton's injury, will share work with Kimani Vidal after OC Greg Roman said it will be "all hands on deck" when asked who the lead back would be. Haskins' advantage comes from his 6-2, 228lb frame and familiarity with Jim Harbaugh's system from their time together at Michigan. While his 3.0 career yards per carry is underwhelming, the Miami Dolphins are dead last against the run, giving up over 200 rushing yards to Carolina Panthers backup Rico Dowdle last week. Despite the favorable matchup, the split workload and a more explosive Vidal should temper volume expectations. RotoBaller projects Haskins as RB30. He's a mid-range RB3/FLEX option based on potential goal-line usage and favorable matchup, but managers shouldn't expect a workhorse role.

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Los Angeles Chargers wide receiver Keenan Allen enters Week 6 as a clear high-floor option, leading the team with five catches on nine targets last week. The veteran faces a favorable matchup against the Miami Dolphins' secondary, which has allowed the ninth-most PPR points per target to perimeter wide receivers, a key area for Allen given his 23.1% target share. Allen is a high-volume receiver who often helps Justin Herbert by making difficult catches in crucial situations. If fellow wide receiver Quentin Johnston (hamstring) is limited or inactive, Allen's already high target share should only grow. RotoBaller ranks Allen as WR20 this week. He is a reliable low-end WR2 and should be started with confidence, especially in PPR formats.

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Baltimore Ravens wide receiver Zay Flowers (shoulder) was limited in practice all week and is listed as questionable for Sunday's game against the visiting Los Angeles Rams in Week 6, according to Brian Wacker of The Baltimore Sun. While it's possible that Flowers could end up suiting up this weekend against the Rams, the 25-year-old's weekly fantasy appeal has already taken a hit now that we know quarterback Lamar Jackson (hamstring) will miss a second straight game. With backup QB Cooper Rush running the offense again on Sunday, Flowers and the rest of Baltimore's offensive skill players will not be as reliable in starting fantasy lineups. Flowers had a decent game in last week's loss to the Houston Texans, catching all five of his targets for 72 yards. However, his fantasy ceiling and floor will be lowered in Week 6 if he's active. If the Ravens give Flowers a rest before their bye next week, DeAndre Hopkins and Rashod Bateman would be the team's top two pass-catchers.

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Dallas Cowboys wide receiver KaVontae Turpin (foot) has been ruled out for a second straight game in Week 6 against the hosting Carolina Panthers on Sunday after he was unable to practice all week, according to Jon Machota of The Athletic. Turpin suffered a foot injury in the Week 4 tie with the Green Bay Packers and will now miss his second straight game. The 29-year-old's next chance to return to action will be in Week 7 against the division-rival Washington Commanders. With both Turpin and CeeDee Lamb (ankle) missing another game, George Pickens should once again dominate pass-game targets, with Ryan Flournoy and Jalen Tolbert serving as secondary options. Tight end Jake Ferguson has been quarterback Dak Prescott's No. 2 weapon in the two weeks that Lamb has been unavailable. At best, Turpin is the team's WR3/kick returner when healthy.

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Los Angeles Chargers wide receiver Ladd McConkey is set for a strong performance against the Miami Dolphins on Sunday after scoring his first touchdown last week. While the Dolphins' secondary is the defense's strongest unit, they are middle of the pack overall and especially vulnerable to slot receivers, giving up the fifth-most PPR points per target and the second-highest passer rating to that position (McConkey runs 61.6% of routes from the slot). With fellow wide receiver Quentin Johnston (hamstring) limited in practice and questionable for Sunday, McConkey could see a noticeable target increase from Justin Herbert. His recent red-zone usage is a positive sign. RotoBaller keeps him at WR21 this week. He should be considered a strong WR3 with clear WR2 upside if Johnston remains limited or is ruled out.

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