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ESPN's Adam Schefter reports that San Francisco 49ers wide receiver Jauan Jennings (ankle, rib) is expected to be available for Sunday's road matchup with the Tampa Bay Buccaneers. Jennings has been in and out of the lineup this season while battling through an ankle injury and other secondary injuries, but he's projected to gut it out in Week 6 against the hosting Buccaneers. San Francisco's offense still has a way to go before returning to full strength, but Jennings' return will also coincide with quarterback Mac Jones (knee, oblique) getting the nod to play, so they won't be without all of their playmakers. With teammate Ricky Pearsall (knee) still sidelined, fellow WRs Kendrick Bourne and Demarcus Robinson will continue to see extra playing time behind Jennings. It wouldn't be surprising to see the 28-year-old eased back in.

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According to ESPN's Adam Schefter, San Francisco 49ers quarterback Mac Jones (oblique) is expected to be active for his team's matchup with the hosting Tampa Bay Buccaneers. Jones has now dealt with knee and oblique injuries over the past few weeks, but will again get the start for the 49ers despite logging a week's worth of limited practices. Schefter also notes that teammate Brock Purdy (toe) has a "chance" to return in Week 7. It's excellent news for San Francisco, as the team is dealing with a mess of injuries on both sides of the ball. Reportedly, the team should also have wide receiver Jauan Jennings (ankle, rib) active, aiding Jones with Ricky Pearsall (knee) still at least a week away.

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Baltimore Ravens wide receiver Zay Flowers (shoulder) is expected to be available for his team's matchup with visiting Los Angeles Rams, according to ESPN's Adam Schefter. The Boston College alum was a limited participant in practice this week due to a shoulder injury. Despite the questionable designation, Flowers will prepare to play on Sunday, but will again be without quarterback Lamar Jackson (hamstring), lowering the floor and ceiling of all Ravens' skill players. The 25-year-old was the team's leading receiver in Week 5 with Cooper Rush at the helm, but it's unclear if his ailing shoulder will limit his snaps. If that's the case, teammates DeAndre Hopkins and Rashod Bateman are the most likely wideouts to see an uptick in targets, with tight end Mark Andrews set to absorb more work as well.

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ESPN's Jeremy Fowler reports that Los Angeles Chargers wide receiver Quentin Johnston (hamstring) is trending toward being inactive for Sunday's road meeting with the Miami Dolphins. Johnston picked up a hamstring injury that limited him at practice leading up to Sunday's outing, leaving him with a questionable tag. However, it appears he won't be healthy enough to suit up against the hosting Dolphins. Fellow wideouts Keenan Allen and Ladd McConkey figure to pick up a few extra looks in his absence, while rookies Tre Harris and Keandre Lambert-Smith should benefit from an uptick in snaps. Tight end Oronde Gadsden could also be in for an elevated workload with Johnston sidelined.

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Washington Commanders wide receiver Chris Moore has played as the primary outside receiver while top receivers Terry McLaurin (quadriceps) and Noah Brown (quad, knee) have missed multiple games. Moore has played at least 50% of the snaps in each of the past three weeks, but hasn't been a real target earner and has dropped multiple balls as well, including a touchdown last week against the Chargers. He's caught just two of six targets since Week 3. If Deebo Samuel Sr. (heel) is unable to go on Monday against the Bears, then Moore could see a bump in targets. Even then, Moore is not a recommended option for Week 6.

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Washington Commanders tight end Zach Ertz was held catchless in a game in Week 5 against the Chargers for the first time since Week 13 of the 2014 season, crazy enough. Ertz has been a reliable target over the middle for quarterback Jayden Daniels, but the two did not connect on just one target in Week 5. He'll look to get back on track Monday night against a Bears defense that has allowed nearly 30 points per game through four weeks. And Ertz could see an increase in targets if star receiver Deebo Samuel Sr. (heel) is unable to play. Ertz remains a low-end TE1 for Monday night.

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Washington Commanders wide receiver Jaylin Lane has made a big impact as a punt returner this season and has made plays when his number has been called on offense. Lane has seen more time on offense with top wide receivers Terry McLaurin (quadriceps) and Noah Brown (quad, knee), both dealing with mult-game absences. Lane caught only one ball in Washington's Week 5 win over the Chargers, but it came on a crucial 3rd and 16 deep in their own territory in the second quarter that helped sustain the drive and lead to their first touchdown of the game. And if Deebo Samuel Sr. (heel) is unable to go, Lane would likely be in line to take some of those designed and underneath targets to get the ball in his hands. Samuel looks like a true game-time decision, which is a frustrating situation on Monday night. The rookie wide receiver has upside against a Bears defense that has allowed the sixth most PPR points per game to opposing wide receivers through four games this season.

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Washington Commanders wide receiver Luke McCaffrey has made a handful of spectacular plays over the last few weeks, with star wide receiver Terry McLaurin (quadriceps) injured. McLaurin is now ruled out for the third consecutive game and opens up more routes for McCaffrey, who has been taking advantage. The second-year wide receiver had one of the highlight plays of Week 5, making an incredibly difficult diving catch on a beautiful 50-yard deep pass from Jayden Daniels. McCaffrey hasn't drawn a high number of targets, but his playmaking ability has been evident, and Daniels' faith in him appears to be growing by the week. McCaffrey will have a chance to stack his positive performances in Week 6 against the Bears, who have allowed the sixth most PPR points per game to opposing wide receivers. He is on the WR4-WR5 line for Week 6.

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According to ESPN's Adam Schefter, Arizona Cardinals quarterback Jacoby Brissett is expected to start in Sunday's clash with the Colts. Kyler Murray (foot) still has a chance to play. However, that's unlikely, although NFL Media's Ian Rapoport reported that a final decision won't come until Sunday morning. Unfortunately, there's belief Murray might miss extended time due to a mid-foot sprain, meaning Brissett could be under center in Week 6 and beyond. The signal-caller has been a reliable fantasy quarterback (at times) over the years. In 89 regular-season appearances, he has thrown for 11,400 yards, 53 touchdowns, and 24 picks, adding 15 scores on the ground. While Brissett potentially has a tough matchup on tap against a capable Colts' defense, the potential for Murray to be sidelined for more than a game makes him worth adding to fantasy rosters, mostly by those participating in deeper Superflex formats.

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Washington Commanders wide receiver Deebo Samuel Sr. (heel) would be in line for another high number of targets on Monday night if he can play. Samuel is currently listed as questionable as he manages a heel issue. The veteran wide receiver has been the engine of Washington's passing attack with Terry McLaurin (quadriceps) out and set to miss his third consecutive game. Samuel was limited in practice throughout the week, and it looks like the team will take the decision into Monday, which is frustrating for fantasy managers. If he can suit up, Samuel would be projected as a firm WR1 against a Chicago defense that is allowing the sixth most PPR points per game to opposing wide receivers. If unable to go, then second-year receiver Luke McCaffrey and rookie Jaylin Lane would be in line for more opportunities.

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According to NFL Media's Ian Rapoport, the Arizona Cardinals "are leaving the door open" for Kyler Murray (foot) to suit up on Sunday versus the Colts. However, the team is realistically "preparing" for Jacoby Brissett to start in Week 6, although a final decision won't come until Sunday morning. The signal-caller is reportedly dealing with a "mid-foot sprain," with Rapoport adding that it's "a version of a Lisfranc injury." Unfortunately, that could sideline Murray for more than just one week. As far as Brissett is concerned, he's had some quality performances over the years. In 89 regular-season games, he's thrown for 11,400 yards, 53 touchdowns, and 24 interceptions, adding 15 more scores on the ground. With that said, Brissett has some value for managers in deeper Superflex formats despite a tough matchup on the horizon, especially with injuries at the quarterback position and a few teams getting the week off.

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Carolina Panthers tight end Tommy Tremble hasn't done much for fantasy managers this season. While he had five catches (eight targets) for 42 yards and a touchdown in the Week 4 loss to the New England Patriots, he has been nearly irrelevant from a production standpoint. Ja'Tavion Sanders (ankle) is listed as questionable heading into the Week 6 meeting with the Dallas Cowboys, so there's a chance he won't be out there once again. Sure, the potential for added involvement should increase Tremble's fantasy potential. Still, even if Sanders remains sidelined, fantasy managers will be taking a gamble by rolling with the 25-year-old as their starting tight end for the favorable matchup with the Cowboys. especially with Xavier Legette in the mix.

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Carolina Panthers wide receiver Hunter Renfrow had seven catches for 48 yards and two touchdowns in the Week 2 loss to the Cardinals. However, outside of that performance, he hasn't done much, most recently catching one pass for seven yards in the Week 5 win over the Dolphins. Xavier Legette found the end zone in that one, so his stock is higher heading into the Week 6 meeting with the Dallas Cowboys, especially with Jalen Coker (quadriceps) unable to make his professional debut. All things considered, none of the Panthers' wideouts can be trusted. Although Tetairoa McMillan should still draw starting consideration versus a weak Cowboys defense, the same can't be said for Renfrow, even if Ja'Tavion Sanders (ankle) doesn't suit up.

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Carolina Panthers wide receiver Tetairoa McMillan remains the team's No. 1 option on the depth chart. He's logged 305 offensive snaps through the first five weeks of the 2025 campaign, with Hunter Renfrow sitting behind him with 192. Unfortunately, that hasn't necessarily translated into consistent production from the rookie. McMillan currently has 24 catches (43 targets) for 351 yards. However, he still hasn't scored a touchdown. With that said, the Panthers may continue to rely mostly on Rico Dowdle against Dallas, his former team, in Week 6. Although McMillan is the favorite to see the most attention from Bryce Young on the receiving end versus a week Cowboys defense, fantasy managers will be taking a gamble by having him in their lineups. Still, the wideout has been a top-30 fantasy producer in standard and PPR formats, so he deserves starting consideration.

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Carolina Panthers quarterback Bryce Young has shown signs of growth in his third season in the National Football League. While he hasn't been consistent, he's still had some favorable outings for fantasy managers. The signal-caller most recently threw for 198 yards, two touchdowns, and one interception off 19-for-30 passing in the Week 5 win over the Miami Dolphins. Although things could have gone better in that one, it's safe to say Young could have played much worse based on his volatile track record. Truth be told, he at least did enough to keep his team competitive in Week 5, with Rico Dowdle handling the rest by amassing 206 yards and one touchdown on the ground. With that in mind, Young has work to do before earning the trust of fantasy managers. However, with injuries at the quarterback position and a few teams getting the week off, the 24-year-old can realistically occupy a spot in Superflex lineups versus a weak Cowboys defense, assuming managers are comfortable taking a gamble.

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According to NFL Media's Tom Pelissero, the Los Angeles Chargers elevated Nyheim Hines off the practice squad ahead of the Week 6 meeting with the Miami Dolphins, marking his first taste of regular-season action since 2022. Najee Harris (Achilles) is done for the rest of the season, and Omarion Hampton (ankle) will miss at least the next four contests. As a result, Hassan Haskins and Kimani Vidal are expected to split carries out of the backfield, presumably leaving Hines with the leftover scraps. It's unknown how long Hines will suit up for the Bolts moving ahead, especially if the team brings in another running back sometime soon. Either way, Haskins, Vidal, and Hines won't be relevant from a fantasy standpoint once Hampton is cleared to return.

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According to NFL Media's Ian Rapoport, the Los Angeles Chargers are "in the market" for a running back. Najee Harris (Achilles) is done for the remainder of the 2025 campaign. To make matters worse, rookie Omarion Hampton (ankle) landed on the Injured Reserve list and will miss at least the next four games. As a result, Hassan Haskins and Kimani Vidal will presumably split carries on Sunday versus the Miami Dolphins. That arrangement may remain the same until Hampton can return. However, it may change depending on who plays better, or if the Bolts bring in another running back. It's also worth mentioning the Chargers elevated Nyheim Hines, although he likely won't see much work in Week 6. With that in mind, fantasy managers should monitor things moving ahead. Still, it will be Hampton getting the bulk of the snaps at the position once he's back to full-strength no matter who's on the depth chart behim him.

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Dynasty | The Cowboys have placed running back Miles Sanders on season-ending injured reserve. Dynasty Analysis: He will reportedly have season-ending knee surgery. It's been a disappointing fall from grace for Sanders, who lost any shot at a time-share early this season when Javonte Williams played much better than expected. Things have just not gone as expected since he left the Eagles as Sanders flamed out with the Panthers and struggled with Dallas. He'll look to latch on with a team next year but he's going to be placed on a lot of waiver wires this coming week.

Washington Commanders running back Chris Rodriguez Jr. (calf) is currently listed as questionable ahead of the Week 6 matchup against the Chicago Bears. It doesn't look good for Rodriguez who has been able to practice all week due to a lingering calf issue. Despite that, Rodriguez still has a chance to suit up for Monday's game. When healthy, Rodriguez hasn't done much with 23 carries for 105 yards and zero touchdowns. If active, Rodriguez figures to play a reserve role with Jeremy McNichols while Jacory Croskey-Merritt serves as the lead back.

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Chicago Bears wide receiver D.J. Moore has gotten off to a sluggish start this season, recording just 16 catches on 21 targets for 173 yards and one touchdown through four games. The veteran wideout appears to have ceded the WR1 role to emerging second-year star Rome Odunze, who has quickly become Caleb Williams' favorite target. Before the bye week, Williams mentioned that Moore could serve as the "Deebo Samuel" of the Bears' offense, which has fantasy managers feeling uneasy. Fortunately, the Week 6 matchup against the Washington Commanders offers some hope. Washington has surrendered the eighth-most fantasy points to opposing wide receivers this season, providing Moore with a chance to bounce back. Still, Moore profiles as a low-end WR3 for Week 6, as his fantasy production will likely hinge on whether he finds the end zone.

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