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Buffalo Bills linebacker Matt Milano (pectoral) is set to miss his third game of the season in Week 6. Milano returned in Week 5 against the New England Patriots, but after not practicing this week, he's been ruled out for Sunday's matchup with the Atlanta Falcons. Injuries have continued to be an issue for the veteran linebacker, who has played just 12 games over the past three seasons. In his absence, Dorian Williams will once again step into a starting role for Buffalo's defense. Williams will have his hands full this week trying to contain Bijan Robinson and the Falcons' strong rushing attack. Milano's next opportunity to return will come after the team's bye week.

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Washington Commanders wide receiver Deebo Samuel Sr. (heel) did not practice on Saturday ahead of the team's Week 6 matchup against the Chicago Bears. Samuel played through the injury in Week 5 and was limited on Friday, but his Saturday absence raises legitimate concern about his availability for Monday Night Football. The former 49er has been a key piece of Washington's offense this season, totaling 346 yards and four touchdowns through five games. If Samuel is unable to suit up, rookie Jaylin Lane could see increased opportunities against a banged-up Bears secondary. With the Commanders playing on Monday night, fantasy managers should monitor the injury report closely and have a backup plan ready in case Samuel is a game-time decision.

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Cincinnati Bengals wide receiver Tee Higgins hasn't looked the best throughout the first five weeks of the 2025 campaign. He has only 13 catches (27 targets) for 158 yards. Fortunately, the wideout has at least found the end zone twice, preventing him from being a complete bust for fantasy managers. In Higgins' defense, the Bengals offense has struggled, and it wasn't much better when Joe Burrow (toe) was healthy and on the field. With Joe Flacco, who was recently acquired in a trade with the Browns, getting the start for Sunday's meeting with the Packers, it's unknown how his presence will impact the offense. However, with only a few days to prepare, it's safe to assume Flacco's knowledge of the playbook will be limited. As such, Higgins may not be the safest fantasy option, especially with a challenging matchup on the horizon. On the other hand, that could change if Ja'Marr Chase (illness) suffers a setback and doesn't suit up.

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Washington Commanders wide receiver Noah Brown (groin/knee) was not spotted early in Saturday's practice session ahead of Monday Night Football against the Chicago Bears. Brown has missed the past three games with a groin injury but managed to practice in a limited capacity on both Thursday and Friday. His Saturday absence could be a rest day as he works his way back toward game readiness. Brown has fond memories against the Bears, as he hauled in the game-winning Hail Mary in last season's matchup. If he's unable to suit up in Week 6, second-year receiver Luke McCaffrey is expected to see additional opportunities, especially with the current injuries in the receiving room.

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Cincinnati Bengals running back Chase Brown hasn't played well this season. After scoring a touchdown in the Bengals' Week 1 win over the Cleveland Browns, the 25-year-old hasn't visited the end zone since then. He only had eight carries for 27 yards in Week 5 versus the Lions. Fortunately, Brown made up for it by catching seven of his eight targets for 21 yards. Cincinnati won the first two games of the 2025 campaign. Unfortunately, the Bengals have lost their last three contests, so the team is desperately looking for a win in Week 6 against Green Bay. Joe Flacco, who was recently acquired in a trade with the Browns, will get the start under center for that one. However, Flacco's knowledge of the playbook will presumably be limited, meaning Brown may see more touches than normal while potentially getting an uptick in short passes out of the backfield. With that said, the Packers defense has been a challenge for opposing offenses throughout the year, which isn't good news for Brown, Flacco, Ja'Marr Chase (illness), and Tee Higgins. Still, the 2023 No. 163 overall pick remains worthy of a start in all fantasy formats based on his upside alone, especially for managers with limited options at the running back position.

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Washington Commanders wide receiver Terry McLaurin (quad) did not practice on Saturday, putting him on track to miss his third straight game. McLaurin has been sidelined since Week 3 and has struggled to make an impact this season, recording just 10 receptions for 149 yards with no touchdowns through three games. After ending his preseason holdout shortly before Week 1, the 2025 campaign has gotten off to a slow start for the Commanders' star receiver. With McLaurin, Deebo Samuel Sr., and Noah Brown all missing practice, Washington's receiving corps could be severely short-handed on Monday Night Football against the Chicago Bears. McLaurin's next opportunity to return will come in Week 7 against the Dallas Cowboys.

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The Jacksonville Jaguars will look to improve to 5-1 against the Seattle Seahawks in Week 6. Quarterback Trevor Lawrence has had an up and down season so far, but he's done enough to win games. Last week's win translated to fantasy, after he put up 275 total yards and three total touchdowns against the Chiefs. It hasn't been the prettiest, but the offense should be feeling confident enough to have a solid outing this week after a big outing against a good Chiefs defense. That makes Lawrence a solid QB2 with upside due to his potential rushing and passing output against the Seahawks.

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Carolina Panthers rookie running back Trevor Etienne is in line for an increased workload in Week 6. Over the past two weeks, Etienne has totaled 62 scrimmage yards on 12 touches, showing flashes of potential in limited opportunities. With Chuba Hubbard (calf) expected to miss his second straight game, both Rico Dowdle and Etienne should see an uptick in carries once again. Carolina draws a favorable matchup against the Dallas Cowboys, who have surrendered the sixth-most fantasy points to running backs this season, including big performances from Josh Jacobs and Breece Hall in consecutive weeks. While Dowdle is expected to handle the starting role, Etienne remains off the fantasy radar outside of deep dynasty formats as he continues to earn more snaps.

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Pittsburgh Steelers cornerback Jalen Ramsey (hamstring) is expected to return in Week 6 against the Cleveland Browns. Ramsey suffered the injury during the team's Week 4 win over the Vikings, a game in which he recorded his first interception of the season. The three-time All-Pro will rejoin Joey Porter Jr. and Darius Slay, in what should be one of the league's top cornerback trios. Ramsey and Porter's return comes at a tough time for Browns quarterback Dillon Gabriel and wide receiver Jerry Jeudy, who have struggled to gain traction this season. With Pittsburgh's elite secondary back at full strength, Jeudy could be in for another quiet outing.

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Kansas City Chiefs wide receiver JuJu Smith-Schuster could be entering his final week of fantasy relevance. Through five games, the veteran has caught 16 of 21 targets for 168 yards and a touchdown, primarily operating out of the slot. Smith-Schuster has been a steady part of the Chiefs' passing attack, logging 74% of snaps and routes, but that role is likely to diminish soon. With Rashee Rice set to return from suspension in Week 7, Smith-Schuster's playing time and target share could take a significant hit. For Week 6, however, he draws a favorable matchup against a Lions defense that's allowed the fourth-most fantasy points to wide receivers this season. Smith-Schuster carries deep-league FLEX appeal in what could be his final start-worthy week for Kansas City.

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Baltimore Ravens wide receiver DeAndre Hopkins was looking like a sleeper pick in deeper leagues when Lamar Jackson (hamstring) found him for some big plays the first couple of weeks. Since then, however, Hopkins has had a combined three receptions for 59 yards in three games and hasn't had a finish better than WR54. Then, we throw Cooper Rush and a defensive unit like the Los Angeles Rams into the mix, and everything gets a lot more bleak. In half-PPR formats, Hopkins is projected as the WR77, so fantasy managers will want to look elsewhere for an option with a higher ceiling in Week 6.

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Baltimore Ravens wide receiver Rashod Bateman has a chance to be the WR1 this week with Zay Flowers (shoulder) listed as questionable. Unfortunately, that won't move the fantasy value needle too much while Lamar Jackson (hamstring) remains sidelined. In Week 5, he saw three targets, but didn't register a single reception. As long as the offensive line continues to struggle, Bateman isn't likely to see many downfield throws, especially in a simplified offense for Cooper Rush. As of right now, he's projected to finish around WR72 in half-PPR formats, so there are probably better options on the waiver wire for fantasy managers in need of a flex.

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Baltimore Ravens running back Justice Hill has hit one very high output among many lows so far this season. His biggest value continues to be in full PPR formats, and the fact that the Ravens' defense has been so terrible that the offense has to abandon the run early. Hill has only registered one week finishing in the top 30 at the position, and has one more finish inside the top 36. The Los Angeles Rams are one of the toughest defenses against opposing backfields, which diminishes his value even further, even though Cooper Rush will likely have plenty of dump-off throws. Hill is projected as the RB51 and is avoidable in most league sizes this week.

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Baltimore Ravens tight end Mark Andrews has accrued two games with seven or more fantasy points, and only one of those equated to a TE1 finish. His best game was in the Week 3 loss with Lamar Jackson (hamstring) at the helm. In his first game with Cooper Rush behind center and Isaiah Likely in the mix, Andrews posted two catches for 11 yards on three targets. Despite the fact that the Los Angeles Rams are 19th against opposing tight ends, Andrews has a major uphill battle with how abysmal this offense has looked with Rush. The veteran tight end is projected as a low-end TE2 heading into this matchup, so fantasy managers may want to look for some better options.

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Denver Broncos wide receiver Marvin Mims Jr. has served mostly behind Courtland Sutton and Troy Franklin this season as the third receiver. Mims had his best game of the season in Week 4 against the Bengals, catching all six targets for 69 yards and rushing for a 16-yard touchdown. But he was unable to follow it up in Week 5 against Philadelphia, catching just two of five targets for 10 yards. The full-time role hasn't been there for Mims as head coach Sean Payton has rotated a lot of players at wide receiver. That leaves Mims as a tough player to trust in lineups for Week 6, where Denver will travel to London to face the Jets.

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Seattle Seahawks running back Kenneth Walker III checks in as a low-end RB2 once again in Week 6 against the Jacksonville Jaguars. Walker continues to split time with running back Zach Charbonnet in Seattle's backfield. The Jaguars are 18th against opposing running backs in fantasy. As such, there should be running lanes available for Walker. Walker has been very efficient over the last couple of weeks, having amassed 167 rushing yards on 29 carries. Unfortunately, his passing game volume remains low, which lowers his floor. However, the Seahawks love to run the ball in neutral and positive game scripts. They should be able to take care of business against Jacksonville, which bodes well for Walker in fantasy. Walker's ceiling will be tapped as long as he is splitting time with Charbonnet, but if he remains efficient, he will provide solid fantasy value. Additionally, Walker is as good a bet as anyone to score a long touchdown.

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Seattle Seahawks wide receiver Tory Horton should remain on your bench in Week 6 against the Jacksonville Jaguars. However, Horton continues to produce at a high level, and he will be difficult for the Seahawks to keep off the field. Horton has a nose for the end zone. He has scored four touchdowns in his first five games in the league. Unfortunately, his volume has been low. Horton has yet to exceed 39 receiving yards or four targets in a game. Despite the low volume, Horton's efficiency has been absurd. Three of his eight receptions this season have gone for touchdowns, and he has returned a punt for a touchdown. While the Jaguars boast a solid defense, they are relatively banged up in the secondary. Their recent addition of Greg Newsome II will help, but Jacksonville needs to worry about wide receivers Jaxon Smith-Njigba and Cooper Kupp first. Horton has a great chance to get lost in the shuffle and find the end zone once again in a game that projects to be relatively competitive. He is still not worthy of a start, but Horton could be a great second-half player in 2025.

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Baltimore Ravens quarterback Cooper Rush is taking over for the injured Lamar Jackson (hamstring) again, and it doesn't seem to be any better of a situation. Even though the Houston Texans have been the toughest fantasy matchup for opposing QBs this season, he now takes on the 12th-ranked unit against the position in the Los Angeles Rams. They allow an average of 16.02 fantasy points per game through five weeks and have only given up seven passing touchdowns total. Rush had an abysmal game last time out by throwing three interceptions with only 179 yards. Fantasy managers should look for different options if a streamer is needed due to bye weeks.

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Jacksonville Jaguars tight end Hunter Long is in line for a significant increase in snaps over the coming weeks, with fellow tight end Brenton Strange (quadriceps) placed on injured reserve. Long stepped in for Strange when he got injured in Jacksonville's Week 6 win over the Chiefs, playing 60% of the snaps and catching one pass for three yards after his departure. He recorded a season-high three receptions for 23 yards in Week 4 against the 49ers and has some appeal for fantasy managers who are desperate at tight end. He'll face a Seattle defense in Week 6 that has allowed the most receptions to tight ends on the season.

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Seattle Seahawks wide receiver Cooper Kupp has only proven to have fantasy value when Seattle's passing game exhibits high volume. Seattle's defense has a solid chance of shutting down the Jaguars' offense in Week 6, which would render Kupp an unnecessary part of the offense. Kupp has earned five or fewer targets in three of his five games this season. He can clearly still get the job done when called upon, but the Seahawks are frankly not calling upon his services often. There are plenty of other players, either on the waiver wire or potentially on your roster, that would be safer bets for consistent production in Week 6. If you need a break-glass option, Kupp could produce if the Jaguars' offense shows up. However, that is an absolute last resort scenario.

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