Indianapolis Colts running back DJ Giddens will look to see a larger role in a Week 5 home matchup against the Las Vegas Raiders. Giddens has been quiet since a Week 1 win where he saw 12 carries. The Colts have leaned heavily on starter Jonathan Taylor since the season opener, which has cut into Giddens' workload. That being said, fellow backup running back Tyler Goodson (groin) has been ruled out for a Week 5 home matchup against the Las Vegas Raiders, which will leave Giddens as the team's main backup running back behind Taylor. Giddens should not be in starting lineups in fantasy, but he remains a top handcuff option in case Taylor is forced to miss time at some point this season.

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Miami Dolphins wide receiver Nick Westbrook-Ikhine will move up the depth chart to the third receiver for his team after Tyreek Hill (knee) was lost for the season. Westbrook-Ikhine signed a two-year, $6.5 million contract with Miami this offseason, and now, he'll have a chance to contribute on a more regular basis. He played a season-high 47% of snaps in Week 4 when Hill was hurt and caught his one target for one yard. For the season, he only has four catches for 26 yards, but he should get many more opportunities going forward. Last year with the Titans, he showed a knack for finding the end zone with nine touchdowns on 32 catches for 497 yards. Miami's offense hasn't been extremely productive this year, but with more work comes the potential that NWI works his way to fantasy relevance. This week's matchup with the Panthers isn't a great one for receivers, though, leaving him as the WR69 in RotoBaller's rankings.

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Tampa Bay Buccaneers kicker Chase McLaughlin (illness) was added to the injury report late in the week, but he carries no game designation and is fully expected to play against the Seattle Seahawks. McLaughlin has been productive through four weeks, hitting nine of 12 field goal attempts, including a 65-yarder against Philadelphia in Week 4. While his 75% field goal percentage ranks just 26th in the league, the Buccaneers' explosive offense has kept him busy, and he currently sits fifth among kickers in fantasy points. With Tampa Bay traveling to Seattle for what projects to be a close matchup, McLaughlin should once again see multiple scoring opportunities. Fantasy managers should treat him as a must-start option in Week 5.

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Indianapolis Colts wide receiver Michael Pittman Jr. has gotten off to a hot start in 2025. The veteran wide receiver has caught 21 passes for 234 yards and three touchdowns through four games. Pittman will look to keep it going in a Week 5 home matchup against the Las Vegas Raiders. The Raiders have been extremely generous to opposing wideouts this season, allowing the third-most fantasy points per game to the position through four games. Pittman sets up as a low-end WR2/high-end WR3 in this prime matchup, making him an excellent fantasy option this weekend.

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Houston Texans wide receiver Christian Kirk caught three of four targets for 20 yards last week in his team's 26-0 win over the Titans, and he will look to continue to work his way into a volume role against the Ravens this week, after missing the first two weeks of the season. He played 61% of snaps in Week 4 after playing 67% in Week 3. With the Texans playing from ahead, they didn't throw the ball as muh in Week 4, though, so his targets decreased. The veteran wideout continues to find a way to carve out a role in Houston's underwhelming passing offense, and he seems to be the primary slot option and secondary receiver behind Nico Collins. The Ravens have been very beatable through the air so he does have potential flier upside even though his WR43 ranking on RotoBaller means he's not an ideal flex solution.

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In Week 4, Indianapolis Colts quarterback Daniel Jones had a small setback in what has been an exciting bounce-back season. Jones completed 24 of his 33 passes for 262 yards, one touchdown, and two interceptions in the 27-20 loss to the Los Angeles Rams. That being said, it should have been a better outing for Jones, who had a touchdown wiped away when Adonai Mitchell lost control of a would-be touchdown pass right before the goal line. Jones will look to get back on track in Week 5's home matchup against the Las Vegas Raiders. The Raiders have been decent against quarterbacks in fantasy this season, allowing the 15th-most fantasy points per game to the position thus far. Treat Jones as a high-end QB2 in Week 5.

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Miami Dolphins wide receiver Malik Washington is in a prime position for a breakout in the coming weeks since he'll likely be taking on a larger workload after the season-ending injury to Tyreek Hill (knee). The second-year receiver has already played 55% of snaps this season and has eight catches on 15 targets for 47 yards. He also has 60 rushing yards on eight carries and returned a punt for a touchdown. The dynamic receiver brings big-play potential on every touch, and more touches will raise his ceiling and his floor, even in the Dolphins' conservative offense. With more work coming his way, he has the potential to be a strong flex consideration at times for the rest of the season. However, this week, he's in an unfavorable matchup against the Panthers, who are very vulnerable to the run, which could limit his chances. He's only the WR46 this week in RotoBaller's rankings, but he has the potential to rise in better matchups with more opportunities moving forward. He's a strong stash candidate if he's available on waivers.

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Indianapolis Colts running back Jonathan Taylor will look to continue a hot start to the season in a Week 5 home matchup against the Las Vegas Raiders. Taylor has already rushed for 414 yards and added 113 receiving yards while notching four all-purpose touchdowns through four games to start the year. The veteran running back should continue to dominate the Indy backfield in a matchup against a Raiders defense that is allowing the 26th-most fantasy points per game to opposing running backs. As one of the few true bell-cow backs in the league, treat Taylor as a top-three fantasy running back in Week 5 despite the difficult matchup.

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Cleveland Browns kicker Andre Szmyt will head to London to take on the Minnesota Vikings in Week 5. Szmyt has been up and down this season, hitting five of his seven field-goal tries while making all but one of his six extra points. The Browns could struggle to move the ball against an excellent Minnesota defense, especially with third-round rookie Dillon Gabriel making his NFL debut on Sunday. Szmyt should not be in starting lineups for fantasy teams in Week 5.

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Miami Dolphins running back Jaylen Wright has yet to get involved for his team this season, even though he has flashed upside in limited opportunities in the past. His name has been swirling in trade rumors since he has yet to play a snap for the Dolphins, even though he has been healthy for their last two games after missing the first two games of the year with a knee injury. Wright had 249 yards on 68 carries as a rookie and had a few big plays. Wright could be an interesting addition for a team that needs another option in the mix in the backfield, but for now, he's not usable in fantasy since he is not in Miami's backfield mix and is only the RB75 in RotoBaller's Week 5 rankings.

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New England Patriots tight end Hunter Henry remains a very appealing fantasy option ahead of Week 5 against the Buffalo Bills. Henry has been quite productive through four weeks this season, catching 15 passes for 204 yards and three touchdowns while ranking as the overall TE4 in PPR leagues. He's coming off a two-touchdown game that isn't replicable, but still offers some insight into his role and productivity going forward. With all this being said, managers should temper their expectations on Sunday despite Henry's big momentum. This week, he's facing the Bills, who have allowed the fewest receiving yards and third-fewest fantasy points to tight ends in 2025. Henry drops to the low-end TE1 tier as a fringe top-12 option at his position.

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Miami Dolphins wide receiver Jaylen Waddle is set to be his team's top wide receiver target the rest of the season after Tyreek Hill (knee) suffered a catastrophic knee injury last week on Monday Night Football. Waddle was already posting strong numbers with either five or six targets in each game this season. He hauled in 17 of his 23 targets for catches, racking up 185 yards and a pair of touchdowns. He could get to double-digit targets per game if he gets enough of Hill's workload, making him a solid WR2 with WR1 upside. Tua Tagovailoa and the Dolphins are running a conservative, short-passing offense and may rely more on De'Von Achane in the running game if playing from ahead this week in Carolina. When the Dolphins have to go pass-heavy, Waddle could be a top-10 receiver, since he's already a goal-line and red zone threat. This week's road matchup against the Panthers is tricky since the Dolphins could play from ahead, and the Panthers have been beatable on the ground. While he has a very high floor now that he should get more looks, this doesn't seem to set up perfectly for his breakout week quite yet. He's the WR20 this week in RotoBaller's rankings, so he's a strong second receiver in most formats this week, with higher-ceiling games potentially further down the road.

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Cleveland Browns wide receiver Isaiah Bond had his best game as a pro in Week 4's loss to the Detroit Lions, catching three of six targets for 58 yards. Bond has a chance to continue to ascend in Week 5's matchup against the Minnesota Vikings in London. The Browns placed Cedric Tillman (hamstring) on injured reserve earlier in the week, which will open up a larger workload for Bond moving forward. The Vikings are allowing the fewest fantasy points per game to opposing wide receivers this season, but Bond is worth a look in fantasy as a boom/bust flex option if you are being hit hard by the Week 5 byes.

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Miami Dolphins running back De'Von Achane should be very busy in an extremely favorable matchup in Week 5, when his team rolls into Carolina. Achane is coming off a season-high 20 carries on Monday night against the Jets in Week 4, totaling a season-high 99 rushing yards and scoring his first rushing touchdown. His targets were down dramatically because the Dolphins played from ahead, but he could get more work as a receiver with Tyreek Hill (knee) done for the season. Coach Mike McDaniel knows that Achane is a key playmaker in the offense ans always is sure to get him his volume. The Panthers have been a good matchup for running backs, giving up three running back touchdowns in four weeks along with 110 rushing yards and 30.3 receiving yards per game to the position. Achane should continue to serve as the primary back in Miami, and even though he is sharing a little work with rookie Ollie Gordon II, he remains a great play in all formats. His big-play ability, consistent volume, and favorable matchup combine to place him at No. 5 in the RotoBaller RB rankings for this week.

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Cleveland Browns tight end David Njoku (knee) will take on the Minnesota Vikings in London in Week 5. Njoku practiced fully on Thursday and Friday after being limited on Wednesday and is listed without an injury designation heading into Sunday's contest. That being said, Njoku sets up as a low-end TE2 in Week 5. He continues to split tight-end looks with Harold Fannin Jr., which has cut into his fantasy value. The Browns will also trot out rookie Dillon Gabriel to make his NFL debut against Minnesota's exceptional pass defense, so expect the offense to skew run-heavy. Njoku is fine to utilize in fantasy, but he's not a must-start this weekend.

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New England Patriots wide receiver Kayshon Boutte desperately needs to bounce back in order to salvage his fantasy value on Sunday against the Buffalo Bills. Boutte caught six passes for 103 yards in Week 1 and then added a touchdown the next week, raising plenty of speculation that he was ready to take on a massive role and could be a strong WR3 in fantasy football. However, he has just four catches over his last three games, looking relatively uninvolved despite a snap share over 70 percent. Time could be ticking for Boutte to get back on track, and it probably won't happen Sunday against the Bills. Buffalo has allowed the sixth-fewest receiving yards and 10th-fewest fantasy points to wide receivers in 2025, as well as the 14th-fewest fantasy points to perimeter receivers like Boutte. He can be benched in all leagues and dropped in leagues with 12 or fewer people.

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Miami Dolphins running back Ollie Gordon II continues to serve as the team's primary backup for De'Von Achane and a change-of-pace option with a specialty in short-yardage situations. In Week 4, he played 26% of snaps on Monday Night Football against the Jets, taking six carries for 10 rushing yards. He played 25% of snaps in Week 3 as well and seems to be settling into a 75-25 split with Achane. Gordon has the potential to return good value in a favorable matchup against the Panthers, but his usability in a flex spot remains very touchdown dependent. He'll probably get a handful of carries, but he'll need to get into the end zone to really be a strong option. Coming into his matchup in Carolina, he is the RB42 in RotoBaller's rankings for the week, leaving him best suited for the bench in most formats.

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Cleveland Browns tight end Harold Fannin Jr. will look to continue his strong start to the season in a Week 5 matchup against the Minnesota Vikings in London. Fannin has been one of the few bright spots on the Cleveland offense this season, catching 17 passes for 160 yards through four games. The Vikings have been tough against tight ends this season, allowing just the 24th-most fantasy points per game to the position thus far. That being said, Fannin should continue to be a focal point of the Cleveland offense, especially with rookie quarterback Dillon Gabriel making his NFL debut. Treat Fannin as a high-end TE2 in fantasy this weekend.

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New England Patriots wide receiver Mack Hollins already has two touchdowns through four games and will look to build on that total during Sunday's Week 5 contest against his old team, the Buffalo Bills. Hollins has just seven catches for 42 yards this year, playing over 50 percent of the snaps in three of his four games. However, he has still managed to cross the goal line twice, building on a strong 2024 campaign with the Bills that saw him lead the team with five touchdown grabs. While Hollins would have some low-end standalone value by scoring a touchdown, that's impossible to predict or guarantee this week, especially against a Bills defense allowing the 10th-fewest fantasy points to receivers. Hollins, 32, has WR3/flex upside, but it's far more likely that he finishes Week 5 off the fantasy radar.

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Cleveland Browns wide receiver Jerry Jeudy will take on the Minnesota Vikings in London in Week 5. Jeudy has been quiet to start the season, catching 13 passes for 182 scoreless yards through four games. He is unlikely to break out against a Vikings defense that is allowing the fewest fantasy points per game to opposing wideouts this season, especially with quarterback Dillon Gabriel making his NFL debut. Jeudy is best treated as a WR4 heading into Week 5, although the absence of Cedric Tillman (hamstring) might push a bit more work onto Jeudy's plate.

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