Buffalo Bills running back Ty Johnson could become an interesting mid-week waiver-wire pickup heading into Week 10 against the division-rival Miami Dolphins on Sunday after it was announced on Wednesday that starting RB James Cook (ankle, foot) is not practicing. Johnson only played 20% of the offensive snaps in the Week 9 win over the Kansas City Chiefs and had just two carries, but he was able to fall into the end zone for his first touchdown of 2025. The 28-year-old has also been Buffalo's preferred choice as the backup to Cook this year over Ray Davis, who played just 5% of the snaps last weekend. If Cook's injury is serious enough to sideline him this weekend, the Bills would likely split backfield touches between Johnson and Davis, but at the very least, fantasy managers should be keeping a close eye on this situation over the next few days. Johnson has only 17 carries on the year for 72 yards and one TD.

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Jacksonville Jaguars wide receiver Brian Thomas Jr. (ankle) was not seen at the portion of practice open to the media on Wednesday, according to Demetrius Harvey of Jaguars.com. Thomas suffered a low-grade high-ankle sprain in the Week 9 win over the Las Vegas Raiders, but the team is optimistic he'll be able to play in Week 10 versus the division-rival Houston Texans. The Jaguars also placed rookie first-rounder Travis Hunter (knee) on Injured Reserve last week, so if Thomas is limited or unable to go this weekend, it will most likely make Parker Washington the top target of quarterback Trevor Lawrence. In addition to Thomas being hurt, Dyami Brown suffered a concussion last Sunday. In the wake of all of Jacksonville's receiver injuries, they acquired Jakobi Meyers from the Raiders on Tuesday. Meyers should eventually have a big role in the passing attack, but fantasy managers will want to temper expectations for him early on as he learns the playbook.

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Washington Commanders head coach Dan Quinn said on Wednesday that the team is still "sorting through the medical opinions" on quarterback Jayden Daniels' elbow, according to John Keim of ESPN. Daniels suffered a gruesome-looking left elbow dislocation late in the Sunday night blowout loss to the Seattle Seahawks, but initial X-rays came back negative for any fractures. It remains to be seen whether the 24-year-old suffered any ligament damage in his arm, though, and at the very least, it seems likely that the second-year signal-caller will be forced to Injured Reserve, which would require him to miss at least four games. While the Commanders are holding out hope that Daniels might return this year, we wouldn't be surprised if he's shut down the rest of the way. In the meantime, veteran Marcus Mariota will start at QB for a banged-up Commanders offense that also lost receiver Luke McCaffrey to a broken collarbone.

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Buffalo Bills head coach Sean McDermott said that wide receiver Joshua Palmer (ankle, knee) will be limited in Wednesday's practice, according to Maddy Glab of BuffaloBills.com. Palmer has not played since getting hurt in Week 6, but a limited showing in the first practice of the week means he is trending in the right direction and could be active for this weekend's divisional clash on the road against the Miami Dolphins. Keon Coleman has continued to disappoint his fantasy managers with Palmer out, catching only five passes on six targets for 47 yards and no touchdowns in two games. The only pass-catchers that have been reliable for fantasy purposes this year in Buffalo have been receiver Khalil Shakir and tight end Dalton Kincaid. Even if Palmer upgrades to a full practice this week and returns on Sunday, he should remain on the waiver wire in 12-team fantasy leagues.

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Washington Commanders running back Chris Rodriguez Jr. is coming off his best showing of the year in Sunday night's blowout loss to the Seattle Seahawks. Rodriguez played 34% of the offensive snaps and saw a season-high 12 rushing attempts for a season-high 65 yards and his second touchdown of the year. The 25-year-old still has not been targeted in the passing game, but both of his touchdowns have come in the last three weeks, and he could start to see more involvement with rookie RB Jacory Croskey-Merritt struggling in recent weeks as the team's lead back. However, fantasy managers should still temper expectations for Washington's backfield now that starting quarterback Jayden Daniels (elbow) is out for the foreseeable future. Expect opposing defenses to load the box and make veteran QB Marcus Mariota beat them. Rodriguez is only a stash candidate for RB depth in deep fantasy leagues.

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Los Angeles Chargers running back Jaret Patterson worked as the team's No. 2 RB behind Kimani Vidal for the second straight week in the Week 9 win over the Tennessee Titans on Sunday. Patterson played a season-high 28% of the offensive snaps and saw nine rushing attempts for a season-high 44 yards. The 25-year-old made his 2025 debut the previous week in the Thursday night win over the Minnesota Vikings, taking 11 carries for 30 yards. He has yet to be involved in the passing game, but it's clear that Patterson has become the Bolts' temporary RB2 behind Vidal with both rookie first-rounder Omarion Hampton (ankle), Hassan Haskins (hamstring), and Najee Harris (Achilles) on Injured Reserve. Hampton might not return until after the Week 12 bye, so Patterson could have two more weeks with an elevated backfield role.

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Buffalo Bills head coach Sean McDermott said that running back James Cook (ankle, foot) will not practice on Wednesday due to an ankle/foot injury, according to Katherine Fitzgerald of The Buffalo News. Cook had another nice game in the team's Week 9 victory over the Kansas City Chiefs, carrying the ball 27 times for 114 yards while also catching one pass for 11 yards. However, the 26-year-old apparently came out of that game a little gimpy, and his status is now up in the air for the team's Week 10 tilt on the road against the division-rival Miami Dolphins. If Cook were to miss this weekend, Ty Johnson and Ray Davis would likely split backfield duties for the Bills in a great matchup. Cook has been a must-start RB1 every week in 2025, as he's currently the RB7 in fantasy in half-PPR scoring with 867 rushing yards and seven touchdowns on 153 carries.

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Cleveland Browns rookie quarterback Shedeur Sanders (back) will return to practice on Wednesday from the back injury that sidelined him in Cleveland's most recent game against the New England Patriots. It appears Sanders is on track to be active for the Browns' Week 10 matchup against the New York Jets. If he's healthy enough to play in Week 10, Sanders would likely be the backup to fellow rookie quarterback Dillon Gabriel. For now, Sanders is still waiting on an opportunity to make his NFL debut. Across six games (four starts), Gabriel has completed 59.9% of his pass attempts for 702 yards, five touchdowns, and two interceptions. Despite the modest production, there's been no indication out of Cleveland that the team is currently considering replacing Gabriel with Sanders any time soon.

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Indianapolis Colts head coach Shane Steichen said that newly acquired cornerback Sauce Gardner (concussion) is in the league's concussion protocol, but he will practice on Wednesday, according to Mike Chappell of FOX 59. The Colts gave up a lot to secure the services of the All-Pro corner at the trade deadline on Tuesday, giving up receiver Adonai Mitchell and two first-round picks. Gardner is still in the concussion protocol despite coming off a bye last week, but the fact that he's going to practice on Wednesday means he has a chance to make his debut with the Colts this Sunday in Berlin, Germany, against the Atlanta Falcons. The Colts are 7-2 and tied for the best record in the AFC heading into Week 10, but their secondary has been a weak spot so far this year. Gardner will definitely shore up their secondary as one of the best cover corners in the NFL.

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Jaguars reporter Ryan O'Halloran of The Florida Times-Union said on a recent radio appearance that the price the team paid to acquire wide receiver Jakobi Meyers indicates that the team views him as more than just a rental. Jacksonville traded fourth and sixth-round draft picks to the Las Vegas Raiders in exchange for Meyers on Tuesday. Meyers will provide immediate aid to a Jaguars wide receiver room that will be without Travis Hunter (knee) for at least three more games and could be without both Brian Thomas Jr. (ankle) and Dyami Brown (concussion) in Week 10. Meyers recorded 33 catches for 352 yards and zero touchdowns on 49 targets across seven games for Las Vegas this season. If O'Halloran is correct and Jacksonville plans to keep Meyers beyond 2025, his presence could be a slight negative for the dynasty value of Hunter and Thomas Jr.

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Cleveland Browns rookie wide receiver Isaiah Bond (foot) is dealing with a foot injury that is expected to keep him from practicing on Wednesday, per ESPN's Daniel Oyefusi. Bond's availability for his team's Week 10 matchup against the New York Jets appears to be in jeopardy. The 21-year-old has recorded 11 catches for 123 yards on 30 targets across eight games so far this season. However, he was held without a catch on four targets in his final two games before the Browns' Week 9 bye. If Bond is sidelined in Week 10, wide receiver Jerry Jeudy and tight ends David Njoku and Harold Fannin Jr. could see a slight bump in target share. Additionally, wide receiver Cedric Tillman (hamstring) could make his return in Week 10 from a hamstring injury that has sidelined him since Week 4. Even if Bond can play, he should likely remain off fantasy radars in Week 10 against New York.

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Tampa Bay Buccaneers wide receiver Chris Godwin (leg) is not expected to practice on Wednesday, per Rick Stroud of the Tampa Bay Times. Godwin missed the team's final three games before their Week 9 bye due to a leg injury, and it appears he may not be ready to return in Week 10 against the New England Patriots. It's beginning to look like somewhat of a lost season due to injury for Godwin, who also missed Tampa Bay's first three games of 2025 while recovering from the dislocated ankle that ended his 2024 season. In the two games he's played this season, Godwin has recorded six catches for 52 yards on 14 targets. If he remains sidelined in Week 10, Buccaneers rookie wideout Tez Johnson could maintain a sizable role in the team's offense. Johnson has recorded 10 catches for 146 yards and two touchdowns on 18 targets over his last three games played. Veteran wideout Sterling Shepard and tight end Cade Otton are also candidates to be the team's number two pass-catcher behind star wide receiver Emeka Egbuka.

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Indianapolis Colts wide receiver Alec Pierce has almost exclusively been known as a downfield pass-catcher throughout his career. Across his first three NFL seasons, Pierce averaged 4.3 targets per game and 17.6 yards per reception. Now in his fourth season, Pierce is still making big plays. However, there are signs that Indianapolis is viewing him as a more well-rounded wide receiver. Through his first seven games played in 2025, Pierce is averaging 6.4 targets per contest. He's been particularly involved in recent weeks with 28 targets over his last three games played. Pierce has yet to find the end zone this season, but he scored seven touchdowns across 16 games in 2024. Heading into a Week 10 matchup against the Atlanta Falcons, Pierce should be rostered in all fantasy leagues with 12 or more teams.

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Tampa Bay Buccaneers running back Bucky Irving (foot, shoulder) is not expected to practice on Wednesday, according to Rick Stroud of the Tampa Bay Times. Stroud reports that Irving is "still in the rehab phase." The 23-year-old has not played since Week 4 as he battles foot and shoulder injuries. There had been hope that Irving would be ready to return for Tampa Bay's Week 10 matchup against the New England Patriots coming off the team's Week 9 bye. However, it appears that Irving's status for the game is still very much up in the air. If Irving misses a fifth consecutive game in Week 10, Buccaneers running backs Rachaad White and Sean Tucker would likely split backfield reps against New England. In Tampa Bay's Week 8 win over the New Orleans Saints, White saw 15 total touches compared to 12 for Tucker.

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Cleveland Browns rookie running back Quinshon Judkins (shoulder) is expected to return to practice on Wednesday ahead of Week 10. Judkins suffered an AC joint sprain in Week 8, but the Week 9 bye provided valuable recovery time. Through seven games, the rookie has handled 118 carries for 486 yards and five rushing touchdowns, while adding 12 receptions for 60 yards, solidifying his role as the lead back in Cleveland's offense. The Browns draw a favorable Week 10 matchup against the New York Jets, who have allowed the 11th-most fantasy points to opposing running backs this year. Judkins is on track to play and should be viewed as a strong RB2 with touchdown upside in this matchup.

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New York Jets running back Isaiah Davis was one of the bigger losers of the trade deadline. After weeks of speculation that the team might move Breece Hall, the Jets ultimately held onto their starter, keeping him locked in as the clear RB1. Davis was coming off the best performance of his young career before the bye, totaling 109 scrimmage yards on 12 touches, showing burst and efficiency when given opportunities. However, his path to meaningful volume remains limited with Hall still leading the backfield. The Jets also face a difficult Week 10 matchup against Cleveland, a defense allowing the second-fewest fantasy points to running backs. Davis currently profiles as a stash-and-hold handcuff rather than a startable option.

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Seattle Seahawks wide receiver Tory Horton has been a touchdown machine in his rookie season, scoring five touchdowns on just 13 receptions. He posted a career day in Week 9 with four catches for 48 yards and two scores while logging a season-high 73% snap share. However, Seattle's trade for Rashid Shaheed may limit Horton's fantasy trajectory. Shaheed recorded 44 receptions in nine games with the Saints this season and is expected to slide in as the No. 2 option alongside Jaxon Smith-Njigba. With Shaheed likely to command consistent snaps and targets, Horton becomes a far more volatile play. He should be viewed as a stash-only option in deeper leagues, not a weekly fantasy starter.

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Chicago Bears wide receiver Olamide Zaccheaus is coming off his best performance of the season, posting six receptions for 58 yards and a touchdown in Week 10 against Cincinnati. With rookie Luther Burden III (concussion) sidelined, Zaccheaus logged his second-highest snap share of the year (66%) and delivered as the primary slot option in Ben Johnson's scheme. He's developed solid chemistry with Caleb Williams, and now draws a favorable Week 11 matchup against the Giants, who allow the fourth-most fantasy points to opposing wideouts. If Burden remains out, Zaccheaus carries deep-league FLEX value against a struggling Giants secondary.

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Dynasty | The Saints did not trade wide receiver Chris Olave prior to Tuesday's deadline. Dynasty Analysis: Olave was rumored to be of interest to several teams, including the Bills (let your imagination wander). However, the Saints kept him in the hopes they could sign him to an extension. We'll see if that pans out in the end, but anyone with Olave on their dynasty roster has to be at least a little disappointed. Let's face it - Olave has a high floor and a low ceiling in an offense led by Tyler Shough or Spencer Rattler.

Chicago Bears rookie tight end Colston Loveland broke out in a big way in Week 9, catching six of seven targets for 118 yards and two touchdowns in the Bears' 47-42 win over the Bengals. The highlight came on a 58-yard game-winning touchdown, capping off a monster performance that pushed Chicago to a 5-3 record. With Cole Kmet exiting early due to a concussion, Loveland stepped in as the primary tight end, logging 79% of the offensive snaps. Now, with Kmet still in concussion protocol entering Week 10, Loveland could once again handle a full workload against the New York Giants, who have allowed the ninth-most passing yards in the NFL this season. If Kmet remains sidelined, Loveland is a must-start fantasy option across all formats, offering TE1 upside in Week 10.

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