Las Vegas Raiders running back Raheem Mostert is inactive for Week 1 of the 2025 regular season on Sunday against the New England Patriots. Mostert is healthy heading into the regular-season opener, so this is a bad sign for his potential involvement in the Raiders' backfield this year in his first year with the team. The Raiders drafted rookie Ashton Jeanty in the first round in April, and he's fully expected to lead Vegas' backfield in his first year in the NFL. The oft-injured Mostert has now been bumped down the depth chart and will open the year as the RB4 behind Jeanty, Zamir White and Dylan Laube. The 33-year-old veteran can be dumped if you were rostering him as a handcuff for Jeanty in redraft leagues. Mostert led the league with 18 rushing touchdowns in 2023 in Miami but played in 13 games last year and fell to just two TDs.

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Carolina Panthers wide receiver Jimmy Horn Jr. (coach's decision) is a healthy scratch for Week 1 against the Jacksonville Jaguars. The Panthers' sixth-round pick was rumored to be an up-and-coming piece in the Carolina offense, with some speculation that he could have an immediate role in Week 1. Instead, his NFL debut will have to wait at least one more week. Dalevon Campbell is also inactive on Sunday, leaving the Panthers with five active receivers on gameday.

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New England Patriots rookie wide receiver Efton Chism III is a healthy inactive for the team's Week 1 regular-season opener on Sunday against the Las Vegas Raiders. Chism had a very strong training camp and preseason for the Patriots despite going undrafted back in April. The 23-year-old is certainly worth stashing for the long term in dynasty/keeper formats, but he belongs on the waiver wire for now in all single-year formats. With Chism being a healthy scratch in the first game of the year for the Patriots, they will roll with Stefon Diggs, DeMario Douglas, Kayshon Boutte, Mack Hollins and Kyle Williams in their wideout corps in quarterback Drake Maye's first full season as the starter under center.

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Ian Rapoport of NFL Network is reporting that Houston Texans running back Nick Chubb will start in Week 1 on Sunday against the Los Angeles Rams at SoFi Stadium and is expected to be the team's bell-cow back with Joe Mixon (foot) on the Non-Football Injury list to begin the season. Chubb reportedly looked really good in training camp, and the Texans are expecting big things from him this year in his first year in Houston. The 29-year-old was a four-time Pro Bowler and was one of the better RBs in the NFL before he suffered a gruesome knee injury in 2023. When he returned for the Browns last year, Chubb did not look the same and averaged a career-worst 3.3 yards per carry. However, if he's closer to his pre-injury form in 2025, he has the opportunity to be a fantastic value pick in fantasy with plenty of volume as the clear starter ahead of Dameon Pierce and rookie Woody Marks.

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New York Giants quarterback Jaxson Dart is active and will operate as the team's backup for Week 1 against the Washington Commanders. Meanwhile, Jameis Winston is inactive as the team's emergency third quarterback. This depth chart decision from the coaching staff aligns with recent rumors that indicated Dart may have earned the backup job and could even make his NFL debut in Week 1. NFL Network's Ian Rapoport recently noted that the Giants have a package of plays ready for Dart, so it's possible that he could relieve starter Russell Wilson for a handful of snaps on Sunday afternoon. Still, Dart is merely a dynasty stash at this point, as he'd need to be inserted as the full-time starter before warranting any interest in redraft leagues. Meanwhile, Winston should be left on waivers in all leagues.

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The New York Giants have declared OG Evan Neal, OT Andrew Thomas, TE Thomas Fidone II, S Beau Brade, DT Darius Alexander and QB Jameis Winston inactive for Week 1.

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Washington Commanders running back Chris Rodriguez Jr. (coach's decision) is a healthy scratch for Sunday's Week 1 contest against the New York Giants. It's no surprise that Washington is only carrying three active running backs on Sunday, but it's a bit stunning to see that Rodriguez is the odd man out. He drew praise from the coaching staff for his ability to step into a larger role this offseason, and he showed bursts of upside last year, such as Week 13, when he rushed for 95 yards and a touchdown. Austin Ekeler should lead the Washington backfield on Sunday while Jacory Croskey-Merritt and Jeremy McNichols also carve out significant roles.

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Indianapolis Colts running back Tyler Goodson (elbow) is officially inactive for the Week 1 season opener on Sunday versus the Miami Dolphin. Goodson was limited all week during practices with his elbow injury and was listed as questionable on the final injury report on Friday. It doesn't appear to be a serious ailment for Goodson, but the Colts will keep him out for the first game of the season. His next chance to make his 2025 debut will be in Week 2 against the Denver Broncos next Sunday. With Goodson sitting in Week 1, it will give rookie DJ Giddens the opportunity to serve as the direct backup to starter Jonathan Taylor. Ulysses Bentley will be the RB3. The 24-year-old Goodson is off the fantasy radar for now and won't be worth a look on the waiver wire unless Taylor misses time with an injury this year.

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The Las Vegas Raiders have declared OT Charles Grant, DT JJ Pegues, RB Raheem Mostert, DE Brennan Jackson, DT Leki Fotu, DB Tristin McCollum and OT Caleb Rogers inactive for Week 1.

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The Miami Dolphins have declared TE Darren Waller, OL Kendall Lamm, WR Tahj Washington, RB Jaylen Wright, DB Ethan Bonner, DT Zeek Biggers and QB Quinn Ewers inactive for Week 1.

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Cincinnati Bengals wide receiver Jermaine Burton is a healthy scratch for the Week 1 season opener on Sunday against the division-rival Cleveland Browns. Burton came down with a knee injury in the preseason finale against the Indianapolis Colts two weeks ago, but he had since returned to full practice and was removed from the final Week 1 injury report heading into the weekend. The 24-year-old still has potential, but he's buried on the current receiver depth chart behind Ja'Marr Chase, Tee Higgins and Andrei Iosivas right now. The former third-rounder (80th overall) last year showed maturity issues in his rookie season and caught only four of his 14 targets for 107 yards in 14 games (one start). The Bengals are still holding out hope he can contribute in the long term, but for now, Burton is off the fantasy radar outside of dynasty/keeper leagues as a bench stash.

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Atlanta Falcons wide receiver Darnell Mooney (shoulder) is officially inactive for Sunday's Week 1 contest against the Atlanta Falcons. He had been listed as questionable after being a limited participant in three consecutive practices. The 27-year-old is looking to build on an impressive 2024 campaign in which he caught 64 passes for 992 yards and five touchdowns, and he likely would have eclipsed 1,000 yards last season if not for missing the season finale due to injury. His quest to top last season's statistics will have to wait at least one week, as Mooney isn't quite healthy enough to play in the 2025 season opener. Drake London and Kyle Pitts project as Michael Penix Jr.'s top options in the passing attack, while Ray-Ray McCloud III should step up into the No. 2 wide receiver role with Mooney sidelined.

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Dynasty | The Browns have signed rookie running back Quinshon Judkins and he could debut in week two. Dynasty Analysis: This has been a drawn-out ordeal but Judkins got a fully guaranteed deal from Cleveland (they certainly hope this one goes a little better than Deshaun Watson's) and could be ready to play as soon as next week. The NFL is scheduled to interview him this week and a suspension is also a possibility, so anyone with Judkins on their roster simply needs to have a backup plan moving forward until everything is settled. He remains a high-risk rookie with a high ceiling.

Dynasty | The Lions have signed wide receiver Jameson Williams to an extension. Dynasty Analysis: Williams gets a three-year, $83 million deal with $67 million guaranteed. This ends any drama that was building around a potential exit from Motor City at the end of they year. The Lions are now fully committed to a core of players that includes Amon-Ra St. Brown, Sam LaPorta, Jahmyr Gibbs and Williams. Set to make a big leap this season, the buying window on Williams may be closing.

San Francisco 49ers RB Christian McCaffrey (calf) will play in Week 1's game versus the Seattle Seahawks, according to a source.

Fantasy Spin: McCaffrey was added to the injury report with a questionable designation due to a calf issue Thursday, Sept. 4, and performed well during the walkthrough Saturday, Sept. 6, after missing practice altogether Friday, Sept. 5. While it remains unknown if he will receive his regular workload, he should be considered a must-start option in all fantasy leagues.

From TheHuddle

San Francisco 49ers running back Christian McCaffrey (calf) will play in Sunday's season opener against the Seattle Seahawks, according to ESPN's Adam Schefter. McCaffrey had been listed as questionable, and there was genuine concern about his availability after he missed practice on Friday. However, in the end, it appears the star running back will suit up. Fantasy managers should expect him to receive a normal workload, which means he could earn around 20 touches. He remains a very strong mid-range RB1 option thanks to his talent, productivity, and role in an effective Niners offense.

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Cleveland Browns running back Quinshon Judkins, who finally signed his rookie contract on Saturday, is likely to make his NFL debut in Week 2 against the Baltimore Ravens, a source told ESPN's Adam Schefter. While Judkins' progression through the normal offseason routine was drastically delayed due to his unsigned contract and an off-the-field legal matter, the former was resolved this weekend and the latter could be put to rest within the upcoming week. As a result, Judkins is on track to play next Sunday against the Ravens. With that said, his exact role is still uncertain. He was away from the team during training camp, so it could take him some time to get up to NFL game speed. In the meantime, returning starter Jerome Ford and rookie Dylan Sampson should both carve out significant roles in the Cleveland backfield. Judkins likely won't be startable in fantasy football for at least a few weeks.

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San Francisco 49ers running back Christian McCaffrey (calf) did not practice on Friday, but he was a "big participant in the walkthrough on Saturday," according to NFL Network's Ian Rapoport. As a result, the star running back is trending toward playing. Fantasy managers are holding their breath and hoping that McCaffrey avoids a repeat of the 2024 season when he was expected to be healthy for Week 1 but then ultimately missed the first nine games. We'll get confirmation on his status around 2:35 p.m. ET when the 49ers post their list of inactive players. If McCaffrey does suit up against the Seahawks, he'll rank as a mid-range RB1 in fantasy football.

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Washington Commanders running back Jacory Croskey-Merritt has been gaining traction throughout training camp and the preseason. The trade of Brian Robinson Jr. has given Croskey-Merritt a clear path to playing time in Washington. The Commanders have stated that Croskey-Merritt will be involved during the season opener. However, it's unclear how much he'll actually play in this game. The Commanders have four backs that they'll probably mix in at some point. Croskey-Merritt is a great stash, but his Week 1 outlook is hard to predict. He's probably best served on the fantasy benches until he has a proven role in the offense.

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Kansas City Chiefs wide receiver Xavier Worthy (shoulder) has suffered a dislocated shoulder from Friday's game in Brazil. Worthy exited in the first quarter of Friday's contest after colliding with teammate Travis Kelce. He underwent additional testing which has now revealed a fairly significant injury. Worthy will still have more testing done, but is hopeful he can return with a brace. It seems tough to imagine Worthy being able to suit up for the Week 2 matchup against the Philadelphia Eagles. If Worthy misses time, Marquise Brown figures to gain the most value. Brown hauled in 10 of 16 targets for 99 yards in the Week 1 loss. Also, JuJu Smith-Schuster, Tyquan Thornton, and Travis Kelce should see increased roles. Brown needs to be rostered in all fantasy formats given Worthy is likely to miss time or be limited.

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