

| On IR: | |||
| Trey Benson | |||
| L.j. Collier | |||
| James Conner | |||
| Justin Jones | |||
| Tip Reiman | |||
| J.J. Russell | |||
| Garrett Williams | |||
| Physically Unable To Perform: | |||
| BJ Ojulari | |||
| On IR: | |||
| Clark Phillips III | |||
| On IR - Designated For Return: | |||
| Jordan Fuller | |||
| Physically Unable To Perform: | |||
| Troy Andersen | |||
| Questionable: | |||
| Tyler Allgeier | Hip | ||
| Zach Harrison | Knee | ||
| Michael Penix Jr. | Knee | ||
| Out: | |||
| Billy Bowman Jr. | Hamstring | ||
| Divine Deablo | Forearm | ||
| Jalon Walker | Groin | ||
| On IR: | |||
| Bilhal Kone | |||
| Robert Longerbeam | |||
| Justin Madubuike | |||
| Tavius Robinson | |||
| Broderick Washington Jr. | |||
| On IR - Designated For Return: | |||
| Adisa Isaac | |||
| Physically Unable To Perform: | |||
| Ar'Darius Washington | |||
| Questionable: | |||
| Lamar Jackson | Hamstring | ||
| On IR: | |||
| Tyler Bass | |||
| DeWayne Carter | |||
| Gabriel Davis | |||
| Damar Hamlin | |||
| T.J. Sanders | |||
| Dorian Strong | |||
| On IR - Designated For Return: | |||
| Maxwell Hairston | |||
| Out: | |||
| DaQuan Jones | Calf | ||
| Josh Palmer | Knee | ||
| Taylor Rapp | Knee | ||
| On IR: | |||
| Patrick Jones II | |||
| Damarri Mathis | |||
| David Moore | |||
| Physically Unable To Perform: | |||
| Jonathon Brooks | |||
| Doubtful: | |||
| Bryce Young | Ankle | ||
| On IR: | |||
| Deion Hankins | |||
| Jaylon Johnson | |||
| Terell Smith | |||
| On IR - Designated For Return: | |||
| Austin Booker | |||
| Amen Ogbongbemiga | |||
| Questionable: | |||
| Cairo Santos | Right Thigh | ||
| D'Andre Swift | Groin | ||
| Out: | |||
| Kyler Gordon | Groin | ||
| Roschon Johnson | Back | ||
| Cole Kmet | Back | ||
| Tyrique Stevenson | Shoulder | ||
| On IR: | |||
| Joe Burrow | |||
| Mike Gesicki | |||
| On IR - Designated For Return: | |||
| Daijahn Anthony | |||
| Cedric Johnson | |||
| Physically Unable To Perform: | |||
| Erick All | |||
| Questionable: | |||
| Trey Hendrickson | Hip | ||
| Doubtful: | |||
| Cameron Sample | Knee | ||
| Marco Wilson | Hamstring | ||
| On IR: | |||
| DeAndre Carter | |||
| Martin Emerson | |||
| Cedric Tillman | |||
| Nathaniel Watson | |||
| On IR - Designated For Return: | |||
| Winston Reid | |||
| Physically Unable To Perform: | |||
| Jeremiah Owusu-Koramoah | |||
| Deshaun Watson | |||
| Questionable: | |||
| Adin Huntington | Concussion | ||
| David Njoku | Knee | ||
| On IR: | |||
| Jalen Brooks | |||
| Malik Hooker | |||
| Phil Mafah | |||
| Miles Sanders | |||
| John Stephens Jr. | |||
| Perrion Winfrey | |||
| On IR - Designated For Return: | |||
| DeMarvion Overshown | |||
| Shavon Revel Jr. | |||
| Payton Turner | |||
| Physically Unable To Perform: | |||
| Josh Butler | |||
| On IR: | |||
| Michael Burton | |||
| Matt Henningsen | |||
| Lucas Krull | |||
| Garret Wallow | |||
| Suspended: | |||
| Dre Greenlaw | |||
| On IR - Designated For Return: | |||
| Drew Sanders | |||
| On IR: | |||
| Zach Cunningham | |||
| Marcus Davenport | |||
| Khalil Dorsey | |||
| Dan Jackson | |||
| Ennis Rakestraw Jr. | |||
| D.J. Reed | |||
| Daniel Thomas | |||
| Ezekiel Turner | |||
| Kenny Yeboah | |||
| Shane Zylstra | |||
| Suspended: | |||
| Brian Branch | |||
| Physically Unable To Perform: | |||
| Levi Onwuzurike | |||
| Malcolm Rodriguez | |||
| On IR: | |||
| Jayden Reed | |||
| On IR - Designated For Return: | |||
| MarShawn Lloyd | |||
| Christian Watson | |||
| Physically Unable To Perform: | |||
| Collin Oliver | |||
| Questionable: | |||
| Warren Brinson | Hamstring | ||
| Matthew Golden | Hip | ||
| Brandon McManus | Quadricep | ||
| Out: | |||
| Lukas Van Ness | Foot | ||
| Dontayvion Wicks | Calf | ||
| On IR: | |||
| Folorunso Fatukasi | |||
| Kyonte Hamilton | |||
| Jakob Johnson | |||
| Brevin Jordan | |||
| Jaylin Smith | |||
| Cade Stover | |||
| Justin Watson | |||
| Physically Unable To Perform: | |||
| Tank Dell | |||
| Jimmie Ward | |||
| Out: | |||
| Christian Kirk | Hamstring | ||
| On IR: | |||
| Salvon Ahmed | |||
| Mike Hilton | |||
| D.J. Montgomery | |||
| Jacob Phillips | |||
| Anthony Richardson | |||
| Daniel Scott | |||
| Spencer Shrader | |||
| Justin Walley | |||
| Charvarius Ward | |||
| Hunter Wohler | |||
| On IR - Designated For Return: | |||
| Jaylon Carlies | |||
| Jaylon Jones | |||
| On IR: | |||
| Joshua Cephus | |||
| Caleb Ransaw | |||
| Brenton Strange | |||
| On IR - Designated For Return: | |||
| Jalen McLeod | |||
| On IR: | |||
| Felix Anudike-Uzomah | |||
| Jake Briningstool | |||
| Deon Bush | |||
| Keaontay Ingram | |||
| Nazeeh Johnson | |||
| Omarr Norman-Lott | |||
| Janarius Robinson | |||
| Eric Scott Jr. | |||
| On IR: | |||
| Junior Colson | |||
| Omarion Hampton | |||
| Da'Shawn Hand | |||
| Najee Harris | |||
| Otito Ogbonnia | |||
| On IR - Designated For Return: | |||
| Deane Leonard | |||
| Questionable: | |||
| Jamaree Caldwell | Illness | ||
| Troy Dye | Thumb | ||
| Elijah Molden | Thumb | ||
| Out: | |||
| Hassan Haskins | Hamstring | ||
| On IR: | |||
| Ahkello Witherspoon | |||
| On IR: | |||
| Brennan Jackson | |||
| Aidan O'Connell | |||
| On IR - Designated For Return: | |||
| Lonnie Johnson | |||
| Out: | |||
| Brock Bowers | Knee | ||
| On IR: | |||
| Artie Burns | |||
| Jalin Conyers | |||
| Tyreek Hill | |||
| Kader Kohou | |||
| Alexander Mattison | |||
| Darren Waller | |||
| On IR - Designated For Return: | |||
| Jason Marshall Jr. | |||
| Jason Sanders | |||
| On IR: | |||
| Ty Chandler | |||
| Rondale Moore | |||
| Physically Unable To Perform: | |||
| Gavin Bartholomew | |||
| Questionable: | |||
| Aaron Jones | Hamstring | ||
| J.J. McCarthy | Ankle | ||
| Zavier Scott | Wrist | ||
| Out: | |||
| C.J. Ham | Hand | ||
| Andrew Van Ginkel | Neck | ||
| On IR: | |||
| Marcellas Dial | |||
| Antonio Gibson | |||
| Lan Larison | |||
| Deneric Prince | |||
| Jaquelin Roy | |||
| Questionable: | |||
| Kyle Dugger | Knee | ||
| On IR: | |||
| Julian Blackmon | |||
| Vernon Broughton | |||
| Bub Means | |||
| Kendre Miller | |||
| Trey Palmer | |||
| Ja'Lynn Polk | |||
| On IR: | |||
| Chris Board | |||
| Da'Quan Felton | |||
| Bryce Ford-Wheaton | |||
| Micah McFadden | |||
| Malik Nabers | |||
| On IR - Designated For Return: | |||
| Graham Gano | |||
| Physically Unable To Perform: | |||
| Eric Gray | |||
| Anthony Johnson Jr. | |||
| Questionable: | |||
| Brian Burns | Hip | ||
| D.J. Davidson | Ankle | ||
| Doubtful: | |||
| Jevon Holland | Neck | ||
| Out: | |||
| Paulson Adebo | Knee | ||
| Chauncey Golston | Neck | ||
| On IR: | |||
| Braelon Allen | |||
| Kris Boyd | |||
| Byron Cowart | |||
| Marcelino McCrary-Ball | |||
| Keilan Robinson | |||
| On IR - Designated For Return: | |||
| Quincy Williams | |||
| Physically Unable To Perform: | |||
| Irvin Charles | |||
| Out: | |||
| Sauce Gardner | Concussion | ||
| Garrett Wilson | Knee | ||
| On IR: | |||
| Darius Cooper | |||
| Ogbonnia Okoronkwo | |||
| Nolan Smith | |||
| Johnny Wilson | |||
| On IR - Designated For Return: | |||
| Jakorian Bennett | |||
| Brandon Graham | |||
| Out: | |||
| A.J. Brown | Hamstring | ||
| Adoree' Jackson | Concussion | ||
| Azeez Ojulari | Hamstring | ||
| On IR: | |||
| Donte Kent | |||
| Miles Killebrew | |||
| Isaiahh Loudermilk | |||
| Dean Lowry | |||
| Donald Parham | |||
| Skylar Thompson | |||
| On IR - Designated For Return: | |||
| Malik Harrison | |||
| Will Howard | |||
| Cory Trice Jr. | |||
| Out: | |||
| Scott Miller | Finger | ||
| On IR: | |||
| Kenny McIntosh | |||
| Robbie Ouzts | |||
| Jacardia Wright | |||
| On IR: | |||
| Nick Bosa | |||
| Jacob Cowing | |||
| Tre'Vius Hodges-Tomlinson | |||
| Tarron Jackson | |||
| Trent Taylor | |||
| Patrick Taylor | |||
| Fred Warner | |||
| Physically Unable To Perform: | |||
| Brandon Aiyuk | |||
| Out: | |||
| Ricky Pearsall | Knee | ||
| Brock Purdy | Toe | ||
| On IR: | |||
| Mike Evans | |||
| Calijah Kancey | |||
| Ko Kieft | |||
| Jalen McMillan | |||
| David Walker | |||
| Rashad Wisdom | |||
| Questionable: | |||
| Vita Vea | Foot | ||
| Out: | |||
| Chris Godwin | Fibula | ||
| Bucky Irving | Foot | ||
| Haason Reddick | Ankle | ||
| On IR: | |||
| Mike Brown | |||
| Will Levis | |||
| Kalel Mullings | |||
| Oluwafemi Oladejo | |||
| Anfernee Orji | |||
| L'Jarius Sneed | |||
| Blake Watson | |||
| Questionable: | |||
| Xavier Woods | Ankle | ||
| Out: | |||
| Bryce Oliver | Knee | ||
| Calvin Ridley | Hamstring | ||
| Jeffery Simmons | Hamstring | ||
| On IR: | |||
| Dorance Armstrong Jr. | |||
| Noah Brown | |||
| Austin Ekeler | |||
| Will Harris | |||
| Tyree Jackson | |||
| Drake Jackson | |||
| Javontae Jean-Baptiste | |||
| Deatrich Wise | |||
| Out: | |||
| Jayden Daniels | Hamstring | ||