

| On IR: | |||
| James Conner | |||
| Simi Fehoko | |||
| Zay Jones | |||
| Justin Jones | |||
| Kyler Murray | |||
| Tip Reiman | |||
| J.J. Russell | |||
| Mack Wilson | |||
| On IR - Designated For Return: | |||
| Trey Benson | |||
| L.j. Collier | |||
| Questionable: | |||
| Xavier Weaver | Hamstring | ||
| Out: | |||
| Emari Demercado | Ankle | ||
| Greg Dortch | Chest | ||
| Marvin Harrison Jr. | Heel | ||
| Max Melton | Heel | ||
| Walter Nolen II | Knee | ||
| Dadrion Taylor-Demerson | Ankle | ||
| On IR: | |||
| Billy Bowman Jr. | |||
| Zach Harrison | |||
| DeAngelo Malone | |||
| Michael Penix Jr. | |||
| Clark Phillips III | |||
| Sam Roberts | |||
| Physically Unable To Perform: | |||
| Troy Andersen | |||
| Questionable: | |||
| David Onyemata | Foot | ||
| Out: | |||
| Brandon Dorlus | Groin | ||
| DeMarcco Hellams | Hamstring | ||
| Drake London | Knee | ||
| On IR: | |||
| Taven Bryan | |||
| Justice Hill | |||
| Bilhal Kone | |||
| Robert Longerbeam | |||
| Justin Madubuike | |||
| Broderick Washington Jr. | |||
| On IR - Designated For Return: | |||
| Adisa Isaac | |||
| Tavius Robinson | |||
| Ar'Darius Washington | |||
| On IR: | |||
| Michael Hoecht | |||
| Landon Jackson | |||
| Taylor Rapp | |||
| Questionable: | |||
| Dalton Kincaid | Hamstring | ||
| Doubtful: | |||
| Josh Palmer | Knee | ||
| Out: | |||
| Terrel Bernard | Elbow | ||
| Joey Bosa | Hamstring | ||
| On IR: | |||
| Patrick Jones II | |||
| Damarri Mathis | |||
| David Moore | |||
| Suspended: | |||
| Trevon Moehrig | |||
| Physically Unable To Perform: | |||
| Jonathon Brooks | |||
| Out: | |||
| Ruben Hyppolite II | Shoulder | ||
| Rome Odunze | Foot | ||
| Tyrique Stevenson | Hip | ||
| On IR - Designated For Return: | |||
| Shaka Heyward | |||
| Out: | |||
| Trey Hendrickson | Hip | ||
| Physically Unable To Perform: | |||
| Deshaun Watson | |||
| Questionable: | |||
| Devin Bush | Foot | ||
| Mason Graham | Ribs | ||
| Michael Hall Jr. | Knee | ||
| Isaiah McGuire | Knee | ||
| Dylan Sampson | Calf | ||
| Out: | |||
| Brenden Bates | Ankle | ||
| Adin Huntington | Quad | ||
| On IR - Designated For Return: | |||
| Trevon Diggs | |||
| Questionable: | |||
| Jadeveon Clowney | Hamstring | ||
| Malik Hooker | Back | ||
| Out: | |||
| Nate Adkins | Knee | ||
| D.J. Jones | Ankle | ||
| On IR: | |||
| Brock Wright | |||
| On IR - Designated For Return: | |||
| Shane Zylstra | |||
| Questionable: | |||
| Brian Branch | Toe | ||
| Amon-Ra St. Brown | Ankle | ||
| Sione Vaki | Thumb | ||
| Out: | |||
| Kerby Joseph | Knee | ||
| Kalif Raymond | Ankle | ||
| On IR: | |||
| Devonte Wyatt | |||
| On IR - Designated For Return: | |||
| MarShawn Lloyd | |||
| Collin Oliver | |||
| Jayden Reed | |||
| Questionable: | |||
| Javon Bullard | Ankle | ||
| Matthew Golden | Wrist | ||
| Nate Hobbs | Knee | ||
| Out: | |||
| Lukas Van Ness | Foot | ||
| Savion Williams | Foot | ||
| Questionable: | |||
| Kamari Lassiter | Foot | ||
| Out: | |||
| Jamal Hill | Hamstring | ||
| Jaylen Reed | Forearm | ||
| On IR - Designated For Return: | |||
| Jaylon Carlies | |||
| Questionable: | |||
| Tyquan Lewis | Ankle | ||
| Out: | |||
| Sauce Gardner | Calf | ||
| On IR - Designated For Return: | |||
| Eric Murray | |||
| Questionable: | |||
| Arik Armstead | Hand | ||
| Travon Walker | Knee | ||
| Parker Washington | Hip | ||
| Out: | |||
| Andrew Wingard | Concussion | ||
| Out: | |||
| Nikko Remigio | Shoulder | ||
| On IR: | |||
| Junior Colson | |||
| Najee Harris | |||
| Hassan Haskins | |||
| Otito Ogbonnia | |||
| On IR - Designated For Return: | |||
| Omarion Hampton | |||
| On IR - Designated For Return: | |||
| Tutu Atwell | |||
| Questionable: | |||
| Poona Ford | Calf | ||
| Doubtful: | |||
| Darious Williams | Tibia | ||
| Questionable: | |||
| Jamal Adams | Knee | ||
| Jeremy Chinn | Back | ||
| Maxx Crosby | Knee | ||
| Out: | |||
| Alex Bachman | Thumb | ||
| Michael Mayer | Ankle | ||
| Dont'e Thornton Jr. | Concussion | ||
| Questionable: | |||
| Elijah Campbell | Ankle | ||
| Ifeatu Melifonwu | Thumb | ||
| On IR - Designated For Return: | |||
| Ty Chandler | |||
| Out: | |||
| Theo Jackson | Neck | ||
| On IR: | |||
| Alex Austin | |||
| Jashaun Corbin | |||
| Marcellas Dial | |||
| Antonio Gibson | |||
| Darius Harris | |||
| Lan Larison | |||
| Deneric Prince | |||
| Jaquelin Roy | |||
| Milton Williams | |||
| Out: | |||
| Alvin Kamara | Knee | ||
| Justin Reid | Knee | ||
| On IR: | |||
| Chris Board | |||
| Beaux Collins | |||
| Da'Quan Felton | |||
| Thomas Fidone II | |||
| Bryce Ford-Wheaton | |||
| Graham Gano | |||
| Micah McFadden | |||
| Darius Muasau | |||
| Malik Nabers | |||
| Cam Skattebo | |||
| Physically Unable To Perform: | |||
| Anthony Johnson Jr. | |||
| On IR - Designated For Return: | |||
| Cam Jones | |||
| Questionable: | |||
| Tony Adams | Groin | ||
| Qwan'tez Stiggers | Concussion | ||
| Out: | |||
| Jarvis Brownlee Jr. | Hip | ||
| Justin Fields | Knee | ||
| Marcelino McCrary-Ball | Hamstring | ||
| On IR: | |||
| Andrew Mukuba | |||
| Azeez Ojulari | |||
| Ogbonnia Okoronkwo | |||
| Johnny Wilson | |||
| On IR - Designated For Return: | |||
| Marcus Epps | |||
| Out: | |||
| Kyle Dugger | Hand | ||
| Derrick Harmon | Knee | ||
| On IR - Designated For Return: | |||
| Rylie Mills | |||
| Dareke Young | |||
| On IR: | |||
| Nick Bosa | |||
| Jacob Cowing | |||
| Yetur Gross-Matos | |||
| Tre'Vius Hodges-Tomlinson | |||
| Tarron Jackson | |||
| Patrick Taylor | |||
| Trent Taylor | |||
| Fred Warner | |||
| Mykel Williams | |||
| Physically Unable To Perform: | |||
| Brandon Aiyuk | |||
| Questionable: | |||
| Kyle Juszczyk | Ribs | ||
| On IR: | |||
| Jalen McMillan | |||
| Rashad Wisdom | |||
| On IR - Designated For Return: | |||
| Mike Evans | |||
| Questionable: | |||
| Benjamin Morrison | Hamstring | ||
| Questionable: | |||
| Shy Tuttle | Concussion | ||
| Out: | |||
| Jalyn Armour-Davis | Achilles | ||
| On IR - Designated For Return: | |||
| Noah Brown | |||
| Questionable: | |||
| Bobby Wagner | Knee | ||
| Out: | |||
| Drake Jackson | Knee | ||