

| On IR: | |||
| Bilal Nichols | |||
| On IR - Designated For Return: | |||
| L.j. Collier | |||
| Questionable: | |||
| Emari Demercado | Ankle | ||
| Elijah Higgins | Illness | ||
| Walter Nolen II | Knee | ||
| Out: | |||
| Marvin Harrison Jr. | Heel | ||
| Max Melton | Heel | ||
| Dadrion Taylor-Demerson | Ankle | ||
| Jalen Thompson | Hamstring | ||
| Xavier Weaver | Hamstring | ||
| Questionable: | |||
| Brandon Dorlus | Groin | ||
| David Onyemata | Foot | ||
| Kyle Pitts | Knee | ||
| Jalon Walker | Quad | ||
| Out: | |||
| Drake London | Knee | ||
| Questionable: | |||
| Rashod Bateman | Ankle | ||
| Tavius Robinson | Foot | ||
| Ar'Darius Washington | Achilles | ||
| Questionable: | |||
| Christian Benford | Toe | ||
| Terrel Bernard | Elbow | ||
| Josh Palmer | Ankle | ||
| Physically Unable To Perform: | |||
| Deshaun Watson | |||
| Questionable: | |||
| Malachi Corley | Concussion | ||
| Mason Graham | Rib | ||
| Cedric Tillman | Concussion | ||
| Out: | |||
| Adin Huntington | Quad | ||
| David Njoku | Knee | ||
| Dylan Sampson | Calf | ||
| Denzel Ward | Calf | ||
| On IR - Designated For Return: | |||
| Trevon Diggs | |||
| Questionable: | |||
| Jadeveon Clowney | Hamstring | ||
| Jake Ferguson | Calf | ||
| Out: | |||
| Pat Bryant | Hamstring | ||
| On IR: | |||
| Brian Branch | |||
| Questionable: | |||
| Kalif Raymond | Ankle | ||
| Sione Vaki | Thumb | ||
| Shane Zylstra | Knee | ||
| Out: | |||
| Kerby Joseph | Knee | ||
| On IR - Designated For Return: | |||
| MarShawn Lloyd | |||
| Collin Oliver | |||
| Questionable: | |||
| Josh Jacobs | Knee | ||
| Lukas Van Ness | Foot | ||
| Savion Williams | Foot | ||
| Emanuel Wilson | Illness | ||
| On IR - Designated For Return: | |||
| Justin Watson | |||
| Questionable: | |||
| Harrison Bryant | Neck | ||
| Nick Chubb | Ribs | ||
| EJ Speed | Knee | ||
| On IR: | |||
| DeForest Buckner | |||
| Questionable: | |||
| Tyquan Lewis | Ankle | ||
| Out: | |||
| Sauce Gardner | Calf | ||
| Anthony Gould | Foot | ||
| Questionable: | |||
| Parker Washington | Hip | ||
| Questionable: | |||
| Troy Dye | Hip | ||
| Quentin Johnston | Groin | ||
| Doubtful: | |||
| Elijah Molden | Hamstring | ||
| Out: | |||
| Derius Davis | Ankle | ||
| Questionable: | |||
| Davante Adams | Hamstring | ||
| Questionable: | |||
| Jeremy Chinn | Back | ||
| Ian Thomas | Calf | ||
| Out: | |||
| Alex Bachman | Thumb | ||
| Geno Smith | Shoulder | ||
| On IR: | |||
| Julius Brents | |||
| Artie Burns | |||
| Jalin Conyers | |||
| Storm Duck | |||
| Tyreek Hill | |||
| Caleb Johnson | |||
| Kader Kohou | |||
| Alexander Mattison | |||
| Kendall Sheffield | |||
| On IR - Designated For Return: | |||
| Jason Sanders | |||
| On IR - Designated For Return: | |||
| Ty Chandler | |||
| On IR: | |||
| Terrell Jennings | |||
| Questionable: | |||
| Robert Spillane | Foot | ||
| On IR: | |||
| Victor Dimukeje | |||
| Nic Jones | |||
| On IR - Designated For Return: | |||
| Beaux Collins | |||
| Questionable: | |||
| D.J. Davidson | Illness | ||
| Demetrius Flannigan-Fowles | Neck | ||
| Dexter Lawrence | Hamstring | ||
| Darius Muasau | Ankle | ||
| Gunner Olszewski | Concussion | ||
| Out: | |||
| Rakeem Nunez-Roches | Ankle | ||
| Kayvon Thibodeaux | Shoulder | ||
| On IR: | |||
| Azareye'h Thomas | |||
| Questionable: | |||
| Cam Jones | Hip | ||
| Stone Smartt | Concussion | ||
| Out: | |||
| Justin Fields | Knee | ||
| Francisco Mauigoa | Neck | ||
| Mason Taylor | Neck | ||
| Tyrod Taylor | Groin | ||
| Out: | |||
| Jalen Carter | Shoulders | ||
| On IR: | |||
| DeShon Elliott | |||
| Miles Killebrew | |||
| Isaiahh Loudermilk | |||
| Dean Lowry | |||
| Donald Parham | |||
| Skylar Thompson | |||
| Suspended: | |||
| Daniel Ekuale | |||
| On IR - Designated For Return: | |||
| Donte Kent | |||
| Cory Trice Jr. | |||
| Out: | |||
| T.J. Watt | Lung | ||
| On IR - Designated For Return: | |||
| Rylie Mills | |||
| Eric Saubert | |||
| Dareke Young | |||
| Out: | |||
| Elijah Arroyo | Knee | ||
| On IR - Designated For Return: | |||
| Yetur Gross-Matos | |||
| Kurtis Rourke | |||
| Questionable: | |||
| Christian McCaffrey | NIR-Rest | ||
| Out: | |||
| Tatum Bethune | Ankle | ||
| Nick Martin | Concussion | ||
| Sam Okuayinonu | Ankle | ||
| On IR: | |||
| Rashad Wisdom | |||
| Questionable: | |||
| Mike Evans | Collarbone | ||
| Jalen McMillan | Neck | ||
| Doubtful: | |||
| Cade Otton | Knee | ||
| Tykee Smith | Neck | ||
| Out: | |||
| SirVocea Dennis | Hip | ||
| Questionable: | |||
| James Williams | Illness | ||
| Out: | |||
| Jalyn Armour-Davis | Achilles | ||
| Questionable: | |||
| Chris Rodriguez Jr. | Groin | ||
| Deebo Samuel | Illness | ||
| Out: | |||
| Jayden Daniels | Elbow | ||
| Drake Jackson | Groin | ||
| Jonathan Jones | Rib | ||