

| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 4 8:49am CT |
| Benched | K | Jake Bates DET | Owner | Tue Nov 4 8:49am CT |
| Benched | D/ST | Jacksonville Jaguars JAX | Owner | Tue Nov 4 8:49am CT |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 8:49am CT |
| Started | K | Chase McLaughlin TB | Owner | Tue Nov 4 8:49am CT |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Nov 4 8:49am CT |
| Benched | K | Brandon Aubrey DAL | Owner | Thu Nov 6 6:34am CT |
| Started | K | Will Reichard MIN | Owner | Thu Nov 6 6:34am CT |
| Benched | QB | Dak Prescott DAL | Owner | Wed Nov 5 5:10pm CT |
| Benched | TE | Travis Kelce KC | Owner | Wed Nov 5 5:10pm CT |
| Started | QB | Matthew Stafford LAR | Owner | Wed Nov 5 5:10pm CT |
| Started | TE | David Njoku CLE | Owner | Wed Nov 5 5:10pm CT |
| Started | K | Andres Borregales NE | Owner | Thu Nov 6 8:01am CT |
| Benched | RB | RJ Harvey DEN | Owner | Tue Nov 4 8:42am CT |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 8:42am CT |
| Benched | K | Joey Slye TEN | Owner | Tue Nov 4 8:41am CT |
| Benched | RB | Jeremy McNichols WAS | Owner | Wed Nov 5 5:30pm CT |
| Benched | RB | Jaylen Wright MIA | Owner | Wed Nov 5 5:30pm CT |
| Benched | WR | Kayshon Boutte NE | Owner | Wed Nov 5 5:30pm CT |
| Started | RB | Isaiah Davis NYJ | Owner | Wed Nov 5 5:30pm CT |
| Started | RB | Dylan Sampson CLE | Owner | Wed Nov 5 5:30pm CT |
| Started | TE | Colston Loveland CHI | Owner | Wed Nov 5 5:30pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 6:50am CT |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 6:50am CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 4 6:50am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 4 6:50am CT |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Thu Nov 6 8:06am CT |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Thu Nov 6 8:06am CT |
| Benched | WR | D.J. Moore CHI | Owner | Wed Nov 5 9:27am CT |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 5 9:27am CT |
| Started | TE | Mark Andrews BAL | Owner | Wed Nov 5 9:27am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Wed Nov 5 10:04pm CT |
| Started | RB | Rachaad White TB | Owner | Wed Nov 5 10:04pm CT |
| Benched | WR | Xavier Worthy KC | Owner | Wed Nov 5 10:04pm CT |
| Benched | TE | George Kittle SF | Owner | Wed Nov 5 10:04pm CT |
| Started | WR | Emeka Egbuka TB | Owner | Wed Nov 5 10:04pm CT |
| Started | WR | DeVonta Smith PHI | Owner | Wed Nov 5 10:04pm CT |
| Benched | QB | Patrick Mahomes KC | Owner | Thu Nov 6 8:39am CT |
| Started | QB | Jared Goff DET | Owner | Thu Nov 6 8:39am CT |
| Benched | WR | Rashod Bateman BAL | Owner | Wed Nov 5 4:39am CT |
| Started | WR | Garrett Wilson NYJ | Owner | Wed Nov 5 4:39am CT |
| Benched | WR | KaVontae Turpin DAL | Owner | Tue Nov 4 7:24am CT |
| Started | RB | Rhamondre Stevenson NE | Owner | Tue Nov 4 7:24am CT |
| Benched | QB | C.J. Stroud HOU | Owner | Thu Nov 6 5:43am CT |
| Started | QB | Marcus Mariota WAS | Owner | Thu Nov 6 5:43am CT |
| Started | WR | Romeo Doubs GB | Owner | Thu Nov 6 5:43am CT |
| Started | D/ST | Cleveland Browns CLE | Owner | Thu Nov 6 5:43am CT |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 8:14am CT |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 8:14am CT |
| Started | RB | Ashton Jeanty LV | Owner | Tue Nov 4 8:14am CT |
| Started | WR | Keon Coleman BUF | Owner | Tue Nov 4 8:14am CT |