

| Benched | QB | Bryce Young CAR | Owner | Wed Nov 19 8:55pm CT |
| Benched | RB | Travis Etienne JAX | Owner | Wed Nov 19 8:55pm CT |
| Started | QB | Patrick Mahomes KC | Owner | Wed Nov 19 8:55pm CT |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 19 8:55pm CT |
| Started | D/ST | New Orleans Saints NO | Owner | Thu Nov 20 6:29am CT |
| Started | TE | Mason Taylor NYJ | Owner | Thu Nov 20 6:29am CT |
| Benched | WR | Ladd McConkey LAC | Owner | Wed Nov 19 9:26pm CT |
| Started | RB | Bhayshul Tuten JAX | Owner | Wed Nov 19 9:26pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 18 6:47pm CT |
| Started | QB | Sam Darnold SEA | Owner | Tue Nov 18 6:47pm CT |
| Benched | RB | Devon Achane MIA | Owner | Tue Nov 18 6:47pm CT |
| Benched | RB | RJ Harvey DEN | Owner | Tue Nov 18 6:47pm CT |
| Benched | WR | Drake London ATL | Owner | Tue Nov 18 6:47pm CT |
| Started | RB | Kyle Monangai CHI | Owner | Tue Nov 18 6:47pm CT |
| Started | RB | David Montgomery DET | Owner | Tue Nov 18 6:47pm CT |
| Started | WR | George Pickens DAL | Owner | Tue Nov 18 6:47pm CT |
| Benched | QB | Bo Nix DEN | Owner | Tue Nov 18 6:06am CT |
| Benched | K | Cameron Dicker LAC | Owner | Tue Nov 18 6:06am CT |
| Started | QB | J.J. McCarthy MIN | Owner | Tue Nov 18 6:06am CT |
| Benched | WR | Jaylen Waddle MIA | Owner | Wed Nov 19 1:51pm CT |
| Started | WR | D.K. Metcalf PIT | Owner | Wed Nov 19 1:51pm CT |
| Benched | D/ST | Green Bay Packers GB | Owner | Wed Nov 19 11:42pm CT |
| Started | RB | Ty Johnson BUF | Owner | Wed Nov 19 11:42pm CT |
| Started | WR | Andrei Iosivas CIN | Owner | Wed Nov 19 11:42pm CT |
| Started | K | Cairo Santos CHI | Owner | Wed Nov 19 11:42pm CT |
| Started | D/ST | Cleveland Browns CLE | Owner | Wed Nov 19 11:42pm CT |
| Benched | RB | Emari Demercado ARI | Owner | Tue Nov 18 11:32am CT |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 18 11:32am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Jauan Jennings SF | Owner | Tue Nov 18 9:04am CT |
| Started | TE | Tyler Warren IND | Owner | Tue Nov 18 9:04am CT |
| Benched | WR | Calvin Ridley TEN | Owner | Tue Nov 18 8:54am CT |
| Started | WR | Chris Olave NO | Owner | Tue Nov 18 8:54am CT |
| No starting lineup changes performed this week. |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Nov 20 8:23am CT |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Nov 18 10:19pm CT |
| Started | TE | Hunter Henry NE | Owner | Tue Nov 18 10:19pm CT |
| Benched | RB | Josh Jacobs GB | Owner | Tue Nov 18 11:53pm CT |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 18 11:53pm CT |
| Benched | D/ST | Tennessee Titans TEN | Owner | Tue Nov 18 11:53pm CT |
| Started | RB | Jonathan Taylor IND | Owner | Tue Nov 18 11:53pm CT |
| Started | WR | Michael Pittman Jr. IND | Owner | Tue Nov 18 11:53pm CT |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 18 11:53pm CT |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Wed Nov 19 5:08pm CT |
| Started | RB | Alvin Kamara NO | Owner | Wed Nov 19 5:08pm CT |