

| Benched | QB | Patrick Mahomes KC | Owner | Wed Nov 5 12:06pm CT |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Wed Nov 5 12:06pm CT |
| Started | QB | Lamar Jackson BAL | Owner | Wed Nov 5 12:06pm CT |
| Started | RB | Saquon Barkley PHI | Owner | Wed Nov 5 12:06pm CT |
| Benched | RB | Alvin Kamara NO | Owner | Tue Nov 4 9:06pm CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 4 9:06pm CT |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 4 7:20pm CT |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 4 7:20pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 4 7:29am CT |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 7:29am CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Tyler Allgeier ATL | Owner | Tue Nov 4 7:22pm CT |
| Started | RB | Nick Chubb HOU | Owner | Tue Nov 4 7:22pm CT |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 7:21pm CT |
| Started | TE | Kyle Pitts ATL | Owner | Tue Nov 4 7:21pm CT |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 7:20pm CT |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 7:20pm CT |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 7:20pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Keenan Allen LAC | Owner | Tue Nov 4 3:28pm CT |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 3:28pm CT |
| Benched | D/ST | New England Patriots NE | Owner | Tue Nov 4 3:28pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 4 3:28pm CT |
| Started | TE | T.J. Hockenson MIN | Owner | Tue Nov 4 3:28pm CT |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Nov 4 3:28pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Kayshon Boutte NE | Owner | Wed Nov 5 11:15am CT |
| Started | WR | Jakobi Meyers JAX | Owner | Wed Nov 5 11:15am CT |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Nov 4 8:52am CT |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 8:52am CT |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Nov 4 8:52am CT |
| Started | QB | Matthew Stafford LAR | Owner | Tue Nov 4 8:52am CT |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 8:52am CT |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 8:52am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 6:07pm CT |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 6:07pm CT |
| Started | RB | Devin Neal NO | Owner | Tue Nov 4 6:07pm CT |
| Started | WR | Pat Bryant DEN | Owner | Tue Nov 4 6:07pm CT |