

| Benched | TE | Noah Fant CIN | Owner | Tue Nov 4 7:23pm CT |
| Started | TE | Mason Taylor NYJ | Owner | Tue Nov 4 7:23pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Sam Darnold SEA | Owner | Wed Nov 5 9:06am CT |
| Benched | K | Brandon Aubrey DAL | Owner | Wed Nov 5 9:06am CT |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 5 9:06am CT |
| Started | QB | Baker Mayfield TB | Owner | Wed Nov 5 9:06am CT |
| Started | K | Matt Prater BUF | Owner | Wed Nov 5 9:06am CT |
| Started | D/ST | Cleveland Browns CLE | Owner | Wed Nov 5 9:06am CT |
| Benched | WR | Jaylen Waddle MIA | Owner | Tue Nov 4 7:38am CT |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 7:38am CT |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 4 7:38am CT |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 7:38am CT |
| Benched | QB | Michael Penix Jr. ATL | Owner | Tue Nov 4 5:14pm CT |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 5:14pm CT |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 5:11pm CT |
| Started | RB | Rhamondre Stevenson NE | Owner | Tue Nov 4 5:11pm CT |
| Benched | WR | Chimere Dike TEN | Owner | Wed Nov 5 1:41am CT |
| Benched | TE | Jake Ferguson DAL | Owner | Wed Nov 5 1:41am CT |
| Started | RB | Saquon Barkley PHI | Owner | Wed Nov 5 1:41am CT |
| Started | TE | Dallas Goedert PHI | Owner | Wed Nov 5 1:41am CT |
| No starting lineup changes performed this week. |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 12:18pm CT |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 4 12:18pm CT |
| Benched | WR | Keon Coleman BUF | Owner | Tue Nov 4 12:18pm CT |
| Benched | WR | Malik Washington MIA | Owner | Tue Nov 4 12:18pm CT |
| Benched | D/ST | Dallas Cowboys DAL | Owner | Tue Nov 4 12:18pm CT |
| Started | QB | Justin Fields NYJ | Owner | Tue Nov 4 12:18pm CT |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 4 12:18pm CT |
| Started | WR | Rashid Shaheed SEA | Owner | Tue Nov 4 12:18pm CT |
| Started | TE | Juwan Johnson NO | Owner | Tue Nov 4 12:18pm CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Wed Nov 5 7:59am CT |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Wed Nov 5 7:59am CT |
| Started | QB | Jared Goff DET | Owner | Wed Nov 5 5:01am CT |
| Benched | QB | Matthew Stafford LAR | Owner | Wed Nov 5 5:01am CT |
| Started | WR | Romeo Doubs GB | Owner | Tue Nov 4 12:34pm CT |
| Started | WR | Calvin Austin III PIT | Owner | Tue Nov 4 12:34pm CT |
| Started | RB | David Montgomery DET | Owner | Tue Nov 4 12:34pm CT |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 12:34pm CT |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 12:34pm CT |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 12:34pm CT |
| No starting lineup changes performed this week. |