

| No starting lineup changes performed this week. |
| Started | RB | Rachaad White TB | Owner | Wed Nov 5 12:12pm CT |
| Benched | QB | Dak Prescott DAL | Owner | Wed Nov 5 12:12pm CT |
| Benched | RB | Javonte Williams DAL | Owner | Wed Nov 5 12:12pm CT |
| Benched | WR | CeeDee Lamb DAL | Owner | Wed Nov 5 12:12pm CT |
| Benched | K | John Parker Romo --- | Owner | Wed Nov 5 12:12pm CT |
| Started | QB | J.J. McCarthy MIN | Owner | Wed Nov 5 12:12pm CT |
| Started | WR | Chris Olave NO | Owner | Wed Nov 5 12:12pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 4 8:34am CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 4 8:34am CT |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 8:34am CT |
| Started | QB | Sam Darnold SEA | Owner | Tue Nov 4 8:34am CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 4 8:34am CT |
| Started | WR | Christian Kirk HOU | Owner | Tue Nov 4 8:34am CT |
| Benched | RB | Zonovan Knight ARI | Owner | Wed Nov 5 11:57pm CT |
| Started | RB | Emari Demercado ARI | Owner | Wed Nov 5 11:57pm CT |
| Started | D/ST | Tampa Bay Buccaneers TB | Owner | Wed Nov 5 11:57pm CT |
| Benched | WR | Deebo Samuel WAS | Owner | Wed Nov 5 9:04pm CT |
| Started | WR | Troy Franklin DEN | Owner | Wed Nov 5 9:04pm CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Tue Nov 4 7:49am CT |
| Started | TE | Cade Otton TB | Owner | Tue Nov 4 7:49am CT |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 4 6:09pm CT |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 6:09pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 6:09pm CT |
| Started | TE | Dalton Kincaid BUF | Owner | Tue Nov 4 6:09pm CT |
| Benched | WR | Darnell Mooney ATL | Owner | Wed Nov 5 10:49am CT |
| Started | WR | Malik Washington MIA | Owner | Wed Nov 5 10:49am CT |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 10:10am CT |
| Started | WR | Jameson Williams DET | Owner | Tue Nov 4 10:10am CT |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 8:49pm CT |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 8:49pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Terry McLaurin WAS | Owner | Tue Nov 4 3:51pm CT |
| Started | WR | Marvin Mims DEN | Owner | Tue Nov 4 3:51pm CT |
| Benched | RB | Tony Pollard TEN | Owner | Tue Nov 4 3:50pm CT |
| Benched | WR | Tyquan Thornton KC | Owner | Tue Nov 4 3:50pm CT |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 4 3:50pm CT |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 3:50pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Tue Nov 4 3:50pm CT |
| Started | TE | Mason Taylor NYJ | Owner | Tue Nov 4 3:50pm CT |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 8:17am CT |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 8:17am CT |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 8:17am CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 4 8:17am CT |
| Started | WR | Tre Tucker LV | Owner | Tue Nov 4 8:17am CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 4 8:17am CT |
| Benched | QB | Matthew Stafford LAR | Owner | Tue Nov 4 8:30pm CT |
| Benched | RB | Jaylen Warren PIT | Owner | Tue Nov 4 8:30pm CT |
| Benched | D/ST | Dallas Cowboys DAL | Owner | Tue Nov 4 8:30pm CT |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 8:30pm CT |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 8:30pm CT |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 4 8:30pm CT |
| Benched | K | Brandon Aubrey DAL | Owner | Thu Nov 6 12:48am CT |
| Started | K | Jake Bates DET | Owner | Thu Nov 6 12:48am CT |
| Started | D/ST | Carolina Panthers CAR | Owner | Thu Nov 6 12:48am CT |
| Benched | RB | Chase Brown CIN | Owner | Wed Nov 5 8:41pm CT |
| Benched | TE | Tucker Kraft GB | Owner | Wed Nov 5 8:41pm CT |
| Started | RB | Devin Neal NO | Owner | Wed Nov 5 8:41pm CT |
| Started | TE | Sam LaPorta DET | Owner | Wed Nov 5 8:41pm CT |