

| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 8:48am CT |
| Started | TE | Mason Taylor NYJ | Owner | Tue Nov 4 8:48am CT |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 4 8:47am CT |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 8:47am CT |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 1:26pm CT |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 1:26pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 4 1:26pm CT |
| Started | TE | Oronde Gadsden II LAC | Owner | Tue Nov 4 1:26pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 4 6:41pm CT |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 4 6:41pm CT |
| Benched | WR | Zay Flowers BAL | Owner | Tue Nov 4 6:41pm CT |
| Started | QB | Matthew Stafford LAR | Owner | Tue Nov 4 6:41pm CT |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 6:41pm CT |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 6:41pm CT |
| Benched | QB | Caleb Williams CHI | Owner | Tue Nov 4 10:10am CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Nov 4 10:10am CT |
| Benched | WR | Keon Coleman BUF | Owner | Tue Nov 4 10:10am CT |
| Benched | D/ST | San Francisco 49ers SF | Owner | Tue Nov 4 10:10am CT |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 10:10am CT |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 10:10am CT |
| Started | WR | Alec Pierce IND | Owner | Tue Nov 4 10:10am CT |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 4 10:10am CT |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Nov 4 6:04am CT |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 6:04am CT |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 6:04am CT |
| Started | QB | J.J. McCarthy MIN | Owner | Tue Nov 4 6:04am CT |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 4 6:04am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 4 6:04am CT |
| Benched | D/ST | Las Vegas Raiders LV | Owner | Wed Nov 5 10:36am CT |
| Started | D/ST | Cleveland Browns CLE | Owner | Wed Nov 5 10:36am CT |
| Benched | RB | Kareem Hunt KC | Owner | Wed Nov 5 10:35am CT |
| Benched | RB | Brashard Smith KC | Owner | Wed Nov 5 10:35am CT |
| Started | RB | Aaron Jones MIN | Owner | Wed Nov 5 10:35am CT |
| Started | WR | A.J. Brown PHI | Owner | Wed Nov 5 10:35am CT |
| No starting lineup changes performed this week. |
| Benched | QB | Dak Prescott DAL | Owner | Wed Nov 5 10:06am CT |
| Benched | RB | Travis Etienne JAX | Owner | Wed Nov 5 10:06am CT |
| Benched | D/ST | Dallas Cowboys DAL | Owner | Wed Nov 5 10:06am CT |
| Started | QB | Daniel Jones IND | Owner | Wed Nov 5 10:06am CT |
| Started | RB | Rico Dowdle CAR | Owner | Wed Nov 5 10:06am CT |
| Started | RB | J.K. Dobbins DEN | Owner | Tue Nov 4 8:25pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 8:25pm CT |
| Started | RB | Kimani Vidal LAC | Owner | Tue Nov 4 8:25pm CT |
| Benched | RB | J.K. Dobbins DEN | Owner | Tue Nov 4 8:04am CT |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 4 8:04am CT |
| Benched | RB | Kimani Vidal LAC | Owner | Tue Nov 4 8:04am CT |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 8:04am CT |
| Started | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 4 8:04am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Luke McCaffrey WAS | Owner | Wed Nov 5 3:39pm CT |
| Started | RB | David Montgomery DET | Owner | Wed Nov 5 3:39pm CT |
| Benched | RB | Chase Brown CIN | Owner | Wed Nov 5 3:38pm CT |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Wed Nov 5 3:38pm CT |
| Started | RB | Rachaad White TB | Owner | Wed Nov 5 3:38pm CT |
| Started | D/ST | Detroit Lions DET | Owner | Wed Nov 5 3:38pm CT |
| Benched | QB | C.J. Stroud HOU | Owner | Wed Nov 5 4:24pm CT |
| Benched | WR | Ja'Marr Chase CIN | Owner | Wed Nov 5 2:32pm CT |
| Started | WR | Nico Collins HOU | Owner | Wed Nov 5 2:32pm CT |