

| No starting lineup changes performed this week. |
| Started | D/ST | Detroit Lions DET | Owner | Tue Nov 4 12:05pm CT |
| Started | QB | Michael Penix Jr. ATL | Owner | Tue Nov 4 12:05pm CT |
| Started | RB | Nick Chubb HOU | Owner | Tue Nov 4 12:05pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 4 12:05pm CT |
| Started | RB | Emanuel Wilson GB | Owner | Tue Nov 4 12:05pm CT |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 12:05pm CT |
| Started | WR | Tez Johnson TB | Owner | Tue Nov 4 12:05pm CT |
| Started | TE | Hunter Henry NE | Owner | Tue Nov 4 12:05pm CT |
| Benched | D/ST | Detroit Lions DET | Owner | Tue Nov 4 12:03pm CT |
| Benched | TE | Hunter Henry NE | Owner | Tue Nov 4 12:03pm CT |
| Benched | WR | Tez Johnson TB | Owner | Tue Nov 4 12:03pm CT |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Nov 4 12:03pm CT |
| Benched | RB | Bhayshul Tuten JAX | Owner | Tue Nov 4 12:03pm CT |
| Benched | RB | Josh Jacobs GB | Owner | Tue Nov 4 12:03pm CT |
| Benched | RB | Nick Chubb HOU | Owner | Tue Nov 4 12:03pm CT |
| Benched | QB | Michael Penix Jr. ATL | Owner | Tue Nov 4 12:03pm CT |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 12:00pm CT |
| Benched | WR | DeAndre Hopkins BAL | Owner | Tue Nov 4 12:00pm CT |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 12:00pm CT |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 12:00pm CT |
| Benched | K | Joey Slye TEN | Owner | Tue Nov 4 12:00pm CT |
| Started | QB | Michael Penix Jr. ATL | Owner | Tue Nov 4 12:00pm CT |
| Started | RB | Nick Chubb HOU | Owner | Tue Nov 4 12:00pm CT |
| Started | RB | Bhayshul Tuten JAX | Owner | Tue Nov 4 12:00pm CT |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 12:00pm CT |
| Started | WR | Tez Johnson TB | Owner | Tue Nov 4 12:00pm CT |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 12:00pm CT |
| Started | D/ST | Los Angeles Rams LAR | Owner | Tue Nov 4 12:29pm CT |
| Started | K | Ka'imi Fairbairn HOU | Owner | Tue Nov 4 12:29pm CT |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 12:29pm CT |
| Started | WR | D.K. Metcalf PIT | Owner | Tue Nov 4 12:29pm CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 4 12:29pm CT |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 12:29pm CT |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Nov 4 12:29pm CT |
| Started | RB | Isaiah Davis NYJ | Owner | Tue Nov 4 12:29pm CT |
| Started | QB | Justin Fields NYJ | Owner | Tue Nov 4 12:29pm CT |
| Benched | D/ST | Los Angeles Rams LAR | Owner | Tue Nov 4 12:28pm CT |
| Benched | K | Ka'imi Fairbairn HOU | Owner | Tue Nov 4 12:28pm CT |
| Benched | TE | Zach Ertz WAS | Owner | Tue Nov 4 12:28pm CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 4 12:28pm CT |
| Benched | WR | Marvin Harrison Jr. ARI | Owner | Tue Nov 4 12:28pm CT |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 12:28pm CT |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 12:28pm CT |
| Benched | RB | Jahmyr Gibbs DET | Owner | Tue Nov 4 12:28pm CT |
| Benched | QB | Tua Tagovailoa MIA | Owner | Tue Nov 4 12:28pm CT |
| Benched | RB | Tony Pollard TEN | Owner | Tue Nov 4 5:57pm CT |
| Benched | D/ST | Chicago Bears CHI | Owner | Tue Nov 4 5:57pm CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Nov 4 5:57pm CT |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Nov 4 5:57pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | TreVeyon Henderson NE | Owner | Tue Nov 4 9:31pm CT |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 9:31pm CT |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 4 9:31pm CT |
| Started | WR | Stefon Diggs NE | Owner | Tue Nov 4 9:31pm CT |
| Started | WR | Courtland Sutton DEN | Owner | Tue Nov 4 9:31pm CT |
| Started | TE | Dalton Kincaid BUF | Owner | Tue Nov 4 9:31pm CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 7:19am CT |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 7:19am CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 7:19am CT |
| Started | TE | T.J. Hockenson MIN | Owner | Tue Nov 4 7:19am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 4 7:48pm CT |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 4 7:48pm CT |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 7:48pm CT |
| Started | TE | Colston Loveland CHI | Owner | Tue Nov 4 7:48pm CT |
| No starting lineup changes performed this week. |