

| Benched | D/ST | Los Angeles Rams LAR | Owner | Wed Oct 22 7:23am CT |
| Benched | QB | Jared Goff DET | Owner | Tue Oct 21 8:13am CT |
| Benched | RB | Trevor Etienne CAR | Owner | Tue Oct 21 8:13am CT |
| Started | QB | Michael Penix Jr. ATL | Owner | Tue Oct 21 8:13am CT |
| Started | RB | Derrick Henry BAL | Owner | Tue Oct 21 8:13am CT |
| Benched | RB | Kenneth Walker III SEA | Owner | Wed Oct 22 5:54pm CT |
| Benched | WR | Cooper Kupp SEA | Owner | Wed Oct 22 5:54pm CT |
| Started | RB | Chuba Hubbard CAR | Owner | Wed Oct 22 5:54pm CT |
| Started | WR | Terry McLaurin WAS | Owner | Wed Oct 22 5:54pm CT |
| Benched | QB | Justin Herbert LAC | Owner | Tue Oct 21 11:07pm CT |
| Benched | RB | TreVeyon Henderson NE | Owner | Tue Oct 21 11:07pm CT |
| Benched | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 21 11:07pm CT |
| Benched | WR | Jameson Williams DET | Owner | Tue Oct 21 11:07pm CT |
| Started | QB | Josh Allen BUF | Owner | Tue Oct 21 11:07pm CT |
| Started | RB | Justice Hill BAL | Owner | Tue Oct 21 11:07pm CT |
| Started | RB | Tyjae Spears TEN | Owner | Tue Oct 21 11:07pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Oct 21 11:07pm CT |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Oct 21 9:33am CT |
| Benched | WR | Davante Adams LAR | Owner | Tue Oct 21 9:33am CT |
| Started | QB | Bo Nix DEN | Owner | Tue Oct 21 9:33am CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Oct 21 9:33am CT |
| Benched | QB | Jordan Love GB | Owner | Tue Oct 21 4:58pm CT |
| Benched | RB | Travis Etienne JAX | Owner | Tue Oct 21 4:58pm CT |
| Benched | RB | Christian McCaffrey SF | Owner | Tue Oct 21 4:58pm CT |
| Benched | RB | Javonte Williams DAL | Owner | Tue Oct 21 4:58pm CT |
| Benched | WR | Kendrick Bourne SF | Owner | Tue Oct 21 4:58pm CT |
| Benched | WR | Courtland Sutton DEN | Owner | Tue Oct 21 4:58pm CT |
| Benched | TE | Dallas Goedert PHI | Owner | Tue Oct 21 4:58pm CT |
| Benched | K | Cameron Dicker LAC | Owner | Tue Oct 21 4:58pm CT |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Tue Oct 21 4:58pm CT |
| Benched | WR | Troy Franklin DEN | Owner | Wed Oct 22 6:32am CT |
| Started | WR | Garrett Wilson NYJ | Owner | Wed Oct 22 6:32am CT |
| Benched | RB | Jahmyr Gibbs DET | Owner | Tue Oct 21 8:00am CT |
| Started | WR | Troy Franklin DEN | Owner | Tue Oct 21 8:00am CT |
| Benched | WR | Tetairoa McMillan CAR | Owner | Wed Oct 22 2:32am CT |
| Started | WR | Chris Olave NO | Owner | Wed Oct 22 2:32am CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | RB | Ashton Jeanty LV | Owner | Wed Oct 22 6:51pm CT |
| Started | WR | Josh Downs IND | Owner | Wed Oct 22 6:51pm CT |
| Benched | K | Ka'imi Fairbairn HOU | Owner | Wed Oct 22 7:22pm CT |
| Started | K | Chase McLaughlin TB | Owner | Wed Oct 22 7:22pm CT |
| Benched | RB | Kyren Williams LAR | Owner | Tue Oct 21 11:28pm CT |
| Benched | TE | Sam LaPorta DET | Owner | Tue Oct 21 11:28pm CT |
| Started | WR | A.J. Brown PHI | Owner | Tue Oct 21 11:28pm CT |
| Started | TE | George Kittle SF | Owner | Tue Oct 21 11:28pm CT |