

| No starting lineup changes performed this week. |
| Benched | K | Eddy Pineiro SF | Owner | Tue Nov 4 12:57pm CT |
| Started | K | Chase McLaughlin TB | Owner | Tue Nov 4 12:57pm CT |
| Benched | RB | Samaje Perine CIN | Owner | Tue Nov 4 11:20am CT |
| Started | RB | D'Andre Swift CHI | Owner | Tue Nov 4 11:20am CT |
| Benched | QB | Trevor Lawrence JAX | Owner | Tue Nov 4 6:31am CT |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 6:31am CT |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 4 6:31am CT |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 6:31am CT |
| Started | RB | Zach Charbonnet SEA | Owner | Tue Nov 4 6:31am CT |
| Started | RB | Rachaad White TB | Owner | Tue Nov 4 6:31am CT |
| No starting lineup changes performed this week. |
| Benched | TE | Mark Andrews BAL | Owner | Tue Nov 4 7:23am CT |
| Started | TE | Cade Otton TB | Owner | Tue Nov 4 7:23am CT |
| Benched | QB | Drake Maye NE | Owner | Tue Nov 4 7:20am CT |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 7:20am CT |
| Started | QB | Lamar Jackson BAL | Owner | Tue Nov 4 7:20am CT |
| Started | WR | Jauan Jennings SF | Owner | Tue Nov 4 7:20am CT |
| Benched | RB | Jordan Mason MIN | Owner | Tue Nov 4 7:19am CT |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 7:19am CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 4 12:16pm CT |
| Benched | RB | TreVeyon Henderson NE | Owner | Tue Nov 4 12:16pm CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 4 12:16pm CT |
| Started | WR | Jameson Williams DET | Owner | Tue Nov 4 12:16pm CT |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 12:03pm CT |
| Started | WR | D.J. Moore CHI | Owner | Tue Nov 4 12:03pm CT |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 6:29pm CT |
| Benched | WR | Kayshon Boutte NE | Owner | Tue Nov 4 6:29pm CT |
| Started | QB | Jared Goff DET | Owner | Tue Nov 4 6:29pm CT |
| Started | TE | Hunter Henry NE | Owner | Tue Nov 4 6:29pm CT |
| Benched | D/ST | Houston Texans HOU | Owner | Tue Nov 4 3:27pm CT |
| Started | D/ST | Denver Broncos DEN | Owner | Tue Nov 4 3:27pm CT |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 4 3:26pm CT |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 3:26pm CT |
| Started | QB | Matthew Stafford LAR | Owner | Tue Nov 4 3:26pm CT |
| Started | TE | Kyle Pitts ATL | Owner | Tue Nov 4 3:26pm CT |
| Benched | RB | Brashard Smith KC | Owner | Tue Nov 4 8:25pm CT |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 8:25pm CT |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 8:25pm CT |
| Started | TE | Mason Taylor NYJ | Owner | Tue Nov 4 8:25pm CT |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Nov 4 9:06pm CT |
| Benched | RB | Tony Pollard TEN | Owner | Tue Nov 4 9:06pm CT |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 9:06pm CT |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 9:06pm CT |
| Started | QB | Justin Fields NYJ | Owner | Tue Nov 4 9:06pm CT |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 9:06pm CT |
| Started | WR | Matthew Golden GB | Owner | Tue Nov 4 9:06pm CT |
| Started | WR | Sterling Shepard TB | Owner | Tue Nov 4 9:06pm CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Tue Nov 4 4:33pm CT |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 4:33pm CT |