

| Benched | QB | Mac Jones SF | Owner | Tue Nov 4 11:27pm CT |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 11:27pm CT |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 4 11:27pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 4 11:27pm CT |
| Started | QB | Brock Purdy SF | Owner | Tue Nov 4 11:27pm CT |
| Started | RB | Aaron Jones MIN | Owner | Tue Nov 4 11:27pm CT |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 11:27pm CT |
| Started | TE | Sam LaPorta DET | Owner | Tue Nov 4 11:27pm CT |
| Benched | RB | Chase Brown CIN | Owner | Wed Nov 5 4:26am CT |
| Started | RB | Rico Dowdle CAR | Owner | Wed Nov 5 4:26am CT |
| No starting lineup changes performed this week. |
| Benched | WR | A.J. Brown PHI | Owner | Tue Nov 4 12:00pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 4 12:00pm CT |
| Benched | QB | Jaxson Dart NYG | Owner | Tue Nov 4 12:00pm CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 4 11:55am CT |
| Benched | RB | Josh Jacobs GB | Owner | Tue Nov 4 11:55am CT |
| Started | TE | Harold Fannin Jr. CLE | Owner | Tue Nov 4 6:16am CT |
| Started | WR | D.K. Metcalf PIT | Owner | Tue Nov 4 6:16am CT |
| Started | WR | Drake London ATL | Owner | Tue Nov 4 6:16am CT |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 6:16am CT |
| Started | RB | Ashton Jeanty LV | Owner | Tue Nov 4 6:16am CT |
| Started | RB | Josh Jacobs GB | Owner | Tue Nov 4 6:16am CT |
| Started | RB | James Cook BUF | Owner | Tue Nov 4 6:16am CT |
| Started | QB | Daniel Jones IND | Owner | Tue Nov 4 6:16am CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 4 6:16am CT |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 4 6:05am CT |
| Benched | RB | James Cook BUF | Owner | Tue Nov 4 6:05am CT |
| Benched | RB | Josh Jacobs GB | Owner | Tue Nov 4 6:05am CT |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 4 6:05am CT |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 4 6:05am CT |
| Benched | WR | Drake London ATL | Owner | Tue Nov 4 6:05am CT |
| Benched | WR | D.K. Metcalf PIT | Owner | Tue Nov 4 6:05am CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Tue Nov 4 6:05am CT |
| Benched | QB | Jaxson Dart NYG | Owner | Tue Nov 4 6:05am CT |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 4 7:09am CT |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 7:09am CT |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 7:09am CT |
| Started | TE | Evan Engram DEN | Owner | Tue Nov 4 7:09am CT |
| Benched | QB | Jayden Daniels WAS | Owner | Wed Nov 5 12:59pm CT |
| Started | QB | Marcus Mariota WAS | Owner | Wed Nov 5 12:59pm CT |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 3:00pm CT |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 3:00pm CT |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 4 9:16pm CT |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Nov 4 9:16pm CT |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 9:16pm CT |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 4 9:16pm CT |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 9:16pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 9:16pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 4 9:16pm CT |
| Started | WR | Christian Watson GB | Owner | Tue Nov 4 9:16pm CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |