

| No starting lineup changes performed this week. |
| Benched | RB | Devin Neal NO | Owner | Tue Nov 4 4:12pm CT |
| Started | RB | Devin Singletary NYG | Owner | Tue Nov 4 4:12pm CT |
| Benched | D/ST | Minnesota Vikings MIN | Owner | Tue Nov 4 4:12pm CT |
| Started | D/ST | Cleveland Browns CLE | Owner | Tue Nov 4 4:12pm CT |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 4:12pm CT |
| Started | WR | Alec Pierce IND | Owner | Tue Nov 4 4:12pm CT |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 9:51am CT |
| Benched | RB | Jordan Mason MIN | Owner | Tue Nov 4 9:51am CT |
| Started | QB | Bo Nix DEN | Owner | Tue Nov 4 9:51am CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 9:51am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Deebo Samuel WAS | Owner | Tue Nov 4 10:27am CT |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 4 10:27am CT |
| Benched | QB | Sam Darnold SEA | Owner | Tue Nov 4 7:47am CT |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 7:47am CT |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Tue Nov 4 7:47am CT |
| Started | QB | Baker Mayfield TB | Owner | Tue Nov 4 7:47am CT |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 7:47am CT |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 7:55am CT |
| Benched | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 4 7:55am CT |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 4 7:55am CT |
| Started | RB | Isaiah Davis NYJ | Owner | Tue Nov 4 7:55am CT |
| Started | WR | Keon Coleman BUF | Owner | Tue Nov 4 7:55am CT |
| Started | TE | Dalton Kincaid BUF | Owner | Tue Nov 4 7:55am CT |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 8:13am CT |
| Started | WR | Rashid Shaheed SEA | Owner | Tue Nov 4 8:13am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 4 2:12pm CT |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 2:12pm CT |
| Started | WR | Romeo Doubs GB | Owner | Tue Nov 4 2:12pm CT |
| Started | TE | Jonnu Smith PIT | Owner | Tue Nov 4 2:12pm CT |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 6:14pm CT |
| Benched | D/ST | Los Angeles Chargers LAC | Owner | Tue Nov 4 6:14pm CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Nov 4 6:14pm CT |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Tue Nov 4 6:14pm CT |
| Benched | RB | Samaje Perine CIN | Owner | Tue Nov 4 11:52am CT |
| Benched | WR | Stefon Diggs NE | Owner | Tue Nov 4 11:52am CT |
| Benched | WR | Courtland Sutton DEN | Owner | Tue Nov 4 11:52am CT |
| Benched | TE | Pat Freiermuth PIT | Owner | Tue Nov 4 11:52am CT |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 11:52am CT |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 11:52am CT |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 11:52am CT |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 11:52am CT |
| No starting lineup changes performed this week. |