

| Benched | QB | Jared Goff DET | Owner | Tue Nov 11 8:36pm CT |
| Started | QB | Joe Flacco CIN | Owner | Tue Nov 11 8:36pm CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | QB | Tyler Shough NO | Owner | Tue Nov 11 9:38am CT |
| Benched | WR | Chris Olave NO | Owner | Tue Nov 11 9:38am CT |
| Started | QB | Patrick Mahomes KC | Owner | Tue Nov 11 9:38am CT |
| Started | WR | Luther Burden III CHI | Owner | Tue Nov 11 9:38am CT |
| Benched | WR | Marvin Harrison Jr. ARI | Owner | Wed Nov 12 4:52pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Wed Nov 12 4:52pm CT |
| Benched | RB | Breece Hall NYJ | Owner | Tue Nov 11 8:35pm CT |
| Benched | TE | Tyler Warren IND | Owner | Tue Nov 11 8:35pm CT |
| Started | WR | Tee Higgins CIN | Owner | Tue Nov 11 8:35pm CT |
| Started | TE | David Njoku CLE | Owner | Tue Nov 11 8:35pm CT |
| Benched | TE | Pat Freiermuth PIT | Owner | Tue Nov 11 7:40am CT |
| Started | TE | Travis Kelce KC | Owner | Tue Nov 11 7:40am CT |
| Benched | QB | Jaxson Dart NYG | Owner | Wed Nov 12 2:49pm CT |
| Started | QB | Justin Fields NYJ | Owner | Wed Nov 12 2:49pm CT |
| Benched | RB | Jonathan Taylor IND | Owner | Tue Nov 11 7:12am CT |
| Benched | WR | Jack Bech LV | Owner | Tue Nov 11 7:12am CT |
| Benched | TE | Elijah Arroyo SEA | Owner | Tue Nov 11 7:12am CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 11 7:12am CT |
| Started | WR | Rashee Rice KC | Owner | Tue Nov 11 7:12am CT |
| Started | TE | Jake Ferguson DAL | Owner | Tue Nov 11 7:12am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 11 6:24pm CT |
| Started | WR | CeeDee Lamb DAL | Owner | Tue Nov 11 6:24pm CT |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 11 8:19am CT |
| Started | QB | Cam Ward TEN | Owner | Tue Nov 11 8:19am CT |