

| Started | QB | Caleb Williams CHI | Owner | Tue Oct 28 7:46pm CT |
| Benched | QB | Matthew Stafford LAR | Owner | Tue Oct 28 7:46pm CT |
| Started | TE | Colston Loveland CHI | Owner | Tue Oct 28 7:45pm CT |
| Benched | TE | Mark Andrews BAL | Owner | Tue Oct 28 7:45pm CT |
| Started | WR | D.J. Moore CHI | Owner | Tue Oct 28 11:51am CT |
| Started | RB | Kareem Hunt KC | Owner | Tue Oct 28 11:51am CT |
| Started | QB | Matthew Stafford LAR | Owner | Tue Oct 28 11:51am CT |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 11:51am CT |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Oct 28 11:51am CT |
| Benched | QB | Caleb Williams CHI | Owner | Tue Oct 28 11:51am CT |
| No starting lineup changes performed this week. |
| Started | WR | Nico Collins HOU | Owner | Thu Oct 30 3:03pm CT |
| Started | K | Chad Ryland ARI | Owner | Wed Oct 29 11:20pm CT |
| Started | QB | Dak Prescott DAL | Owner | Tue Oct 28 6:35am CT |
| Benched | QB | Justin Herbert LAC | Owner | Tue Oct 28 6:35am CT |
| Started | TE | Trey McBride ARI | Owner | Tue Oct 28 6:22am CT |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 28 6:22am CT |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 6:22am CT |
| Started | WR | Puka Nacua LAR | Owner | Tue Oct 28 6:22am CT |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Oct 28 6:22am CT |
| Benched | K | Chase McLaughlin TB | Owner | Tue Oct 28 6:22am CT |
| Benched | TE | Dalton Schultz HOU | Owner | Tue Oct 28 6:22am CT |
| Benched | TE | Hunter Henry NE | Owner | Tue Oct 28 6:22am CT |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Oct 28 6:22am CT |
| Benched | WR | Alec Pierce IND | Owner | Tue Oct 28 6:22am CT |
| Benched | RB | J.K. Dobbins DEN | Owner | Tue Oct 28 6:22am CT |
| Benched | D/ST | Pittsburgh Steelers PIT | Owner | Thu Oct 30 7:58am CT |
| Started | D/ST | Los Angeles Rams LAR | Owner | Thu Oct 30 7:58am CT |
| Benched | WR | Deebo Samuel WAS | Owner | Wed Oct 29 9:32pm CT |
| Started | RB | Jaylen Warren PIT | Owner | Wed Oct 29 9:32pm CT |
| Benched | RB | Jaylen Warren PIT | Owner | Wed Oct 29 9:31pm CT |
| Started | RB | Kyren Williams LAR | Owner | Wed Oct 29 9:31pm CT |
| Benched | QB | Carson Wentz MIN | Owner | Wed Oct 29 9:30pm CT |
| Started | QB | Trevor Lawrence JAX | Owner | Wed Oct 29 9:30pm CT |
| Started | RB | J.K. Dobbins DEN | Owner | Thu Oct 30 2:45pm CT |
| Benched | WR | Tre Tucker LV | Owner | Thu Oct 30 2:45pm CT |
| Started | WR | Amon-Ra St. Brown DET | Owner | Thu Oct 30 2:44pm CT |
| Started | QB | J.J. McCarthy MIN | Owner | Wed Oct 29 2:59pm CT |
| Benched | QB | Brock Purdy SF | Owner | Wed Oct 29 2:59pm CT |
| Started | QB | Brock Purdy SF | Owner | Tue Oct 28 3:06pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Oct 28 3:06pm CT |
| Started | TE | Zach Ertz WAS | Owner | Tue Oct 28 7:33am CT |
| Started | WR | Tre Tucker LV | Owner | Tue Oct 28 7:33am CT |
| Started | WR | Jakobi Meyers LV | Owner | Tue Oct 28 7:33am CT |
| Started | WR | Nico Collins HOU | Owner | Tue Oct 28 7:33am CT |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Oct 28 7:33am CT |
| Benched | WR | Darnell Mooney ATL | Owner | Tue Oct 28 7:33am CT |
| Benched | WR | Xavier Hutchinson HOU | Owner | Tue Oct 28 7:33am CT |
| Benched | RB | Tony Pollard TEN | Owner | Tue Oct 28 7:33am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Rachaad White TB | Owner | Tue Oct 28 10:56am CT |
| Started | RB | TreVeyon Henderson NE | Owner | Tue Oct 28 10:56am CT |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Oct 28 5:51pm CT |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 5:51pm CT |
| Benched | QB | Bo Nix DEN | Owner | Tue Oct 28 5:50pm CT |
| Started | QB | Daniel Jones IND | Owner | Tue Oct 28 5:50pm CT |
| Benched | QB | C.J. Stroud HOU | Owner | Tue Oct 28 1:43pm CT |
| Started | TE | Theo Johnson NYG | Owner | Tue Oct 28 1:43pm CT |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Oct 28 1:43pm CT |
| Started | RB | Travis Etienne JAX | Owner | Tue Oct 28 1:43pm CT |
| Started | QB | Jared Goff DET | Owner | Tue Oct 28 1:43pm CT |
| Benched | K | Will Reichard MIN | Owner | Tue Oct 28 1:43pm CT |
| Benched | TE | T.J. Hockenson MIN | Owner | Tue Oct 28 1:43pm CT |
| Benched | WR | A.J. Brown PHI | Owner | Tue Oct 28 1:43pm CT |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Oct 28 1:43pm CT |
| Started | K | Jason Myers SEA | Owner | Tue Oct 28 1:43pm CT |
| Started | K | Blake Grupe NO | Owner | Thu Oct 30 6:52am CT |
| Benched | QB | Jalen Hurts PHI | Owner | Tue Oct 28 6:29am CT |
| Benched | RB | Cam Skattebo NYG | Owner | Tue Oct 28 6:29am CT |
| Benched | TE | Cade Otton TB | Owner | Tue Oct 28 6:29am CT |
| Benched | K | Nick Folk NYJ | Owner | Tue Oct 28 6:29am CT |
| Started | QB | Sam Darnold SEA | Owner | Tue Oct 28 6:29am CT |
| Started | WR | Davante Adams LAR | Owner | Tue Oct 28 6:29am CT |
| Started | TE | Jonnu Smith PIT | Owner | Tue Oct 28 6:29am CT |
| Benched | WR | Josh Downs IND | Owner | Thu Oct 30 9:17am CT |
| Benched | TE | Dalton Kincaid BUF | Owner | Thu Oct 30 9:17am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Thu Oct 30 9:17am CT |
| Started | TE | Brock Bowers LV | Owner | Thu Oct 30 9:17am CT |
| Started | D/ST | Detroit Lions DET | Owner | Thu Oct 30 9:17am CT |
| Benched | RB | Jordan Mason MIN | Owner | Tue Oct 28 12:49pm CT |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Oct 28 12:49pm CT |
| Started | WR | Josh Downs IND | Owner | Tue Oct 28 12:49pm CT |
| Started | WR | Rashid Shaheed NO | Owner | Tue Oct 28 12:49pm CT |
| Benched | QB | Baker Mayfield TB | Owner | Wed Oct 29 1:11pm CT |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Wed Oct 29 1:11pm CT |
| Started | QB | Lamar Jackson BAL | Owner | Wed Oct 29 1:11pm CT |
| Started | D/ST | Green Bay Packers GB | Owner | Wed Oct 29 1:11pm CT |