

| Benched | TE | George Kittle SF | Owner | Tue Nov 4 6:32pm CT |
| Started | TE | David Njoku CLE | Owner | Tue Nov 4 6:32pm CT |
| Benched | QB | Dak Prescott DAL | Owner | Tue Nov 4 9:17am CT |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 9:17am CT |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 4 9:17am CT |
| Started | QB | Brock Purdy SF | Owner | Tue Nov 4 9:17am CT |
| No starting lineup changes performed this week. |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 6:32am CT |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 4 6:32am CT |
| Started | QB | Aaron Rodgers PIT | Owner | Tue Nov 4 6:32am CT |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 6:32am CT |
| Benched | QB | C.J. Stroud HOU | Owner | Tue Nov 4 6:00pm CT |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 4 6:00pm CT |
| Benched | WR | Kendrick Bourne SF | Owner | Tue Nov 4 5:51pm CT |
| Started | WR | Quentin Johnston LAC | Owner | Tue Nov 4 5:51pm CT |
| Benched | QB | Michael Penix Jr. ATL | Owner | Tue Nov 4 5:59pm CT |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 5:59pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 4 5:59pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 5:41pm CT |
| Started | WR | Jameson Williams DET | Owner | Tue Nov 4 5:41pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 4 6:42pm CT |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Tue Nov 4 6:42pm CT |
| Benched | WR | Josh Downs IND | Owner | Tue Nov 4 6:42pm CT |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 6:42pm CT |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 6:42pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 6:42pm CT |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 6:42pm CT |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 6:42pm CT |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 7:00am CT |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 7:00am CT |
| Started | QB | Justin Fields NYJ | Owner | Tue Nov 4 7:00am CT |
| Started | WR | Malik Washington MIA | Owner | Tue Nov 4 7:00am CT |
| No starting lineup changes performed this week. |
| Benched | TE | Sam LaPorta DET | Owner | Tue Nov 4 6:45pm CT |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 6:45pm CT |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Nov 4 6:31am CT |
| Benched | RB | Zonovan Knight ARI | Owner | Tue Nov 4 6:31am CT |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 6:31am CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 4 6:31am CT |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 6:31am CT |
| Started | TE | Sam LaPorta DET | Owner | Tue Nov 4 6:31am CT |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 9:07am CT |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 4 9:07am CT |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 9:07am CT |
| Started | WR | Jordan Addison MIN | Owner | Tue Nov 4 9:07am CT |