

| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | TE | Darren Waller MIA | Owner | Tue Oct 21 1:22pm CT |
| Started | D/ST | Chicago Bears CHI | Owner | Tue Oct 21 1:22pm CT |
| Benched | WR | Davante Adams LAR | Owner | Tue Oct 21 9:28am CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Tue Oct 21 11:13am CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Oct 21 11:13am CT |
| Benched | QB | Trevor Lawrence JAX | Owner | Tue Oct 21 8:56am CT |
| Started | QB | Michael Penix Jr. ATL | Owner | Tue Oct 21 8:56am CT |
| Benched | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 21 8:56am CT |
| Started | WR | Kayshon Boutte NE | Owner | Tue Oct 21 8:56am CT |
| Benched | RB | Jacory Croskey-Merritt WAS | Owner | Tue Oct 21 2:28pm CT |
| Started | RB | James Cook BUF | Owner | Tue Oct 21 2:28pm CT |
| Benched | QB | Jared Goff DET | Owner | Tue Oct 21 11:06am CT |
| Benched | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 21 11:06am CT |
| Benched | WR | Jameson Williams DET | Owner | Tue Oct 21 11:06am CT |
| Started | QB | Daniel Jones IND | Owner | Tue Oct 21 11:06am CT |
| Started | WR | Romeo Doubs GB | Owner | Tue Oct 21 11:06am CT |
| Started | TE | Kyle Pitts ATL | Owner | Tue Oct 21 11:06am CT |