

| Started | D/ST | Seattle Seahawks SEA | Owner | Thu Oct 30 7:33am CT |
| Benched | WR | Marquise Brown KC | Owner | Tue Oct 28 6:13pm CT |
| Started | WR | Nico Collins HOU | Owner | Tue Oct 28 6:13pm CT |
| Benched | D/ST | Philadelphia Eagles PHI | Owner | Thu Oct 30 12:09pm CT |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Thu Oct 30 12:09pm CT |
| Benched | RB | Kyle Monangai CHI | Owner | Wed Oct 29 4:11pm CT |
| Benched | RB | Cam Skattebo NYG | Owner | Wed Oct 29 4:11pm CT |
| Started | RB | Jahmyr Gibbs DET | Owner | Wed Oct 29 4:11pm CT |
| Started | RB | David Montgomery DET | Owner | Wed Oct 29 4:11pm CT |
| Benched | QB | Jalen Hurts PHI | Owner | Tue Oct 28 9:43am CT |
| Benched | WR | Matthew Golden GB | Owner | Tue Oct 28 9:43am CT |
| Started | QB | Daniel Jones IND | Owner | Tue Oct 28 9:43am CT |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 9:43am CT |
| Started | RB | Blake Corum LAR | Owner | Wed Oct 29 10:17pm CT |
| Benched | RB | Tony Pollard TEN | Owner | Wed Oct 29 10:17pm CT |
| Started | D/ST | Minnesota Vikings MIN | Owner | Tue Oct 28 8:18am CT |
| Started | K | Ka'imi Fairbairn HOU | Owner | Tue Oct 28 8:18am CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Oct 28 8:18am CT |
| Started | RB | Tyler Allgeier ATL | Owner | Tue Oct 28 8:18am CT |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Oct 28 8:18am CT |
| Benched | K | Chase McLaughlin TB | Owner | Tue Oct 28 8:18am CT |
| Benched | WR | Emeka Egbuka TB | Owner | Tue Oct 28 8:18am CT |
| Benched | RB | Breece Hall NYJ | Owner | Tue Oct 28 8:18am CT |
| Benched | RB | Kareem Hunt KC | Owner | Wed Oct 29 9:26am CT |
| Started | RB | D'Andre Swift CHI | Owner | Wed Oct 29 9:26am CT |
| Benched | WR | A.J. Brown PHI | Owner | Wed Oct 29 9:25am CT |
| Started | WR | Amon-Ra St. Brown DET | Owner | Wed Oct 29 9:25am CT |
| Benched | QB | Kyler Murray ARI | Owner | Sat Nov 1 10:48pm CT |
| Started | QB | Bo Nix DEN | Owner | Sat Nov 1 10:48pm CT |
| Benched | QB | Bo Nix DEN | Owner | Thu Oct 30 5:58pm CT |
| Started | QB | Kyler Murray ARI | Owner | Thu Oct 30 5:58pm CT |
| Benched | RB | Rico Dowdle CAR | Owner | Thu Oct 30 11:02am CT |
| Started | RB | Zonovan Knight ARI | Owner | Thu Oct 30 11:02am CT |
| Benched | RB | Justice Hill BAL | Owner | Thu Oct 30 4:45pm CT |
| Benched | WR | Drake London ATL | Owner | Thu Oct 30 4:45pm CT |
| Benched | K | Blake Grupe NO | Owner | Thu Oct 30 4:45pm CT |
| Benched | D/ST | Denver Broncos DEN | Owner | Thu Oct 30 4:45pm CT |
| Started | RB | Zach Charbonnet SEA | Owner | Thu Oct 30 4:45pm CT |
| Started | WR | Davante Adams LAR | Owner | Thu Oct 30 4:45pm CT |
| Started | K | Jake Bates DET | Owner | Thu Oct 30 4:45pm CT |
| Started | D/ST | Los Angeles Rams LAR | Owner | Thu Oct 30 4:45pm CT |
| Benched | QB | Joe Flacco CIN | Owner | Thu Oct 30 7:35am CT |
| Started | QB | Lamar Jackson BAL | Owner | Thu Oct 30 7:35am CT |
| Benched | RB | Rachaad White TB | Owner | Tue Oct 28 8:34am CT |
| Started | RB | Kenneth Walker III SEA | Owner | Tue Oct 28 8:34am CT |
| Benched | WR | Terry McLaurin WAS | Owner | Thu Oct 30 4:52am CT |
| Started | WR | Troy Franklin DEN | Owner | Thu Oct 30 4:52am CT |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Oct 28 7:12am CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Oct 28 7:12am CT |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 10:09pm CT |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 10:09pm CT |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 10:09pm CT |
| Started | WR | Puka Nacua LAR | Owner | Tue Oct 28 10:09pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Jaxson Dart NYG | Owner | Wed Oct 29 3:28pm CT |
| Started | QB | Matthew Stafford LAR | Owner | Wed Oct 29 3:28pm CT |