

| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 11:29pm CT |
| Benched | RB | Kareem Hunt KC | Owner | Tue Nov 4 11:29pm CT |
| Started | QB | Jacoby Brissett ARI | Owner | Tue Nov 4 11:29pm CT |
| Started | RB | Aaron Jones MIN | Owner | Tue Nov 4 11:29pm CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Nov 4 7:44pm CT |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 4 7:44pm CT |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 7:44pm CT |
| Started | QB | Marcus Mariota WAS | Owner | Tue Nov 4 7:44pm CT |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Nov 4 7:44pm CT |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 4 7:44pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Cam Ward TEN | Owner | Tue Nov 4 5:47pm CT |
| Benched | RB | Michael Carter ARI | Owner | Tue Nov 4 5:47pm CT |
| Started | RB | Blake Corum LAR | Owner | Tue Nov 4 5:47pm CT |
| Started | WR | Matthew Golden GB | Owner | Tue Nov 4 5:47pm CT |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 11:59am CT |
| Benched | RB | Saquon Barkley PHI | Owner | Tue Nov 4 11:59am CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 4 11:57am CT |
| Benched | RB | Jaylen Warren PIT | Owner | Tue Nov 4 11:57am CT |
| Started | TE | Theo Johnson NYG | Owner | Tue Nov 4 6:31am CT |
| Started | WR | Drake London ATL | Owner | Tue Nov 4 6:31am CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 4 6:31am CT |
| Started | WR | DeVonta Smith PHI | Owner | Tue Nov 4 6:31am CT |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 6:31am CT |
| Started | RB | Kyren Williams LAR | Owner | Tue Nov 4 6:31am CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 4 6:31am CT |
| Started | QB | Lamar Jackson BAL | Owner | Tue Nov 4 6:30am CT |
| Started | QB | Justin Herbert LAC | Owner | Tue Nov 4 6:30am CT |
| Benched | QB | Lamar Jackson BAL | Owner | Tue Nov 4 6:06am CT |
| Benched | RB | Jaylen Warren PIT | Owner | Tue Nov 4 6:06am CT |
| Benched | RB | Kyren Williams LAR | Owner | Tue Nov 4 6:06am CT |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 6:06am CT |
| Benched | WR | Drake London ATL | Owner | Tue Nov 4 6:06am CT |
| Benched | WR | Ladd McConkey LAC | Owner | Tue Nov 4 6:06am CT |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 4 6:06am CT |
| Benched | TE | Theo Johnson NYG | Owner | Tue Nov 4 6:06am CT |
| Benched | QB | Justin Herbert LAC | Owner | Tue Nov 4 6:06am CT |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 6:52pm CT |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 6:52pm CT |
| Benched | RB | Woody Marks HOU | Owner | Tue Nov 4 2:35pm CT |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 2:35pm CT |
| Started | RB | Bucky Irving TB | Owner | Tue Nov 4 2:35pm CT |
| Started | WR | Rashid Shaheed SEA | Owner | Tue Nov 4 2:35pm CT |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 7:59am CT |
| Started | TE | Theo Johnson NYG | Owner | Tue Nov 4 7:59am CT |
| No starting lineup changes performed this week. |