

| No starting lineup changes performed this week. |
| Benched | TE | T.J. Hockenson MIN | Owner | Tue Nov 4 9:10pm CT |
| Started | TE | Cade Otton TB | Owner | Tue Nov 4 9:10pm CT |
| Benched | WR | Tee Higgins CIN | Owner | Tue Nov 4 9:09pm CT |
| Started | WR | Garrett Wilson NYJ | Owner | Tue Nov 4 9:09pm CT |
| Benched | QB | Patrick Mahomes KC | Owner | Tue Nov 4 8:21pm CT |
| Benched | WR | Rashee Rice KC | Owner | Tue Nov 4 8:21pm CT |
| Benched | TE | Tucker Kraft GB | Owner | Tue Nov 4 8:21pm CT |
| Benched | K | Harrison Butker KC | Owner | Tue Nov 4 8:21pm CT |
| Started | QB | Bryce Young CAR | Owner | Tue Nov 4 8:21pm CT |
| Started | WR | Brian Thomas Jr. JAX | Owner | Tue Nov 4 8:21pm CT |
| Started | TE | Juwan Johnson NO | Owner | Tue Nov 4 8:21pm CT |
| No starting lineup changes performed this week. |
| Benched | WR | Dyami Brown JAX | Owner | Tue Nov 4 7:55pm CT |
| Started | WR | Khalil Shakir BUF | Owner | Tue Nov 4 7:55pm CT |
| Benched | QB | Tua Tagovailoa MIA | Owner | Tue Nov 4 8:51am CT |
| Benched | WR | Chimere Dike TEN | Owner | Tue Nov 4 8:51am CT |
| Benched | TE | Travis Kelce KC | Owner | Tue Nov 4 8:51am CT |
| Started | QB | Baker Mayfield TB | Owner | Tue Nov 4 8:51am CT |
| Started | WR | Jerry Jeudy CLE | Owner | Tue Nov 4 8:51am CT |
| Started | TE | Jonnu Smith PIT | Owner | Tue Nov 4 8:51am CT |
| Benched | QB | Joe Flacco CIN | Owner | Tue Nov 4 4:43pm CT |
| Benched | RB | Javonte Williams DAL | Owner | Tue Nov 4 4:43pm CT |
| Benched | WR | Wan'Dale Robinson NYG | Owner | Tue Nov 4 4:43pm CT |
| Started | QB | Jalen Hurts PHI | Owner | Tue Nov 4 4:43pm CT |
| Started | RB | David Montgomery DET | Owner | Tue Nov 4 4:43pm CT |
| Started | WR | Emeka Egbuka TB | Owner | Tue Nov 4 4:43pm CT |
| Benched | RB | Chase Brown CIN | Owner | Tue Nov 4 2:15pm CT |
| Started | K | Chase McLaughlin TB | Owner | Tue Nov 4 2:15pm CT |
| Started | TE | Colston Loveland CHI | Owner | Tue Nov 4 2:15pm CT |
| Started | WR | Deebo Samuel WAS | Owner | Tue Nov 4 2:15pm CT |
| Started | WR | Ladd McConkey LAC | Owner | Tue Nov 4 2:15pm CT |
| Started | WR | Josh Downs IND | Owner | Tue Nov 4 2:15pm CT |
| Started | RB | Ashton Jeanty LV | Owner | Tue Nov 4 2:15pm CT |
| Benched | D/ST | Green Bay Packers GB | Owner | Tue Nov 4 2:15pm CT |
| Benched | K | Andres Borregales NE | Owner | Tue Nov 4 2:15pm CT |
| Benched | TE | Hunter Henry NE | Owner | Tue Nov 4 2:15pm CT |
| Benched | WR | Xavier Worthy KC | Owner | Tue Nov 4 2:15pm CT |
| Benched | WR | Tetairoa McMillan CAR | Owner | Tue Nov 4 2:15pm CT |
| Benched | WR | Keon Coleman BUF | Owner | Tue Nov 4 2:15pm CT |
| Started | D/ST | Pittsburgh Steelers PIT | Owner | Tue Nov 4 2:15pm CT |
| Benched | WR | Ja'Marr Chase CIN | Owner | Tue Nov 4 11:11am CT |
| Benched | WR | CeeDee Lamb DAL | Owner | Tue Nov 4 11:11am CT |
| Benched | K | Evan McPherson CIN | Owner | Tue Nov 4 11:11am CT |
| Started | WR | Rome Odunze CHI | Owner | Tue Nov 4 11:11am CT |
| Started | TE | Dalton Kincaid BUF | Owner | Tue Nov 4 11:11am CT |
| Benched | WR | George Pickens DAL | Owner | Tue Nov 4 11:51am CT |
| Started | RB | Breece Hall NYJ | Owner | Tue Nov 4 11:51am CT |
| Benched | QB | Jayden Daniels WAS | Owner | Tue Nov 4 11:50am CT |
| Started | QB | Trevor Lawrence JAX | Owner | Tue Nov 4 11:50am CT |
| Benched | TE | George Kittle SF | Owner | Tue Nov 4 4:14pm CT |
| Started | RB | Quinshon Judkins CLE | Owner | Tue Nov 4 4:14pm CT |
| Benched | QB | Jordan Love GB | Owner | Tue Nov 4 7:08pm CT |
| Benched | TE | Jake Ferguson DAL | Owner | Tue Nov 4 7:08pm CT |
| Started | QB | Jaxson Dart NYG | Owner | Tue Nov 4 7:08pm CT |
| Started | WR | Jayden Higgins HOU | Owner | Tue Nov 4 2:20pm CT |
| Benched | RB | Tony Pollard TEN | Owner | Tue Nov 4 7:08am CT |
| Benched | TE | Pat Freiermuth PIT | Owner | Tue Nov 4 7:08am CT |
| Started | RB | Saquon Barkley PHI | Owner | Tue Nov 4 7:08am CT |
| Started | TE | Dallas Goedert PHI | Owner | Tue Nov 4 7:08am CT |