

| Benched | RB | Jordan Mason MIN | Owner | Tue Nov 11 3:33pm CT |
| Started | WR | CeeDee Lamb DAL | Owner | Tue Nov 11 3:33pm CT |
| Benched | QB | Daniel Jones IND | Owner | Tue Nov 11 2:06pm CT |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Nov 11 2:06pm CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Tue Nov 11 2:06pm CT |
| Benched | TE | Tyler Warren IND | Owner | Tue Nov 11 2:06pm CT |
| Started | QB | Patrick Mahomes KC | Owner | Tue Nov 11 2:06pm CT |
| Started | RB | Jaylen Warren PIT | Owner | Tue Nov 11 2:06pm CT |
| Started | WR | Rashee Rice KC | Owner | Tue Nov 11 2:06pm CT |
| Started | TE | Mark Andrews BAL | Owner | Tue Nov 11 2:06pm CT |
| Benched | WR | Jaylen Waddle MIA | Owner | Tue Nov 11 7:32am CT |
| Benched | TE | Juwan Johnson NO | Owner | Tue Nov 11 7:32am CT |
| Started | RB | Javonte Williams DAL | Owner | Tue Nov 11 7:32am CT |
| Started | TE | Jake Ferguson DAL | Owner | Tue Nov 11 7:32am CT |
| Benched | RB | Rachaad White TB | Owner | Tue Nov 11 7:45pm CT |
| Started | WR | Nico Collins HOU | Owner | Tue Nov 11 7:45pm CT |
| Benched | WR | Nico Collins HOU | Owner | Tue Nov 11 7:45pm CT |
| Started | RB | Rachaad White TB | Owner | Tue Nov 11 7:45pm CT |
| Started | WR | Ja'Marr Chase CIN | Owner | Tue Nov 11 7:44pm CT |
| Benched | RB | RJ Harvey DEN | Owner | Tue Nov 11 8:09pm CT |
| Benched | WR | Quentin Johnston LAC | Owner | Tue Nov 11 8:09pm CT |
| Started | RB | TreVeyon Henderson NE | Owner | Tue Nov 11 8:09pm CT |
| Started | WR | D.K. Metcalf PIT | Owner | Tue Nov 11 8:09pm CT |
| Benched | WR | D.J. Moore CHI | Owner | Tue Nov 11 9:17pm CT |
| Started | RB | Chase Brown CIN | Owner | Tue Nov 11 9:17pm CT |
| No starting lineup changes performed this week. |
| Benched | RB | Jonathan Taylor IND | Owner | Tue Nov 11 6:26am CT |
| Benched | WR | Zay Flowers BAL | Owner | Tue Nov 11 6:26am CT |
| Started | WR | Keenan Allen LAC | Owner | Tue Nov 11 6:26am CT |
| Started | WR | A.J. Brown PHI | Owner | Tue Nov 11 6:26am CT |