

| Benched | D/ST | Buffalo Bills BUF | Owner | Wed Dec 10 7:37pm CT |
| Started | D/ST | Philadelphia Eagles PHI | Owner | Wed Dec 10 7:37pm CT |
| Benched | RB | Jordan Mason MIN | Owner | Tue Dec 9 9:42am CT |
| Benched | RB | Samaje Perine CIN | Owner | Tue Dec 9 9:42am CT |
| Benched | WR | Keon Coleman BUF | Owner | Tue Dec 9 9:42am CT |
| Benched | WR | Dontayvion Wicks GB | Owner | Tue Dec 9 9:42am CT |
| Started | RB | Christian McCaffrey SF | Owner | Tue Dec 9 9:42am CT |
| Started | RB | Tyrone Tracy Jr. NYG | Owner | Tue Dec 9 9:42am CT |
| Started | WR | Darius Slayton NYG | Owner | Tue Dec 9 9:42am CT |
| Started | TE | George Kittle SF | Owner | Tue Dec 9 9:42am CT |
| Benched | WR | Rashid Shaheed SEA | Owner | Wed Dec 10 8:25pm CT |
| Started | WR | Chris Olave NO | Owner | Wed Dec 10 8:25pm CT |
| Benched | D/ST | Denver Broncos DEN | Owner | Tue Dec 9 6:58pm CT |
| Started | D/ST | Jacksonville Jaguars JAX | Owner | Tue Dec 9 6:58pm CT |
| Benched | WR | Chris Olave NO | Owner | Tue Dec 9 7:58am CT |
| Started | WR | Rashid Shaheed SEA | Owner | Tue Dec 9 7:58am CT |
| No starting lineup changes performed this week. |
| Benched | RB | D'Andre Swift CHI | Owner | Wed Dec 10 5:01pm CT |
| Started | RB | Omarion Hampton LAC | Owner | Wed Dec 10 5:01pm CT |
| Benched | QB | Bo Nix DEN | Owner | Tue Dec 9 11:28am CT |
| Started | QB | Jared Goff DET | Owner | Tue Dec 9 11:28am CT |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Wed Dec 10 9:01am CT |
| Benched | TE | Colston Loveland CHI | Owner | Wed Dec 10 9:01am CT |
| Started | WR | Jauan Jennings SF | Owner | Wed Dec 10 9:01am CT |
| Started | WR | Tetairoa McMillan CAR | Owner | Wed Dec 10 9:01am CT |
| Benched | QB | Justin Herbert LAC | Owner | Wed Dec 10 8:59am CT |
| Benched | RB | Tyler Allgeier ATL | Owner | Wed Dec 10 8:59am CT |
| Started | QB | Brock Purdy SF | Owner | Wed Dec 10 8:59am CT |
| Started | RB | TreVeyon Henderson NE | Owner | Wed Dec 10 8:59am CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| Started | QB | Jaxson Dart NYG | Owner | Thu Dec 11 12:10pm CT |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |
| No starting lineup changes performed this week. |