

| Benched | WR | Emeka Egbuka TB | Owner | Tue Oct 28 3:09pm CT |
| Benched | TE | Cade Otton TB | Owner | Tue Oct 28 3:09pm CT |
| Started | WR | Calvin Ridley TEN | Owner | Tue Oct 28 3:09pm CT |
| Started | TE | Brock Bowers LV | Owner | Tue Oct 28 3:09pm CT |
| Benched | RB | Saquon Barkley PHI | Commissioner | Tue Oct 28 4:13am CT |
| Started | RB | Travis Etienne JAX | Commissioner | Tue Oct 28 4:13am CT |
| Benched | TE | Dallas Goedert PHI | Commissioner | Tue Oct 28 4:12am CT |
| Benched | D/ST | San Francisco 49ers SF | Commissioner | Tue Oct 28 4:12am CT |
| Started | TE | T.J. Hockenson MIN | Commissioner | Tue Oct 28 4:12am CT |
| Started | D/ST | Seattle Seahawks SEA | Commissioner | Tue Oct 28 4:12am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Kyle Monangai CHI | Owner | Tue Oct 28 9:24am CT |
| Started | RB | David Montgomery DET | Owner | Tue Oct 28 9:24am CT |
| Benched | RB | Tony Pollard TEN | Owner | Tue Oct 28 7:46am CT |
| Started | RB | RJ Harvey DEN | Owner | Tue Oct 28 7:46am CT |
| Benched | WR | Sterling Shepard TB | Owner | Tue Oct 28 7:46am CT |
| Started | WR | Marvin Harrison Jr. ARI | Owner | Tue Oct 28 7:46am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Breece Hall NYJ | Owner | Tue Oct 28 8:34am CT |
| Benched | WR | Jerry Jeudy CLE | Owner | Tue Oct 28 8:34am CT |
| Benched | TE | Harold Fannin Jr. CLE | Owner | Tue Oct 28 8:34am CT |
| Benched | D/ST | Kansas City Chiefs KC | Owner | Tue Oct 28 8:34am CT |
| Started | RB | Ashton Jeanty LV | Owner | Tue Oct 28 8:34am CT |
| Started | WR | Amon-Ra St. Brown DET | Owner | Tue Oct 28 8:34am CT |
| Started | TE | Trey McBride ARI | Owner | Tue Oct 28 8:34am CT |
| Started | D/ST | Buffalo Bills BUF | Owner | Tue Oct 28 8:34am CT |
| Started | RB | Chase Brown CIN | Owner | Tue Oct 28 1:01pm CT |
| Benched | RB | Isiah Pacheco KC | Owner | Tue Oct 28 5:34pm CT |
| Started | RB | Rhamondre Stevenson NE | Owner | Tue Oct 28 5:34pm CT |
| Benched | WR | Josh Downs IND | Owner | Tue Oct 28 5:32pm CT |
| Started | WR | Jaxon Smith-Njigba SEA | Owner | Tue Oct 28 5:32pm CT |
| Benched | RB | Nick Chubb HOU | Owner | Tue Oct 28 5:23pm CT |
| Started | RB | Aaron Jones MIN | Owner | Tue Oct 28 5:23pm CT |
| Benched | RB | Quinshon Judkins CLE | Owner | Tue Oct 28 5:06pm CT |
| Started | RB | Nick Chubb HOU | Owner | Tue Oct 28 5:06pm CT |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Oct 28 5:06pm CT |
| Started | D/ST | Chicago Bears CHI | Owner | Tue Oct 28 5:06pm CT |
| Benched | WR | Rashid Shaheed NO | Owner | Tue Oct 28 5:06pm CT |
| Started | WR | Puka Nacua LAR | Owner | Tue Oct 28 5:06pm CT |
| No starting lineup changes performed this week. |
| Benched | QB | Bo Nix DEN | Owner | Tue Oct 28 7:42am CT |
| Benched | RB | Jordan Mason MIN | Owner | Tue Oct 28 7:42am CT |
| Benched | WR | Tez Johnson TB | Owner | Tue Oct 28 7:42am CT |
| Benched | WR | DeVonta Smith PHI | Owner | Tue Oct 28 7:42am CT |
| Started | QB | Daniel Jones IND | Owner | Tue Oct 28 7:42am CT |
| Started | RB | Jahmyr Gibbs DET | Owner | Tue Oct 28 7:42am CT |
| Started | WR | Nico Collins HOU | Owner | Tue Oct 28 7:42am CT |
| Started | WR | Jameson Williams DET | Owner | Tue Oct 28 7:42am CT |