

| Benched | WR | Luther Burden III CHI | Owner | Wed Dec 10 7:12am CT |
| Started | RB | Kimani Vidal LAC | Owner | Wed Dec 10 7:12am CT |
| Benched | D/ST | Tampa Bay Buccaneers TB | Owner | Tue Dec 9 8:10am CT |
| Started | D/ST | New England Patriots NE | Owner | Tue Dec 9 8:10am CT |
| Benched | RB | Tyjae Spears TEN | Owner | Tue Dec 9 8:06am CT |
| Started | RB | TreVeyon Henderson NE | Owner | Tue Dec 9 8:06am CT |
| No starting lineup changes performed this week. |
| Benched | WR | Tee Higgins CIN | Owner | Wed Dec 10 1:32pm CT |
| Started | WR | D.K. Metcalf PIT | Owner | Wed Dec 10 1:32pm CT |
| Benched | WR | Brian Thomas Jr. JAX | Owner | Tue Dec 9 9:31am CT |
| Started | WR | Tetairoa McMillan CAR | Owner | Tue Dec 9 9:31am CT |
| No starting lineup changes performed this week. |
| Benched | RB | Tyler Allgeier ATL | Commissioner | Tue Dec 9 11:17am CT |
| Benched | WR | Troy Franklin DEN | Commissioner | Tue Dec 9 11:17am CT |
| Started | RB | Devin Singletary NYG | Commissioner | Tue Dec 9 11:17am CT |
| Started | TE | Theo Johnson NYG | Commissioner | Tue Dec 9 11:17am CT |
| Benched | WR | Ricky Pearsall SF | Owner | Wed Dec 10 1:21pm CT |
| Started | WR | Rashid Shaheed SEA | Owner | Wed Dec 10 1:21pm CT |
| Benched | RB | Kenneth Gainwell PIT | Owner | Wed Dec 10 1:20pm CT |
| Benched | WR | Quentin Johnston LAC | Owner | Wed Dec 10 1:20pm CT |
| Benched | TE | Pat Freiermuth PIT | Owner | Wed Dec 10 1:20pm CT |
| Started | RB | Christian McCaffrey SF | Owner | Wed Dec 10 1:20pm CT |
| Started | WR | Ricky Pearsall SF | Owner | Wed Dec 10 1:20pm CT |
| Started | TE | George Kittle SF | Owner | Wed Dec 10 1:20pm CT |
| Benched | WR | D.J. Moore CHI | Owner | Tue Dec 9 8:15am CT |
| Started | WR | Demario Douglas NE | Owner | Tue Dec 9 8:15am CT |
| Benched | QB | Indianapolis Colts IND | Owner | Tue Dec 9 8:10am CT |
| Started | QB | Seattle Seahawks SEA | Owner | Tue Dec 9 8:10am CT |
| No starting lineup changes performed this week. |
| Benched | D/ST | Buffalo Bills BUF | Owner | Tue Dec 9 11:19am CT |
| Started | D/ST | Chicago Bears CHI | Owner | Tue Dec 9 11:19am CT |
| No starting lineup changes performed this week. |
| Benched | RB | David Montgomery DET | Owner | Wed Dec 10 12:09am CT |
| Benched | WR | Michael Pittman Jr. IND | Owner | Wed Dec 10 12:09am CT |
| Benched | K | Riley Patterson MIA | Owner | Wed Dec 10 12:09am CT |
| Started | RB | Rhamondre Stevenson NE | Owner | Wed Dec 10 12:09am CT |
| Started | WR | Wan'Dale Robinson NYG | Owner | Wed Dec 10 12:09am CT |
| Started | K | Andres Borregales NE | Owner | Wed Dec 10 12:09am CT |
| No starting lineup changes performed this week. |