Indianapolis Colts wide receiver Josh Downs is off to a quiet start to the season, catching 10 passes for 97 scoreless yards through three games. As emerging as the Colts' top option in 2024, the slot receiver has taken a backseat to Michael Pittman Jr. and Tyler Warren in the team's passing attack with quarterback Daniel Jones under center. That being said, he could see more work come his way with Alec Pierce (concussion) already ruled out for Week 4. Downs will look to get on track in a road matchup against the Los Angeles Rams on Sunday. The Rams are allowing the 14th-most fantasy points per game to receivers this season. Downs sets up as a middling flex option in fantasy this weekend with the hope that he sees more targets with Pierce unavailable.

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Indianapolis Colts wide receiver Adonai Mitchell has been quiet through the first three games of the season, catching just four passes for 41 scoreless yards thus far. He has a chance to earn more work in Week 4, however, as Alec Pierce (concussion) has already been ruled out after suffering a concussion in Week 3. Mitchell will slide into the starting lineup across from Michael Pittman Jr. heading into a Week 4 road matchup against the Los Angeles Rams. While it is a risky move for managers, Mitchell is on the board as a boom/bust flex option in fantasy heading into Sunday's games.

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Indianapolis Colts tight end Tyler Warren will look to continue a hot start to his rookie season in a Week 4 road matchup against the Los Angeles Rams. Warren has caught 14 passes for 193 yards through three games as he and Michael Pittman Jr. have been the focal points for Daniel Jones in the passing attack. The Rams represent a decent matchup for Warren as they are allowing the 18th-most fantasy points per game to tight ends this year. Warren sets up as a top-eight fantasy tight end heading into Week 4.

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Indianapolis Colts running back DJ Giddens has become an afterthought in his team's offense. The rookie saw 12 carries in Week 1 but has handled just one touch in the two games since, as Indy has leaned heavily on starter Jonathan Taylor. The return to health of Tyler Goodson has also cut into Giddens' workload as the former is now over a preseason elbow injury. It appears that Goodson is still behind Giddens for now, as he saw four snaps to Giddens' eight in Week 3, but his return to health muddies the backup running-back role in Indianapolis. For now, Giddens remains the better stash in case of injury to Taylor, but neither he nor Goodson is a must-roster heading into a Week 4 matchup against the Los Angeles Rams.

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Indianapolis Colts wide receiver Michael Pittman Jr. has emerged as the favorite target of new quarterback Daniel Jones through the first three weeks of the season. Pittman has been excellent thus far, catching 16 passes for 193 yards and two touchdowns, easily pacing the Colts in all three categories. The veteran wideout will look to keep it going in a Week 4 road matchup against the Los Angeles Rams. The Rams have been decent against wideouts this season, allowing the 14th-most fantasy points per game to the position. Pittman should remain the focal point of the Indy offense as they look to improve to 4-0 on the year. He sets up as a high-end WR3/flex option in Week 4.

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Indianapolis Colts running back Jonathan Taylor has been one of the top fantasy players through the first three weeks of the season, rushing for 338 yards and three touchdowns while adding 93 receiving yards and another score through the air. Taylor will look to stay hot in Week 4 in a road matchup against the Los Angeles Rams. The Rams represent a tough matchup for Taylor as they are allowing the fewest fantasy points per game to the running back position through three weeks. That being said, Taylor remains one of the few true workhorses left in the league and can still be trusted as a top-six fantasy running back this weekend despite the difficult matchup.

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Indianapolis Colts quarterback Daniel Jones' performance has been a pleasant surprise over the first month of the season. Jones has led one of the top offenses in the league thus far, throwing for 816 yards, three touchdowns, and no interceptions while adding three rushing touchdowns. The Colts will look to stay hot in a road matchup against the Los Angeles Rams. The Rams are allowing the 17th-most fantasy points per game to opposing quarterbacks, giving Jones a decent matchup to stay hot. He checks in as a low-end QB1 in fantasy heading into Sunday.

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San Francisco 49ers tight end Jake Tonges has emerged as the team's top receiving option at the position during George Kittle's (hamstring) absence. Even though Luke Farrell is listed at the top of the team's depth chart, Tonges has more targets (11, to Farrell's four) and is seeing considerably more time on the field. Still, Tonges is well behind Christian McCaffrey and the 49ers' wide receiver corps in the pecking order of pass distribution. However, there is a chance for Tonges to get more attention in Week 4, since Ricky Pearsall (knee) and Jauan Jennings (ankle/shoulder) are both questionable. Also benefiting Tonges is the return of quarterback Brock Purdy (toe/shoulder) following a two-week absence. Even with those factors in play, Tonges is projected just outside of TE2 territory and should be left on the waiver wire for Week 4.

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San Francisco 49ers wide receiver Kendrick Bourne drew a start in Week 3, thanks to Jauan Jennings (ankle/shoulder) being scratched just hours before gametime. With Demarcus Robinson returning from suspension this week, the expectation was that Bourne would be crowded out of the wide receiver rotation. However, the door may be open for a second start as both Jennings and Ricky Pearsall (knee) are listed as questionable for Week 4. Last week, Bourne turned six targets into four catches for 38 yards. With Brock Purdy (toe/shoulder) deemed Sunday's starter, Bourne would see better quarterbacking than he had with Mac Jones (knee) under center, improving his odds for a more productive day. Everything rides on the health of his teammates, though, so interested fantasy managers need to monitor the situation through the weekend.

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San Francisco 49ers wide receiver Jordan Watkins (calf) has been ruled out for the team's Week 4 game against the Jacksonville Jaguars. Watkins is listed with a calf injury, a possible symptom of the high ankle sprain he suffered in the first week of preseason action. He was cleared to make his regular season debut in Week 2, but was ultimately declared inactive ahead of the game. In Week 3, he had one limited practice sandwiched between two DNPs and did not practice at all this week. Even after he heals, he has little to no value in fantasy football (dynasty leagues excepted), as it will be hard for the rookie to crack the rotation of Ricky Pearsall (knee), Jauan Jennings (ankle/shoulder), and Demarcus Robinson at the top of the depth chart.

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San Francisco 49ers running back Jordan James did not appear on the team's injury report for the first time this season. James suffered a broken finger in early August, before preseason games started, and it lingered into the regular season. James had one full practice in Week 2 and three consecutive full sessions in Week 3, but was a healthy scratch from both games, so he is still waiting to make his professional debut. With Christian McCaffrey at the top of the depth chart and Brian Robinson Jr. having a firm grasp as his direct backup, James is unlikely to see much, if any, time on the field if he suits up on Sunday. As such, he has no value in fantasy football going into San Francisco's Week 4 game against Jacksonville.

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San Francisco 49ers running back Isaac Guerendo has yet to see an offensive snap in 2025, and there is little reason to expect that to change in Week 4. Christian McCaffrey is the team's unquestioned starter, and Brian Robinson Jr. has the second position on the depth chart locked down. The team's official depth chart lists both Guerendo and rookie Jordan James as the third-string running back, raising the question of which of the two would be given an opportunity in the backfield should the need arise. In the meantime, Guerendo has been relegated to kick return duty. Through three games, he has taken back four kicks for a grand total of 82 yards. Until an injury shakes up the depth chart, Guerendo has no place on fantasy football rosters.

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San Francisco 49ers running back Brian Robinson Jr. enters Week 4 still looking to make his mark with his new team. It won't be easy while relegated to a change-of-pace role behind one of the league's most dynamic players, Christian McCaffrey. Robinson's touches have decreased in each game, from 10 in Week 1, to seven in Week 2, to two in Week 3. The 49ers might have to rely more on the ground game in Week 4, depending on the health of wide receivers Ricky Pearsall (knee) and Jauan Jennings (ankle/shoulder), who are both listed as questionable for Week 4. That, in turn, would lead to more work for Robinson, but it is hard to see him being given any more than what he saw in Week 1. As such, Robinson should be treated as a handcuff that is best left on the bench on Sunday.

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San Francisco 49ers running back Christian McCaffrey has started the season with three straight RB1 performances, be it standard, half-PPR scoring, or full-PPR scoring. Narrowed down to full-PPR, he has finished in the top five among running backs in each of the first three weeks of 2025. McCaffrey is poised to continue the streak on Sunday when he squares off against the Jacksonville Jaguars. The Jags have been successful at limiting the productivity of opposing backs, but McCaffrey is as matchup-proof as they come. The team's reliance on him will be heightened with wide receivers Jauan Jennings (ankle/shoulder) and Ricky Pearsall (knee) both questionable for the game. Through three weeks, McCaffrey has 52 carries for 176 rushing yards, and his team-leading 25 receptions rank fourth-most in the league. McCaffrey should be locked into starting lineups for Week 4.

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Kansas City Chiefs kicker Harrison Butker will face the Baltimore Ravens in Week 4. Butker was busy in last week's matchup against the New York Giants. The Chiefs kicker knocked in his only extra-point attempt and three of four field goal attempts, with his longest make coming from 54 yards away. Butker could be busy again this week as the Chiefs face the highest scoring offense in the league. The Ravens are averaging 37 points per game through three weeks, nearly three points higher than the Detroit Lions and Indianapolis Colts, who are tied for second. The Chiefs are also home underdogs this week, meaning that they could be chasing points in this game. Butker is ranked K10 in our RotoBaller rankings, making him worthy of a start in most leagues.

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Los Angeles Rams wide receiver Jordan Whittington has been a consistent target for quarterback Matthew Stafford this season. However, as long as he's third on the depth chart behind Puka Nacua and Davante Adams, he can't be trusted in fantasy football. Nacua and Adams are target hogs, and justifiably so, as the two superstars form one of the best wide receiver duos in the NFL. To his credit, Whittington has played well as the No. 3, getting on the field for more than half of the offensive snaps while catching four passes for 49 receiving yards (plus 12 rushing yards). The 24-year-old is a name to keep in the back of your mind, as he could jump to the WR3/flex tier if Nacua or Adams were to miss time. For now, though, he can be left on waivers in redraft leagues.

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Los Angeles Rams kicker Joshua Karty is riding plenty of momentum after a tremendous performance against the Philadelphia Eagles last week. However, he'll fall back off the fantasy radar this week against the Indianapolis Colts for a couple of reasons. First, Karty's four field goals and two extra points last week were likely a statistical anomaly, as he had previously attempted just two field goals over the first two weeks of the season. It's also worth noting that while Karty did make four field goals, he also missed two, indicating some accuracy problems going forward. Furthermore, the Colts' defense has been stingy this year, which rubs off on kicker fantasy value. In fact, Indianapolis has allowed the second-fewest fantasy points to kickers in 2025. Managers should feel compelled to add someone else off waivers this week and leave Karty untouched.

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Los Angeles Rams running back Blake Corum has turned some heads lately, as he's averaging 6.7 yards per carry over his last two contests and has played more than one-quarter of the offensive snaps during that span. Kyren Williams remains the lead back in Los Angeles, but Corum has made a case to earn more touches. We do expect the 24-year-old to play at least 25 percent of the snaps in Week 4 against the Indianapolis Colts, but he's not yet a reliable fantasy option for managers looking to round out their starting lineups. Instead, Corum is best viewed as a handcuff, which means he can be stashed on the bench in leagues with at least 12 teams. Most of his value comes from the points he'd score if Williams ever missed time due to injury, though he could eventually carve out a little bit of standalone value here and there. Fantasy managers should heed this warning and leave Corum out of their lineups, as RotoBaller's experts have him ranked as the overall RB43 in PPR leagues this week.

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Los Angeles Rams quarterback Puka Nacua has exceeded expectations through his first three games of the 2025 season, turning in 29 catches for 333 yards (plus one rushing touchdown) while ranking as the overall WR1. There has been nobody better at the position in fantasy football this season, and he has a chance to finish atop the podium once again in Week 4 against the Indianapolis Colts. Nacua has shown that he can have extremely positive standalone value while co-existing with Davante Adams, but he could be even more valuable if Adams (hamstring) isn't 100 percent against the Colts. Plus, the young receiver is catching passes from Matthew Stafford, who owns a 66.3 percent completion rate so far. RotoBaller's experts have Nacua ranked as the overall WR1 in fantasy football this week.

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Kansas City Chiefs tight end Travis Kelce takes on the Baltimore Ravens this Sunday in Week 4. Kelce finished second on the team in targets last week but finished with four catches for just 26 yards. It is clear to see that the veteran tight end is past his prime, but he's still a top-12 tight end for the season. Kelce will look to make an impact this week against the Ravens, who've allowed the eighth-most fantasy points to opposing tight ends this season. The 35-year-old should still be a viable fantasy option due to his level of utilization in the Chiefs offense. Kelce has run the seventh-most routes and earned the 10th-most targets among tight ends this season. Kelce is ranked TE8 in our RotoBaller Half-PPR rankings, making him a mid-range TE1 this week.

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