Tennessee Titans running back Tyjae Spears (ankle) suffered a high ankle sprain in preseason action and was placed on Injured Reserve before the start of the regular season. Given the nature of Spears' injury, he may be able to return as soon as he is eligible in Week 5 against the Arizona Cardinals. The Titans have been a one-man show at running back so far this season, with Tony Pollard having logged 38 of the team's 40 rush attempts by running backs through the team's first two games. However, this was not the case down the stretch of 2024, when Spears logged double-digit touches in each of the final three games he played. Spears finished the 2024 season with 536 yards from scrimmage and five touchdowns across 12 games and should have a consistent role in the Titans' offense once healthy in 2025. In fantasy leagues where he is available, Spears is a worthy stash in an IR spot ahead of his impending return.

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Heading into Week 2, Kansas City Chiefs wide receiver Marquise Brown was a popular waiver-wire target following his 16-target, 10-catch performance in Week 1. Even with top Chiefs wideouts Xavier Worthy (shoulder) and Rashee Rice (suspension) sidelined in Week 2, Brown was not nearly as prolific against the Philadelphia Eagles, finishing with five receptions for 30 yards. Early indications are that Worthy could return for Kansas City's Week 3 matchup against the New York Giants, which could limit Brown's target volume even further. Still, the 28-year-old looks like the Chiefs' clear WR2 until Rice is eligible to return in Week 7. Brown profiles as a WR4/low-end flex option in Week 3, although his outlook would improve if Worthy misses another game.

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San Francisco 49ers tight end George Kittle (hamstring) suffered a hamstring injury and was placed on Injured Reserve prior to Week 2. As a result, the 31-year-old will not play until at least Week 6, when San Francisco is set to take on the Tampa Bay Buccaneers. In the 49ers' first game without Kittle in Week 2, tight ends Luke Farrell and Jake Tonges combined for six catches, 45 receiving yards, and a touchdown. Kittle's return timeline could coincide with returns for 49ers quarterback Brock Purdy (toe) and wide receiver Brandon Aiyuk (knee). That could mean that San Francisco's offense could be firing on all cylinders when it welcomes Kittle back to the lineup. For fantasy managers with an open IR spot, this could be an interesting time to try and buy low on Kittle.

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Houston Texans wide receiver Tank Dell (knee) suffered a gruesome knee injury in December 2024, dislocating his knee and tearing his ACL, MCL, and LCL. The 25-year-old wideout was placed on the reserve/physically unable to perform list in August, meaning he is not eligible to return until Week 5. The most likely scenario remains that Dell will be out far longer than that. Given the timing of his 2024 injury, it would not be surprising if Dell does see any game action in 2025. Dell is worth stashing for future production in dynasty leagues, but he should not be on the radar of redraft fantasy managers unless there is a significant change in his return status.

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Seattle Seahawks running back Kenneth Walker III acknowledged that Zach Charbonnet is expected to continue splitting the backfield with him. Through two games, Charbonnet has outsnapped Walker (56% to 38%) and handled more carries (27 to 23). Head coach Mike MacDonald reinforced that approach, saying, "We're playing the long game. We want both backs to play the whole year." Walker also stated that he's buying into the committee approach to preserve his health. "I believe we have two great backs." Walker's history of injuries is expanding, as he missed six games in 2024 and multiple others earlier in his career. For fantasy purposes, Walker's upside is capped, and he should be valued as a high-end RB3 rather than his typical high-end RB2 profile.

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Carolina Panthers wide receiver Jalen Coker (quad) is expected to play a significant role in the team's passing attack once he returns from injury. The second-year receiver suffered a notable quad strain prior to the season and was placed on injured reserve. In his absence, Hunter Renfrow has stepped into a larger role, playing 79% of the snaps through two weeks and catching seven passes on nine targets for 48 yards and two touchdowns in Week 2. While Renfrow has been serviceable, the Panthers view Coker as a core piece moving forward. Fantasy managers should consider stashing him ahead of his potential Week 6 return.

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Miami Dolphins CB Storm Duck (ankle) and S Ifeatu Melifonwu (calf) did not practice on Tuesday, Sept. 16. CB Ethan Bonner (hamstring), C Aaron Brewer (hip), DT Benito Jones (oblique), LB Chop Robinson (knee), WR Jaylen Waddle (shoulder), TE Darren Waller (hip), WR Malik Washington (thumb) and RB Jaylen Wright (knee) were limited.

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New England Patriots rookie wide receiver Kyle Williams has yet to carve out a meaningful role in the offense. Through the first two games of the season, the 2025 third-round pick has been on the field for just 13% of the team's snaps and has only one target to show for it. Williams has been buried on the depth chart behind veterans Stefon Diggs, Mack Hollins, and younger receivers Kayshon Boutte and DeMario Douglas, all of whom have earned more consistent playing time. Until his role grows, Williams holds little fantasy appeal and is droppable in most formats.

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Minnesota Vikings wide receiver Jordan Addison will return from suspension in Week 4 when the team faces the Pittsburgh Steelers in London. Addison is serving the final game of his three-game suspension for offseason DUI charges. As a key piece of the Vikings' offense, Addison has posted 133 receptions for 1,786 yards and 19 touchdowns through his first 32 NFL games. However, his fantasy outlook has dipped with rookie quarterback J.J. McCarthy battling inconsistency and a high-ankle sprain early in the season. Addison should be reinserted into lineups as a low-end FLEX option upon his return, with room for upside if McCarthy improves from under center.

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Kansas City Chiefs wide receiver Rashee Rice is expected to return to a full workload in Week 7 after serving his six-game suspension for reckless driving charges stemming from the 2024 offseason. In his three full games last year, Rice was highly efficient, catching 24 of 29 targets for 288 yards and two touchdowns. The Chiefs' passing attack has struggled in his absence, with Patrick Mahomes currently sitting outside the top 15 in passing yards through two weeks. Rice's return should immediately boost the offense, making him a high-end WR2 in fantasy and providing Mahomes with a much-needed reliable weapon. His presence will likely cut into the target shares of Travis Kelce and Marquise Brown, though both will remain heavily involved.

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San Francisco 49ers legend Jerry Rice urged fans to temper expectations for wide receiver Brandon Aiyuk earlier this offseason, noting, "It's going to take some time for him. I'd rely on those other guys to do most of the work and blend (Aiyuk) back in." Aiyuk is still recovering from the torn ACL and MCL he suffered in Week 7 of last season and has yet to resume practicing. In his absence, the 49ers have started 2-0 with steady contributions from Jauan Jennings and rookie Ricky Pearsall. With no firm return timeline, Aiyuk remains an uncertain fantasy asset and should not be counted on for meaningful production in 2025.

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Miami Dolphins quarterback Tua Tagovailoa bounced back statistically in Week 2, completing 26 of 32 passes for 315 yards, two touchdowns, and one interception in the loss to the New England Patriots. While he topped 300 passing yards, he was sacked five times and sealed the defeat with a late fourth-quarter interception. Tagovailoa now faces the Buffalo Bills on a short week, a matchup that has consistently given him trouble. He has lost five straight starts against Buffalo, posting seven touchdowns and five interceptions during that span. With Miami's offensive line struggling to protect him, Tagovailoa is best left on fantasy benches in Week 3.

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Cleveland Browns running back Quinshon Judkins has been listed as the team's starting back on this week's depth chart. The rookie played just 26% of the snaps in Week 2 but was effective with his touches, rushing 10 times for 66 yards in his NFL debut. Judkins signed his rookie deal shortly before Week 1 and eased into action against the Baltimore Ravens, but being elevated to the top of the depth chart is an encouraging sign for his role going forward. That said, Week 3 sets up as a tough spot. The Browns face the Green Bay Packers, who have been one of the league's stingiest defenses to start the season. With a negative game script possible, Judkins should be viewed as a low-end FLEX option in deeper leagues this week, though his long-term outlook is trending up.

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Cleveland Browns rookie running back Dylan Sampson was listed as the No. 2 back on the Week 3 depth chart, slotting in ahead of veteran Jerome Ford but behind second-round pick Quinshon Judkins. However, the usage tells a different story. In last week's loss to the Baltimore Ravens, Ford played 49% of the snaps compared to just 24% for Sampson, suggesting the coaching staff still trusts the veteran on passing downs. It's unclear whether the updated depth chart reflects a genuine shift or is more of a formality, but for fantasy purposes, Sampson managers should be cautious. With the Browns set to face the red-hot Green Bay Packers defense in Week 3, Sampson is highly unlikely to make a fantasy impact and is best left on benches in all formats.

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Miami Dolphins wide receiver Jaylen Waddle (shoulder) was limited in Tuesday's practice ahead of Thursday night's divisional matchup with the Buffalo Bills. Waddle wasn't listed on Monday's injury report, but his appearance Tuesday raises some concern given the short week. The former 1,000-yard receiver briefly exited Week 1 with a shoulder issue before returning, and while he found the end zone in Week 2 against New England, he finished third on the team in targets behind Tyreek Hill and De'Von Achane. Waddle has also historically struggled against Buffalo's defense, putting up under 50 yards in their last three contests. With Miami's offense searching for rhythm and Waddle not at full strength, he profiles as more of a low-end FLEX option in Week 3.

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Through two weeks of the 2025 campaign, Pittsburgh Steelers tight end Jonnu Smith has caught nine passes for 42 yards and a touchdown on 10 targets. While the production hasn't popped for fantasy yet, Smith's usage in his first year as a Steeler is encouraging. In addition to besting teammate Pat Freiermuth in snaps and routes run, Smith is averaging three designed opportunities per game, the most of any tight end in the NFL. Pittsburgh's offense still needs to find its rhythm before Smith can be trusted every week, but he's firmly on the streaming radar. The ninth-year pro carries some PPR upside in Week 3 against the New England Patriots.

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Houston Texans wide receiver Braxton Berrios (hamstring) is expected to return in Week 3 against the Jacksonville Jaguars after missing the first two games of the season. Head coach DeMeco Ryans expressed optimism about his availability for the divisional matchup. The veteran slot receiver and return specialist, who previously spent time with the Jets and Dolphins, faces an uphill battle for snaps. With Christian Kirk also on track to return and rookie Jaylin Noel making noise in the return game, Berrios is buried on the depth chart. He should remain well off the fantasy radar in all formats.

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Las Vegas Raiders running back Dylan Laube could be in line for a slight uptick in playing time this week against the Washington Commanders. Laube logged just 18% of the offensive snaps in the Week 2 loss to the Los Angeles Chargers but managed to catch two passes for 17 yards, flashing the receiving skills that made him a standout in college. Head coach Pete Carroll suggested the team may work him in more on offense after limiting him almost exclusively to special teams in Week 1. For now, Laube remains buried on the depth chart behind Ashton Jeanty and Zamir White, leaving him without any immediate fantasy value. Still, the fact that the Raiders are looking to carve out a role for him in the passing game is a positive sign for his long-term outlook.

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Green Bay Packers wide receiver Jayden Reed (foot, shoulder) announced on social media on Tuesday that he had successful surgeries on his clavicle and foot. Reed had been dealing with a Jones fracture in his foot since late in training camp, but he played in the first two weeks of the season before fracturing his collarbone early in last Thursday night's win over the Washington Commanders. The 25-year-old has since been placed on Injured Reserve and was given an estimated timetable for a return of six to eight weeks. By the time Reed returns, there's a chance fellow wideout Christian Watson (knee) will be back after he tore his ACL in Week 18 of last year. Reed is a stash candidate in pretty much all fantasy leagues, but Green Bay's receiving corps will be even more crowded when he makes his way back. In the meantime, Romeo Doubs, Dontayvion Wicks, and rookie first-rounder Matthew Golden will operate in three-wide sets, while tight end Tucker Kraft may continue to be quarterback Jordan Love's top target.

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Pittsburgh Steelers rookie running back Kaleb Johnson "probably" will lose kickoff-return duties in Week 3 against the New England Patriots after a crucial special-teams gaffe in the Week 2 loss to the Seattle Seahawks, according to head coach Mike Tomlin. Johnson allowed a kickoff to bounce over his head and into the end zone on Sunday in the fourth quarter because he thought the play would be called dead. But with the NFL's new kickoff rules, it was a live ball, which the Seahawks recovered for a game-changing touchdown. The Steelers will give Johnson a chance to work his way back into the special teams role, but in the short term, he'll be benched. Fantasy managers had high hopes for the 22-year-old during draft season, but Jaylen Warren's demise has been premature, and Kenneth Gainwell has operated as the No. 2. Johnson only played two snaps on offense in Week 2 and has just two carries for a loss of one yard in his first two NFL games. His special-teams gaffe on Sunday certainly didn't help his cause for a bigger role on offense.

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