Indianapolis Colts wide receiver Alec Pierce will host the Denver Broncos in Week 2 after enjoying a blowout win over the Miami Dolphins in Week 1. Pierce was mostly quiet, catching just one of his three targets for a 36-yard gain in the contest. The veteran will look for more work in a tough matchup against a Broncos secondary that shut down the Tennessee Titans pass-catchers in Week 1. Pierce can be very boom/bust, but is not a recommended fantasy option unless desperate in Week 2.

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Indianapolis Colts wide receiver Adonai Mitchell will take on the Denver Broncos at home in Week 2. Mitchell only played on 15 snaps in Week 1's win over the Miami Dolphins, catching both of his targets for 21 yards. The Broncos represent a difficult matchup for the Colts' pass-catchers this weekend as they shut down the Tennessee Titans' pass attack in Week 1. Mitchell is not playing enough to be trustworthy in fantasy and should remain on benches heading into Week 2.

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Indianapolis Colts kicker Spencer Shrader will host the Denver Broncos in Week 2. Shrader had a big Week 1, hitting all four of his field-goal attempts and adding three extra points in a 33-8 win over the Miami Dolphins. The Colts might have a tougher time moving the ball on offense in Week 2 as the Broncos possess one of the top defenses in the league. Shrader is worth monitoring in fantasy thanks to his strong Week 1, but he should not be in fantasy lineups heading into Week 2 due to the imposing matchup.

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Indianapolis Colts wide receiver Josh Downs will take on the Denver Broncos at home in Week 2. Downs turned in a disappointing Week 1 performance in a win over the Miami Dolphins despite the Colts scoring 33 points, catching just two of three targets for 12 yards. The veteran slot receiver will look to bounce back after that performance, but might have a tough time doing so against an intimidating Broncos secondary. That being said, top Denver cornerback Patrick Surtain II is likely to spend more time on the outside covering Michael Pittman Jr., Adonai Mitchell, and Alec Pierce, which should open things up for Downs in the middle of the field. Downs has some appeal as a dart-throw flex option in PPR leagues, but he is better left on fantasy benches this weekend unless desperate.

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Indianapolis Colts wide receiver Michael Pittman Jr. (glute) will host the Denver Broncos in Week 2. Pittman was listed on the injury report with a glute issue after Week 1, but he practiced fully all week and has no injury status heading into Sunday. The veteran wideout turned in a solid game in a Week 1 win over the Miami Dolphins, leading the team with 80 receiving yards and a touchdown. He might have a tougher time getting going against lockdown corner Patrick Surtain II in Week 2, however. Treat Pittman as a flex option, but don't be afraid to leave him on the bench if you have a better option due to the tough matchup.

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Baltimore Ravens wide receiver DeAndre Hopkins proved why he's a three-time All-Pro with an amazing one-handed grab against the Buffalo Bills for a touchdown. While his days of 100+ targets per season are in the rearview mirror, he can still play that outlet role whenever called upon. The biggest issue for fantasy managers is that it's nearly impossible to predict which games he'll be more involved in compared to the others. In Week 2, he'll go up against the Cleveland Browns, who do have a better and more aggressive defensive unit. Hopkins might be viable in very deep leagues, but he likely won't receive more targets than Mark Andrews again, which would leave him around fourth in the target pecking order. So managers in 12-team leagues can safely leave him on the bench.

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Indianapolis Colts running back Jonathan Taylor will host the Denver Broncos in Week 2. Taylor turned in a solid, if unspectacular, Week 1 performance in a win over the Miami Dolphins, rushing for 71 yards and catching three passes for 27 yards. He will look to find the end zone against a talented Denver defense that allowed just the 21st-most fantasy points per game to running backs in 2024. The Broncos continued that trend in Week 1 as they shut down the running game of the Tennessee Titans, holding Tony Pollard to 3.3 yards per carry. Taylor should see plenty of volume, but the tough matchup downgrades him to more of a low-end RB1 in fantasy this weekend.

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Carolina Panthers rookie wide receiver Tetairoa McMillan led the Panthers with 68 receiving yards and five receptions on nine targets in their Week 1 loss to the Jacksonville Jaguars. Considering the poor play of quarterback Bryce Young and the Panthers' offense as a whole, McMillan's fantasy output in PPR leagues wasn't terrible (11.8 PPR points). However, if you roster McMillan in fantasy, you likely need him to produce WR2 numbers, which he didn't quite do in Week 1. Heading into Week 2 against the Arizona Cardinals, McMillan will once again have opportunities, as he was on the field for 83% of the Panthers' offensive plays in Week 1, leading all Panthers wideouts. The question is whether the Panthers' offensive line can give Young enough time to get the ball downfield for big plays to the big-bodied McMillan. If Young can improve in Week 2, it is expected that McMillan will outscore his Week 1 total. McMillan is a solid WR3/Flex option with WR2 upside heading into Week 2 against Arizona.

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Kansas City Chiefs kicker Harrison Butker will face the Philadelphia Eagles on Sunday in Week 2. This Super Bowl rematch could prove beneficial for Butker's fantasy relevance because of the strong Eagles defense. If the Kansas City offense is unable to complete drives, Butker could be asked to pick up the points with his leg. The veteran kicker knocked through all three of his field goal attempts in their Week 1 loss to the Los Angeles Chargers, but ultimately missed the extra point attempt following a rushing touchdown from Patrick Mahomes in the third quarter. Butker has been one of the most consistent kickers in the league since his debut, and he will hope to continue the trend in Week 2. Butker is ranked K13 in our RotoBaller rankings this week, making him a fringe starter in a 12-team league.

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Kansas City Chiefs tight end Travis Kelce will face the Philadelphia Eagles in a Super Bowl rematch this Sunday. The 35-year-old reeled in just two passes for 47 yards and a touchdown in their Week 1 loss to the Los Angeles Chargers. 37 of Kelce's 47 yards came on his long touchdown catch and run in the fourth quarter. Despite salvaging his fantasy day with a long scoring play, the usage for Kelce in last week's game was concerning, to say the least. Xavier Worthy was knocked out early in the first quarter when he and Kelce collided. Despite the loss of Worthy and the absence of Rashee Rice due to suspension, Kelce was still only targeted four times in 39 pass attempts for Patrick Mahomes. The veteran tight end will have to take on the Eagles, who held him to four catches for 39 yards in the Super Bowl. Kelce is ranked TE5 in our RotoBaller rankings this week, making him a mid-range TE1 despite the matchup. Kelce should still be considered a TE1, but his floor could be much lower than it has been in years past.

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Kansas City Chiefs running back Isiah Pacheco will face the Philadelphia Eagles in Week 2. The defending Super Bowl champions defeated the Chiefs in their last matchup, and Pacheco only had seven rushing yards on three carries. The 26-year-old will have the chance to exact some revenge, but he must first overcome the timeshare he's in with Kareem Hunt. Pacheco and Hunt had the same number of opportunities in Week 1; both handled five carries and two catches on three targets. The former ultimately finished with more total yards, but it was not an impressive performance by either back. Pacheco did manage 5.0 yards per carry when given the opportunity, so maybe he can build on that efficiency with more usage. That said, the Eagles defense was one of the toughest in the league to run against last season, and that looks to be the case again this year. Pacheco will have his work cut out for him if he wants to carve out a larger role in the Kansas City backfield. Pacheco is ranked RB35 in our RotoBaller rankings this week, making him an RB3/Flex option. He'll be a tough player to trust this week.

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Kansas City Chiefs running back Kareem Hunt will take on the Philadelphia Eagles at home this Sunday. Hunt received an identical workload to Isiah Pacheco and produced similar results. The veteran back was less efficient with his carries but picked up more receiving yards in his three opportunities. It is also important to note that Hunt appeared to be the preferred back on passing downs and short yardage situations. If this usage continues, Hunt could end up being the more fantasy-relevant player in this backfield. The Chiefs deployed Hunt in goal-line situations last season, and he was successful in that role, so it's possible that he retains that job. That said, the backfield usage was split 50/50, and it will be a difficult situation to deal with unless one player starts commanding more touches. Hunt will have to face a stout Eagles defense this week, so even if he gets more work, it could be hard to get anything going. Hunt is ranked RB48 in our RotoBaller rankings this week, making him a deeper league flex option. It might be best to wait and see how this backfield shakes out.

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San Francisco 49ers kicker Eddy Pineiro signed with the team on September 10, in the wake of the release of Jake Moody. Pineiro does not have Moody's leg strength, but he is certainly more accurate. Despite attempting twice as many field goals as Moody in his career (126 to 62), Pineiro has one fewer miss (15 to Moody's 16). San Francisco's offense has been bitten by the injury bug, including quarterback Brock Purdy (toe, shoulder), who has been ruled out for Sunday's game against the Saints. With Mac Jones at the helm, the offense's potential takes a step back, placing greater reliance on the team's kicker to put up points, however possible. Consider Pineiro a serviceable streamer for Week 2.

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Kansas City Chiefs quarterback Patrick Mahomes will take on the Philadelphia Eagles in Week 2 for a Super Bowl rematch. The last time these two teams matched up, the Eagles ended up taking home the Lombardi trophy. Jalen Hurts and the gang are coming off a Thursday night win over the Dallas Cowboys in Week 1, while the Chiefs suffered a one-possession loss to the Los Angeles Chargers on Friday. The 29-year-old had a decent performance against the Chargers, passing for 258 yards and a touchdown while adding 57 yards and a score on the ground. That said, Mahomes will have the odds stacked against him on Sunday, facing one of the best defenses in the league without two of his top offensive weapons. Rashee Rice is still serving his suspension, and Xavier Worthy is listed as doubtful for the upcoming matchup. Despite playing at Arrowhead this weekend, Mahomes and the Chiefs are home underdogs against the Eagles. The Chiefs quarterback is ranked QB11 in our RotoBaller rankings this week, making him a fringe-QB1.

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San Francisco 49ers tight end Jake Tonges was the hero of the team's Week 1 victory over the Seattle Seahawks. Tonges stepped in for an injured George Kittle (hamstring) and caught the go-ahead touchdown with just over a minute and a half left in the game. With Kittle now on injured reserve, Tonges is now the favorite to act as San Francisco's first-string tight end. Unfortunately, quarterback Brock Purdy (toe, shoulder) has been ruled out for the 49ers' next game, meaning Mac Jones will be under center when they face the Saints on Sunday. Tonges had the play of the game but saw only two other targets in Kittle's stead last week. Fantasy managers looking for streaming tight end options can probably find a more reliable option on the wire for Week 2.

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Wide receiver Kendrick Bourne signed a one-year deal with the San Francisco 49ers on September 9, returning to the team that gave him his start in the NFL in 2017. The signing was in light of injuries sustained in Week 1 by key pass catchers George Kittle (hamstring), who is now on injured reserve, and Jauan Jennings (shoulder), who is questionable for Week 2. Quarterback Brock Purdy (toe, shoulder) is also dealing with injuries and has been ruled out for Sunday's game against the Saints. Taking over the offense will be Mac Jones, who was Bourne's teammate for three years in New England, from 2021 to 2023. Bourne should not be in starting lineups but could be a bench stash in deeper leagues in case he shows renewed chemistry with Jones, given Purdy might be facing a multi-week absence.

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San Francisco 49ers wide receiver Skyy Moore stands little chance of making an impact in Week 2, despite the injury bug biting key players on offense. Even though tight end George Kittle (hamstring) is on injured reserve and wide receiver Jauan Jennings (shoulder) is questionable for Sunday's game against the Saints, veterans Marquez Valdes-Scantling and Kendrick Bourne stand in Moore's way on the depth chart. Moore played just three snaps in Week 1, and even if he does see a greater run on Sunday, the offense will be helmed by Mac Jones and not Brock Purdy (toe, shoulder), who has been ruled out. Moore's only path to fantasy relevance is in leagues that count return yards. Last week against Seattle, he fielded one kickoff and four punts, totaling 63 return yards.

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San Francisco 49ers wide receiver Marquez Valdes-Scantling saw zero targets on 15 routes run in Week 1. With George Kittle (hamstring) now on injured reserve and Jauan Jennings (shoulder) tagged as questionable for San Francisco's Week 2 matchup against the Saints, it is possible that Valdes-Scantling plays a bigger role on Sunday. Unfortunately, Brock Purdy (toe, shoulder) has been ruled out so it will be Mac Jones under center, limiting Valdes-Scantling's upside even if he does see more playing time. MVS does have the ability to stretch the field but Jones' career completion rate on passes of 20 or more air yards is a mere 30%, effectively negating that threat. If it were Purdy running the show, Valdes-Scantling would have more potential but as it is, he has little viability in Week 2.

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New York Giants kicker Graham Gano is a possible fantasy option for Week 2 against the Dallas Cowboys, depending on your league. Gano was responsible for all six of the Giants' points in Week 1, making both of his field goal attempts, including a long of 52 yards, for 8 fantasy points. This puts him in a decent position among fantasy kickers, especially since he has a 100% field goal percentage so far. His opportunities for scoring could increase against a Dallas team that gave up 11 fantasy points to kickers in Week 1 of the 2025 season. Given the Giants' offensive struggles and Gano's reliable leg, he should be considered for Week 2.

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New York Giants quarterback Jaxson Dart is not a recommended fantasy option for Week 2 against the Dallas Cowboys, as he is not expected to play. Although the rookie first-round draft pick has impressed in the preseason and is the team's QB2, head coach Brian Daboll has publicly stated that Russell Wilson will remain the starter for Sunday's game. There is some speculation that Dart could see action if Wilson struggles, but given that he has no regular-season statistics for 2025, his fantasy outlook is entirely dependent on an in-game change. Therefore, Dart should be left on the bench or waiver wire for this matchup.

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