New York Giants wide receiver Malik Nabers (right knee) will undergo an MRI on Monday to confirm his diagnosis of a torn ACL, according to ESPN's Adam Schefter. Nabers suffered a severe knee injury while attempting to make a catch near the sideline during the first quarter of Sunday's Week 4 contest against the Los Angeles Chargers. Several NFL media insiders have already reported that the Giants fear Nabers tore his ACL, but we won't get official confirmation until Monday. Assuming his season is over, Wan'Dale Robinson and Darius Slayton will operate as the primary receivers in Jaxson Dart's offense.

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Los Angeles Rams tight ends Tyler Higbee (hip) and Colby Parkinson (shoulder) are officially active for Sunday's Week 4 contest against the Indianapolis Colts. Both players had been listed as questionable, and Higbee's status in particular was uncertain after he missed practice on Friday. In the end, Higbee will suit up, looking to turn around what has been a disappointing start to the season. He has just four catches so far, and all of them came in a singular Week 2 game. Meanwhile, Parkinson has two catches and a lost fumble through two games. Neither tight end should be rostered in fantasy football.

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Baltimore Ravens tight end Isaiah Likely (foot) is officially active for Sunday's Week 4 contest against the Kansas City Chiefs. He had been listed as questionable but was trending in the right direction after logging a full practice Friday. The 25-year-old is making his 2025 season debut after being sidelined for the first three weeks. He's looking to build off an impressive 2024 campaign in which he had a career-high 42 catches, 477 yards, and six touchdowns while ranking as the overall TE16. Mark Andrews is still the No. 1 tight end in Baltimore, especially after catching two touchdown passes last week, but Likely will still carve out a role and could also be a top-24 fantasy tight end.

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San Francisco 49ers quarterback Mac Jones (knee) is active for Sunday's Week 4 contest against the Jacksonville Jaguars. He had been listed as questionable. Jones led the 49ers to a pair of victories in place of Brock Purdy (shoulder) over the last two weeks, and while he played admirably, he'll head back to the bench with Purdy healthy. Jones can be dropped to waivers in all redraft leagues.

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Atlanta Falcons wide receiver Darnell Mooney (hamstring) has been ruled out for the remainder of Sunday's Week 4 contest against the Washington Commanders in Week 4. He exited during the second half and was initially listed as questionable before being downgraded to out. Mooney caught just one pass for 15 yards before his departure, but his role seemed to be trending upward after he earned 11 targets in Week 3. Ray-Ray McCloud will operate as the No. 2 wide receiver alongside Drake London until Mooney is healthy enough to play.

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San Francisco 49ers wide receiver Ricky Pearsall (knee) is officially active for Sunday's Week 4 contest against the Jacksonville Jaguars. He had been listed as questionable but was trending in the right direction ahead of kickoff. Pearsall and Jauan Jennings (ankle, shoulder) are both healthy for Sunday's game, and they'll get a bit of a boost now that Brock Purdy (shoulder) is healthy enough to play for the first time since Week 1. Pearsall had 108 yards in his last game with Purdy, and he's averaging 94 yards per game this season, so we expect the second-year receiver to continue making a big impact Sunday. He ranks as a low-end WR2 versus Jacksonville.

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Chicago Bears running back D'Andre Swift (hip) is officially active for Sunday's Week 4 contest against the Las Vegas Raiders. He was listed as questionable after being a limited participant in practice. Swift has delivered modest production through the first three games of the season, amassing 143 rushing yards, 69 receiving yards, and one touchdown. He ranks as the 24th-best running back in terms of fantasy scoring but should really be viewed as a mid-to-low RB3/flex, especially given that his snap share has declined since Week 1. We could see more Kyle Monangai on Sunday, but Swift will still be the primary option.

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Chicago Bears tight end Colston Loveland (hip) is officially inactive for Sunday's game against the Las Vegas Raiders. The rookie had been listed as questionable. He missed two practices before being able to log a limited session Friday, but it evidently wasn't quite enough for him to play this week. Loveland has operated in a depth role this season, catching just three of his six targets through three games. On the other hand, Cole Kmet has played at least 90 percent of the snaps in all three contests so far, so he remains an interesting fantasy option whose value will only increase with Loveland sidelined. Kmet should be viewed as a mid-range TE2 for the duration of Loveland's absence.

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Las Vegas Raiders running back Zamir White (coach's decision) is a healthy scratch for Sunday's Week 4 contest against the Chicago Bears. White had operated as the direct backup to Ashton Jeanty for each of the first three weeks of the season, but it appears that he has fallen to fourth on the depth chart for the time being. Dylan Laube and Raheem Mostert will be active as depth options behind Jeanty.

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New York Giants wide receiver Malik Nabers (knee) is believed to have suffered a torn ACL during his team's Week 4 matchup against the Los Angeles Chargers, according to Ian Rapoport and Tom Pelissero of NFL Network. Nabers was carted off during the first half after planting awkwardly on his knee. The superstar wideout recorded two catches for 20 yards on three targets before getting injured. Losing Nabers is a devastating blow for the Giants' offense. Without him, wide receivers Darius Slayton and Wan'Dale Robinson should both be expected to see an uptick in targets.

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Atlanta Falcons wide receiver Darnell Mooney (hamstring) is questionable to return against the Washington Commanders in Week 4. He exited during the second half and caught just one pass for 15 yards before his departure. The 27-year-old has seen mixed results this season, as his usage was underwhelming in Week 2 and the start of Week 4. However, he was heavily involved last week, converting 11 targets into four catches. What seemed like a potential ascension into a 1B role for Mooney has been halted as he now battles a hamstring injury. In the meantime, Kyle Pitts and Ray-Ray McCloud will operate as some of the supplementary pass catchers behind Drake London.

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Los Angeles Rams TE Tyler Higbee (hip) is officially active for the Week 4 game.

Fantasy Spin: Higbee is off to a quiet start to the season and probably will not see many targets this week. He can be avoided in fantasy leagues.

From TheHuddle

The Chicago Bears have declared OT Darnell Wright, LB T.J. Edwards, QB Case Keenum, DT Chris Williams, TE Colston Loveland, DL Grady Jarrett and CB Kyler Gordon inactive for Week 4.

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San Francisco 49ers wide receiver Jauan Jennings (ankle, shoulder) is officially active for his team's Week 4 matchup against the Jacksonville Jaguars, per Tom Pelissero of NFL Network. Jennings missed Week 3 and was only able to log one limited practice this week. The 28-year-old has recorded seven catches for 105 yards and a touchdown on 15 targets across two games so far in 2025. Jennings may be working on a limited snap count in Week 4, so fantasy managers may be wise to temper their expectations. He profiles as a WR3/flex option against Jacksonville in Week 4.

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Jacksonville Jaguars wide receiver Dyami Brown (shoulder) is inactive for his team's Week 4 matchup against the San Francisco 49ers due to a shoulder injury. Brown has recorded 10 catches for 116 yards and a touchdown through his first three games of 2025. In his absence, Jaguars wide receivers Brian Thomas Jr. and Parker Washington should see an uptick in targets. Additionally, rookie wideout/cornerback Travis Hunter could see a larger workload on the offensive side of the ball to make up for Brown being sidelined. Both Washington and Hunter profile as low-end, deep-league flex options in Week 4.

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Los Angeles Rams wide receiver Davante Adams (hamstring) is officially active for his team's Week 4 matchup against the Indianapolis Colts, per NFL Network's Tom Pelissero. Adams missed practice on both Wednesday and Thursday of this week and was listed on the injury report as questionable heading into Sunday. The veteran wideout has recorded 13 catches for 213 yards and two touchdowns so far in 2025. Now that he's officially good to go, Adams is a must-start fantasy wide receiver in Week 4 against the Colts.

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The San Francisco 49ers have declared WR Marquez Valdes-Scantling, RB Jordan James, WR Jordan Watkins, DT CJ West, LB Nick Martin and CB Renardo Green inactive for Week 4.

From TheHuddle

Los Angeles Rams WR Davante Adams (hamstring) is officially active for the Week 4 game.

Fantasy Spin: Adams missed some practice this week but should be able to see his normal workload against the Indianapolis Colts. He can be at least a No. 2 receiver in all fantasy leagues.

From TheHuddle

New York Giants wide receiver Malik Nabers (knee) has been carted off the field from his team's Week 4 matchup against the Los Angeles Chargers due to a knee injury, per ESPN's Adam Schefter. Nabers had recorded two catches for 20 yards on three targets before getting injured. Losing Nabers would be a devastating blow for the Giants' offense. While the severity of his injury is not yet known, it's not a good sign that he was unable to leave the field under his own power. If Nabers is sidelined, Giants wide receivers Darius Slayton and Wan'Dale Robinson would likely see an increase in targets.

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Cleveland Browns wide receiver Cedric Tillman (hamstring) has been ruled out for the remainder of his team's Week 4 matchup against the Detroit Lions due to a hamstring injury. Tillman had one catch for six yards on two targets before getting injured. The 25-year-old is a key piece of the Cleveland passing game. In his absence, Browns wide receivers Jerry Jeudy and Isaiah Bond will likely see an uptick in both playing time and target share.

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