Tampa Bay Buccaneers wide receiver Mike Evans (hamstring) exited during the fourth quarter of Sunday's Week 3 contest against the New York Jets. He is officially questionable to return. At the time of his departure, he had caught four of his eight targets for 33 yards and one touchdown. Tampa Bay has plenty of talent on the offensive side of the ball, but Evans is arguably the Bucs' most reliable playmaker, so losing him is a tough blow. Until he can return, Ryan Miller and Sterling Shepard will rotate in alongside Emeka Egbuka.

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Indianapolis Colts wide receiver Alec Pierce (concussion) has been ruled out for the remainder of Sunday's Week 3 contest against the Tennessee Titans. He exited after an incomplete pass downfield that resulted in Pierce's head violently banging off the turf. The 25-year-old finishes Sunday's game with four receptions for 67 yards through the air. He will now enter concussion protocol, raising immediate concerns about his Week 4 availability. The Colts play against the Los Angeles Rams next Sunday, giving Pierce just one week to recover and clear protocol. Ashton Dulin and Adonai Mitchell should command additional targets behind Michael Pittman Jr. and Josh Downs.

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Chicago Bears running back D'Andre Swift (quadriceps) is officially active for Sunday's Week 3 contest against the Dallas Cowboys. He had been listed as questionable but was trending in the right direction ahead of gameday. The veteran running back will play through his injury while leading Chicago's backfield against Dallas. He has delivered very modest production through two weeks, totaling 35 touches, 134 scrimmage yards, one touchdown, and one lost fumble. He ranks as a mid-range RB3/flex in fantasy football.

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Washington Commanders CB Marshon Lattimore (concussion) is being evaluated for concussion in the Week 3 game against the Las Vegas Raiders.

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Philadelphia Eagles CB Adoree' Jackson (groin) suffered a groin injury during the Week 3 game and is considered questionable to return.

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Washington Commanders wide receiver Terry McLaurin (quad) exited during the third quarter of Sunday's Week 3 contest against the Las Vegas Raiders. He is officially questionable to return. At the time of his departure, he had caught three of four targets for 74 yards through the air, coming just inches short of a touchdown reception. While McLaurin's production may appear modest, he actually leads the Commanders in targets, receptions, and receiving yards. Washington has been able to run the ball effectively while leading Las Vegas by multiple touchdowns, resulting in a reduced passing workload for Marcus Mariota. Jaylin Lane, Chris Moore, and Luke McCaffrey should earn more targets behind Deebo Samuel Sr. until McLaurin can return.

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Jacksonville Jaguars wide receiver Dyami Brown (shoulder) exited during the second quarter of Sunday's Week 3 contest against the Houston Texans. He suffered the injury on a reception near the goal line and is officially questionable to return. At the time of his departure, he had caught two of three targets for seven yards through the air. Brown's absence should lead to more opportunities for Tim Patrick and Parker Washington behind Brian Thomas Jr. and Travis Hunter.

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Las Vegas Raiders tight end Michael Mayer (concussion) has been ruled out for the remainder of Sunday's Week 3 contest against the Washington Commanders. He exited near the end of the first quarter and was taken to the locker room to be evaluated for a concussion before being ruled out. The 24-year-old finishes this week with zero catches on one target. Ian Thomas will now take over as the Raiders' backup tight end behind superstar Brock Bowers.

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Cincinnati Bengals running back Samaje Perine (right thumb) has been ruled out for the remainder of Sunday's Week 3 contest against the Minnesota Vikings. He exited the contest late in the second quarter after fumbling the football. Cincinnati initially listed him as questionable before eventually downgrading him to out. He finishes Sunday's game with four carries, 21 rushing yards, four kick returns, 88 return yards, and the fumble. Tahj Brooks will operate as Chase Brown's backup until Perine is healthy again.

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Cincinnati Bengals RB Samaje Perine (thumb) suffered a thumb injury during the Week 3 game and will not return.

From TheHuddle

Seattle Seahawks wide receiver Jaxon Smith-Njigba (illness) is officially active for his team's Week 3 matchup against the New Orleans Saints. Smith-Njigba was a late addition to the team's injury report heading into Sunday due to an illness, but it appears he'll still be able to suit up. Smith-Njigba has 17 catches for 227 yards on 23 targets through his first two games of 2025. He may see a slightly reduced snap share if he's still under the weather. Still, Smith-Njigba is a must-start fantasy wide receiver in Week 3.

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The Dallas Cowboys have declared CB DaRon Bland, OT Ajani Cornelius, DT Jay Toia, LB Shemar James, RB Jaydon Blue, OG Trevor Keegan and LB Jadeveon Clowney inactive for Week 3.

From TheHuddle

The Chicago Bears have declared CB Jaylon Johnson, LB T.J. Edwards, OT Ozzy Trapilo, QB Case Keenum, LB D'Marco Jackson and CB Kyler Gordon inactive for Week 3.

From TheHuddle

Seattle Seahawks running back Zach Charbonnet (foot) has officially been ruled out for his team's Week 3 matchup against the New Orleans Saints. Charbonnet is the team's leader in rush attempts (27) heading into Week 3. His absence should mean a significant increase in workload for Seattle running back Kenneth Walker III. Walker III has a touchdown and 125 rushing yards so far this season, 105 of which came in Week 2 against the Pittsburgh Steelers. With Charbonnet officially inactive, Walker III is a must-start fantasy running back in Week 3.

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Los Angeles Chargers rookie wide receiver Keandre Lambert-Smith is a healthy scratch for his team's Week 3 matchup with the Denver Broncos, per The Athletic's Daniel Popper. Lambert-Smith has not recorded an NFL catch and saw just one target across the Chargers' first two games of 2025. He's currently buried on the Chargers depth chart at wide receiver behind Ladd McConkey, Keenan Allen, Quentin Johnston, Derius Davis, and fellow rookie Tre' Harris. Lambert-Smith should remain off the radar of fantasy managers in redraft leagues.

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The Denver Broncos have declared TE Evan Engram, DE Sai'vion Jones, QB Sam Ehlinger, OT Frank Crum, RB Jaleel McLaughlin and DE Que Robinson inactive for Week 3.

From TheHuddle

Minnesota Vikings DT Javon Hargrave (chest) suffered a chest injury during the Week 3 game and is considered questionable to return.

From TheHuddle

Las Vegas Raiders tight end Michael Mayer (head) is being evaluated for a head injury and is questionable to return to his team's Week 2 matchup against the Washington Commanders. Mayer had one target in the game before getting injured. If he is unable to return, it could mean an increase in snaps for star Las Vegas tight end Brock Bowers. Third-string Raiders tight end Ian Thomas could also step into Mayer's role, particularly as an in-line blocker.

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Washington Commanders quarterback Jayden Daniels (knee) has a ligament sprain that prevented him from playing Sunday against the Las Vegas Raiders, according to FOX's Jay Glazer. The sophomore quarterback is able to move forward, but the injury has hampered his ability to move side-to-side, according to Glazer. In the meantime, Washington will start veteran backup Marcus Mariota while Daniels recovers.

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The San Francisco 49ers officially ruled out quarterback Brock Purdy (shoulder, toe) from playing in Week 3 against the Arizona Cardinals. The Iowa State product was initially feared to be out for upwards of a month, but made a late push to return earlier than expected. In any case, the 49ers will exercise caution and keep Purdy out for at least another week. Mac Jones will earn another start in his absence.

From RotoBaller