Dallas Cowboys running back Jaydon Blue logged 11 offensive snaps in the Week 5 win over the New York Jets after not getting any action through the first four weeks. However, despite the increased involvement, the rookie ended Week 5 with only four carries for seven yards. With Miles Sanders (ankle, knee) now done for the remainder of the 2025 campaign, Blue will slide into the No. 2 spot on the depth chart behind Javonte Williams. Without question, Williams has had a fantastic year, meaning he'll likely continue to handle the bulk of the snaps out of the backfield. As a result, Blue shouldn't be much of a factor offensively in Week 6 versus the Panthers, so he can be left out of all fantasy lineups. That probably won't change moving ahead unless Williams goes down with an injury.

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Pittsburgh Steelers wide receiver Ben Skowronek (illness) was limited in practice earlier this week but carries no injury designation into a Week 6 showdown with the Cleveland Browns. Although the fifth-year pro has just one reception this season, he could be in line for additional opportunities on Sunday with Calvin Austin III (knee) sidelined. Scotty Miller and Roman Wilson may also step into expanded roles, but Skowronek logged the most snaps of the three in Week 4 before the team's bye. He's also the only one with any meaningful fantasy output this year, taking his lone catch into the end zone for a 22-yard score back in Week 1. With the Browns stifling the run through the first five weeks, quarterback Aaron Rodgers could be forced to throw the ball early and often. Skowronek can't be considered a viable option in most redraft formats, but he does have some sneaky appeal as a deep-league dart throw.

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Kansas City Chiefs wide receiver Marquise Brown will take on the Detroit Lions in Week 6. Brown has been a serviceable fantasy receiver this season, catching at least four passes or a touchdown in every game. In Week 5 against the Jacksonville Jaguars, Brown caught four of his eight targets for 48 yards. The 28-year-old has been a consistent possession receiver for Kansas City, but has lacked the explosive gains that the Chiefs turn to Xavier Worthy and Tyquan Thornton for. Despite not having any blowup games since Week 1, Brown could see a bump in production on Sunday night against Detroit. The Lions are the highest-scoring team in the league, and Kansas City will likely have to pass early and often to stay competitive. Worthy will be the focal point of the offense, but Brown could be a useful chain-mover in Week 6. Brown is ranked WR48 in our RotoBaller Half-PPR rankings, making him a deeper league flex option this week.

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Tennessee Titans tight end Chig Okonkwo was highly regarded by the fantasy community heading into the season. However, the 26-year-old hasn't lived up to expectations through the first five games of the 2025 campaign, catching 17 passes for 172 yards while failing to find the end zone. To be fair, Cam Ward hasn't played the best, resulting in below-average showings from Okonkwo and Calvin Ridley, among others. With Tennessee looking for a second-straight win, the team will head to Las Vegas for a meeting with the Raiders in Week 6. Although Okonkwo has a better chance of doing something meaningful for managers versus the struggling Raiders, his lack of production makes him hard to trust, even in multi-TE setups.

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Kansas City Chiefs wide receiver Xavier Worthy will face the Detroit Lions on Sunday night in Week 6. Worthy was listed as a DNP on Thursday after practicing in full on Wednesday, leaving his status for the weekend in doubt heading into Friday. The young receiver then logged a full practice on Friday and does not have an injury designation for Sunday night's game. Worthy had six catches for 42 yards in last week's 28-31 loss to the Jacksonville Jaguars. The speedster led the team in targets but finished fourth in yardage, averaging just 7.0 yards per reception. Worthy has been battling shoulder and ankle injuries, but has still been the team's WR1 in the absence of Rashee Rice. With Rice still suspended until Week 7, Worthy should lead the team in targets against Detroit. The Lions have scored the most points in the league this season, and the Chiefs will need to score often to keep up. In a game with a 52.5 O/U, Worthy should have plenty of opportunities to score fantasy points. Worthy is ranked WR11 in our RotoBaller Half-PPR rankings, making him an WR1 this week.

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Pittsburgh Steelers wide receiver DK Metcalf is fresh off a Week 5 bye and set to take on the Cleveland Browns in Week 6. Two weeks ago, Metcalf came through with his best showing yet in the black and gold, hanging 126 yards and a touchdown on the Minnesota Vikings. With fellow wideout Calvin Austin III (shoulder) inactive this week, Metcalf should command plenty of looks from quarterback Aaron Rodgers. While Cleveland's defense has been stout this season, it has surrendered seven touchdowns and the eighth-most fantasy points per game to opposing receivers. Even in a matchup that is projected to be low-scoring, Pittsburgh may need to air it out with the Browns shutting down the run through the first five weeks. Fantasy managers can confidently start Metcalf as a WR2 with a relatively high ceiling on Sunday.

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Tennessee Titans wide receiver Elic Ayomanor had a two-catch, 18-yard showing in the Week 5 meeting with the Arizona Cardinals. While that performance didn't sit well with fantasy managers, the rookie has played relatively well in an offense that's struggled throughout the 2025 campaign. In Ayomanor's first five games in the league, he's totaled 14 grabs (29 targets) for 169 yards. He also leads the team with two receiving touchdowns. With the Titans coming off their first win of the year, Tennessee will look to pick up another victory on Sunday against the Raiders. Without question, Las Vegas hasn't looked the best either, so Cam Ward and company have a chance to get something going on the offensive end. However, even with a favorable opportunity on the horizon, Ayomanor's lack of volume this season means he'll need to find the end zone, or fantasy managers will likely be extremely disappointed. With that in mind, the 22-year-old can be viewed as a desperation flex choice in 12-team leagues and up.

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Pittsburgh Steelers running back Kenneth Gainwell played incredibly well in Week 4 and will return from a bye to face the Cleveland Browns in Week 6. Though he should still be involved, the return of Jaylen Warren (knee) certainly puts a cap on Gainwell's upside. To make matters worse, Gainwell will need to overcome a Cleveland defense that has limited opposing backs to the third-fewest fantasy points per contest. Because he can contribute in the passing game, Gainwell isn't entirely touchdown-dependent, but it's difficult to expect another big performance. Fantasy managers should treat Gainwell as a low-end flex option that can be started in a pinch this week.

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Tennessee Titans wide receiver Tyler Lockett was once considered a top wideout in the National Football League. Unfortunately, it appears those days are well behind him. In his first five games as a Titan, he's caught only seven passes (16 targets) for 52 yards. While the veteran had his first touchdown of the year in Week 5 against the Cardinals, it wasn't as a pass-catcher. Instead, it came after a wild sequence of events that included a Cam Ward interception followed by a Dadrion Taylor-Demerson fumble. With the Titans coming off a win, their first of the 2025 campaign, the team will look for another victory on Sunday versus the Raiders. Like Tennessee, Las Vegas hasn't looked good throughout the season. With that in mind, despite the favorable matchup on tap, Lockett hasn't played well enough to be classified as a starting option in any fantasy format.

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Pittsburgh Steelers running back Jaylen Warren (knee) is set to return to action in Week 6 against the division-rival Cleveland Browns. Though Kenneth Gainwell impressed in Warren's absence, the latter is expected to reclaim RB1 duties immediately after practicing in full all week. Fantasy managers should keep expectations in check, however, as the Browns are allowing the fewest yards per carry and third-fewest fantasy points per game to opposing running backs. If Pittsburgh is forced to lean on the passing attack, Warren should remain involved as a key target for quarterback Aaron Rodgers, especially with Calvin Austin III (shoulder) sidelined. While this isn't the most appealing matchup, Warren still checks in as the RB26 in RotoBaller's half-PPR rankings and profiles as a high-end flex play in most formats.

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Kansas City Chiefs quarterback Patrick Mahomes will take on the Detroit Lions on Sunday night in Week 6. Mahomes completed 29 of 41 pass attempts (71%) for 318 yards and a touchdown in last week's loss to the Jacksonville Jaguars. Despite the loss, the Chiefs superstar set a new season-high for passing yards and completion percentage. Mahomes also rushed six times for 60 yards and a touchdown in Week 5. Kansas City's offense hasn't quite hit its stride, but Mahomes has still been valuable for fantasy. The 30-year-old has recorded at least 57 rushing yards and a rushing touchdown three times in five weeks, giving him a strong floor to go along with his passing production. Mahomes should continue being a valuable fantasy asset against the Lions, who have scored the most points in the league this season. The Sunday night matchup has the highest total of the week, meaning that Mahomes and the Chiefs will need to score a lot to keep up with Detroit. Mahomes is ranked QB4 in our RotoBaller rankings, making him a strong QB1 this week.

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Pittsburgh Steelers quarterback Aaron Rodgers is returning from a bye in Week 5 for an AFC North showdown against the Cleveland Browns on Sunday. Cleveland has been tough on opposing quarterbacks, holding the position to the sixth-fewest fantasy points per game. However, with the Browns even more dominant against the run, Pittsburgh may be forced to lean on Rodgers and the air attack despite Jaylen Warren's return. Though receiver Calvin Austin III (shoulder) has been ruled out, Rodgers could find success with his favorite target, DK Metcalf, after the two displayed strong chemistry in Week 4. Still, this contest is expected to be a low-scoring defensive battle, keeping Rodgers in the low-end QB2 range in superflex leagues.

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Dallas Cowboys quarterback Dak Prescott has been on another level lately. Over the last two games, Prescott has thrown for 556 yards with seven touchdowns and zero interceptions. He's missing his top wide receiver in CeeDee Lamb (ankle), but somehow is putting together fantastic numbers without him. Now, Prescott heads into a plus-matchup against the Carolina Panthers defense in Week 6. The 32-year-old has found a way to get it done without Lamb and he figures to do it again on Sunday. Fantasy managers should consider Prescott a top tier QB1 for this weekend

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Dallas Cowboys running back Javonte Williams has been one of the best backs in the league early in the season. The 25-year-old has found a new home in Dallas and appears to be earning himself a nice payday at the end of the season. Last week, Williams rushed 16 times for a season-high 135 yards with a touchdown in the win over the New York Jets. Williams has rushed for over 75 yards in four of the first five games this season. He remains an elite RB1 for the upcoming plus-matchup against the Carolina Panthers in Week 6.

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Tennessee Titans wide receiver Calvin Ridley finally was able to have success on the field during last week's game against the Arizona Cardinals. Ridley came into last week's game with three receptions for 57 yards over his last two games. The 30-year-old came out of nowhere and posted a huge performance in the win. Ridley hauled in five of his 10 targets for 131 yards, but was held out of the endzone. The hope is that Ridley and rookie quarterback Cam Ward continue building chemistry each week. Ridley has a plus matchup against the Las Vegas Raiders in Week 6. Fantasy managers should feel fine with plugging in Ridley as a WR3.

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Tennessee Titans running back Tony Pollard continues to be a solid contributor early in the season. Last week, Pollard rushed the ball 14 times for 67 yards and a touchdown in the win over the Arizona Cardinals. Pollard has rushed for 60 yards or more in four of his first five games of the season. The return of Tyjae Spears figures to slowly take away some of Pollard's value, but for now fantasy managers shouldn't be worried. Pollard has a plus matchup against the Las Vegas Raiders defense in Week 6. He should be able to offer low-end RB2 value for this weekend. Pollard continues succeeding, so the Titans are likely going to continue feeding him the ball.

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Las Vegas Raiders kicker Daniel Carlson remains a low-upside option for fantasy owners despite a potentially favorable Week 6 matchup against the Titans. The Raiders' offense has struggled to sustain drives, posting the league's second-highest turnover rate at 18.5%, and quarterback Geno Smith's inconsistency compounds Carlson's limited scoring opportunities. Even in games with red zone chances, the Raiders' inefficiency reduces Carlson's fantasy ceiling, making him a risky play. Until Las Vegas' offense becomes more consistent and turnover-prone plays are minimized, Carlson is unlikely to provide the reliable fantasy production owners hope for, and those with stronger options at the position should continue looking elsewhere for week-to-week stability.

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Tennessee Titans quarterback Cam Ward was able to have more success through the air during last week's game against the Arizona Cardinals. Ward completed 21-of-39 passing attempts for a career-high 265 passing yards with zero touchdowns and one interception in the win. The 23-year-old helped lead a fourth quarter comeback and finally started building chemistry with Calvin Ridley. Despite that, Ward hasn't done enough on the field to warrant starting even against the shaky Las Vegas Raiders defense in Week 6.

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San Francisco 49ers wide receiver Jauan Jennings (ankle) is currently listed as questionable ahead of the Week 6 matchup against the Tampa Bay Buccaneers. After missing last week's game, Jennings has been a limited participant in practice this week. It sounds like Jennings is trending towards being a game-time decision for Sunday's game. That's not exactly great news for fantasy managers with this game being a 4:25 pm ET kickoff this weekend. That means, fantasy managers will need to have another late afternoon option in case Jennings is unable to go. If active, Jennings should offer WR3 value with quarterback Mac Jones (oblique, knee) also questionable for this game.

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Miami Dolphins wide receiver Malik Washington had his busiest game of the season in Week 5 against the Panthers. He played about his normal amount of snaps but set a season-high with four catches on his five targets. He ended up with no yards on those four catches, but he did seem to get a little more work with Tyreek Hill (knee) unavailable for the first time this year. Washington has shown big-play ability in the return game, but he hasn't been able to get loose for any big receptions. He'll have a tough matchup this week against the Chargers, which is why he's only the WR57 in RotoBaller's rankings, but he does bring boom-or-bust potential if you need a deep league or DFS flier at receiver

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